microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• Yiu AJ, Yiu CY. Biomarkers in Colorectal Cancer. Anticancer Res. 2016;36(3):1093–1102.26977004
   PubMed Web of Science ®Google Scholar
• Ji K, Zhang M, Chu Q, et al. The Role of p-STAT3 as a prognostic and clinicopathological marker in colorectal cancer: a systematic review and meta-analysis. PLoS One. 2016;11(8):e0160125. doi:10.1371/journal.pone.016012527504822
   PubMed Web of Science ®Google Scholar
• Dyson JK, Rutter MD. Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk? World J Gastroenterol. 2012;18(29):3839–3848. doi:10.3748/wjg.v18.i29.383922876036
   PubMed Web of Science ®Google Scholar
• Cassia B. Impact of tumor location and variables associated with overall survival in patients with colorectal cancer: a Mayo Clinic Colon and Rectal Cancer Registry Study. Front Oncol. 2019;76(9). doi:10.3389/fonc.2019.00076
   Web of Science ®Google Scholar
• Mohr AM, Mott JL. Overview of microRNA biology. Semin Liver Dis. 2015;35(1):3–11. doi:10.1055/s-0034-139734425632930
   PubMed Web of Science ®Google Scholar
• Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014;505(7483):344–352. doi:10.1038/nature1298624429633
   PubMed Web of Science ®Google Scholar
• Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597–610. doi:10.1038/nrg284320661255
   PubMed Web of Science ®Google Scholar
• Huang S, Tan X, Huang Z, Chen Z, Lin P, Fu SW. microRNA biomarkers in colorectal cancer liver metastasis. J Cancer. 2018;9(21):3867–3873. doi:10.7150/jca.2858830410589
   PubMed Web of Science ®Google Scholar
• Tokarz P, Blasiak J. The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.. Acta Biochim Pol. 2012;59(4):467–474. doi:10.18388/abp.2012_207923173124
   PubMed Web of Science ®Google Scholar
• Wei L, Wang X, Lv L, Zheng Y, Zhang N, Yang M. The emerging role of noncoding RNAs in colorectal cancer chemoresistance. Cellular Oncology. 2019;42(6):757–768. doi:10.1007/s13402-019-00466-8
   PubMed Web of Science ®Google Scholar
• Takahashi H, Takahashi M, Ohnuma S, et al. microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer. BMC Cancer. 2017;17(1):723. doi:10.1186/s12885-017-3739-x29115941
   PubMed Web of Science ®Google Scholar
• Shen X, Ye Y, Qi J, et al. Identification of a novel microRNA, miR-4449, as a potential blood based marker in multiple myeloma. Clin Chem Lab Med. 2017;55(5):748–754. doi:10.1515/cclm-2015-110827155004
   PubMed Web of Science ®Google Scholar
• Furqan M, Akinleye A, Mukhi N, Mittal V, Chen Y, Liu D. STAT inhibitors for cancer therapy. J Hematol Oncol. 2013;6(1):90. doi:10.1186/1756-8722-6-9024308725
   PubMed Web of Science ®Google Scholar
• Li Y, de Haar C, Chen M, et al. van der Woude CJ. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut. 2010;59(2):227–235. doi:10.1136/gut.2009.18417619926618
   PubMed Web of Science ®Google Scholar
• Zhong Z, Wen Z, Darnell JE. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264(5155):95–98. doi:10.1126/science.81404228140422
   PubMed Web of Science ®Google Scholar
• Inagaki-Ohara K, Kondo T, Ito M, Yoshimura A. SOCS, inflammation, and cancer. JAKSTAT. 2013;2(3):e24053. doi:10.4161/jkst.2405324069550
   PubMedGoogle Scholar
• Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007;7(6):454–465. doi:10.1038/nri209317525754
   PubMed Web of Science ®Google Scholar
• Chu Q, Shen D, He L, Wang H, Liu C, Zhang W. Prognostic significance of SOCS3 and its biological function in colorectal cancer. Gene. 2017;627:114–122. doi:10.1016/j.gene.2017.06.01328603075
   PubMed Web of Science ®Google Scholar
• Grandis JR, Drenning SD, Zeng Q, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A. 2000;97(8):4227–4232. doi:10.1073/pnas.97.8.422710760290
   PubMed Web of Science ®Google Scholar
• Slattery ML, Herrick JS, Pellatt DF, et al. MicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression. Carcinogenesis. 2016;37(3):245–261. doi:10.1093/carcin/bgv24926740022
   PubMed Web of Science ®Google Scholar
• Soutto M, Chen Z, Bhat AA, et al. Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia. Nat Commun. 2019;10(1):3039. doi:10.1038/s41467-019-11011-431292446
   PubMed Web of Science ®Google Scholar
• Croker BA, Krebs DL, Zhang J-G, et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003;4(6):540–545. doi:10.1038/ni93112754505
   PubMed Web of Science ®Google Scholar
• Zhang T. Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World J Gastroenterol. 2015;21(6):1804–1813. doi:10.3748/wjg.v21.i6.180425684945
   PubMed Web of Science ®Google Scholar
• Zhang J, Lu Y, Yue X, et al. MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3. PLoS One. 2013;8(8):e70300. doi:10.1371/journal.pone.007030023940556
   PubMed Web of Science ®Google Scholar
• Zhu Y, Wang C, Becker SA, et al. miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer. Mol Ther. 2018;26(3):744–754. doi:10.1016/j.ymthe.2017.12.02329475734
   PubMed Web of Science ®Google Scholar
• Sheng N, Tan G, You W, et al. MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway. Cancer Med. 2017;6(6):1331–1340. doi:10.1002/cam4.102928440035
   PubMed Web of Science ®Google Scholar
• Shen X, Jiang H, Chen Z, et al. MicroRNA-145 inhibits cell migration and invasion in colorectal cancer by targeting TWIST. Onco Targets Ther. 2019;12:10799–10809. doi:10.2147/OTT.S21614731849487
   PubMed Web of Science ®Google Scholar
• He Q, Fang Y, Lu F, et al. Analysis of differential expression profile of miRNA in peripheral blood of patients with lung cancer. J Clin Lab Anal. 2019;33(9):e23003. doi:10.1002/jcla.2300331541491
   PubMed Web of Science ®Google Scholar
• Zhang X, Hu F, Li G, et al. Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. Cell Death Dis. 2018;9(2):25. doi:10.1038/s41419-017-0176-329348540
   PubMed Web of Science ®Google Scholar
• Zhou J, Jiang Y, Zhao J, et al. Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma. Cellular Oncology. 2020;43(3):461–475. doi:10.1007/s13402-020-00502-y
   PubMed Web of Science ®Google Scholar
• Pan S, Deng Y, Fu J, et al. TRIM52 promotes colorectal cancer cell proliferation through the STAT3 signaling. Cancer Cell Int. 2019;19(1):57. doi:10.1186/s12935-019-0775-430918473
   PubMed Web of Science ®Google Scholar
• Li LX, Lam IH, Liang FF, et al. MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23(4):1487–1493. doi:10.26355/eurrev_201902_1710630840270
   PubMed Web of Science ®Google Scholar
• Hong YG, Xin C, Zheng H, et al. miR-365a-3p regulates ADAM10-JAK-STAT signaling to suppress the growth and metastasis of colorectal cancer cells. J Cancer. 2020;11(12):3634–3644. doi:10.7150/jca.4273132284760
   PubMed Web of Science ®Google Scholar
• Wang Y, Lu Z, Wang N, Zhang M, Zeng X, Zhao W. MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncol Rep. 2017;37(6):3227–3234. doi:10.3892/or.2017.560528498395
   PubMed Web of Science ®Google Scholar
• Ren D, Lin B, Zhang X, et al. Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway. Oncotarget. 2017;8(30):49807–49823. doi:10.18632/oncotarget.1797128591704
   PubMed Web of Science ®Google Scholar
• Wang X, Chen S, Ni J, Cheng J, Jia J, Zhen X. miRNA-3473b contributes to neuroinflammation following cerebral ischemia. Cell Death Dis. 2018;9(1):11. doi:10.1038/s41419-017-0014-729317607
   PubMed Web of Science ®Google Scholar
• Xu JZ, Shao CC, Wang XJ, et al. circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis. Cell Death Dis. 2019;10(3):175. doi:10.1038/s41419-019-1382-y30787278
   PubMed Web of Science ®Google Scholar
• Li XD, Li XM, Gu JW, Sun XC. MiR-155 regulates lymphoma cell proliferation and apoptosis through targeting SOCS3/JAK-STAT3 signaling pathway. Eur Rev Med Pharmacol Sci. 2017;21(22):5153–5159. doi:10.26355/eurrev_201711_1383229228427
   PubMed Web of Science ®Google Scholar
• Wang SW, Sun YM. The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol. 2014;44(4):1032–1040. doi:10.3892/ijo.2014.225924430672
   PubMed Web of Science ®Google Scholar
• Cheng CC, Liao PN, Ho AS, et al. STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: rNAseq analysis and therapeutic screening. J Biomed Sci. 2018;25(1):60. doi:10.1186/s12929-018-0456-y30068339
   PubMed Web of Science ®Google Scholar