LAPTM4B facilitates tumor growth and induces autophagy in hepatocellular carcinoma

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi:10.3322/caac.2144229313949
   PubMed Web of Science ®Google Scholar
• Hoshida Y. Molecular epidemiology of hepatocellular carcinoma. Clin liver dis. 2012;1(6):177–179.
   Google Scholar
• Lafaro KJ, Demirjian AN, Pawlik TM. Epidemiology of hepatocellular carcinoma. Surg Oncol Clin N Am. 2015;24(1):1–17.25444466
   PubMed Web of Science ®Google Scholar
• Liu XR, Zhou RL, Zhang QY, et al. Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. World J Gastroenterol. 2004;10(11):1555–1559.15162524
   PubMed Web of Science ®Google Scholar
• Kasper G, Vogel A, Klaman I, et al. The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. Cancer Lett. 2005;224(1):93–103.15911104
   PubMed Web of Science ®Google Scholar
• Yang H, Xiong F, Wei X, Yang Y, McNutt MA, Zhou R. Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 2010;294(2):236–244.20202745
   PubMed Web of Science ®Google Scholar
• Xie CR, Wang F, Zhang S, et al. Long noncoding RNA HCAL facilitates the growth and metastasis of hepatocellular carcinoma by acting as a ceRNA of LAPTM4B. Mol Ther Nucleic Acids. 2017;9:440–451.29246322
   PubMedGoogle Scholar
• Li L, Wei XH, Pan YP, et al. LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling. Oncogene. 2010;29(43):5785–5795.20711237
   PubMed Web of Science ®Google Scholar
• White E, Mehnert JM, Chan CS. Autophagy, metabolism, and cancer. Clin Cancer Res. 2015;21(22):5037–5046.26567363
   PubMed Web of Science ®Google Scholar
• Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol. 2007;9(10):1102–1109. doi:10.1038/ncb1007-110217909521
   PubMed Web of Science ®Google Scholar
• Doria A, Gatto M, Punzi L. Autophagy in human health and disease. N Engl J Med. 2013;368(19):1845.
   PubMed Web of Science ®Google Scholar
• Yang S, Wang X, Contino G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011;25(7):717–729.21406549
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang Q, Tian R, et al. Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res. 2011;71(24):7481–7489.22037872
   PubMed Web of Science ®Google Scholar
• Wang K, Lim HY, Shi S, et al. Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma. Hepatology. 2013;58(2):706–717.23505090
   PubMed Web of Science ®Google Scholar
• Li Y, Zou L, Li Q, et al. Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med. 2010;16(2):214–218.20098429
   PubMed Web of Science ®Google Scholar
• Zhang M, Xu JJ, Zhou RL, Zhang QY. cAMP responsive element binding protein-1 is a transcription factor of lysosomal-associated protein transmembrane-4 beta in human breast cancer cells. PLoS One. 2013;8(2):e57520.23469012
   PubMed Web of Science ®Google Scholar
• Meng Y, Wang L, Chen D, et al. LAPTM4B: an oncogene in various solid tumors and its functions. Oncogene. 2016;35(50):6359–6365.27212036
   PubMed Web of Science ®Google Scholar
• Meng Y, Wang L, Xu J, Zhang Q. AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity. Mol Oncol. 2018;12(3):373–390.29337428
   PubMed Web of Science ®Google Scholar
• Zhang H, Qi S, Zhang T, et al. miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression. Oncotarget. 2015;6(8):6092–6104.25714029
   PubMedGoogle Scholar
• Zhou L, He XD, Yu JC, et al. Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro. Am J Surg. 2010;199(4):515–521.19954766
   PubMed Web of Science ®Google Scholar
• Zhou L, He XD, Cui QC, et al. Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma. Cancer Lett. 2008;264(2):209–217.18334282
   PubMed Web of Science ®Google Scholar
• Yang H, Xiong FX, Lin M, Yang Y, Nie X, Zhou RL. LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2010;136(2):275–281.19690886
   PubMed Web of Science ®Google Scholar
• Yang Y, Yang H, McNutt MA, et al. LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep. 2008;20(5):1077–1083.18949404
   PubMed Web of Science ®Google Scholar
• Brech A, Ahlquist T, Lothe RA, Stenmark H. Autophagy in tumour suppression and promotion. Mol Oncol. 2009;3(4):366–375.19559660
   PubMed Web of Science ®Google Scholar
• Shao GZ, Zhou RL, Zhang QY, et al. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Oncogene. 2003;22(32):5060–5069.12902989
   PubMed Web of Science ®Google Scholar
• Vergarajauregui S, Martina JA, Puertollano R. LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV. J Cell Sci. 2011;124(Pt 3):459–468.21224396
   PubMed Web of Science ®Google Scholar
• Tan X, Thapa N, Sun Y, Anderson RA. A kinase-independent role for EGF receptor in autophagy initiation. Cell. 2015;160(1–2):145–160.25594178
   PubMed Web of Science ®Google Scholar
• Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell. 2010;40(2):280–293.20965422
   PubMed Web of Science ®Google Scholar
• Maki Y, Fujimoto J, Lang W, et al. LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells. Sci Rep. 2015;5:13846.26343532
   PubMed Web of Science ®Google Scholar