Upfront whole brain radiotherapy for multiple brain metastases in patients with EGFR-mutant lung adenocarcinoma

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30. doi:10.3322/caac.2138728055103
   PubMed Web of Science ®Google Scholar
• Barnholtz-Sloan JS, Sloan AE, Davis FG, et al. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan detroit cancer surveillance system. J Clin Oncol. 2004;22:2865–2872. doi:10.1200/JCO.2004.12.14915254054
   PubMed Web of Science ®Google Scholar
• Nussbaum ES, Djalilian HR, Cho KH, et al. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer. 1996;78:1781–1788. 8859192
   PubMed Web of Science ®Google Scholar
• Shin D-Y, Na II, Kim CH, Park S, Baek H, Yang SH. EGFR mutation and brain metastasis in pulmonary adenocarcinomas. J Thorac Oncol. 2014;9:195–199. doi:10.1097/JTO.000000000000006924419416
   PubMed Web of Science ®Google Scholar
• Khuntia D, Brown P, Li J, Mehta MP. Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol. 2006;24:1295–1304. doi:10.1200/JCO.2005.04.618516525185
   PubMed Web of Science ®Google Scholar
• Chang EL, Wefel JS, Hess KR, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009;10:1037–1044. doi:10.1016/S1470-2045(09)70263-319801201
   PubMed Web of Science ®Google Scholar
• Kocher M, Soffietti R, Abacioglu U, et al. Adjuvant whole- brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol. 2011;29:134–141. doi:10.1200/JCO.2010.30.165521041710
   PubMed Web of Science ®Google Scholar
• Khozin S, Blumenthal GM, Jiang X, et al. U.S. food and drug administration approval summary: erlotinib for the first-line treatment of metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or exon 21 (L858R) substitution mutations. Oncologist. 2014;19:774–779. doi:10.1634/theoncologist.2014-008924868098
   PubMed Web of Science ®Google Scholar
• Zhang J, Yu J, Sun X, Meng X. Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of central nerve system metastases from non-small cell lung cancer. Cancer Lett. 2014;351:6–12. doi:10.1016/j.canlet.2014.04.01924861428
   PubMed Web of Science ®Google Scholar
• Zhang J, Shi X, Cai D, et al. MINI01.11: radiotherapy plus EGFR TKIs for brain metastasis in EGFR-mutant non-small cell lung cancer: a retrospective analysis of a single institution: topic: medical oncology. J Thorac Oncol. 2016;11:S263. doi:10.1016/j.jtho.2016.09.026
   Web of Science ®Google Scholar
• Jiang T, Min W, Li Y, Yue Z, Wu C, Zhou C. Radiotherapy plus EGFR TKIs in non‐small cell lung cancer patients with brain metastases: an update meta‐analysis. Cancer Med. 2016;5:1055–1065. doi:10.1002/cam4.67326990668
   PubMed Web of Science ®Google Scholar
• Chen Y, Yang J, Li X, et al. First-line epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor alone or with whole-brain radiotherapy for brain metastases in patients with EGFR-mutated lung adenocarcinoma. Cancer Sci. 2016;107:1800–1805. doi:10.1111/cas.1307927627582
   PubMed Web of Science ®Google Scholar
• Tsao MN, Rades D, Wirth A, et al. Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): an American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol. 2012;2:210–225. doi:10.1016/j.prro.2011.12.00425925626
   PubMedGoogle Scholar
• Yang W-C, Xiao F, Shih J-Y, et al. Epidermal growth factor receptor mutation predicts favorable outcomes in non-small cell lung cancer patients with brain metastases treated with stereotactic radiosurgery. Radiother Oncol. 2018;126:368–374. doi:10.1016/j.radonc.2017.10.01029111173
   PubMed Web of Science ®Google Scholar
• Magnuson WJ, Lester-Coll NH, Wu AJ, et al. Management of brain metastases in tyrosine kinase inhibitor-naive epidermal growth factor receptor-mutant non-small-cell lung cancer: a retrospective multi-institutional analysis. J Clin Oncol. 2017;35:1070–1077. doi:10.1200/JCO.2016.69.714428113019
   PubMed Web of Science ®Google Scholar
• Wilhelm I, Molnar J, Fazakas C, Haskó J, Krizbai IA. Role of the blood-brain barrier in the formation of brain metastases. Int J Mol Sci. 2013;14:1383–1411. doi:10.3390/ijms1401138323344048
   PubMed Web of Science ®Google Scholar
• Minchom A, Yu KC, Bhosle J, et al. The diagnosis and treatment of brain metastases in EGFR mutant lung cancer. J Clin Oncol. 2017;35:1070–1077. doi:10.1200/JCO.2016.69.714428113019
   PubMedGoogle Scholar
• Ceresoli GL, Cappuzzo F, Gregorc V, Bartolini S, Crinò L, Villa E. Gefitinib in patients with brain metastases from nonsmall-cell lung cancer: a prospective trial. Ann Oncol. 2004;15:1042–1047. doi:10.1093/annonc/mdh27615205197
   PubMed Web of Science ®Google Scholar
• Hotta K, Kiura K, Ueoka H, et al. Effect of gefitinib (‘Iressa’, ZD1839) on brain metastases in patients with advanced non-small-cell lung cancer. Lung Cancer. 2004;46:255–261. doi:10.1016/j.lungcan.2004.04.03615474674
   PubMed Web of Science ®Google Scholar
• Takahashi H, Ohrui T, Ebihara S, Yamada M, Sasaki H. Effect of gefitinib (ZD1839) on metastatic brain tumour. Lung Cancer. 2004;43:371–372. doi:10.1016/j.lungcan.2003.09.01715165100
   PubMed Web of Science ®Google Scholar
• Kim J-E, Lee DH, Choi Y, et al. Epidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasis. Lung Cancer. 2009;65:351–354. doi:10.1016/j.lungcan.2008.12.01119157632
   PubMed Web of Science ®Google Scholar
• Yi-Long W, Ahn M-J, Garassino MC, et al. CNS efficacy of osimertinib in patients with T790M-positive advanced non–small-cell lung cancer: data from a randomized phase III trial (AURA3). J Clin Oncol. 2018;36:2702–2709. doi:10.1200/JCO.2018.77.936330059262
   PubMedGoogle Scholar
• Cho BC, Chewaskulyong B, Lee KH, et al. Osimertinib versus standard of care EGFR TKI as first-line treatment in patients with EGFRm advanced NSCLC: FLAURA Asian subset. J Thorac Oncol. 2018;18:S1556-0864(18)33091–0.
   Google Scholar
• Aguiar PN Jr, Haaland B, Park W, et al. Cost-effectiveness of osimertinib in the first-line treatment of patients with EGFR-mutated advanced non-small cell lung cancer. JAMA Oncol. 2018;4:1080–1084. doi:10.1001/jamaoncol.2018.139529852038
   PubMed Web of Science ®Google Scholar
• Wu B, Gu X, Zhang Q. Cost-effectiveness of osimertinib for EGFR mutation–positive non–small cell lung cancer after progression following first-line EGFR TKI therapy. J Thorac Oncol. 2018;13:184–193. doi:10.1016/j.jtho.2017.10.01229101057
   PubMed Web of Science ®Google Scholar
• Sung S, Lee S-W, Kwak Y-K, et al. Intracranial control and survival outcome of tyrosine kinase inhibitor (TKI) alone versus TKI plus radiotherapy for brain metastasis of epidermal growth factor receptor-mutant non-small cell lung cancer. J Neurooncol. 2018;139:205–213. doi:10.1007/s11060-018-2861-129644484
   PubMed Web of Science ®Google Scholar
• Jiang T, Su C, Li X, et al. EGFR TKIs plus WBRT demonstrated no survival benefit other than that of TKIs alone in patients with NSCLC and EGFR mutation and brain metastases. J Thorac Oncol. 2016;11:1718–1728. doi:10.1016/j.jtho.2016.05.01327237825
   PubMed Web of Science ®Google Scholar
• Magnuson WJ, Yeung JT, Guillod PD, Gettinger SN, Yu JB, Chiang VL. Impact of deferring radiation therapy in patients with epidermal growth factor receptor-mutant non-small cell lung cancer who develop brain metastases. Int J Radiat Oncol Biol Phys. 2016;95:673–679. doi:10.1016/j.ijrobp.2016.01.03727034176
   PubMed Web of Science ®Google Scholar
• Chen Y, Wang M, Zhong W, Zhao J. Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis. Lung Cancer. 2013;82:313–318. doi:10.1016/j.lungcan.2013.08.01324011632
   PubMed Web of Science ®Google Scholar
• Chinnaiyan P, Huang S, Vallabhaneni G, et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 2005;65:3328–3335. doi:10.1158/0008-5472.CAN-04-354715833866
   PubMed Web of Science ®Google Scholar
• Bianco C, Tortora G, Bianco R, et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res. 2002;8:3250–3258. 12374696
   PubMed Web of Science ®Google Scholar
• Huang SM, Li J, Armstrong EA, et al. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res. 2002;62:4300–4306. 12154033
   PubMed Web of Science ®Google Scholar
• d’Avella D, Cicciarello R, Albiero F, et al. Quantitative study of blood-brain barrier permeability changes after experimental whole-brain radiation. Neurosurgery. 1992;30:30–34. 1738452
   PubMed Web of Science ®Google Scholar
• Qin D, Ma J, Xiao J, et al. Effect of brain irradiation on blood-CSF barrier permeability of chemotherapeutic agents. Am J Clin Oncol. 1997;20:263–265. 9167750
   PubMed Web of Science ®Google Scholar
• Qin DX, Zheng R, Tang J, et al. Influence of radiation on the blood-brain barrier and optimum time of chemotherapy. Int J Radiat Oncol Biol Phys. 1990;19:1507–1510. 2262373
   PubMed Web of Science ®Google Scholar
• Zhou L, He J, Xiong W, et al. Impact of whole brain radiation therapy on CSF penetration ability of Icotinib in EGFR-mutated non-small cell lung cancer patients with brain metastases: results of phase I dose-escalation study. Lung Cancer. 2016;96:93–100. doi:10.1016/j.lungcan.2016.04.00327133757
   PubMed Web of Science ®Google Scholar
• Cao Y, Tsien CI, Shen Z, et al. Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy. J Clin Oncol. 2005;23:4127–4136. doi:10.1200/JCO.2005.07.14415961760
   PubMed Web of Science ®Google Scholar
• Sperduto PW, Kased N, Roberge D, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 2012;30:419–425. doi:10.1200/JCO.2011.38.052722203767
   PubMed Web of Science ®Google Scholar
• Mulvenna P, Nankivell M, Barton R, et al. Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Lancet. 2016;388:2004–2014. doi:10.1016/S0140-6736(16)30825-X27604504
   PubMed Web of Science ®Google Scholar