Clinical Characteristics And Outcome Of Biphenotypic Acute Leukemia: 10 Case Reports And Literature Review

References

• Béné MC, Porwit A. Acute leukemias of ambiguous lineage. Semin Diagn Pathol. 2012;29:12–18.22372202
   PubMed Web of Science ®Google Scholar
• Rubnitz JE, Onciu M, Pounds S, et al. Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital. Blood. 2009;113:5083–5089. doi:10.1182/blood-2008-10-18735119131545
   PubMed Web of Science ®Google Scholar
• Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9:1783–1786.7564526
   PubMed Web of Science ®Google Scholar
• Matutes E, Morilla R, Farahat N, et al. Definition of acute biphenotypic leukemia. Haematologica. 1997;82:64–66.9107085
   PubMed Web of Science ®Google Scholar
• Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114:937–951. doi:10.1182/blood-2009-03-20926219357394
   PubMed Web of Science ®Google Scholar
• Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–2405. doi:10.1182/blood-2016-03-64354427069254
   PubMed Web of Science ®Google Scholar
• Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E. Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis. Leukemia. 2018;32(7 ):1515–1528. Epub 2018 Feb 27. doi:10.1038/s41375-018-0058-429550836
   PubMed Web of Science ®Google Scholar
• Lee MY, Tan TD, Feng AC. Clinicopathologic analysis of acute myeloid leukemia in a single institution: biphenotypic acute myeloid leukemia may not be an aggressive subtype. J Chin Med Assoc. 2007;70:269–273. doi:10.1016/S1726-4901(07)70003-517631462
   PubMedGoogle Scholar
• Matutes E, Pickl WF, Van’t Veer M, et al. Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Blood. 2011;117:3163–3171. doi:10.1182/blood-2010-10-31468221228332
   PubMed Web of Science ®Google Scholar
• Gerr H, Zimmermann M, Schrappe M, et al. Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations. Br J Haematol. 2010;149:84–92. doi:10.1111/j.1365-2141.2009.08058.x20085575
   PubMed Web of Science ®Google Scholar
• Hrusak O, de Haas V, Stancikova J, et al. International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia. Blood. 2018;132:264–276. doi:10.1182/blood-2017-12-82136329720486
   PubMed Web of Science ®Google Scholar
• Weinberg OK, Seetharam M, Ren L, Alizadeh A, Arber DA. Mixed phenotype acute leukemia: a study of 61 cases using World Health Organization and European Group for the immunological classification of leukaemias criteria. Am J Clin Pathol. 2014;142:803–808. doi:10.1309/AJCPPVUPOTUVOIB525389334
   PubMed Web of Science ®Google Scholar
• Wolach O, Stone RM. How I treat mixed-phenotype acute leukemia. Blood. 2015;125:2477–2485. doi:10.1182/blood-2014-10-55146525605373
   PubMed Web of Science ®Google Scholar
• Charles NJ, Boyer DF. Mixed-phenotype acute leukemia: diagnostic criteria and pitfalls. Arch Pathol Lab Med. 2017;141:1462–1468. doi:10.5858/arpa.2017-0218-RA29072953
   PubMed Web of Science ®Google Scholar
• Al-Seraihy AS, Owaidah TM, Ayas M, et al. Clinical characteristics and outcome of children with biphenotypic acute leukemia. Haematologica. 2009;94:1682–1690. doi:10.3324/haematol.2009.00928219713227
   PubMed Web of Science ®Google Scholar
• Carbonell F, Swansbury J, Min T, et al. Cytogenetic findings in acute biphenotypic leukaemia. Leukemia. 1996;10:1283–1287.8709632
   PubMed Web of Science ®Google Scholar
• Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT. Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system. Leukemia. 2006;20:620–626. doi:10.1038/sj.leu.240412816437134
   PubMed Web of Science ®Google Scholar
• Xu XQ, Wang JM, Lü SQ, et al. Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population. Haematologica. 2009;94:919–927. doi:10.3324/haematol.2008.00320219454497
   PubMed Web of Science ®Google Scholar
• Kern W, Grossmann V, Roller A, et al. Mixed phenotype acute leukemia, T/ myeloid,NOS (MPAL-TM) has a high DNMT3A mutation frequency and carries further genetic features of both AML and T-ALL: results of a comprehensive next-generation sequencing study analyzing 32 genes. Blood. 2012;120(21 ):403. doi:10.1182/blood.V120.21.403.403
   Web of Science ®Google Scholar
• Yan L, Ping N, Zhu M, et al. Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification. Haematologica. 2012;97(11 ):1708–1712. doi:10.3324/haematol.2012.06448522581002
   PubMed Web of Science ®Google Scholar
• Ma Q, Tong Y, Jin J, Lou Y. Mixed T/myeloid phenotype acute leukemia with rare variants of IDH1 and CEBPA. Leuk Lymphoma. 2013;54(11 ):2568–2570. doi:10.3109/10428194.2013.78321223469962
   PubMed Web of Science ®Google Scholar
• Manola KN. Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview. Br J Haematol. 2013;163(1 ):24–39. doi:10.1111/bjh.1248423888868
   PubMed Web of Science ®Google Scholar
• Eckstein OS, Wang L, Punia JN, et al. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016;44(8 ):740–744. doi:10.1016/j.exphem.2016.05.00327208809
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Kawamoto S, Mizutani Y, et al. Mixed phenotype acute leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and other chromosome abnormalities. Cytogenet Genome Res. 2016;149(3 ):165–170. doi:10.1159/00044844727607436
   PubMed Web of Science ®Google Scholar
• Pallavajjala A, Kim D, Li T, et al. Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia. Leuk Lymphoma. 2017;59:1231–1238. doi:10.1080/10428194.2017.137257728882084
   PubMed Web of Science ®Google Scholar
• Yao L, Cen J, Pan J, et al. TAF15-ZNF384 fusion gene in childhood mixed phenotype acute leukemia. Cancer Genet. 2017;211:1–4. doi:10.1016/j.cancergen.2016.12.00228279306
   PubMed Web of Science ®Google Scholar
• Lee HG, Baek HJ, Kim HS, et al. Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome. Blood Res. 2019;54:63–73. doi:10.5045/br.2019.54.1.6330956966
   PubMed Web of Science ®Google Scholar
• Jia Y, Li Y, Gong XY, et al. Clinical characteristics of patients with Ph+ mixed phenotype acute leukemia. J Exp Hematol. 2019;27(2 ):354–359.
   Google Scholar
• Shi R, Munker R. Survival of patients with mixed phenotype acute leukemias: a large population-based study. Leuk Res. 2015;39:606–616. doi:10.1016/j.leukres.2015.03.01225858895
   PubMed Web of Science ®Google Scholar
• Killick S, Matutes E, Powles RL, et al. Outcome of biphenotypic acute leukemia. Haematologica. 1999;84:699–706.10457405
   PubMed Web of Science ®Google Scholar