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Original Research

Eupatilin inhibits glioma proliferation, migration, and invasion by arresting cell cycle at G1/S phase and disrupting the cytoskeletal structure

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Pages 4781-4796 | Published online: 24 May 2019

References

  • Ostrom QT, Gittleman H, Farah P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro-Oncology. 2013;15:ii1–ii56. doi:10.1093/neuonc/not15124137015
  • Posti JP, Bori M, Kauko T, et al. Presenting symptoms of glioma in adults. Acta Neurol Scand. 2015;131(2):88–93. doi:10.1111/ane.1228525263022
  • Borghei-Razavi H, Shibao S, Schick U. Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome. Neurosurg Rev. 2017;40(1):1–7. doi:10.1007/s10143-016-0709-827085859
  • Corradini S, Hadi I, Hankel V, et al. Radiotherapy of spinal cord gliomas: a retrospective mono-institutional analysis. Strahlentherapie Und Onkologie. 2016;192(3):139–145. doi:10.1007/s00066-015-0917-026519080
  • Kinno R, Ohta S, Muragaki Y, Maruyama T, Sakai KL. Left frontal glioma induces functional connectivity changes in syntax-related networks. Springerplus. 2015;4(1):317. doi:10.1186/s40064-015-1104-626155456
  • Zinn PO, Colen RR, Kasper EM, Jan-Karl B. Extent of resection and radiotherapy in GBM: a 1973 to 2007 surveillance, epidemiology and end results analysis of 21,783 patients. Int J Oncol. 2013;42(3):929–934. doi:10.3892/ijo.2013.177023338774
  • Kreth FW, Thon N, Simon M, et al. Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy. Ann of Oncol. 2013;24(12):3117–3123. doi:10.1093/annonc/mdt38824130262
  • Chen G, Yue Y, Qin J, Xiao X, Ren Q, Xiao B. Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro. J Pharmacol Sci. 2017;134(1):59–67. doi:10.1016/j.jphs.2017.04.00328506595
  • Lin TH, Kuo HC, Chou FP, Lu FJ. Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer. 2008;8(1):1–15. doi:10.1186/1471-2407-8-118173856
  • Choi EJ, Lee S, Chae JR, Lee HS, Jun CD, Kim SH. Eupatilin inhibits lipopolysaccharide-induced expression of inflammatory mediators in macrophages. Life Sci. 2011;88(25):1121–1126. doi:10.1016/j.lfs.2011.04.01121565208
  • Cheong JH, Hong SY, Zheng Y, Noh SH. Eupatilin inhibits gastric cancer cell growth by blocking STAT3-mediated VEGF expression. J Gastric Cancer. 2011;11(1):16–22. doi:10.5230/jgc.2011.11.1.1622076197
  • Park BB, Yoon JS, Kim ES, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumor Biol. 2013;34(2):875–885. doi:10.1007/s13277-012-0621-y
  • Cho JH, Lee JG, Yang YI, et al. Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells. Food Chem Toxicol. 2011;49(8):1737–1744. doi:10.1016/j.fct.2011.04.01921554918
  • Jun YP, Do HP, Youngsic J, et al. Eupatilin inhibits angiogenesis-mediated human hepatocellular metastasis by reducing MMP-2 and VEGF signaling. Bioorg Med Chem Lett. 2018;28(19):3150–3154.30177376
  • Wang Y, Hou H, Li M, Yang Y, Sun L. Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway. Mol Med Rep. 2016;13(2):1141–1146. doi:10.3892/mmr.2015.467126676446
  • Lauper N, Beck AR, Cariou S, et al. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 1998;17(20):2637. doi:10.1038/sj.onc.12020159840927
  • Pestell R, Albanese C, Reutens AT, Segall J, Lee R, Arnold A. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev. 1999;20(4):501–534. doi:10.1210/edrv.20.4.037310453356
  • Zindy F, Lamas E, Chenivesse X, et al. Cyclin A is required in S phase in normal epithelial cells. Biochem Biophys Res Commun. 1992;182(3):1144–1154.1531751
  • Preuss U, Landsberg G, Scheidtmann KH. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. Nucleic Acids Res. 2003;31(3):878–885. doi:10.1093/nar/gkg17612560483
  • Goto H, Tomono Y, Ajiro K, et al. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Bio Chem. 1999;274(36):25543–25549.10464286
  • Lane HA, Fernandez A, Lamb NJC, Thomas G. p70 s6k function is essential for G1 progression. Nature. 1993;363(6425):170–172. doi:10.1038/363170a08483501
  • Satija YK, Das S. Tyr99 phosphorylation determines the regulatory milieu of tumor suppressor p73. Oncogene. 2015;35(4):513. doi:10.1038/onc.2015.11125893286
  • Lorca T, Labbé JC, Devault A, et al. Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase. Embo J. 1992;11(7):2381–2390.1321030
  • Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. Embo J. 1995;14(9):1878–1891.7743995
  • Mcgowan CH, Russell P. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. Embo J. 1993;12(1):75–85.8428596
  • Gahan PB. The cell: a molecular approach (3rd edn) G. M. Cooper and R. E. Hausman, Palgrave-Macmillans Global Academic Publishing, 713 pp., ISBN 0-87893-214-3 (2004). Cell Biochem Funct. 2010;23(3):222.
  • Maekawa M, Ishizaki T, Boku S, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 1999;285(5429):895. doi:10.1126/science.285.5429.89510436159
  • Sumi T, Matsumoto K, Nakamura T. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem. 2001;276(1):670–676. doi:10.1074/jbc.M00707420011018042
  • Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Bio Chem. 2000;275(5):3577. doi:10.1074/jbc.275.5.357710652353
  • Arber S, Barbayannis FA, Hanser H, et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature. 1998;393(6687):805–809. doi:10.1038/317299655397
  • Hazan RB, Qiao R, Keren R, Badano I, Suyama K. Cadherin switch in tumor progression. Ann N Y Acad Sci. 2010;1014(1):155–163. doi:10.1196/annals.1294.016
  • Yokoyama K, Kamata N, Hayashi E, et al. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol. 2001;37(1):65–71.11120485
  • Yokoyama K, Kamata N, Fujimoto R, et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol. 2003;22(4):891.12632084
  • Michiko E, Shunya K, Rei T, et al. The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Oncogene. 2005;24(38):5850–5857. doi:10.1038/sj.onc.120873316007210
  • Shunya K, Chisa S, Yoko M, et al. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells. J Cell Sci. 2007;120(5):849–857. doi:10.1242/jcs.0338817298979
  • Joe Eun S, Eunjung L, Gwon SS, et al. Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6, and MKK4 activities. Planta Med. 2013;79(12):1009–1016. doi:10.1055/s-0033-135062123877919
  • Do-Hee K, Hye-Kyung N, Tae Young O, Chang-Yell S, Young-Joon S. Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells. J Environ Pathol Toxicol Oncol. 2005;24(4):251–259.16393119
  • Seo HJ, Surh YJ. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells ☆. Mutat Res Genet Toxicol Environ Mutagen. 2001;496(1):191–198. doi:10.1016/S1383-5718(01)00234-0
  • Kim MJ, Kim DHNa HK, Oh TY, Shin CY, Yj SPD. Eupatilin, a pharmacologically active flavone derived from artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. J Environ Pathol Toxicol Oncol. 2005;24(4):261–270. doi:10.1615/JEnvironPatholToxicolOncol.v24.i4.3016393120
  • Hongjiang L, Zhongqiang L, Erkun G. Knockdown of long noncoding RNA SPRY4-IT1 suppresses glioma cell proliferation, metastasis and epithelial-mesenchymal transition. Int J Clin Exp Pathol. 2015;8(8):9140.26464658
  • Weigel MT, Dowsett M. Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocr Relat Cancer. 2010;17(4):R245. doi:10.1677/ERC-10-013620647302