Small RNA sequencing reveals a novel tsRNA-26576 mediating tumorigenesis of breast cancer

References

• Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74.15761078
   PubMed Web of Science ®Google Scholar
• Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, Mcguire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177. doi:10.1126/science.37981063798106
   PubMed Web of Science ®Google Scholar
• Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989;41(2):219–219.
   Google Scholar
• Veer LJVT, Dai H, Vijver MJVD, et al. Gene expression profiling predicts clinical outcome of breast cancer. nature. 2002;415(6871):530.11823860
   PubMed Web of Science ®Google Scholar
• Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res. 2018;13(15 Pt 1):4429–4434.
   Google Scholar
• Lee YS, Shibata Y, Malhotra A, Dutta A. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes Dev. 2009;23(22):2639–2649. doi:10.1101/gad.183760919933153
   PubMed Web of Science ®Google Scholar
• Venkatesh T, Suresh PS, Tsutsumi RJG. tRFs: miRNAs in disguise. Gene. 2016;579(2):133–138.26743126
   PubMed Web of Science ®Google Scholar
• Canella D, Praz V, Reina JH, Cousin P, Hernandez NJGR. Defining the RNA polymerase III transcriptome: genome-wide localization of the RNA polymerase III transcription machinery in human cells. Genome Res. 2010;20(6):710.20413673
   PubMed Web of Science ®Google Scholar
• Haussecker D, Huang YA, Parameswaran P, Fire AZ, Kay MAJR. Human tRNA-derived small RNAs in the global regulation of RNA silencing. Rna. 2010;16(4):673–695. doi:10.1261/rna.200081020181738
   PubMed Web of Science ®Google Scholar
• Fu H, Feng J, Liu Q, et al. Stress induces tRNA cleavage by angiogenin in mammalian cells. FEBS Lett. 2009;583(2):437–442. doi:10.1016/j.febslet.2008.12.04319114040
   PubMed Web of Science ®Google Scholar
• Cole C, Sobala A, Lu C, et al. Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. Rna. 2009;15(12):2147–2160. doi:10.1261/rna.173840919850906
   PubMed Web of Science ®Google Scholar
• Thompson DM, Parker R. Stressing out over tRNA cleavage. Cell. 2009;138(2):215–219. doi:10.1016/j.cell.2009.07.00119632169
   PubMed Web of Science ®Google Scholar
• Gebetsberger J, Polacek N. Slicing tRNAs to boost functional ncRNA diversity. RNA Biol. 2013;10(12):1798–1806. doi:10.4161/rna.2717724351723
   PubMed Web of Science ®Google Scholar
• Bahrami A, Aledavood A, Anvari K, et al. The prognostic and therapeutic application of microRNAs in breast cancer: tissue and circulating microRNAs. J Cell Physiol. 2017;233:2.
   Web of Science ®Google Scholar
• Nassar FJ, Nasr R, Talhouk RJPT. MicroRNAs as biomarkers for early breast cancer diagnosis, prognosis and therapy prediction. Pharmacol Therapeut. 2017;172:34–49. doi:10.1016/j.pharmthera.2016.11.012
   PubMed Web of Science ®Google Scholar
• Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer. 2005;65(16):7065.
   Web of Science ®Google Scholar
• Zhang L, Huang J, Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A. 2006;103(24):9136–9141. doi:10.1073/pnas.050888910316754881
   PubMed Web of Science ®Google Scholar
• *
   Google Scholar
• Blenkiron C, Goldstein LD, Thorne NP, et al. MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Res. 2007;8(10):1–16.
   Google Scholar
• Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci. 2006;103:2257–2261. doi:10.1073/pnas.051056510316461460
   PubMed Web of Science ®Google Scholar
• Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006;9(3):189–198. doi:10.1016/j.ccr.2006.01.02516530703
   PubMed Web of Science ®Google Scholar
• Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131(6):1109–1123. doi:10.1016/j.cell.2007.10.05418083101
   PubMed Web of Science ®Google Scholar
• Balatti V, Pekarsky Y, Croce CM. Role of the tRNA-derived small RNAs in cancer: new potential biomarkers and target for therapy. Adv Cancer Res 2017;135:173.
   Google Scholar
• Balatti V, Nigita G, Veneziano D, et al. tsRNA signatures in cancer. Proc Natl Acad Sci. 2017;114(30):201706908.
   Web of Science ®Google Scholar
• Maute RL, Christof S, Pavel S, et al. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci. 2013;110(4):1404–1409.23297232
   PubMed Web of Science ®Google Scholar
• Légaré S, Cavallone L, Mamo A, et al. The Estrogen receptor cofactor SPEN functions as a tumor suppressor and candidate biomarker of drug responsiveness in hormone-dependent breast cancers. Cancer Res. 2015;75(20):4351–4363. doi:10.1158/0008-5472.CAN-14-347526297734
   PubMed Web of Science ®Google Scholar
• Légaré S, Chabot C, Basik M. SPEN, a new player in primary cilia formation and cell migration in breast cancer. Breast Cancer Res 2017;19(1):104.
   Google Scholar
• Hou L, Chen M, Zhao X, et al. FAT4 functions as a tumor suppressor in triple-negative breast cancer. Tumour Biol 2016;1–7.
   Google Scholar
• Katoh M. Function and cancer genomics of FAT family genes (review). Int J Oncol. 2012;41(6):1913–1918. doi:10.3892/ijo.2012.166923076869
   PubMed Web of Science ®Google Scholar
• Katoh Y, Katoh M. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Int J Mol Med. 2006;18(3):523–528.16865240
   PubMed Web of Science ®Google Scholar
• Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6(11):857–866. doi:10.1038/nrc199717060945
   PubMed Web of Science ®Google Scholar
• Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597–610. doi:10.1038/nrg284320661255
   PubMed Web of Science ®Google Scholar
• Goodarzi H, Liu X, Nguyen HC, Zhang S, Fish L, Tavazoie SF. Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement. Cell. 2015;161(4):790–802. doi:10.1016/j.cell.2015.02.05325957686
   PubMed Web of Science ®Google Scholar
• Müller V, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res. 2005;16(4):331–332.
   Google Scholar
• Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016;13(11):674.27184417
   PubMed Web of Science ®Google Scholar