Oxycodone/Acetaminophen: The Tailoring Combination Treatment for Specific Clinical Profile of Opioid Well-Responsive Cancer Pain

References

• Organization WH. Cancer Pain Relief. World Health Organization; 1986 https://apps.who.int/iris/handle/10665/43944. Accessed 722, 2020.
   Google Scholar
• Linee Guida Terapia Del Dolore In Oncologia. AIOM. 2018 Accessed 722, 2020 https://www.aiom.it/linee-guida-aiom-2018-terapia-del-dolore-in-oncologia/.
   Google Scholar
• Caraceni A, Hanks G, Kaasa S, et al. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012;13(2):e58–68. doi:10.1016/S1470-2045(12)70040-222300860
   PubMed Web of Science ®Google Scholar
• Fallon M, Giusti R, Aielli F, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Suppl 4):iv166–iv191. doi:10.1093/annonc/mdy152
   PubMed Web of Science ®Google Scholar
• Kwon JH. Overcoming barriers in cancer pain management. J Clin Oncol. 2014;32(16):1727–1733. doi:10.1200/JCO.2013.52.482724799490
   PubMed Web of Science ®Google Scholar
• Mercadante S, Portenoy RK. Opioid poorly-responsive cancer pain. Part 3. Clinical strategies to improve opioid responsiveness. J Pain Symptom Manage. 2001;21(4):338–354. doi:10.1016/s0885-3924(01)00250-011312049
   PubMed Web of Science ®Google Scholar
• Greco MT, Roberto A, Corli O, et al. Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer. J Clin Oncol. 2014;32(36):4149–4154. doi:10.1200/JCO.2014.56.038325403222
   PubMed Web of Science ®Google Scholar
• Reis-Pina P, Lawlor PG, Barbosa A. Adequacy of cancer-related pain management and predictors of undertreatment at referral to a pain clinic. J Pain Res. 2017;10:2097–2107. doi:10.2147/JPR.S13971528919809
   PubMed Web of Science ®Google Scholar
• Gatti A, Sabato AF, Carucci A, Bertini L, Mammucari M, Occhioni R. Adequacy assessment of oxycodone/paracetamol (acetaminophen) in multimodal chronic pain: a prospective observational study. Clin Drug Investig. 2009;29(Suppl 1):31–40. doi:10.2165/0044011-200929001-00005
   PubMed Web of Science ®Google Scholar
• Mao J, Gold MS, Backonja M. Combination drug therapy for chronic pain: a call for more clinical studies. J Pain. 2011;12(2):157–166. doi:10.1016/j.jpain.2010.07.00620851058
   PubMed Web of Science ®Google Scholar
• Gilron I, Jensen TS, Dickenson AH. Combination pharmacotherapy for management of chronic pain: from bench to bedside. Lancet Neurol. 2013;12(11):1084–1095. doi:10.1016/S1474-4422(13)70193-524074723
   PubMed Web of Science ®Google Scholar
• Gammaitoni AR, Galer BS, Bulloch S, et al. Randomized, double-blind, placebo-controlled comparison of the analgesic efficacy of oxycodone 10 mg/acetaminophen 325 mg versus controlled-release oxycodone 20 mg in postsurgical pain. J Clin Pharmacol. 2003;43(3):296–304. doi:10.1177/009127000325114712638399
   PubMed Web of Science ®Google Scholar
• Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF. Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain. Clin Drug Invest. 2010;30(Suppl 2):3–14. doi:10.2165/1158414-S0-000000000-00000
   PubMed Web of Science ®Google Scholar
• Gaskell H, Derry S, Moore RA, McQuay HJ. Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009;3:CD002763. doi:10.1002/14651858.CD002763.pub2
   Web of Science ®Google Scholar
• Sima L, Fang WX, Wu XM, Li F. Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. J Clin Pharm Ther. 2012;37(1):27–31. doi:10.1111/j.1365-2710.2010.01239.x21208247
   PubMed Web of Science ®Google Scholar
• Leppert W. Role of oxycodone and oxycodone/naloxone in cancer pain management. Pharmacol Rep. 2010;62(4):578–591. doi:10.1016/s1734-1140(10)70316-920884999
   PubMed Web of Science ®Google Scholar
• Olkkola KT, Kontinen VK, Saari TI, Kalso EA. Does the pharmacology of oxycodone justify its increasing use as an analgesic? Trends Pharmacol Sci. 2013;34(4):206–214. doi:10.1016/j.tips.2013.02.00123465410
   PubMed Web of Science ®Google Scholar
• De Santis S, Borghesi C, Ricciardi S, et al. Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain: an observational analysis. Onco Targets Ther. 2016;9:4043–4052. doi:10.2147/OTT.S10814427445495
   PubMed Web of Science ®Google Scholar
• Gao T, Zhu H, Zhang C, et al. Efficacy of acetaminophen with and without oxycodone for analgesia in non-operative treatment of extremity fractures in adults: protocol for a double-blind randomized clinical trial. Trials. 2019;20(1):510. doi:10.1186/s13063-019-3579-x31420055
   PubMed Web of Science ®Google Scholar
• Mercadante S, Marchetti P, Cuomo A, et al. Factors Influencing the Clinical Presentation of Breakthrough Pain in Cancer Patients. Cancers. 2018;10:6. doi:10.3390/cancers10060175
   PubMed Web of Science ®Google Scholar
• Løhre ET, Klepstad P, Bennett MI, et al. From “Breakthrough” to “Episodic” Cancer Pain? A european association for palliative care research network expert delphi survey toward a common terminology and classification of transient cancer pain exacerbations. J Pain Symptom Manage. 2016;51(6):1013–1019. doi:10.1016/j.jpainsymman.2015.12.32926921493
   PubMed Web of Science ®Google Scholar
• Mercadante S, Lazzari M, Reale C, et al. Italian Oncological Pain Survey (IOPS): a multicentre Italian study of breakthrough pain performed in different settings. Clin J Pain. 2015;31(3):214–221. doi:10.1097/AJP.000000000000016125654429
   PubMed Web of Science ®Google Scholar
• Mercadante S, Adile C, Torta R, et al. Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients. Curr Med Res Opin. 2013;29(1):93–97. doi:10.1185/03007995.2012.75512023198976
   PubMed Web of Science ®Google Scholar
• Mercadante S, Adile C, Masedu F, Marchetti P, Costanzi A, Aielli F. Factors influencing the use of opioids for breakthrough cancer pain: a secondary analysis of the IOPS-MS study. Eur J Pain. 2019;23(4):719–726. doi:10.1002/ejp.133930421474
   PubMed Web of Science ®Google Scholar
• WHO. WHO’s Cancer Pain Ladder for Adults. WHO https://www.who.int/cancer/palliative/painladder/en/. Accessed 722, 2020.
   Google Scholar
• Hui D, Bruera E. A personalized approach to assessing and managing pain in patients with cancer. J Clin Oncol. 2014;32(16):1640–1646. doi:10.1200/JCO.2013.52.250824799495
   PubMed Web of Science ®Google Scholar
• Caraceni A, Shkodra M. Cancer Pain Assessment and Classification. Cancers. 2019;11:4. doi:10.3390/cancers11040510
   Web of Science ®Google Scholar
• Mercadante S. The Patient with Difficult Cancer Pain. Cancers. 2019;11:4. doi:10.3390/cancers11040565
   Web of Science ®Google Scholar
• Niscola P, Tendas A, Scaramucci L, et al. Pain in malignant hematology. Exp Rev Hematol. 2011;4(1):81–93. doi:10.1586/ehm.10.79
   PubMed Web of Science ®Google Scholar
• Mercadante S. Reviewing without a Clinical Background Is Detrimental for Cancer Pain Management. Cancers. 2019;11:7. doi:10.3390/cancers11071005
   Web of Science ®Google Scholar
• Grond S, Radbruch L, Meuser T, Loick G, Sabatowski R, Lehmann KA. High-dose tramadol in comparison to low-dose morphine for cancer pain relief. J Pain Symptom Manage. 1999;18(3):174–179. doi:10.1016/s0885-3924(99)00060-310517038
   PubMed Web of Science ®Google Scholar
• Mercadante S, Porzio G, Ferrera P, et al. Low morphine doses in opioid-naive cancer patients with pain. J Pain Symptom Manage. 2006;31(3):242–247. doi:10.1016/j.jpainsymman.2006.01.00116563318
   PubMed Web of Science ®Google Scholar