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Original Research

Silencing of Long Non-Coding RNA HOTAIR Alleviates Epithelial–Mesenchymal Transition in Pancreatic Cancer via the Wnt/β-Catenin Signaling Pathway

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Pages 3247-3257 | Published online: 14 Apr 2021

References

  • Neoptolemos JP, Stocken DD, Bassi C, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010;304(10):1073–1081. doi:10.1001/jama.2010.127520823433
  • Fric P, Sedo A, Skrha J, et al. Early detection of sporadic pancreatic cancer: time for change. Eur J Gastroenterol Hepatol. 2017;29(8):885–891. doi:10.1097/MEG.000000000000090428471824
  • Arslan AA. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med. 2010;170(9):791–802. doi:10.1001/archinternmed.2010.6320458087
  • Campbell PJ, Yachida S, Mudie LJ, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010;467(7319):1109–1113. doi:10.1038/nature0946020981101
  • Butturini G, et al. Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials. Arch Surg. 2008;143(1):75–83. doi:10.1001/archsurg.2007.1718209156
  • Nentwich MF, Konig A, Izbicki JR. Limits of surgery for pancreatic cancer. Rozhl Chir. 2014;93(9):445–449.25301342
  • Jayakodi M, Jung JW, Park D, et al. Genome-wide characterization of long intergenic non-coding RNAs (lincRNAs) provides new insight into viral diseases in honey bees Apis cerana and Apis mellifera. BMC Genomics. 2015;16(1):680. doi:10.1186/s12864-015-1868-726341079
  • Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A, Mandal SS. Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol. 2013;425(19):3707–3722. doi:10.1016/j.jmb.2013.01.02223375982
  • Li H, An J, Wu M, et al. LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget. 2015;6(29):27847–27864. doi:10.18632/oncotarget.444326172293
  • Kim K, Jutooru I, Chadalapaka G, et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2013;32(13):1616–1625. doi:10.1038/onc.2012.19322614017
  • Tarapore RS, Siddiqui IA, Mukhtar H. Modulation of Wnt/ -catenin signaling pathway by bioactive food components. Carcinogenesis. 2012;33(3):483–491. doi:10.1093/carcin/bgr30522198211
  • Yao H, Ashihara E, Maekawa T. Targeting the Wnt/β-catenin signaling pathway in human cancers. Expert Opin Ther Targets. 2011;15(7):873–887. doi:10.1517/14728222.2011.57741821486121
  • Taube JH, Herschkowitz JI, Komurov K, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A. 2010;107(35):15449–15454. doi:10.1073/pnas.100490010720713713
  • Cascioferro S, Petri GL, Parrino B, et al. Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells. Eur J Med Chem. 2020;189:112088. doi:10.1016/j.ejmech.2020.11208832007666
  • Zhu H, Wang D, Zhang L, et al. Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia. Oncol Rep. 2014;32(3):935–942. doi:10.3892/or.2014.329824994549
  • Liu -Q-Q, Chen K, Ye Q, Jiang X-H, Sun Y-W. Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway. Cancer Cell Int. 2016;16(1):57. doi:10.1186/s12935-016-0336-z27453691
  • Zhou W, Li Y, Gou S, et al. MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway. Oncotarget. 2015;6(35):37557–37569. doi:10.18632/oncotarget.531726485754
  • Cui J, Jiang W, Wang S, Wang L, Xie K. Role of Wnt/β-catenin Signaling in Drug Resistance of Pancreatic Cancer. Curr Pharm Des. 2012;18(17):2464–2471. doi:10.2174/1381612811209246422372504
  • Khalaileh A, Dreazen A, Khatib A, et al. Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. Cancer Res. 2013;73(6):1811–1820. doi:10.1158/0008-5472.CAN-12-201423361300
  • Zelinkova Z, van der Ent C, Bruin KF, et al. Effects of Discontinuing Anti–Tumor Necrosis Factor Therapy During Pregnancy on the Course of Inflammatory Bowel Disease and Neonatal Exposure. Clin Gastroenterol Hepatol. 2013;11(3):318–321. doi:10.1016/j.cgh.2012.10.02423103819
  • Ma J, Fang B, Zeng F, et al. Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Oncotarget. 2015;6(3):1740–1749. doi:10.18632/oncotarget.271425638153
  • Li Z, Zhao X, Zhou Y, et al. The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. J Transl Med. 2015;13(1):84. doi:10.1186/s12967-015-0442-z25889214
  • Yoshimura H, Matsuda Y, Yamamoto M, et al. Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis. Lab Invest. 2018;98(6):814–824. doi:10.1038/s41374-018-0048-129581580
  • Endo H, Shiroki T, Nakagawa T, et al. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One. 2013;8(10):e77070. doi:10.1371/journal.pone.007707024130837
  • Yang Z, Zhou L, Wu L-M, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011;18(5):1243–1250. doi:10.1245/s10434-011-1581-y21327457
  • Cai H, An Y, Chen X, et al. Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2. Oncotarget. 2016;7(52):86857–86870. doi:10.18632/oncotarget.1349027895308
  • Yang S-Z, Xu F, Zhou T, Zhao X, McDonald JM, Chen Y. The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand. J Biol Chem. 2017;292(25):10390–10397. doi:10.1074/jbc.M117.78683028476883
  • Wang Q, Cai J, Cai X-H, Chen L, Shi X-M. miR-346 Regulates Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting the Wnt/β-Catenin Pathway. PLoS One. 2013;8(9):e72266. doi:10.1371/journal.pone.007226624023731
  • Sarkar S, Mandal C, Sangwan R, Mandal C. Coupling G2/M arrest to the Wnt/β-catenin pathway restrains pancreatic adenocarcinoma. Endocr Relat Cancer. 2014;21(1):113–125. doi:10.1530/ERC-13-031524402132
  • Yan D, Avtanski D, Saxena NK, Sharma D. Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways. J Biol Chem. 2012;287(11):8598–8612. doi:10.1074/jbc.M111.32280022270359
  • Gao J-Z, Li J, Du J-L, Li X-L. Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence. Oncol Lett. 2016;11(3):1791–1798. doi:10.3892/ol.2016.413026998078
  • Wang M-T, Chen G, An S-J, et al. Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinoma. Dis Esophagus. 2012;25(7):664–670. doi:10.1111/j.1442-2050.2011.01291.x22150974
  • Huang L, Li F, Deng P, Hu C. [ARTICLE WITHDRAWN] MicroRNA-223 Promotes Tumor Progression in Lung Cancer A549 Cells via Activation of the NF-κB Signaling Pathway. Oncol Res. 2016;24(6):405–413. doi:10.3727/096504016X1468503410343728281961
  • Ge X-S, Ma H-J, Zheng X-H, et al. HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci. 2013;104(12):1675–1682. doi:10.1111/cas.1229624118380
  • Li J, Yang S, Su N, et al. Erratum to: overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. Tumour Biol. 2015;36(11):9093–9094. doi:10.1007/s13277-015-4210-826518770
  • Yang H, Zhan L, Yang T, et al. Ski prevents TGF-β-induced EMT and cell invasion by repressing SMAD-dependent signaling in non-small cell lung cancer. Oncol Rep. 2015;34(1):87–94. doi:10.3892/or.2015.396125955797
  • Han M, Wang Y, Liu M, et al. MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1α expression in third-sphere forming breast cancer stem cell-like cells. Cancer Sci. 2012;103(6):1058–1064. doi:10.1111/j.1349-7006.2012.02281.x22435731
  • Vuoriluoto K, Haugen H, Kiviluoto S, et al. Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene. 2011;30(12):1436–1448. doi:10.1038/onc.2010.50921057535
  • Chaw SY, Abdul Majeed A, Dalley AJ, Chan A, Stein S, Farah CS. Epithelial to mesenchymal transition (EMT) biomarkers – E-cadherin, beta-catenin, APC and Vimentin – in oral squamous cell carcinogenesis and transformation. Oral Oncol. 2012;48(10):997–1006. doi:10.1016/j.oraloncology.2012.05.01122704062
  • Wu Y, Zhang L, Zhang L, et al. Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol. 2015;46(6):2586–2594. doi:10.3892/ijo.2015.297625901533
  • Cheng H, Cui X, Guo Y, et al. The central role of HOTAIR in the malignancy of CD44+ human hypopharyngeal carcinoma cells. Am J Transl Res. 2016;8(11):5052–5058.27904706
  • Zhang Q, Major MB, Takanashi S, et al. Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007;104(18):7444–7448. doi:10.1073/pnas.070213610417460038
  • Yang S, Liu Y, Li M-Y, et al. FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer. Mol Cancer. 2017;16(1):124. doi:10.1186/s12943-017-0700-128716029
  • Cai J, Guan H, Fang L, et al. MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis.. J Clin Invest. 2013;123(2):566–579. doi:10.1172/JCI6587123321667