Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29. doi:10.3322/caac.2125425559415
   PubMed Web of Science ®Google Scholar
• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi:10.3322/caac.2133826808342
   PubMed Web of Science ®Google Scholar
• Dawood S, Austin L, Cristofanilli M. Cancer stem cells: implications for cancer therapy. Oncology (Williston Park). 2014;28(12):1101–7, 10.25510809
   PubMed Web of Science ®Google Scholar
• Yamashita T, Wang XW. Cancer stem cells in the development of liver cancer. J Clin Invest. 2013;123(5):1911–1918. doi:10.1172/JCI6602423635789
   PubMed Web of Science ®Google Scholar
• De Simone V, Franze E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015;34(27):3493–3503. doi:10.1038/onc.2014.28625174402
   PubMed Web of Science ®Google Scholar
• Don-Doncow N, Escobar Z, Johansson M, et al. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem. 2014;289(23):15969–15978. doi:10.1074/jbc.M114.56425224755219
   PubMed Web of Science ®Google Scholar
• Cui Y, Sun S, Ren K, et al. Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation. Oncol Rep. 2016;35(5):2952–2962. doi:10.3892/or.2016.463726935885
   PubMed Web of Science ®Google Scholar
• Kundu J, Choi BY, Jeong CH, Kundu JK, Chun KS. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and srcmediated phosphorylation of EGF receptor tyrosine kinase. Oncol Rep. 2014;32(2):821–828. doi:10.3892/or.2014.322324890449
   PubMed Web of Science ®Google Scholar
• Rokavec M, Oner MG, Li H, et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest. 2014;124(4):1853–1867. doi:10.1172/JCI7353124642471
   PubMed Web of Science ®Google Scholar
• Schroeder A, Herrmann A, Cherryholmes G, et al. Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res. 2014;74(4):1227–1237. doi:10.1158/0008-5472.CAN-13-059424177177
   PubMed Web of Science ®Google Scholar
• Zhang H, Cai K, Wang J, et al. MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway. Stem Cells. 2014;32(11):2858–2868. doi:10.1002/stem.179525070049
   PubMed Web of Science ®Google Scholar
• Wu C, Sun M, Liu L, Zhou GW. The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene. 2003;306:1–12.12657462
   PubMed Web of Science ®Google Scholar
• Fan LC, Shiau CW, Tai WT, et al. SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma. Oncogene. 2015;34(41):5252–5263. doi:10.1038/onc.2014.44525619838
   PubMed Web of Science ®Google Scholar
• Sun Z, Pan X, Zou Z, Ding Q, Wu G, Peng G. Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells. Radiat Oncol. 2015;10:152. doi:10.1186/s13014-015-0445-126215037
   PubMed Web of Science ®Google Scholar
• Lz W, Ding K, Zr W, et al. SHP-1 acts as a tumor suppressor in hepatocarcinogenesis and HCC progression. Cancer Res. 2018;78(16):4680–4691.doi:10.1158/0008-5472.
   Google Scholar
• Liu CY, Tseng LM, Su JC, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63. doi:10.1186/bcr345723938089
   PubMed Web of Science ®Google Scholar
• Tai WT, Shiau CW, Chen PJ, et al. Discovery of novel Src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma. Hepatology. 2014;59(1):190–201. doi:10.1002/hep.2664023908138
   PubMed Web of Science ®Google Scholar
• Chen YH, Yang ZS, Wen CC, et al. Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. Food Chem. 2012;134(2):717–724. doi:10.1016/j.foodchem.2012.02.16623107683
   PubMed Web of Science ®Google Scholar
• Gresa-Arribas N, Serratosa J, Saura J, Sola C. Inhibition of CCAAT/enhancer binding protein delta expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects. J Neurochem. 2010;115(2):526–536. doi:10.1111/j.1471-4159.2010.06952.x20722966
   PubMed Web of Science ®Google Scholar
• Kasala ER, Bodduluru LN, Madana RM, Gogoi R, Barua CC. Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. Toxicol Lett. 2015;233(2):214–225. doi:10.1016/j.toxlet.2015.01.00825596314
   PubMed Web of Science ®Google Scholar
• Kasala ER, Bodduluru LN, Barua CC, Gogoi R. Chrysin and its emerging role in cancer drug resistance. Chem Biol Interact. 2015;5(236):7–8. doi:10.1016/j.cbi.2015.04.017
   Google Scholar
• Xia Y, Lian S, Khoi PN, et al. Chrysin inhibits cell invasion by inhibition of recepteur d’origine nantais via suppressing early growth response-1 and NF-kappaB transcription factor activities in gastric cancer cells. Int J Oncol. 2015;46(4):1835–1843. doi:10.3892/ijo.2015.284725625479
   PubMed Web of Science ®Google Scholar
• Jia WZ, Zhao JC, Sun XL, Yao ZG, Wu HL, Xi ZQ. Additive anticancer effects of chrysin and low dose cisplatin in human malignant glioma cell (U87) proliferation and evaluation of the mechanistic pathway. JBUON. 2015;20(5):1327–1336.26537082
   PubMedGoogle Scholar
• Li X, Huang JM, Wang JN, Xiong XK, Yang XF, Zou F. Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53. Chem Biol Interact. 2015;232:12–20. doi:10.1016/j.cbi.2015.03.00325770930
   PubMed Web of Science ®Google Scholar
• Lirdprapamongkol K, Sakurai H, Abdelhamed S, et al. Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 2013;43(1):329–337. doi:10.3892/ijo.2013.192623636231
   PubMed Web of Science ®Google Scholar
• Li HZ, Chen YH, Fang YL, et al. Effects of chrysin on sphere formation and CK2alpha expression of ovarian cancer stem-like cells derived from SKOV3 cell line. Zhonghua Yi Xue Za Zhi. 2016;96(25):2013–2016. doi:10.3760/cma.j.issn.0376-2491.2016.25.01227470961
   PubMedGoogle Scholar
• Zheng X, Meng WD, Xu YY, Cao JG, Qing FL. Synthesis and anticancer effect of chrysin derivatives. Bioorg Med Chem Lett. 2003;13(5):881–884. doi:10.1016/S0960-894X(02)01081-812617913
   PubMed Web of Science ®Google Scholar
• Luo Y, Cui Y, Cao X, et al. 8-Bromo-7-methoxychrysin-blocked STAT3/Twist axis inhibits the stemness of cancer stem cell-like cell originated from SMMC-7721 cells. Acta Biochim Biophys Sin (Shanghai). 2017;49(5):458–464. doi:10.1093/abbs/gmx02528369327
   PubMed Web of Science ®Google Scholar
• Lim W, Ryu S, Bazer FW, Kim SM, Song G. Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. J Cell Physiol. 2018;233(4):3129–3140. doi:10.1002/jcp.2615028816359
   PubMed Web of Science ®Google Scholar
• Ryu S, Lim W, Bazer FW, Song G. Chrysin induces death of prostate cancer cells by inducing ROS and ER stress. J Cell Physiol. 2017;232(12):3786–3797. doi:10.1002/jcp.2586128213961
   PubMed Web of Science ®Google Scholar
• Xu D, Jin J, Yu H, et al. Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2. J Exp Clin Cancer Res. 2017;36(1):44. doi:10.1186/s13046-017-0514-428320429
   PubMedGoogle Scholar
• Zhang Q, Ma S, Liu B, Liu J, Zhu R, Li M. Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Exp Ther Med. 2016;12(1):469–474. doi:10.3892/etm.2016.328227347080
   PubMed Web of Science ®Google Scholar
• Abbaszadegan MR, Bagheri V, Razavi MS, Momtazi AA, Sahebkar A, Gholamin M. Isolation, identification, and characterization of cancer stem cells: a review. J Cell Physiol. 2017;232(8):2008–2018. doi:10.1002/jcp.2575928019667
   PubMed Web of Science ®Google Scholar
• Su JC, Chiang HC, Tseng PH, et al. RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells. Carcinogenesis. 2014;35(12):2807–2814. doi:10.1093/carcin/bgu21025322871
   PubMed Web of Science ®Google Scholar
• Lin CM, Shyu KG, Wang BW, Chang H, Chen YH, Chiu JH. Chrysin suppresses IL-6-induced angiogenesis via down-regulation of JAK1/STAT3 and VEGF: an in vitro and in ovo approach. J Agric Food Chem. 2010;58(11):7082–7087. doi:10.1021/jf100421w20443595
   PubMed Web of Science ®Google Scholar
• Su JC, Tseng PH, Hsu CY, et al. RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget. 2014;5(13):4909–4919. doi:10.18632/oncotarget.205424952874
   PubMedGoogle Scholar