The Future of Lung Cancer Screening: Current Challenges and Research Priorities

References

• Aberle DR, Adams AM; National Lung Screening Trial Research T. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365(5):395–409. doi:10.1056/NEJMoa1102873.
   PubMed Web of Science ®Google Scholar
• de Koning HJ, van der Aalst CM, de Jong PA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med. 2020;382(6):503–513. doi:10.1056/NEJMoa1911793
   PubMed Web of Science ®Google Scholar
• Matthijs Oudkerk AD, Vliegenthart R, Henzler T, et al. European position statement on lung cancer screening. Lancet Oncol. 2017;18(12):e754–e66. doi:10.1016/S1470-2045(17)30861-6
   PubMed Web of Science ®Google Scholar
• Kauczor HU, Baird AM, Blum TG, et al. ESR/ERS statement paper on lung cancer screening. Eur Respir J. 2020;55(2). doi:10.1183/13993003.00506-2019
   PubMed Web of Science ®Google Scholar
• Tammemagi MC, Church TR, Hocking WG, et al. Evaluation of the lung cancer risks at which to screen ever- and never-smokers: screening rules applied to the PLCO and NLST cohorts. PLoS Med. 2014;11(12):e1001764. doi:10.1371/journal.pmed.1001764
   PubMed Web of Science ®Google Scholar
• Humphrey LL, Deffebach M, Pappas M, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the US preventive services task force recommendation. Ann Intern Med. 2013;159(6):411–420. doi:10.7326/0003-4819-159-6-201309170-00690
   PubMed Web of Science ®Google Scholar
• Force USPST, Krist AH, Davidson KW, et al. Screening for lung cancer: US preventive services task force recommendation statement. JAMA. 2021;325(10):962–970. doi:10.1001/jama.2021.1117
   PubMed Web of Science ®Google Scholar
• Cassidy A, Myles JP, van Tongeren M, et al. The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer. 2008;98(2):270–276.
   PubMed Web of Science ®Google Scholar
• Tammemagi MC, Katki HA, Hocking WG, et al. Selection criteria for lung-cancer screening. N Engl J Med. 2013;368(8):728–736. doi:10.1056/NEJMoa1211776
   PubMed Web of Science ®Google Scholar
• Robbins HA, Alcala K, Swerdlow AJ, et al. Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom. Br J Cancer. 2021;124(12):2026–2034. doi:10.1038/s41416-021-01278-0
   PubMed Web of Science ®Google Scholar
• Baldwin DR, Duffy SW, Wald NJ, et al. UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer. Thorax. 2011;66(4):308–313. doi:10.1136/thx.2010.152066
   PubMed Web of Science ®Google Scholar
• Field JK, Duffy SW, Baldwin DR, et al. UK lung cancer RCT pilot screening trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening. Thorax. 2016;71(2):161–170. doi:10.1136/thoraxjnl-2015-207140
   PubMed Web of Science ®Google Scholar
• Ruparel M, Quaife SL, Dickson JL, et al. Lung screen uptake trial: results from a single lung cancer screening round. Thorax. 2020;75(10):908–912. doi:10.1136/thoraxjnl-2020-214703
   PubMed Web of Science ®Google Scholar
• Duffy SW, Maroni R, Vulkan D, et al. Liverpool healthy lung programme – second year evaluation report; 2018. Available from: https://www.liverpoolccg.nhs.uk/media/3245/final-lhlp-2nd-year-report-10-july-2018-with-logos.pdf. Accessed February 1, 2022.
   Google Scholar
• National Health Service England -N, Cancer, Programme. Targeted screening for lung cancer with low radiation dose computed tomography. Standard protocol prepared for the targeted lung health checks programme; 2019 [ cited UK Government]. Available from: https://www.england.nhs.uk/wp-content/uploads/2019/02/targeted-lung-health-checks-standard-protocol-v1.pdf. Accessed February 1, 2022.
   Google Scholar
• Ten Haaf K, Bastani M, Cao P, et al. A comparative modeling analysis of risk-based lung cancer screening strategies. J Natl Cancer Inst. 2020;112(5):466–479. doi:10.1093/jnci/djz164
   PubMedGoogle Scholar
• Park S, Nam BH, Yang HR, et al. Individualized risk prediction model for lung cancer in Korean men. PLoS One. 2013;8(2):e54823. doi:10.1371/journal.pone.0054823
   PubMed Web of Science ®Google Scholar
• Centers f, Medicare, &, Medicaid, Services. Screening for lung cancer with Low Dose Computed Tomography (LDCT); 2015. Available from: https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=N&NCAId=274. Accessed January 5, 2022.
   Google Scholar
• Verma V, Beriwal S. Medicare approves coverage for lung cancer screening: the case for symptomatic screening. JAMA Oncol. 2015;1(8):1027–1028. doi:10.1001/jamaoncol.2015.2165
   PubMed Web of Science ®Google Scholar
• Pham D, Bhandari S, Pinkston C, et al. Lung cancer screening registry reveals low-dose CT screening remains heavily underutilized. Clin Lung Cancer. 2020;21(3):e206–e11. doi:10.1016/j.cllc.2019.09.002
   PubMed Web of Science ®Google Scholar
• Ali N, Lifford KJ, Carter B, et al. Barriers to uptake among high-risk individuals declining participation in lung cancer screening: a mixed methods analysis of the UK Lung Cancer Screening (UKLS) trial. BMJ Open. 2015;5(7):e008254. doi:10.1136/bmjopen-2015-008254
   PubMed Web of Science ®Google Scholar
• Quaife SL, Ruparel M, Dickson JL, et al. Lung Screen Uptake Trial (LSUT): randomized controlled clinical trial testing targeted invitation materials. Am J Respir Crit Care Med. 2020;201(8):965–975. doi:10.1164/rccm.201905-0946OC
   PubMed Web of Science ®Google Scholar
• Baldwin DR, Brain K, Quaife S. Participation in lung cancer screening. Transl Lung Cancer Res. 2021;10(2):1091–1098. doi:10.21037/tlcr-20-917
   PubMed Web of Science ®Google Scholar
• Quaife SL, McEwen A, Janes SM, Wardle J. Attitudes towards lung cancer screening within socioeconomically deprived and heavy smoking communities: a qualitative study. Lancet. 2014;384:S16.
   Web of Science ®Google Scholar
• Ghimire B, Maroni R, Vulkan D, et al. Evaluation of a health service adopting proactive approach to reduce high risk of lung cancer: the Liverpool Healthy Lung Programme. Lung Cancer. 2019;134:66–71. doi:10.1016/j.lungcan.2019.05.026
   PubMed Web of Science ®Google Scholar
• Engela-Volker J, Eccles S. P163 Preparing wales for lung cancer screening – updating GP record smoking data using an automated text message system. Thorax. 2021;76(Suppl2):A156–A56. doi:10.1136/thorax-2021-BTSabstracts.272
   Web of Science ®Google Scholar
• Gesthalter YB, Koppelman E, Bolton R, et al. Evaluations of implementation at early-adopting lung cancer screening programs: lessons learned. Chest. 2017;152(1):70–80. doi:10.1016/j.chest.2017.02.012
   PubMed Web of Science ®Google Scholar
• Triplette M, Kross EK, Mann BA, et al. An assessment of primary care and pulmonary provider perspectives on lung cancer screening. Ann Am Thorac Soc. 2018;15(1):69–75. doi:10.1513/AnnalsATS.201705-392OC
   PubMed Web of Science ®Google Scholar
• Bol N, Helberger N, Weert JCM. Differences in mobile health app use: a source of new digital inequalities? Inf Soc. 2018;34(3):183–193. doi:10.1080/01972243.2018.1438550
   Web of Science ®Google Scholar
• Quaife SL, Janes SM, Brain KE. The person behind the nodule: a narrative review of the psychological impact of lung cancer screening. Transl Lung Cancer Res. 2021;10(5):2427–2440. doi:10.21037/tlcr-20-1179
   PubMed Web of Science ®Google Scholar
• Kummer S, Waller J, Ruparel M, et al. Mapping the spectrum of psychological and behavioural responses to low-dose CT lung cancer screening offered within a Lung Health Check. Health Expect. 2020;23(2):433–441. doi:10.1111/hex.13030
   PubMed Web of Science ®Google Scholar
• Slatore CG, Wiener RS, Golden SE, et al. Longitudinal assessment of distress among veterans with incidental pulmonary nodules. Ann Am Thorac Soc. 2016;13(11):1983–1991. doi:10.1513/AnnalsATS.201607-555OC
   PubMed Web of Science ®Google Scholar
• National Lung Screening Trial Research T. Lung cancer incidence and mortality with extended follow-up in the national lung screening trial. J Thorac Oncol. 2019;14(10):1732–1742. doi:10.1016/j.jtho.2019.05.044.
   PubMed Web of Science ®Google Scholar
• American College Radiology. Lung RADS v 1.1; 2019. Available from: https://www.acr.org/-/media/ACR/Files/RADS/Lung-RADS/LungRADSAssessmentCategoriesv1-1.pdf?la=en. Accessed February 1, 2022.
   Google Scholar
• Callister ME, Baldwin DR, Akram AR, et al. British thoracic society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015;70(Suppl 2):ii1–ii54. doi:10.1136/thoraxjnl-2015-207168
   PubMed Web of Science ®Google Scholar
• Soo E, Edey AJ, Mak SM, et al. Impact of choice of volumetry software and nodule management guidelines on recall rates in lung cancer screening. Eur J Radiol. 2019;120:108646. doi:10.1016/j.ejrad.2019.108646
   PubMed Web of Science ®Google Scholar
• Yousaf-Khan U, van der Aalst C, de Jong PA, et al. Final screening round of the Nelson lung cancer screening trial: the effect of a 2.5-year screening interval. Thorax. 2017;72(1):48–56. doi:10.1136/thoraxjnl-2016-208655
   PubMed Web of Science ®Google Scholar
• de Koning HJ, Meza R, Plevritis SK, et al. Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. preventive services task force. Ann Intern Med. 2014;160(5):311–320. doi:10.7326/M13-2316
   PubMed Web of Science ®Google Scholar
• Silva M, Milanese G, Sestini S, et al. Lung cancer screening by nodule volume in lung-RADS v1.1: negative baseline CT yields potential for increased screening interval. Eur Radiol. 2021;31(4):1956–1968. doi:10.1007/s00330-020-07275-w
   PubMed Web of Science ®Google Scholar
• Mendoza DP, Chintanapakdee W, Zhang EW, et al. Management and outcomes of suspected infectious and inflammatory lung abnormalities identified on lung cancer screening CT. AJR Am J Roentgenol. 2021:1–10. doi:10.2214/AJR.20.25124.
   Web of Science ®Google Scholar
• Quaife SL, Vrinten C, Ruparel M, et al. Smokers’ interest in a lung cancer screening programme: a national survey in England. BMC Cancer. 2018;18(1):497. doi:10.1186/s12885-018-4430-6
   PubMed Web of Science ®Google Scholar
• National Health Service. England -N, Cancer, Programme. Targeted screening for lung cancer with low radiation dose computed tomography. Quality assurance standards prepared for the targeted lung health checks programme; 2020 [ cited UK Government]. Available from: https://www.england.nhs.uk/wp-content/uploads/2019/02/targeted-screening-for-lung-cancer-quality-assurance-standard.pdf. Accessed February 1, 2022.
   Google Scholar
• Field JK, Hansell DM, Duffy SW, et al. CT screening for lung cancer: countdown to implementation. Lancet Oncol. 2013;14(13):e591–600. doi:10.1016/S1470-2045(13)70293-6
   PubMed Web of Science ®Google Scholar
• Balata H, Ruparel M, O’Dowd E, et al. Analysis of the baseline performance of five UK lung cancer screening programmes. Lung Cancer. 2021;161:136–140. doi:10.1016/j.lungcan.2021.09.012
   PubMed Web of Science ®Google Scholar
• Cressman S, Peacock SJ, Tammemagi MC, et al. The cost-effectiveness of high-risk lung cancer screening and drivers of program efficiency. J Thorac Oncol. 2017;12(8):1210–1222. doi:10.1016/j.jtho.2017.04.021
   PubMed Web of Science ®Google Scholar
• van der Aalst CM, van den Bergh KA, Willemsen MC, et al. Lung cancer screening and smoking abstinence: 2 year follow-up data from the Dutch-Belgian randomised controlled lung cancer screening trial. Thorax. 2010;65(7):600–605. doi:10.1136/thx.2009.133751
   PubMed Web of Science ®Google Scholar
• Tammemagi MC, Berg CD, Riley TL, et al. Impact of lung cancer screening results on smoking cessation. J Natl Cancer Inst. 2014;106(6):dju084. doi:10.1093/jnci/dju084
   PubMedGoogle Scholar
• Brain K, Carter B, Lifford KJ, et al. Impact of low-dose CT screening on smoking cessation among high-risk participants in the UK lung cancer screening trial. Thorax. 2017;72(10):912–918. doi:10.1136/thoraxjnl-2016-209690
   PubMed Web of Science ®Google Scholar
• Cadham CJ, Cao P, Jayasekera J, et al. Cost-effectiveness of smoking cessation interventions in the lung cancer screening setting: a simulation study. J Natl Cancer Inst. 2021;113(8):1065–1073. doi:10.1093/jnci/djab002
   PubMedGoogle Scholar
• Royal C, of, Radiologists. Clinical radiology: UK workforce consensus 2020 report; 2021. Available from: https://www.rcr.ac.uk/system/files/publication/field_publication_files/clinical-radiology-uk-workforce-census-2020-report.pdf. Accessed February 1, 2022.
   Google Scholar
• Chamberlin J, Kocher MR, Waltz J, et al. Automated detection of lung nodules and coronary artery calcium using artificial intelligence on low-dose CT scans for lung cancer screening: accuracy and prognostic value. BMC Med. 2021;19(1):55. doi:10.1186/s12916-021-01928-3
   PubMed Web of Science ®Google Scholar
• Smieliauskas F, MacMahon H, Salgia R, et al. Geographic variation in radiologist capacity and widespread implementation of lung cancer CT screening. J Med Screen. 2014;21(4):207–215. doi:10.1177/0969141314548055
   PubMed Web of Science ®Google Scholar
• Blom EF, Ten Haaf K, Arenberg DA, et al. Treatment capacity required for full-scale implementation of lung cancer screening in the United States. Cancer. 2019;125(12):2039–2048. doi:10.1002/cncr.32026
   PubMed Web of Science ®Google Scholar