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Original Research

The systemic inflammation response index predicts survival and recurrence in patients with resectable pancreatic ductal adenocarcinoma

Shuo Li1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Huaxiang Xu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Wenquan Wang1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Heli Gao1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Hao Li1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Shirong Zhang1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Jinzhi Xu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Wuhu Zhang1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
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Shuaishuai Xu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Tianjiao Li1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Quanxing Ni1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Xianjun Yu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
,
Chuntao Wu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Liang Liu1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China;3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, People’s Republic of China;4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, People’s Republic of China
 show all
Pages 3327-3337 | Published online: 17 Apr 2019

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi:10.3322/caac.2144229313949
  • Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi:10.3322/caac.2133826808342
  • Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet (London, England). 2016;388(10039):73–85. doi:10.1016/S0140-6736(16)00141-0
  • Crusz SM, Balkwill FR. Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol. 2015;12(10):584–596. doi:10.1038/nrclinonc.2015.10526122183
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.01321376230
  • Viers BR, Boorjian SA, Frank I, et al. Pretreatment neutrophil-to-lymphocyte ratio is associated with advanced pathologic tumor stage and increased cancer-specific mortality among patients with urothelial carcinoma of the bladder undergoing radical cystectomy. Eur Urol. 2014;66(6):1157–1164. doi:10.1016/j.eururo.2014.02.04224630414
  • Grilz E, Posch F, Konigsbrugge O, et al. Association of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with the risk of thromboembolism and mortality in patients with cancer. Thromb Haemost. 2018;118(11):1875–1884. doi:10.1055/s-0038-167340130296815
  • Pinato DJ, North BV, Sharma R. A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI). Br J Cancer. 2012;106(8):1439–1445. doi:10.1038/bjc.2012.9222433965
  • Hu B, Yang X-R, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212–6222. doi:10.1158/1078-0432.CCR-14-044225271081
  • Qi Q, Zhuang L, Shen Y, et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158–2167. doi:10.1002/cncr.3005727152949
  • Geng Y, Zhu D, Wu C, et al. A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma. Int Immunopharmacol. 2018;65:503–510. doi:10.1016/j.intimp.2018.10.00230408627
  • Li S, Lan X, Gao H, et al. Systemic Inflammation Response Index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection. J Cancer Res Clin Oncol. 2017;143(12):2455–2468. doi:10.1007/s00432-017-2506-328828692
  • Chen Y, Jiang W, Xi D, et al. Development and validation of nomogram based on SIRI for predicting the clinical outcome in patients with nasopharyngeal carcinomas. J Investig Med. 2019;67(3):691–698. doi:10.1136/jim-2018-000801
  • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444. doi:10.1038/nature0720518650914
  • Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 2003;6(4):283–287. doi:10.1023/B:AGEN.0000029415.62384.ba15166496
  • Muller I, Munder M, Kropf P, Hansch GM. Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms? Trends Immunol. 2009;30(11):522–530. doi:10.1016/j.it.2009.07.00719775938
  • Galdiero MR, Garlanda C, Jaillon S, Marone G, Mantovani A. Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol. 2013;228(7):1404–1412. doi:10.1002/jcp.2426023065796
  • Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 2006;25(3):315–322. doi:10.1007/s10555-006-9001-716967326
  • Ferrone C, Dranoff G. Dual roles for immunity in gastrointestinal cancers. J Clin Oncol. 2010;28(26):4045–4051. doi:10.1200/JCO.2010.27.999220644090
  • Cheng H, Luo G, Lu Y, et al. The combination of systemic inflammation-based marker NLR and circulating regulatory T cells predicts the prognosis of resectable pancreatic cancer patients. Pancreatology. 2016;16(6):1080–1084. doi:10.1016/j.pan.2016.09.00727665172
  • Diem S, Schmid S, Krapf M, et al. Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab. Lung Cancer. 2017;111:176–181. doi:10.1016/j.lungcan.2017.07.02428838390
  • Ferrucci PF, Gandini S, Battaglia A, et al. Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab-treated metastatic melanoma patients. Br J Cancer. 2015;112(12):1904–1910. doi:10.1038/bjc.2015.18026010413
  • Hasegawa S, Eguchi H, Tomokuni A, et al. Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer. Oncol Lett. 2016;11(2):1560–1566. doi:10.3892/ol.2015.405726893780
  • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg (Chicago, IL: 1960). 1985;120(8):899–903.
  • Klinkenbijl JH, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999;230(6):776–782, discussion 782–774.
  • Neoptolemos JP, Dunn JA, Stocken DD, et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. Lancet (London, England). 2001;358(9293):1576–1585.
  • Knoop RF, Sparn M, Waldmann J, et al. Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Neoplasia (New York, NY). 2014;16(6):463–470. doi:10.1016/j.neo.2014.05.010

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