HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer

References

• SiegelRLMillerKDJemalACancer statistics, 2017CA Cancer J Clin201767173028055103
   PubMed Web of Science ®Google Scholar
• MillerKDSiegelRLLinCCCancer treatment and survivorship statistics, 2016CA Cancer J Clin201666427128927253694
   PubMed Web of Science ®Google Scholar
• ChenWZhengRBaadePDCancer statistics in China, 2015CA Cancer J Clin201666211513226808342
   PubMed Web of Science ®Google Scholar
• SteegPSTargeting metastasisNat Rev Cancer201616420121827009393
   PubMed Web of Science ®Google Scholar
• FidlerIJKripkeMLThe challenge of targeting metastasisCancer Metastasis Rev201534463564126328524
   PubMed Web of Science ®Google Scholar
• ValastyanSWeinbergRATumor metastasis: molecular insights and evolving paradigmsCell2011147227529222000009
   PubMed Web of Science ®Google Scholar
• TorreLABrayFSiegelRLFerlayJLortet-TieulentJJemalAGlobal cancer statistics, 2012CA Cancer J Clin20156528710825651787
   PubMed Web of Science ®Google Scholar
• HiranoTIshiharaKHibiMRoles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsOncogene200019212548255610851053
   PubMed Web of Science ®Google Scholar
• BrombergJFWrzeszczynskaMHDevganGStat3 as an oncogeneCell199998329530310458605
   PubMed Web of Science ®Google Scholar
• BuettnerRMoraLBJoveRActivated STAT signaling in human tumors provides novel molecular targets for therapeutic interventionClin Cancer Res20028494595411948098
   PubMed Web of Science ®Google Scholar
• FurtekSLBackosDSMathesonCJReiganPStrategies and approaches of targeting STAT3 for cancer treatmentACS Chem Biol201611230831826730496
   PubMed Web of Science ®Google Scholar
• YuSLiGWangZThe prognostic value of pSTAT3 in gastric cancer: a meta-analysisJ Cancer Res Clin Oncol2016142364965726233579
   PubMed Web of Science ®Google Scholar
• PanYMWangCGZhuMSTAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancerMol Cancer20161517927938379
   PubMedGoogle Scholar
• DengJYSunDLiuXYPanYLiangHSTAT-3 correlates with lymph node metastasis and cell survival in gastric cancerWorld J Gastroenterol201016425380538721072904
   PubMed Web of Science ®Google Scholar
• JuddLMBredinKKalantzisAJenkinsBJErnstMGiraudASSTAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesisGastroenterology200613141073108517030178
   PubMed Web of Science ®Google Scholar
• ChenHYangZDingCDiscovery of O-alkylamino tethered niclosamide derivatives as potent and orally bioavailable anticancer agentsACS Med Chem Lett20134218018523459613
   PubMed Web of Science ®Google Scholar
• WangYWangSWuYSuppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152Mol Cancer Ther201716457859028138036
   PubMed Web of Science ®Google Scholar
• KimEKChoiEJCompromised MAPK signaling in human diseases: an updateArch Toxicol201589686788225690731
   PubMed Web of Science ®Google Scholar
• BurottoMChiouVLLeeJMKohnECThe MAPK pathway across different malignancies: a new perspectiveCancer2014120223446345624948110
   PubMed Web of Science ®Google Scholar
• ScuteriAGalimbertiAMaggioniDRole of MAPKs in platinum-induced neuronal apoptosisNeurotoxicology200930231231919428505
   PubMed Web of Science ®Google Scholar
• ChangLKarinMMammalian MAP kinase signalling cascadesNature20014106824374011242034
   PubMed Web of Science ®Google Scholar
• ChenYRaoXHuangKJiangXWangHTengLFH535 inhibits proliferation and motility of colon cancer cells by targeting Wnt/β-catenin signaling pathwayJ Cancer20178163142315329158786
   PubMed Web of Science ®Google Scholar
• YeJFangLZhengHWEGO: a web tool for plotting GO annotationsNucleic Acids Res200634Web Server issueW293W29716845012
   PubMed Web of Science ®Google Scholar
• KanehisaMSatoYKawashimaMFurumichiMTanabeMKEGG as a reference resource for gene and protein annotationNucleic Acids Res201644D1D457D46226476454
   PubMed Web of Science ®Google Scholar
• LiYRogoffHAKeatesSSuppression of cancer relapse and metastasis by inhibiting cancer stemnessProc Natl Acad Sci USA201511261839184425605917
   PubMed Web of Science ®Google Scholar
• HuangSRegulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implicationsClin Cancer Res20071351362136617332277
   PubMed Web of Science ®Google Scholar
• BanerjeeKResatHConstitutive activation of STAT3 in breast cancer cells: a reviewInt J Cancer2016138112570257826559373
   PubMed Web of Science ®Google Scholar
• BourguignonLYEarleCWongGSpevakCCKruegerKStem cell marker (nanog) and Stat-3 signaling promote microRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cellsOncogene201231214916021685938
   PubMed Web of Science ®Google Scholar
• AnglesioMSGeorgeJKulbeHIL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancerClin Cancer Res20111782538254821343371
   PubMed Web of Science ®Google Scholar
• TakemotoSUshijimaKKawanoKExpression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinomaBr J Cancer2009101696797219638983
   PubMed Web of Science ®Google Scholar
• MoraLBBuettnerRSeigneJConstitutive activation of STAT3 in human prostate tumors and cell lines: direct inhibition of STAT3 signaling induces apoptosis of prostate cancer cellsCancer Res200262226659666612438264
   PubMed Web of Science ®Google Scholar
• XuYHLuSA meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancerEur J Surg Oncol201440331131724332948
   PubMed Web of Science ®Google Scholar
• KimEKChoiEJPathological roles of MAPK signaling pathways in human diseasesBiochim Biophys Acta20101802439640520079433
   PubMed Web of Science ®Google Scholar
• TemrazSMukherjiDShamseddineADual inhibition of MEK and PI3K pathway in KRAS and BRAF mutated colorectal cancersInt J Mol Sci2015169229762298826404261
   PubMed Web of Science ®Google Scholar
• GehringerMMuthFKochPLauferSAc-Jun N-terminal kinase inhibitors: a patent review (2010 – 2014)Expert Opin Ther Pat201525884987225991433
   PubMed Web of Science ®Google Scholar
• AstolfiAIraciNManfroniGBarrecaMLCecchettiVA comprehensive structural overview of p38α MAPK in complex with type I inhibitorsChem Med Chem201510695796926012502
   PubMedGoogle Scholar
• ChengYZhangGLiGTargeting MAPK pathway in melanoma therapyCancer Metastasis Rev2013323–456758423584575
   PubMed Web of Science ®Google Scholar
• ChengBMoralesLDZhangYMitoSTsinANiclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell linePLoS One2017129e018432428877265
   PubMed Web of Science ®Google Scholar
• FonsecaBDDieringGHBidinostiMAStructure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signalingJ Biol Chem201228721175301754522474287
   PubMed Web of Science ®Google Scholar
• PratherGRMacleanJAIIShiMBoaduDKPaquetMHayashiKNiclosamide as a potential nonsteroidal therapy for endometriosis that preserves reproductive function in an experimental mouse modelBiol Reprod20169547627535961
   PubMed Web of Science ®Google Scholar