Advanced search
Publication Cover
Cancer Management and Research Volume 11, 2019 - Issue
Submit an article Journal homepage
97
Views
11
CrossRef citations to date
0
Altmetric
Original Research

A novel 4-gene prognostic signature for hypermutated colorectal cancer

Weiting Ge1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
,
Wen Cai1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected];2 Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
,
Rui Bai1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
,
Wangxiong Hu1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
,
Dehao Wu1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected];2 Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
,
Shu Zheng1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]
&
Hanguang Hu1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected];2 Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, [email protected]Correspondence[email protected]
 show all
Pages 1985-1996 | Published online: 04 Mar 2019

References

  • WolfAMDFonthamETHChurchTRColorectal cancer screening for average-risk adults: 2018 guideline update from the American cancer SocietyCA Cancer J Clin201868425028129846947
  • AkbaniRAkdemirKCAksoyBAGenomic classification of cutaneous melanomaCell201516171681169626091043
  • GovindanRDingLGriffithMGenomic landscape of non-small cell lung cancer in smokers and never-smokersCell201215061121113422980976
  • Cancer Genome Atlas Research NetworkComprehensive molecular characterization of urothelial bladder carcinomaNature2014507749231532224476821
  • RehderDSNelsonRWBorgesCRGlycosylation status of vitamin D binding protein in cancer patientsProtein Sci200918102036204219642159
  • de La ChapelleAHampelHClinical relevance of microsatellite instability in colorectal cancerJ Clin Oncol201028203380338720516444
  • IonovYPeinadoMAMalkhosyanSShibataDPeruchoMUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisNature199336364295585618505985
  • AaltonenLAPeltomäkiPLeachFSClues to the pathogenesis of familial colorectal cancerScience199326051098128168484121
  • JiricnyJThe multifaceted mismatch-repair systemNat Rev Mol Cell Biol20067533534616612326
  • LeeVMurphyALeDTDiazLAMismatch repair deficiency and response to immune checkpoint blockadeOncologist201621101200121127412392
  • LeeSYChungHDevarajBMicrosatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasiasGastroenterology201013951519152520708618
  • CampbellBBLightNFabrizioDComprehensive analysis of hypermutation in human cancerCell201717151042105629056344
  • JoverRNguyenTPPérez-CarbonellL5-fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancerGastroenterology201114041174118121185836
  • WangKLiMHakonarsonHANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataNucleic Acids Res20103816e16420601685
  • SalipanteSJScrogginsSMHampelHLTurnerEHPritchardCCMicrosatellite instability detection by next generation sequencingClin Chem20146091192119924987110
  • Cancer Genome Atlas NetworkComprehensive molecular characterization of human colon and rectal cancerNature2012487740733033722810696
  • TianSRoepmanPPopoviciVA robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequencyJ Pathol2012228458659522926706
  • AroraSYanHChoIGenetic variants that predispose to DNA double-strand breaks in lymphocytes from a subset of patients with familial colorectal carcinomasGastroenterology201514971872188326344056
  • DudleyJCLinMTLeDTEshlemanJRMicrosatellite instability as a biomarker for PD-1 blockadeClin Cancer Res201622481382026880610
  • LaDPD-1 blockade in tumors with mismatch-repair deficiencyN Engl J Med2015373201979
  • ShoSCourtCMWinogradPRussellMMTomlinsonJSA prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancerJ Surg Oncol20171168996100428767131
  • DulakAMStojanovPPengSExome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexityNat Genet201345547848623525077
  • DobbsKDomínguez CondeCZhangSYInherited DOCK2 deficiency in patients with early-onset invasive infectionsN Engl J Med2015372252409242226083206
  • LiuZManSMZhuQDOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infectionSci Rep2016612781427291827
  • MiaoSZhangRYWangWOverexpression of dedicator of cytokinesis 2 correlates with good prognosis in colorectal cancer associated with more prominent CD8+ lymphocytes infiltration: a colorectal cancer analysisJ Cell Biochem2018119118962897030076747
  • RoutyBLe ChatelierEDerosaLGut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumorsScience20183596371919729097494
  • HamptonTGut microbes may shape response to cancer immunotherapyJAMA2018319543043129411013
  • HempenPMZhangLBansalRKEvidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancersCancer Res200363599499912615714
  • JungBDoctoleroRTTajimaALoss of activin receptor type 2 protein expression in microsatellite unstable colon cancersGastroenterology2004126365465914988818
  • LochheadPKuchibaAImamuraYMicrosatellite instability and BRAF mutation testing in colorectal cancer prognosticationJ Natl Cancer Inst2013105151151115623878352

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.