The Prognostic Value Of Lymph Node Ratio In Patients With N2 Stage Lung Squamous Cell Carcinoma: A Nomogram And Heat Map Approach

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.30207593
   PubMed Web of Science ®Google Scholar
• Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung cancert. Ann Glob Health. 2019;85(1):505–516.
   Web of Science ®Google Scholar
• PORT Meta-analysis Trialists Group. Postoperative radiotherapy in non- small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. Lancet. 1998;352:257–263.9690404
   PubMed Web of Science ®Google Scholar
• Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative radiotherapy for stage II or III non-small-cell lung ca cer using the surveillance, epidemiology, and end results database. J Clin Oncol. 2006;24:2998–3006. doi:10.1200/JCO.2005.04.611016769986
   PubMed Web of Science ®Google Scholar
• Douillard JY, Rosell R, De Lena M, Riggi M, Hurteloup P, Mahe MA. Adjuvant Navelbine International Trialist Association. Impact of post- operative radiation therapy on survival in patients with complete resec- tion and stage I, II, or IIIA non-small-cell lung cancer treated with adjuvant chemotherapy: the adjuvant Navelbine International Trialist Association (ANITA) randomized trial. Int J Radiat Oncol Biol Phys. 2008;72:695–701.18439766
   PubMed Web of Science ®Google Scholar
• Burdett S, Rydzewska L, Tierney J, et al. Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst Rev. 2016;(10):CD002142.
   Web of Science ®Google Scholar
• Katsumata S, Aokage K, Ishii G, et al. Prognostic impact of the number of metastatic lymph nodes on the eighth edition of the TNM classification of non-small cell lung cancer. J Thorac Oncol. 2019;14(8):1408–141831055075
   PubMed Web of Science ®Google Scholar
• Zhao Y, Li G, Zheng D, et al. The prognostic value of lymph node ratio and log odds of positive lymph nodes in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg. 2017;153(3):702–709.e1. doi:10.1016/j.jtcvs.2016.11.05328212778
   PubMed Web of Science ®Google Scholar
• Deng W, Xu T, Xu Y, et al. Survival patterns for patients with resected N2 non-small cell lung cancer and postoperative radiotherapy: a prognostic scoring model and heat map approach. J Thorac Oncol. 2018;13:1–7.
   Web of Science ®Google Scholar
• Wang C-L, Li Y, Yue D-S, Zhang L-M, Zhang Z-F, Sun B-S. Value of the metastatic lymph node ratio for predicting the prognosis of non-small-cell lung cancer patients. World J Surg. 2011;36(2):455–462.
   Web of Science ®Google Scholar
• Chiappetta M, Leuzzi G, Sperduti I, et al. Lymph-node ratio predicts survival among the different stages of non-small-cell lung cancer: a multicentre analysis†. Eur J Cardiothorac Surg. 2018;55(3):405–412.
   Web of Science ®Google Scholar
• Taylor MD, LaPar DJ, Thomas CJ, et al. Lymph node ratio predicts recurrence and survival after r0 resection for non-small cell lung cancer. Ann Thorac Surg. 2013;96(4):1163–1170.23998409
   PubMed Web of Science ®Google Scholar
• Urban D, Bar J, Solomon B, Ball D. David ball MBBS MF. lymph node ratio may predict the benefit of postoperative radiotherapy in non-small-cell lung cancer. J Thorac Oncol. 2013;8(7):940–946.23695418
   PubMed Web of Science ®Google Scholar
• Detterbeck FC. The eighth edition TNM stage classification for lung cancer: what does it mean on main street? J Thorac Cardiovasc Surg. 2018;155(1):356–359.29061464
   PubMed Web of Science ®Google Scholar
• Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252–7259.15534099
   PubMed Web of Science ®Google Scholar
• Qian K, Sun W, Guo K, et al. The number and ratio of positive lymph nodes are independent prognostic factors for patients with major salivary gland cancer: results from the surveillance, epidemiology, and end results dataset. Eur J Surg Oncol. 2018;45(6):1025–103230472214
   PubMed Web of Science ®Google Scholar
• Harrell FEJ, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15(4):361–387.8668867
   PubMed Web of Science ®Google Scholar
• Kim HI, Kim K, Park SY, et al. Refining the eighth edition AJCC TNM classification and prognostic groups for papillary thyroid cancer with lateral nodal metastasis. Oral Oncol. 2018;78:80–86.29496063
   PubMed Web of Science ®Google Scholar
• Wen J, Yang Y, Liu P, et al. Development and validation of a nomogram for predicting survival on the base of modified lymph node ratio in breast cancer patients. Breast. 2017;33:14–22.28259045
   PubMed Web of Science ®Google Scholar
• Amini N, Kim Y, Wilson A, et al. Prognostic implications of lymph node status for patients with gallbladder cancer: a multi-institutional study. Ann Surg Oncol. 2016;23(9):3016–3023.27150440
   PubMed Web of Science ®Google Scholar
• Cheraghlou S, Agogo GO, Girardi M. Evaluation of lymph node ratio association with long-term patient survival after surgery for node-positive merkel cell carcinoma. JAMA Dermatol. 2019;155:1–9.
   Web of Science ®Google Scholar
• Jonnalagadda S, Arcinega J, Smith C, Wisnivesky JP. Validation of the lymph node ratio as a prognostic factor in patients with N1 nonsmall cell lung cancer. Cancer. 2011;117(20):4724–4731.21452193
   PubMed Web of Science ®Google Scholar
• Nwogu CE, Groman A, Fahey D, et al. Number of lymph nodes and metastatic lymph node ratio are associated with survival in lung cancer. Ann Thorac Surg. 2012;93(5):1614–1620.22440365
   PubMed Web of Science ®Google Scholar
• Wang J, Hassett JM, Dayton MT, Kulaylat MN. The prognostic superiority of log odds of positive lymph nodes in stage III colon cancer. J Gastrointest Surg. 2008;12(10):1790–1796.18709510
   PubMed Web of Science ®Google Scholar
• Stiles BM, Mao J, Harrison S, et al. Extent of lymphadenectomy is associated with oncological efficacy of sublobar resection for lung cancer ≤2 cm. J Thorac Cardiovasc Surg. 2019;157(6):2454–2465.e1. doi:10.1016/j.jtcvs.2019.01.13630954298
   PubMed Web of Science ®Google Scholar
• Ludwig MS, Goodman M, Miller DL, Johnstone PA. Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. Chest. 2005;128(3):1545–1550.16162756
   PubMed Web of Science ®Google Scholar
• Zeng Y, Mayne N, Yang C-FJ, et al. A nomogram for predicting cancer-specific survival of TNM 8th edition stage I non-small-cell lung cancer. Ann Surg Oncol. 2019;26:1–10.
   Web of Science ®Google Scholar
• Ettinger DS, Aisner DL, Wood DE, et al. NCCN guidelines insights: non–small cell lung cancer, version 5.2018. J Natl Compr Canc Netw. 2018;16(7):807–821.30006423
   PubMed Web of Science ®Google Scholar
• Shi W, Zhang W, Sun H, Shao Y. Sleeve lobectomy versus pneumonectomy for non-small cell lung cancer: a meta-analysis. World J Surg Oncol. 2012;10:265.23231962
   PubMed Web of Science ®Google Scholar
• Deslauriers J, Gregoire J, Jacques LF, Piraux M, Guojin L, Lacasse Y. Sleeve lobectomy versus pneumonectomy for lung cancer: a comparative analysis of survival and sites or recurrences. Ann Thorac Surg. 2004;77(4):1152–1156.15063224
   PubMed Web of Science ®Google Scholar
• Demaria S, Formenti SC. Role of T lymphocytes in tumor response to radiotherapy. Front Oncol. 2012;2:95.22937524
   PubMedGoogle Scholar