64
Views
7
CrossRef citations to date
0
Altmetric
Original Research

Whole-brain helical tomotherapy with integrated boost for brain metastases in patients with malignant melanoma – final results of the BRAIN-RT trial

, , , , , , & show all
Pages 4669-4676 | Published online: 24 May 2019

References

  • Karimkhani C, Green AC, Nijsten T, et al. The global burden of melanoma: results from the Global Burden of Disease Study 2015. Br J Dermatol. 2017;177(1):134–140.28369739
  • Samlowski WE, Moon J, Witter M, et al. High frequency of brain metastases after adjuvant therapy for high-risk melanoma. Cancer Med. 2017;6(11):2576–2585. doi:10.1002/cam4.122328994212
  • Patel JK, Didolkar MS, Prickren JW, Moore RH. Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. Am J Surg. 1978;135(6):807–810. doi:10.1016/0002-9610(78)90171-X665907
  • Fife KM, Colman MH, Stevens GN, et al. Determinants of outcome in melanoma patients with cerebral metastases. J Clin Oncol. 2004;22(7):1293–1300. doi:10.1200/JCO.2004.08.14015051777
  • Hauswald H, Dittmar JO, Habermehl D, et al. Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma. Radiat Oncol. 2012;7:130. doi:10.1186/1748-717X-7-13022857154
  • Gabani P, Fischer-Valuck BW, Johanns TM, et al. Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: patterns of care and treatment outcomes. Radiother Oncol. 2018;128(2):266–273. doi:10.1016/j.radonc.2018.06.01729960685
  • Kluger HM, Chiang V, Mahajan A, et al. Long-term survival of patients with melanoma with active brain metastases treated with pembrolizumab on a Phase II trial. J Clin Oncol. 2019;37(1):52–60. doi:10.1200/JCO.18.0161630407895
  • Tawbi HA, Forsyth PA, Algazi A, et al. Combined nivolumab and ipilimumab in melanoma metastatic to the brain. N Engl J Med. 2018;379(8):722–730. doi:10.1056/NEJMoa180545330134131
  • Long GV, Trefzer U, Davies MA, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol. 2012;13(11):1087–1095. doi:10.1016/S1470-2045(12)70140-723051966
  • Gondi V, Paulus R, Bruner DW, et al. Decline in tested and self-reported cognitive functioning after prophylactic cranial irradiation for lung cancer: pooled secondary analysis of Radiation Therapy Oncology Group randomized trials 0212 and 0214. Int J Radiat Oncol Biol Phys. 2013;86(4):656–664. doi:10.1016/j.ijrobp.2013.02.03323597420
  • Sun A, Bae K, Gore EM, et al. Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis. J Clin Oncol. 2011;29(3):279–286. doi:10.1200/JCO.2010.29.605321135267
  • Abayomi OK. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 1996;35(6):659–663. doi:10.3109/028418696090839958938210
  • Gondi V, Tolakanahalli R, Mehta MP, et al. Hippocampal-sparing whole-brain radiotherapy: a “how-to” technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2010;78(4):1244–1252. doi:10.1016/j.ijrobp.2010.01.03920598457
  • Marsh JC, Godbole RH, Herskovic AM, Gielda BT, Turian JV. Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy. Int J Radiat Oncol Biol Phy. 2010;78(3):946–954. doi:10.1016/j.ijrobp.2009.12.012
  • Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol. 2014;32(34):3810–3816. doi:10.1200/JCO.2013.54.691125349290
  • Gondi V, Deshmukh S, Brown PD, et al. Preservation of Neurocognitive Function (NCF) with conformal avoidance of the hippocampus during whole-brain radiotherapy (HA-WBRT) for brain metastases: preliminary results of phase III trial NRG oncology CC001. Int J Radiat Oncol Biol Phys. 2018;102(5):1607. doi:10.1016/j.ijrobp.2018.08.056
  • Hsu F, Carolan H, Nichol A, et al. Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1-3 brain metastases: a feasibility study using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys. 2010;76(5):1480–1485. doi:10.1016/j.ijrobp.2009.03.03219625140
  • Lagerwaard FJ, van der Hoorn EA, Verbakel WF, Haasbeek CJ, Slotman BJ, Senan S. Whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys. 2009;75(1):253–259. doi:10.1016/j.ijrobp.2009.03.02919577856
  • Yamamoto M, Kawabe T, Sato Y, et al. Stereotactic radiosurgery for patients with multiple brain metastases: a case-matched study comparing treatment results for patients with 2–9 versus 10 or more tumors. J Neurosurg. 2014;121 Suppl:16–25.25434933
  • Sperduto PW, Jiang W, Brown PD, et al. Estimating survival in melanoma patients with brain metastases: an update of the graded prognostic assessment for melanoma using molecular markers (Melanoma-molGPA). Int J Radiat Oncol Biol Phys. 2017;99(4):812–816. doi:10.1016/j.ijrobp.2017.06.245429063850
  • Hauswald H, Habl G, Krug D, et al. Whole brain helical Tomotherapy with integrated boost for brain metastases in patients with malignant melanoma-a randomized trial. Radiat Oncol. 2013;8:234. doi:10.1186/1748-717X-8-23424112545
  • Glitza Oliva IC, Schvartsman G, Tawbi H. Advances in the systemic treatment of melanoma brain metastases. Ann Oncol. 2018;29(7):1509–1520. doi:10.1093/annonc/mdx80729790899
  • Greene-Schloesser D, Robbins ME, Peiffer AM, Shaw EG, Wheeler KT, Chan MD. Radiation-induced brain injury: A review. Front Oncol. 2012;2:73. doi:10.3389/fonc.2012.0007322833841
  • Connor M, Karunamuni R, McDonald C, et al. Regional susceptibility to dose-dependent white matter damage after brain radiotherapy. Radiother Oncol. 2017;123(2):209–217. doi:10.1016/j.radonc.2017.04.00628460824
  • Redmond KJ, Hildreth M, Sair HI, et al. Association of neuronal injury in the genu and body of corpus callosum after cranial irradiation in children with impaired cognitive control: a prospective study. Int J Radiat Oncol Biol Phys. 2018;101(5):1234–1242. doi:10.1016/j.ijrobp.2018.04.03729908790
  • Awad R, Fogarty G, Hong A, et al. Hippocampal avoidance with volumetric modulated arc therapy in melanoma brain metastases - the first Australian experience. Radiat Oncol. 2013;8:62. doi:10.1186/1748-717X-8-6223497418
  • El Shafie RA, Paul A, Bernhardt D, et al. Robotic radiosurgery for brain metastases diagnosed with either SPACE or MPRAGE sequence (CYBER-SPACE)-A single-center prospective randomized trial. Neurosurgery. 2019;84(1):253–260. doi:10.1093/neuros/nyy13729554321
  • Fiorentino A, Tebano U, Sicignano G, et al. Hippocampal dose during Linac-based stereotactic radiotherapy for brain metastases: an observational study. Phys Med. 2018;49:135–138. doi:10.1016/j.ejmp.2017.09.12928951047
  • Ostheimer C, Bormann C, Fiedler E, Marsch W, Vordermark D. Malignant melanoma brain metastases: treatment results and prognostic factors–a single-center retrospective study. Int J Oncol. 2015;46(6):2439–2448. doi:10.3892/ijo.2015.297025891163
  • Frinton E, Tong D, Tan J, et al. Metastatic melanoma: prognostic factors and survival in patients with brain metastases. J Neurooncol. 2017;135(3):507–512. doi:10.1007/s11060-017-2588-428819707
  • Dobi A, Fodor E, Maraz A, et al. Boost irradiation integrated to whole brain radiotherapy in the management of brain metastases. Pathol Oncol Res. 2018. doi:10.1007/s12253-018-0383-y