Silencing of TAZ inhibits the motility of hepatocellular carcinoma cells through autophagy induction

References

• Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301–1314. doi:10.1016/S0140-6736(18)30302-729307467
   PubMed Web of Science ®Google Scholar
• Xu X, Lou Y, Tang J, et al. The long non-coding RNA Linc-GALH promotes hepatocellular carcinoma metastasis via epigenetically regulating Gankyrin. Cell Death Dis. 2019;10(2):86. doi:10.1038/s41419-019-1300-330692513
   PubMedGoogle Scholar
• Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG, Hynes RO. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Nat Acad Sci USA. 2012;109(37):E2441–E2450. doi:10.1073/pnas.121202110922891335
   PubMed Web of Science ®Google Scholar
• Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, inflammation, and immunity: a troika governing cancer and its treatment. Cell. 2016;166(2):288–298. doi:10.1016/j.cell.2016.05.05127419869
   PubMed Web of Science ®Google Scholar
• Mowers EE, Sharifi MN, Macleod KF. Autophagy in cancer metastasis. Oncogene. 2017;36(12):1619–1630. doi:10.1038/onc.2016.33327593926
   PubMed Web of Science ®Google Scholar
• Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D, Moreau R. Autophagy in liver diseases. J Hepatol. 2010;53(6):1123–1134. doi:10.1016/j.jhep.2010.07.00620810185
   PubMed Web of Science ®Google Scholar
• Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137(6):1062–1075.19524509
   PubMed Web of Science ®Google Scholar
• Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes Dev. 2013;27(4):355–371.23431053
   PubMed Web of Science ®Google Scholar
• Panciera T, Azzolin L, Cordenonsi M, Piccolo S. Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol. 2017;18(12):758–770.28951564
   PubMed Web of Science ®Google Scholar
• Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes Dev. 2016;30(1):1–17. doi:10.1101/gad.274027.11526728553
   PubMed Web of Science ®Google Scholar
• Zhou X, Lei QY. Regulation of TAZ in cancer. Protein Cell. 2016;7(8):548–561. doi:10.1007/s13238-016-0288-z27412635
   PubMed Web of Science ®Google Scholar
• Shen S, Huang K, Wu Y, et al. A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma. Cancer Lett. 2017;407:32–44. doi:10.1016/j.canlet.2017.08.00528823959
   PubMed Web of Science ®Google Scholar
• Ge L, Li DS, Chen F, Feng JD, Li B, Wang TJ. TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cells. Int J Oncol. 2017;51(1):307–315. doi:10.3892/ijo.2017.399828534974
   PubMed Web of Science ®Google Scholar
• Xiao H, Jiang N, Zhou B, Liu Q, Du C. TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma. Cancer Sci. 2015;106(2):151–159. doi:10.1111/cas.1258725495189
   PubMed Web of Science ®Google Scholar
• Tuloup-Minguez V, Hamaï A, Greffard A, Nicolas V, Codogno P, Botti J. Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle. 2013;12(20):3317–3328. doi:10.4161/cc.2629824036548
   PubMed Web of Science ®Google Scholar
• Qiang L, He YY. Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition. Autophagy. 2014;10(10):1864–1865. doi:10.4161/auto.3217125126736
   PubMed Web of Science ®Google Scholar
• Lan SH, Wu SY, Zuchini R, et al. Autophagy suppresses tumorigenesis of hepatitis B virusassociated hepatocellular carcinoma through degradation of micro-RNA-224. Hepatology. 2014;59(2):505–517. doi:10.1002/hep.2665923913306
   PubMed Web of Science ®Google Scholar
• Wu W, Zhang X, Qin H, et al. Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2. Oncol Rep. 2015;33(5):2495–2503. doi:10.3892/or.2015.385525779224
   PubMed Web of Science ®Google Scholar
• Hayashi H, Higashi T, Yokoyama N, et al. An imbalance in TAZ and YAP expression in hepatocellular carcinoma confers cancer stem cell-like behaviors contributing to disease progression. Cancer Res. 2015;75(22):4985–4997. doi:10.1158/0008-5472.CAN-15-029126420216
   PubMed Web of Science ®Google Scholar
• Kaizuka T, Morishita H, Hama Y, et al. An autophagic flux probe that releases an internal control. Mol Cell. 2016;64(4):835–849. doi:10.1016/j.molcel.2016.09.03727818143
   PubMed Web of Science ®Google Scholar
• Coly PM, Perzo N, Le Joncour V, et al. Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Autophagy. 2016;12(12):2344–2362. doi:10.1080/15548627.2016.123512527715446
   PubMed Web of Science ®Google Scholar
• Catalano M, D’Alessandro G, Lepore F, et al. Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells. Mol Oncol. 2015;9(8):1612–1625. doi:10.1016/j.molonc.2015.04.01626022108
   PubMed Web of Science ®Google Scholar
• Jiang P, Mizushima N. Autophagy and human diseases. Cell Res. 2014;24(1):69–79. doi:10.1038/cr.2013.16124323045
   PubMed Web of Science ®Google Scholar
• Wu SY, Lan S-H, Wu S-R, et al. Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system. Hepatology. 2018;68(1):141–154. doi:10.1002/hep.2978129328502
   PubMed Web of Science ®Google Scholar
• Higashi T, Hayashi H, Ishimoto T, et al. miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells. Br J Cancer. 2015;113(2):252–258. doi:10.1038/bjc.2015.17026125451
   PubMed Web of Science ®Google Scholar
• Higashi T, Hayashi H, Kitano Y, et al. Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma. Med Oncol. 2016;33(11):123. doi:10.1007/s12032-016-0845-627734263
   PubMed Web of Science ®Google Scholar
• Choi KS. Autophagy and cancer. Exp Mol Med. 2012;44(2):109–120. doi:10.3858/emm.2012.44.2.03322257886
   PubMed Web of Science ®Google Scholar
• Li X, Xu HL, Liu YX, An N, Zhao S, Bao JK. Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacol Sin. 2013;34(5):612–624. doi:10.1038/aps.2013.2323564085
   PubMed Web of Science ®Google Scholar
• Kenific CM, Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015;25(1):37–45. doi:10.1016/j.tcb.2014.09.00125278333
   PubMed Web of Science ®Google Scholar