104
Views
0
CrossRef citations to date
0
Altmetric
Original Research

HER2 Overexpression and Mismatch Repair Deficiency are Correlated with Malignancy in Colorectal Cancer

, , , , & ORCID Icon
Pages 3443-3454 | Published online: 20 Apr 2021

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. Cancer J Clin. 2015;65(1):5–29. doi:10.3322/caac.21254
  • Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2(2):127–137. doi:10.1038/3505207311252954
  • Krishnamurti U, Silverman JF. HER2 in breast cancer: a review and update. Adv Anat Pathol. 2014;21(2):100–107. doi:10.1097/PAP.000000000000001524508693
  • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a Phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–697; PMID: 20728210. doi: 10.1016/S0140-6736(10)61121-X20728210
  • Miller K, Cortes J, Hurvitz SA, et al. A randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer. BMC Cancer. 2016;16(1):352. PMID: 27259714; PMCID: PMC4893300. doi:10.1186/s12885-016-2385-z.27259714
  • Greally M, Kelly CM, Cercek A. HER2: an emerging target in colorectal cancer. Curr Probl Cancer. 2018;42(6):560–571. doi:10.1016/j.currproblcancer.2018.07.00130100092
  • Richman SD, Southward K, Chambers P, et al. HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. J Pathol. 2016;238(4):562–570. doi:10.1002/path.467926690310
  • De Cuyper A, Van Den Eynde M, Machiels JP. HER2 as a predictive biomarker and treatment target in colorectal cancer. Clin Colorectal Cancer. 2020;19(2):65–72. doi:10.1016/j.clcc.2020.02.00732229076
  • Lee W-S, Park YH, Lee JN, et al. Comparison of HER2 expression between primary colorectal cancer and their corresponding metastases. Cancer Med. 2014;3(3):674–680. doi:10.1002/cam4.22824668895
  • Schuell B, Gruenberger T, Scheithauer W, Zielinski C, Wrba F. HER 2/neu protein expression in colorectal cancer. BMC Cancer. 2006;6(1):123. doi:10.1186/1471-2407-6-12316681853
  • Karahan B, Argon A, Yıldırım M, Vardar E. Relationship between MLH-1, MSH-2, PMS-2, MSH-6 expression and clinicopathological features in colorectal cancer. Int J Clin Exp Pathol. 2015;8(4):4044–4053. PMID: 26097592; PMCID: PMC4466979.26097592
  • Kumar V. Robbins and Cotran Pathologic Basis of Disease. Kumar V, Abbas AK, Fausto N, editors. Philadelphia PA: Elsevier Saunders; 2005:269–342.
  • Boland CR. Evolution of the nomenclature for the hereditary colorectal cancer syndromes. Fam Cancer. 2005;4(3):211–218. doi:10.1007/s10689-004-4489-x16136380
  • Delahunty R, Mcmurrick P, Carne P, et al. Screening for mismatch repair deficiency in colorectal cancer[J]. Asia Pac Clin Oncol. 2015;11(S3):52.
  • Ramchander NC, Ryan NA, Crosbie EJ, Evans DG. Homozygous germ-line mutation of the PMS2 mismatch repair gene: a unique case report of constitutional mismatch repair deficiency (CMMRD). BMC Med Genet. 2017;18(1):40. doi:10.1186/s12881-017-0391-x28381238
  • Rex DK, Boland CR, Dominitz JA, et al. Colorectal cancer screening: recommendations for physicians and patients from the U.S. multi-society task force on colorectal cancer. Gastroenterology. 2017;153(1):307–323. doi:10.1053/j.gastro.2017.05.01328600072
  • Amin MB, Edge SB, Greene FL, et al.; Organization of the AJCC Cancer Staging Manual. AJCC Cancer Staging Manual; 2017
  • Editing group for guidelines for the detection of HER2 in gastric cancer. Guidelines for HER2 detection in gastric cancer. Chin J Pathol. 2011;40(8):553–557.
  • Li C, Liu DR, Ye LY, et al. HER-2 overexpression and survival in colorectal cancer: a meta-analysis. J Zhejiang Univ Sci B. 2014;15(6):582–589. doi:10.1631/jzus.B130025824903996
  • Tu J, Yu Y, Liu W, Chen S. Significance of human epidermal growth factor receptor 2 expression in colorectal cancer. Exp Ther Med. 2015;9(1):17–24. doi:10.3892/etm.2014.206325452770
  • Ingold Heppner B, Behrens HM, Balschun K, et al. HER2/neu testing in primary colorectal carcinoma. Br J Cancer. 2014;111(10):1977–1984. doi:10.1038/bjc.2014.48325211663
  • Seo AN, Kwak Y, Kim DW, et al. HER2 status in colorectal cancer: its clinical significance and the relationship between HER2 gene amplification and expression. PLoS One. 2014;9(5):e98528. doi:10.1371/journal.pone.009852824879338
  • Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol. 2016;17(6):738–746. doi:10.1016/S1470-2045(16)00150-927108243
  • Ye JX, Liu Y, Qin Y, Zhong HH, Yi WN, Shi XY. KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients. World J Gastroenterol. 2015;21(5):1595–1605. doi:10.3748/wjg.v21.i5.159525663779
  • Benson AB 3rd, Venook AP, Cederquist L,et al. Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017;15(3):370–398. doi:10.6004/jnccn.2017.0036
  • Li Q, Wang D, Li J, Chen P. Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas. BMC Cancer. 2011;11(1):1–6. doi:10.1186/1471-2407-11-27721194487
  • Sun SJ, Lin Q, Sun Q, et al. High HER-2 protein levels correlate with clinicopathological features in colorectal cancer. J Cancer Res Ther. 2016;12(2):323–333. doi:10.4103/0973-1482.15408127072259
  • Laurentpuig P, Balogoun R, Cayre A, et al. ERBB2 alterations a new prognostic biomarker in stage III colon cancer from a FOLFOX based adjuvant trial (PETACC8). Ann Oncol. 2016;27(6):4590–4597.
  • Stahler A, Heinemann V, Neumann J, et al. Prevalence and influence on outcome of HER2/neu, HER3 and NRG1 expression in patients with metastatic colorectal cancer. Anticancer Drugs. 2017;28(7):717–722. doi:10.1097/CAD.000000000000051028582279
  • McKeown E, Nelson DW, Johnson EK, et al. Current approaches and challenges for monitoring treatment response in colon and rectal cancer. J Cancer. 2014;5(1):31–43. PMID: 24396496. doi:10.7150/jca.798724396496
  • Chapusot C, Martin L, Mungra N, et al. Sporadic colorectal cancers with defective mismatch repair display a number of specific morphological characteristics: relationship between the expression of hMLH1 and hMSH2 proteins and clinicopathological features of 273 adenocarcinomas. Histopathology. 2003;43(1):40–47. doi:10.1046/j.1365-2559.2003.01641.x12823711
  • Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895–2015. Nat Rev Cancer. 2015;15(3):181–194. doi:10.1038/nrc387825673086
  • Michailidi C, Papavassiliou AG, Troungos C. DNA repair mechanisms in colorectal carcinogenesis. Curr Mol Med. 2012;12(3):237–246. doi:10.2174/15665241279921885922082485
  • Mecklin JP. Frequency of hereditary colorectal carcinoma. Gastroenterology. 1987;93(5):1021–1025. doi:10.1016/0016-5085(87)90565-82820826
  • Edelbrock MA, Kaliyaperumal S, Williams KJ. Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res. 2013;743-744:53–66. PMID: 23391514; PMCID: PMC3659183. doi:10.1016/j.mrfmmm.2012.12.00823391514
  • van der Klift HM, Mensenkamp AR, Drost M, et al. Comprehensive mutation analysis of PMS2 in a large cohort of probands suspected of lynch syndrome or constitutional mismatch repair deficiency syndrome. Hum Mutat. 2016;37(11):1162–1179; PMID: 27435373. doi: 10.1002/humu.2305227435373
  • Seifert M, Reichrath J. The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer. J Mol Histol. 2006;37(5–7):301–307. doi:10.1007/s10735-006-9062-517080293
  • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353(16):1659–1672. doi:10.1056/NEJMoa05230616236737
  • Otsu H, Oki E, Ikawa-Yoshida A, et al. Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer. Anticancer Res. 2015;35(4):2441–2446. PMID: 25862912.25862912
  • Lu Y, Jingyan G, Baorong S, Peng J, Xu Y, Cai S. Expression of EGFR, Her2 predict lymph node metastasis (LNM)-associated metastasis in colorectal cancer. Cancer Biomark. 2012;11(5):219–226. PMID: 23220854. doi:10.3233/CBM-2012-0028223220854
  • Ellina MI, Bouris P, Aletras AJ, Theocharis AD, Kletsas D, Karamanos NK. EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. Biochim Biophys Acta. 2014;1840(8):2651–2661. PMID: 24792576. doi:10.1016/j.bbagen.2014.04.01924792576
  • Willis JA, Reyes-Uribe L, Chang K, Lipkin SM, Vilar E. Immune activation in mismatch repair-deficient carcinogenesis: more than just mutational rate. Clin Cancer Res. 2020;26(1):11–17. PMID: 31383734; PMCID: PMC6942620. doi:10.1158/1078-0432.CCR-18-085631383734
  • Yan WY, Hu J, Xie L, et al. Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population. Onco Targets Ther. 2016;9:7415–7424. doi:10.2147/OTT.S11708927994472
  • Carethers JM, Chauhan DP, Fink D, et al. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 1999;117(1):123–131. PMID: 10381918; PMCID: PMC4343206. doi:10.1016/s0016-5085(99)70558-510381918
  • Bertagnolli MM, Niedzwiecki D, Compton CC, et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and leukemia Group B protocol 89803. J Clin Oncol. 2009;27(11):1814–1821; PMID: 19273709; PMCID: PMC2668707. doi: 10.1200/JCO.2008.18.207119273709