Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• Tryfonidis K, Senkus E, Cardoso MJ, Cardoso F. Management of locally advanced breast cancer-perspectives and future directions. Nat Rev Clin Oncol. 2015;12(3):147–162. doi:10.1038/nrclinonc.2015.1325668732
   PubMed Web of Science ®Google Scholar
• Azim HA Jr, de Azambuja E, Colozza M, Bines J, Piccart MJ. Long-term toxic effects of adjuvant chemotherapy in breast cancer. Ann Oncol. 2011;22(9):1939–1947. doi:10.1093/annonc/mdq68321289366
   PubMed Web of Science ®Google Scholar
• Niu L, Liu L, Yang S, Ren J, Lai P, Chen GG. New insights into sorafenib resistance in hepatocellular carcinoma: responsible mechanisms and promising strategies. Biochim Biophys Acta Rev Cancer. 2017;1868(2):564–570. doi:10.1016/j.bbcan.2017.10.00229054475
   PubMed Web of Science ®Google Scholar
• Kim W, Lee WB, Lee JW, et al. Traditional herbal medicine as adjunctive therapy for breast cancer: a systematic review. Complement Ther Med. 2015;23(4):626–632. doi:10.1016/j.ctim.2015.03.01126275657
   PubMed Web of Science ®Google Scholar
• Nakhjavani M, Palethorpe HM, Tomita Y, et al. Stereoselective anti-cancer activities of ginsenoside Rg3 on triple negative breast cancer cell models. Pharmaceuticals (Basel). 2019;12(3):117. doi:10.3390/ph12030117
   PubMedGoogle Scholar
• Palethorpe HM, Smith E, Tomita Y, et al. Bacopasides I and II act in synergy to inhibit the growth, migration and invasion of breast cancer cell lines. Molecules. 2019;24(19). doi:10.3390/molecules24193539.
   PubMed Web of Science ®Google Scholar
• Fujiki H, Suganuma M, Kurusu M, et al. New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mutat Res. 2003;523–524:119–125. doi:10.1016/S0027-5107(02)00327-5
   PubMed Web of Science ®Google Scholar
• Schröder L, Marahrens P, Koch JG, et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. Oncol Rep. 2019;41(1):387–396. doi:10.3892/or.2018.678930320348
   PubMed Web of Science ®Google Scholar
• Tajbakhsh A, Hasanzadeh M, Rezaee M, et al. Therapeutic potential of novel formulated forms of curcumin in the treatment of breast cancer by the targeting of cellular and physiological dysregulated pathways. J Cell Physiol. 2018;233(3):2183–2192. doi:10.1002/jcp.2596128419458
   PubMed Web of Science ®Google Scholar
• Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics. 2017;7(14):3461–3477. doi:10.7150/thno.2065728912888
   PubMed Web of Science ®Google Scholar
• Li X, Wang K, Ren Y, et al. MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study. Cell Death Dis. 2014;5:e1356. doi:10.1038/cddis.2014.32125077542
   PubMed Web of Science ®Google Scholar
• Zhang H, Ren Y, Tang X, et al. Vascular normalization induced by sinomenine hydrochloride results in suppressed mammary tumor growth and metastasis. Sci Rep. 2015;5(1):8888. doi:10.1038/srep0888825749075
   PubMed Web of Science ®Google Scholar
• Li X, Li P, Liu C, et al. Sinomenine hydrochloride inhibits breast cancer metastasis by attenuating inflammation-related epithelial-mesenchymal transition and cancer stemness. Oncotarget. 2017;8(8):13560–13574. doi:10.18632/oncotarget.1459328088791
   PubMedGoogle Scholar
• Yang S, Peng LY, Peng W, et al. Anticancer potentials of sinomenine from sinomenium acutum: a mini-review. Trop J Pharm Res. 2018;17(12):2519–2526. doi:10.4314/tjpr.v17i12.30
   Web of Science ®Google Scholar
• Song L, Liu D, Zhao Y, et al. Sinomenine reduces growth and metastasis of breast cancer cells and improves the survival of tumor-bearing mice through suppressing the SHh pathway. Biomed Pharmacother. 2018;98:687–693. doi:10.1016/j.biopha.2017.12.06529304494
   PubMed Web of Science ®Google Scholar
• Gao G, Liang X, Ma W. Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis. Artif Cells Nanomed Biotechnol. 2019;47(1):3839–3846. doi:10.1080/21691401.2019.166686131556312
   PubMed Web of Science ®Google Scholar
• Zhang YS, Han JY, Iqbal O, Liang AH. Research advances and prospects on mechanism of sinomenin on histamine release and the binding to histamine receptors. Int J Mol Sci. 2018;20(1):70. doi:10.3390/ijms20010070
   PubMed Web of Science ®Google Scholar
• Hopkins AL. Network pharmacology. Nat Biotechnol. 2007;25(10):1110–1111. doi:10.1038/nbt1007-111017921993
   PubMed Web of Science ®Google Scholar
• Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682–690. doi:10.1038/nchembio.11818936753
   PubMed Web of Science ®Google Scholar
• Niu X, Zhang J, Ni J, et al. Network pharmacology-based identification of major component of angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. Biosci Rep. 2018;38(6):6. doi:10.1042/BSR20180519
   Web of Science ®Google Scholar
• Zhang R, Zhu X, Bai H, Ning K. Network pharmacology databases for traditional Chinese medicine: review and assessment. Front Pharmacol. 2019;10:123. doi:10.3389/fphar.2019.0012330846939
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.011822455463
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504. doi:10.1101/gr.123930314597658
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–607D613. doi:10.1093/nar/gky113130476243
   PubMed Web of Science ®Google Scholar
• Trott O, Olson AJ. AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455–461. doi:10.1002/jcc.2133419499576
   PubMed Web of Science ®Google Scholar
• Laskowski RA, Swindells MB. LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model. 2011;51(10):2778–2786. doi:10.1021/ci200227u21919503
   PubMed Web of Science ®Google Scholar
• Huang SY, Zou X. Efficient molecular docking of NMR structures: application to HIV-1 protease. Protein Sci. 2007;16(1):43–51. doi:10.1110/ps.06250150717123961
   PubMed Web of Science ®Google Scholar
• Yu B, Li H, Chen J, et al. Extensively expanded murine-induced hepatic stem cells maintain high-efficient hepatic differentiation potential for repopulation of injured livers. Liver Int. 2020;40(9):2293–2304. doi:10.1111/liv.1450932394491
   PubMed Web of Science ®Google Scholar
• Yang LH, Wang Y, Qiao S, et al. Liver-enriched activator protein 1 as an isoform of CCAAT/enhancer-binding protein beta suppresses stem cell features of hepatocellular carcinoma. Cancer Manag Res. 2018;10:873–885. doi:10.2147/CMAR.S16017229731667
   PubMed Web of Science ®Google Scholar
• He X, Maimaiti M, Jiao Y, Meng X, Li H. Sinomenine induces G1-phase cell cycle arrest and apoptosis in malignant glioma cells via downregulation of sirtuin 1 and induction of p53 acetylation. Technol Cancer Res Treat. 2018;17:1533034618770305. doi:10.1177/153303461877030529756546
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–98W102. doi:10.1093/nar/gkx24728407145
   PubMed Web of Science ®Google Scholar
• Lu H, Tran L, Park Y, et al. Reciprocal regulation of DUSP9 and DUSP16 expression by HIF1 controls ERK and p38 MAP kinase activity and mediates chemotherapy-induced breast cancer stem cell enrichment. Cancer Res. 2018;78(15):4191–4202. doi:10.1158/0008-5472.CAN-18-027029880481
   PubMed Web of Science ®Google Scholar
• Moody TW, Nuche-Berenguer B, Jensen RT. Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer. Curr Opin Endocrinol Diabetes Obes. 2016;23(1):38–47. doi:10.1097/MED.000000000000021826702849
   PubMedGoogle Scholar
• Cao WH, Liu XP, Meng SL, et al. USP4 promotes invasion of breast cancer cells via relaxin/TGF-β1/Smad2/MMP-9 signal. Eur Rev Med Pharmacol Sci. 2016;20(6):1115–1122.27049265
   PubMed Web of Science ®Google Scholar
• Clarke R, Tyson JJ, Dixon JM, Endocrine resistance in breast cancer – an overview and update. Mol Cell Endocrinol. 2015;418(Pt 3):220–234. doi:10.1016/j.mce.2015.09.03526455641
   PubMed Web of Science ®Google Scholar
• Subramani R, Nandy SB, Pedroza DA, Lakshmanaswamy R. Role of growth hormone in breast cancer. Endocrinology. 2017;158(6):1543–1555. doi:10.1210/en.2016-192828379395
   PubMed Web of Science ®Google Scholar
• Geisler J, Touma J, Rahbar A, Söderberg-Nauclér C, Vetvik KA. Review of the potential role of human cytomegalovirus (HCMV) infections in breast cancer carcinogenesis and abnormal immunity. Cancers (Basel). 2019;11(12):12. doi:10.3390/cancers11121842
   Web of Science ®Google Scholar
• Yuan J, Dong X, Yap J, Hu J. The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. J Hematol Oncol. 2020;13(1):113.32807225
   PubMed Web of Science ®Google Scholar
• Huerta S, Chilka S, Bonavida B. Nitric oxide donors: novel cancer therapeutics (review). Int J Oncol. 2008;33(5):909–927.18949354
   PubMed Web of Science ®Google Scholar
• Dávila-González D, Choi DS, Rosato RR, et al. Pharmacological inhibition of NOS activates ASK1/JNK pathway augmenting docetaxel-mediated apoptosis in triple-negative breast cancer. Clin Cancer Res. 2018;24(5):1152–1162. doi:10.1158/1078-0432.CCR-17-143729301832
   PubMed Web of Science ®Google Scholar
• Granados-Principal S, Liu Y, Guevara ML, et al. Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer. Breast Cancer Res. 2015;17(1):25. doi:10.1186/s13058-015-0527-x25849745
   PubMed Web of Science ®Google Scholar
• Basudhar D, Somasundaram V, de Oliveira GA, et al. Nitric oxide synthase-2-derived nitric oxide drives multiple pathways of breast cancer progression. Antioxid Redox Signal. 2017;26(18):1044–1058. doi:10.1089/ars.2016.681327464521
   PubMed Web of Science ®Google Scholar
• Juríková M, Danihel Ľ, Polák Š. Ki67, PCNA, and MCM proteins: markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 2016;118(5):544–552. doi:10.1016/j.acthis.2016.05.00227246286
   PubMed Web of Science ®Google Scholar
• Niu XL, Wang Y, Yao Z, et al. Autocrine interferon-γ may affect malignant behavior and sensitivity to tamoxifen of MCF-7 via estrogen receptor β subtype. Oncol Rep. 2015;34(6):3120–3130. doi:10.3892/or.2015.429426397740
   PubMed Web of Science ®Google Scholar
• Yip CH, Rhodes A. Estrogen and progesterone receptors in breast cancer. Future Oncol. 2014;10(14):2293–2301. doi:10.2217/fon.14.11025471040
   PubMed Web of Science ®Google Scholar
• Zheng Y, Shao X, Huang Y, et al. Role of estrogen receptor in breast cancer cell gene expression. Mol Med Rep. 2016;13(5):4046–4050. doi:10.3892/mmr.2016.501827035558
   PubMed Web of Science ®Google Scholar
• Burotto M, Chiou VL, Lee JM, Kohn EC. The MAPK pathway across different malignancies: a new perspective. Cancer. 2014;120(22):3446–3456. doi:10.1002/cncr.2886424948110
   PubMed Web of Science ®Google Scholar
• Xu M, Liu S, Wan R, Chen Y. Combined treatment with sinomenine and acupuncture on collagen-induced arthritis through the NF-κB and MAPK signaling pathway. Oncol Lett. 2018;15(6):8770–8776. doi:10.3892/ol.2018.839429805616
   PubMed Web of Science ®Google Scholar
• MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997;15(1):323–350. doi:10.1146/annurev.immunol.15.1.3239143691
   PubMed Web of Science ®Google Scholar
• Chinje EC, Stratford IJ. Role of nitric oxide in growth of solid tumours: a balancing act. Essays Biochem. 1997;32:61–72.9493011
   PubMed Web of Science ®Google Scholar
• Lechner M, Lirk P, Rieder J. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. Semin Cancer Biol. 2005;15(4):277–289. doi:10.1016/j.semcancer.2005.04.00415914026
   PubMed Web of Science ®Google Scholar
• Dhar A, Brindley JM, Stark C, Citro ML, Keefer LK, Colburn NH. Nitric oxide does not mediate but inhibits transformation and tumor phenotype. Mol Cancer Ther. 2003;2(12):1285–1293.14707269
   PubMed Web of Science ®Google Scholar
• Liu SH, Otal-Brun M, Webb TE. Glucocorticoid receptors in human tumors. Cancer Lett. 1980;10(3):269–275. doi:10.1016/0304-3835(80)90080-47191771
   PubMed Web of Science ®Google Scholar
• Nesset KA, Perri AM, Mueller CR. Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors. Epigenetics. 2014;9(6):851–859. doi:10.4161/epi.2848424622770
   PubMed Web of Science ®Google Scholar
• Tonsing-Carter E, Hernandez KM, Kim CR, et al. Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res. 2019;21(1):82. doi:10.1186/s13058-019-1164-631340854
   PubMed Web of Science ®Google Scholar