References
- RenLLiuJGouKXingCCopy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysisJ Cancer20189122082209229937926
- WangAWangSZhuCCoffee and cancer risk: a meta-analysis of prospective observational studiesSci Rep201663371127665923
- TorreLABrayFSiegelRLFerlayJLortet-TieulentJJemalAGlobal cancer statistics, 2012CA Cancer J Clin20156528710825651787
- WangYHuangYXiangPTianWLncRNA expression and implication in osteosaroma: a systematic review and meta-analysisOncoTargets Ther20171053555361
- NaganoKHigashisakaKTsunodaSITsutsumiYDevelopment of a fundamental technology to seek drug targets, and its application to cancer targeting therapyYakugaku Zasshi2018138790390929962467
- HaoMFranqui-MachinRXuHNEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myelomaLeukemia20173171648165028400617
- HuangJSunSGHouSAberrant NEK2 expression might be an independent predictor for poor recurrence-free survival and overall survival of skin cutaneous melanomaEur Rev Med Pharmacol Sci201822123694370229949142
- FangYZhangXTargeting NEK2 as a promising therapeutic approach for cancer treatmentCell Cycle201615789590727019372
- PrigentCGloverDMGietRDrosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failureExp Cell Res2005303111315572022
- NaroCBarbagalloFChieffiPBourgeoisCFParonettoMPSetteCThe centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survivalNucleic Acids Res20144253218322724369428
- LeeJGollahonLMitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cellsCell Cycle201312233599361424091727
- Nuncia-CantareroMMartinez-CanalesSAndrés-PretelFSantpereGOcañaAGalan-MoyaEMFunctional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancerBreast Cancer Res Treat2018168361362329330624
- ZhaoDHanWLiuXCuiDChenYMicroRNA-128 promotes apoptosis in lung cancer by directly targeting NIMA-related kinase 2Thorac Cancer20178430431128514100
- TakahashiYIwayaTSawadaGUp-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancerAnn Surg Oncol201421120521224046120
- KochMWieseMGene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancerJ Cancer Res Clin Oncol2013139225926723052694
- KokuryoTSengaTYokoyamaYNek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.NEK2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinomaCancer Res200767209637964217942892
- ZengYRHanZDWangCOverexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancerBMC Urol201515909826320076
- FuLLiuSWangHLow expression of NEK2 is associated with hepatocellular carcinoma progression and poor prognosisCancer Biomark201720110110628759960
- NingZWangALiangJAbnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosisInt J Clin Exp Pathol2014752462246924966957
- LiGZhongYShenQNEK2 serves as a prognostic biomarker for hepatocellular carcinomaInt J Oncol201750240541328101574
- LiuHLiuBHouXOverexpression of NIMA-related kinase 2 is associated with poor prognoses in malignant gliomaJ Neurooncol2017132340941728321704
- ZhongXGuanXLiuWZhangLAberrant expression of NEK2 and its clinical significance in non-small cell lung cancerOncol Lett2014841470147625202351
- TakahashiYIwayaTSawadaGUp-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancerAnn Surg Oncol201421120521224046120
- ZhongXGuanXDongQYangSLiuWZhangLExamining Nek2 as a better proliferation marker in non-small cell lung cancer prognosisTumour Biol20143577155716224763826
- LuLZhaiXYuanRExamining Nek2 as a better proliferation marker in non-small cell lung cancer prognosisInt J Clin Exp Pathol20158154671547326823916
- WubetuGYMorineYTeraokuHHigh NEK2 expression is a predictor of tumor recurrence in hepatocellular carcinoma patients after hepatectomyAnticancer Res201636275776226851035
- ShiYXYinJYShenYZhangWZhouHHLiuZQGenome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancerSci Rep201771807228808310
- ZhangYWangWWangYNEK2 promotes hepatocellular carcinoma migration and invasion through modulation of the epithelial-mesenchymal transitionOncol Rep20183931023103329399700
- NealCPFryAMMoremanCOverexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survivalJ Surg Oncol2014110782883825043295
- GuZXiaJXuHNEK2 promotes aerobic glycolysis in multiple myeloma through regulating splicing of pyruvate kinaseJ Hematol Oncol2017101172828086949
- MarinaMSaavedraHINek2 and PIk4: prognostic markers, drivers of breast tumorigenesis and drug resistanceFront Biosci (Landmark Ed)20141935236524389189
- BarbagalloFParonettoMPFrancoRIncreased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomasJ Pathol2009217343144119023884
- CappelloPBlaserHGorriniCRole of Nek2 on centrosome duplication and aneuploidy in breast cancer cellsOncogene201433182375238423708664
- ChenCTianFLuLCharacterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunctionJ Cell Sci2015128203837330326471995
- Nuncia-CantareroMMartinez-CanalesSAndrés-PretelFSantpereGOcañaAGalan-MoyaEMFunctional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancerBreast Cancer Res Treat2018168361362329330624
- WangJChengPPavlyukovMSTargeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2J Clin Invest201712783075308928737508
- HaywardDGFryAMNek2 kinase in chromosome instability and cancerCancer Lett2006237215516616084011
- ZhaoDHanWLiuXCuiDChenYDeguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2Thorac Cancer20178432032728509438
- LaiXBNieYQHuangHLNIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationOncol Lett20171331587159428454295
- ZhangMXXuXMZhangPEffect of silencing NEK2 on biological behaviors of HepG2 in human hepatoma cells and MAPK signal pathwayTumour Biol20163722023203526337275
- TsunodaNKokuryoTOdaKNek2 as a novel molecular target for the treatment of breast carcinomaCancer Sci2009100111111619038001
- ZhouWYangYXiaJNEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancersCancer Cell2013231486223328480
- LiGZhongYShenQNEK2 serves as a prognostic biomarker for hepatocellular carcinomaInt J Oncol201750240541328101574