Impact of high-mobility-group A2 overexpression on epithelial-mesenchymal transition in pancreatic cancer

References

• Kim DH, Xing T, Yang Z, Dudek R, Lu Q, Chen YH. Epithelial mesenchymal transition in embryonic development, tissue repair and cancer: a comprehensive overview. J Clin Med. 2017;7:1.
   Web of Science ®Google Scholar
• Creighton CJ, Gibbons DL, Kurie JM. The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res. 2013;5:187–195. doi:10.2147/CMAR.S3517123986650
   PubMedGoogle Scholar
• Bendinelli P, Maroni P, Matteucci E, Desiderio MA. Hgf and tgfbeta1 differently influenced wwox regulatory function on twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells. Mol Cancer. 2015;14:112. doi:10.1186/s12943-014-0278-926041563
   PubMed Web of Science ®Google Scholar
• Wang KH, Kao AP, Chang CC, Lin TC, Kuo TC. Bisphenol a-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells. Reprod Toxicol. 2015;58:229–233. doi:10.1016/j.reprotox.2015.10.01126546977
   PubMed Web of Science ®Google Scholar
• Fujikane R, Komori K, Sekiguchi M, Hidaka M. Function of high-mobility group a proteins in the dna damage signaling for the induction of apoptosis. Sci Rep. 2016;6:31714. doi:10.1038/srep3171427538817
   PubMed Web of Science ®Google Scholar
• Chen B, Young J, Leng F. Dna bending by the mammalian high-mobility group protein at hook 2. Biochemistry. 2010;49:1590–1595. doi:10.1021/bi901881c20108983
   PubMed Web of Science ®Google Scholar
• Li O, Li J, Droge P. Dna architectural factor and proto-oncogene hmga2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett. 2007;581:3533–3537. doi:10.1016/j.febslet.2007.06.07217624332
   PubMed Web of Science ®Google Scholar
• Morishita A, Zaidi MR, Mitoro A, et al. Hmga2 is a driver of tumor metastasis. Cancer Res. 2013;73:4289–4299. doi:10.1158/0008-5472.CAN-12-384823722545
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang S, Shan J, et al. Elevated hmga2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer. Cancer Lett. 2016;376:284–292. doi:10.1016/j.canlet.2016.04.00527063096
   PubMed Web of Science ®Google Scholar
• Wu J, Lai M, Shao C, Wang J, Wei JJ. Stc2 overexpression mediated by hmga2 is a biomarker for aggressiveness of high-grade serous ovarian cancer. Oncol Rep. 2015;34:1494–1502. doi:10.3892/or.2015.412026165228
   PubMed Web of Science ®Google Scholar
• Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M. Clinical significance of high mobility group a2 in human gastric cancer and its relationship to let-7 microrna family. Clin Cancer Res. 2008;14:2334–2340. doi:10.1158/1078-0432.CCR-07-466718413822
   PubMed Web of Science ®Google Scholar
• Wang X, Liu X, Li AY, et al. Overexpression of hmga2 promotes metastasis and impacts survival of colorectal cancers. Clin Cancer Res. 2011;17:2570–2580. doi:10.1158/1078-0432.CCR-10-254221252160
   PubMed Web of Science ®Google Scholar
• Guo X, Shi J, Wen Y, et al. Increased high-mobility group a2 correlates with lymph node metastasis and prognosis of non-small cell lung cancer. Cancer Biomark. 2018;21:547–555. doi:10.3233/CBM-17040129278873
   PubMed Web of Science ®Google Scholar
• Strell C, Norberg KJ, Mezheyeuski A, et al. Stroma-regulated hmga2 is an independent prognostic marker in pdac and aac. Br J Cancer. 2017;117:65–77. doi:10.1038/bjc.2017.14028524160
   PubMed Web of Science ®Google Scholar
• Chen D, Hu C, Wen G, Yang Q, Zhang C, Yang H. Downregulated sox4 expression suppresses cell proliferation, migration, and induces apoptosis in osteosarcoma in vitro and in vivo. Calcif Tissue Int. 2018;102:117–127. doi:10.1007/s00223-017-0340-x29038881
   PubMed Web of Science ®Google Scholar
• Nishiyama M, Tsunedomi R, Yoshimura K, et al. Metastatic ability and the epithelial-mesenchymal transition in induced cancer stem-like hepatoma cells. Cancer Sci. 2018. doi:10.1111/cas.13527
   Google Scholar
• Campbell K, Lebreton G, Franch-Marro X, Casanova J. Differential roles of the drosophila emt-inducing transcription factors snail and serpent in driving primary tumour growth. PLoS Genet. 2018;14:e1007167. doi:10.1371/journal.pgen.100766429420531
   PubMed Web of Science ®Google Scholar
• Krebs AM, Mitschke J, Lasierra LM, et al. The emt-activator zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol. 2017;19:518–529. doi:10.1038/ncb351328414315
   PubMed Web of Science ®Google Scholar
• Kou B, Liu W, Tang X, Kou Q. Hmga2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the tgf-beta/smad2 signaling pathway. Oncol Rep. 2018;39:101–108. doi:10.3892/or.2017.609129138866
   PubMed Web of Science ®Google Scholar
• Li W, Wang Z, Zha L, Kong D, Liao G, Li H. Hmga2 regulates epithelial-mesenchymal transition and the acquisition of tumor stem cell properties through twist1 in gastric cancer. Oncol Rep. 2017;37:185–192. doi:10.3892/or.2016.525527878307
   PubMed Web of Science ®Google Scholar
• Xia YY, Yin L, Tian H, et al. Hmga2 is associated with epithelial-mesenchymal transition and can predict poor prognosis in nasopharyngeal carcinoma. OncoTargets Ther. 2015;8:169–176. doi:10.2147/OTT.S74397
   PubMed Web of Science ®Google Scholar
• Piscuoglio S, Zlobec I, Pallante P, et al. Hmga1 and hmga2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma. Histopathology. 2012;60:397–404. doi:10.1111/j.1365-2559.2011.04121.x22276603
   PubMed Web of Science ®Google Scholar
• Cano CE, Motoo Y, Iovanna JL. Epithelial-to-mesenchymal transition in pancreatic adenocarcinoma. ScientificWorldJournal. 2010;10:1947–1957. doi:10.1100/tsw.2010.18320890584
   PubMedGoogle Scholar
• Liu H, Wang H, Liu X, Yu T. Mir-1271 inhibits migration, invasion and epithelial-mesenchymal transition by targeting zeb1 and twist1 in pancreatic cancer cells. Biochem Biophys Res Commun. 2016;472:346–352. doi:10.1016/j.bbrc.2016.02.09626940738
   PubMed Web of Science ®Google Scholar
• Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y, Nakao M. Hmga2 maintains oncogenic ras-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol. 2009;174:854–868. doi:10.2353/ajpath.2009.08052319179606
   PubMed Web of Science ®Google Scholar