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Original Research

SSBP1 Upregulation In Colorectal Cancer Regulates Mitochondrial Mass

, , , , , , , & show all
Pages 10093-10106 | Published online: 02 Dec 2019

References

  • De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011;12(6):594–603. doi:10.1016/S1470-2045(10)70209-621163703
  • Varghese V, Magnani L, Harada-Shoji N, et al. FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression. Sci Rep. 2019;9(1):1505. doi:10.1038/s41598-018-38017-030728402
  • Wasserman I, Lee LH, Ogino S, et al. SMAD4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance. Clin Cancer Res. 2019;25(6):1948–1956. doi:10.1158/1078-0432.CCR-18-172630587545
  • Zaanan A, Shi Q, Taieb J, et al. Role of deficient DNA mismatch repair status in patients with stage III colon cancer treated with FOLFOX adjuvant chemotherapy: a pooled analysis from 2 randomized clinical trials. JAMA Oncol. 2018;4(3):379–383. doi:10.1001/jamaoncol.2017.289928983557
  • Ou J, Peng Y, Yang W, et al. ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. Nat Commun. 2019;10(1):1078. doi:10.1038/s41467-019-08902-x30842415
  • Wang M, Han D, Yuan Z, et al. Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy. Cell Death Dis. 2018;9(12):1149. doi:10.1038/s41419-018-1187-430451820
  • Morgan MJ, Fitzwalter BE, Owens CR, et al. Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proc Natl Acad Sci U S A. 2018;115(36):E8479–E8488. doi:10.1073/pnas.170652611530127018
  • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. doi:10.1126/science.116080919460998
  • Chiang SC, Meagher M, Kassouf N, et al. Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Sci Adv. 2017;3(4):e1602506. doi:10.1126/sciadv.160250628508041
  • Márquez-Jurado S, Díaz-Colunga J, Das Neves RP, et al. Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression. Nat Commun. 2018;9(1):389. doi:10.1038/s41467-017-02787-429374163
  • Shin YK, Yoo BC, Chang HJ, et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Res. 2005;65(8):3162–3170. doi:10.1158/0008-5472.CAN-04-330015833846
  • Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411–420. doi:10.1038/nbt.409629608179
  • Li H, Courtois ET, Sengupta D, et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nat Genet. 2017;49(5):708–718. doi:10.1038/ng.381828319088
  • van der Maaten LJP. Accelerating t-SNE using Tree-Based Algorithms. J Med Learn Res. 2014;15:(Oct):3221–3245.
  • Blighe K. EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling. R Package Version 1.1.1. 2019 Available from: htps://github.com/kevinblighe/EnhancedVolcano Accessed 1014, 2019.
  • Koh CWQ, Goh YT, Toh JDW, et al. Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome. Nucleic Acids Res. 2018;46(22):11659–11670. doi:10.1093/nar/gky110430412255
  • Morin JA, Cerrón F, Jarillo J, et al. DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein. Nucleic Acids Res. 2017;45(12):7237–7248. doi:10.1093/nar/gkx39528486639
  • Sykora P, Kanno S, Akbari M, et al. DNA polymerase beta participates in mitochondrial DNA repair. Mol Cell Biol. 2017 pii: MCB.00237-17. doi:10.1128/MCB.00237-17
  • Richard DJ, Bolderson E, Cubeddu L, et al. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 2008;453(7195):677–681. doi:10.1038/nature0688318449195
  • Ye Y, Huang A, Huang C, et al. Comparative mitochondrial proteomic analysis of hepatocellular carcinoma from patients. Proteomics Clin Appl. 2013;7(5–6):403–415. doi:10.1002/prca.20110010323589362
  • Jiang HL, Sun HF, Gao SP, et al. SSBP1 suppresses TGFβ-driven epithelial-to-mesenchymal transition and metastasis in triple-negative breast cancer by regulating mitochondrial retrograde signaling. Cancer Res. 2016;76(4):952–964. doi:10.1158/0008-5472.CAN-15-163026676758
  • Cecconi D, Carbonare LD, Mori A, et al. An integrated approach identifies new oncotargets in melanoma. Oncotarget. 2017;9(14):11489–11502. doi:10.18632/oncotarget.2372729545914
  • Wang Y, Hu L, Zhang X, et al. Downregulation of mitochondrial single stranded DNA binding protein (SSBP1) induces mitochondrial dysfunction and increases the radiosensitivity in non-small cell lung cancer cells. J Cancer. 2017;8(8):1400–1409. doi:10.7150/jca.1817028638454
  • Schiabor KM, Quan AS, Eisen MB. Saccharomyces cerevisiae mitochondria are required for optimal attractiveness to Drosophila melanogaster. PLoS One. 2014;9(12):e113899. doi:10.1371/journal.pone.011389925462617
  • Vyas S, Zaganjor E, Haigis MC. Mitochondria and Cancer. Cell. 2016;166(3):555–566. doi:10.1016/j.cell.2016.07.00227471965
  • Hu L, Wang H, Huang L, Zhao Y, Wang J. The protective roles of ROS-mediated mitophagy on 125I seeds radiation induced cell death in HCT116 cells. Oxid Med Cell Longev. 2016;2016:9460462. doi:10.1155/2016/946046228119765
  • Zhu M, Barbas AS, Lin L, Scheuermann U, Bishawi M, Brennan TV. Mitochondria released by apoptotic cell death initiate innate immune responses. Immunohorizons. 2018;2(11):384–397. doi:10.4049/immunohorizons.180006330847435