Development and Validation of a Nomogram for Preoperative Prediction of Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma and Type 2 Diabetes Mellitus

References

• Rydén L, Grant PJ, Anker SD, et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2013;34(39):3035–3087.23996285
   PubMed Web of Science ®Google Scholar
• De Rooij SR, Nijpels G, Nilsson PM, et al. Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile. Diabetes Care. 2009;32(7):1295–1301. doi:10.2337/dc08-179519366964
   PubMed Web of Science ®Google Scholar
• Garcia C, Feve B, Ferré P, et al. Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab. 2010;36(5):327–338. doi:10.1016/j.diabet.2010.07.00120851652
   PubMed Web of Science ®Google Scholar
• Bruun JM, Lihn AS, Verdich C, et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab. 2003;285(3):E527–E533. doi:10.1152/ajpendo.00110.200312736161
   PubMed Web of Science ®Google Scholar
• Demirtas L, Degirmenci H, Akbas EM, et al. Association of hematological indicies with diabetes, Impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8(7):1420–1427.25785149
   PubMed Web of Science ®Google Scholar
• Lou M, Luo P, Tang R, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15(1):4–9. doi:10.1186/s12902-015-0002-925631825
   PubMed Web of Science ®Google Scholar
• Wang DS, Ren C, Qiu MZ, et al. Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer. Tumour Biol. 2012;33:749–756. doi:10.1007/s13277-011-0285-z22198641
   PubMedGoogle Scholar
• Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol. 2010;6:149–163. doi:10.2217/fon.09.13620021215
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Kawamura M, Hato T, et al. Neutrophil-lymphocyte ratio as a prognostic marker for lung adenocarcinoma after complete resection. World J Surg. 2016;40(2):365–372. doi:10.1007/s00268-015-3275-226493696
   PubMed Web of Science ®Google Scholar
• Zhang WW, Liu KJ, Hu GL, et al. Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients. Tumour Biol. 2015;36(11):8831–8837. doi:10.1007/s13277-015-3533-926063409
   PubMedGoogle Scholar
• Wang SC, Chou JF, Strong VE, et al. Pretreatment neutrophil to lymphocyte ratio independently predicts disease-specific survival in resectable gastroesophageal junction and gastric adenocarcinoma. Ann Surg. 2016;263(2):292–297. doi:10.1097/SLA.000000000000118925915915
   PubMed Web of Science ®Google Scholar
• Xiao WK, Chen D, Li SQ, et al. Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis. BMC Cancer. 2014;14(1):117. doi:10.1186/1471-2407-14-11724559042
   PubMed Web of Science ®Google Scholar
• Chen ZY, Raghav K, Lieu CH, et al. Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer. Br J Cancer. 2015;112(6):1088–1097. doi:10.1038/bjc.2015.6125688736
   PubMed Web of Science ®Google Scholar
• Duan H, Zhang X, Wang FX, et al. Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma. World J Gastroenterol. 2015;21:5591–5597. doi:10.3748/wjg.v21.i18.559125987784
   PubMed Web of Science ®Google Scholar
• Templeton AJ, Ace O, McNamara MG, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2014;23(7):1204–1212.24793958
   PubMed Web of Science ®Google Scholar
• Stotz M, Gerger A, Eisner F, et al. Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer. Br J Cancer. 2013;109(2):416–421. doi:10.1038/bjc.2013.33223799847
   PubMed Web of Science ®Google Scholar
• Kocer D, Karakukcu C, Karaman H, Gokay F, Bayram F. Gokay F and Bayram F: may the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders? Asian Pac J Cancer Prev. 2015;16(9):3875‑3879.
   Google Scholar
• Wang Y, Guan Q, Xiang J. Nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma: a retrospective cohort study of 8668 patients. Int J Surg. 2018:1;S1743919118307714.
   Google Scholar
• Ning L, Ju-hua H, Song C, Yang L-C, Zhang H-J, Li Z-H. Nomogram Including Elastography for Prediction of Contralateral Central Lymph Node Metastasis in Solitary Papillary Thyroid Carcinoma Preoperatively. Cancer Manag Res. 2020;12:10789–10797. doi:10.2147/CMAR.S27838233149684
   PubMed Web of Science ®Google Scholar
• Ceylan Y, Kumanlolu K, Oral A, et al. The Correlation of Clinicopathological Findings and Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Papillary Thyroid Carcinoma[J]. Mol Imaging Radionucl Ther. 2019;28(1):15–20. doi:10.4274/mirt.galenos.2018.6049030942057
   PubMed Web of Science ®Google Scholar
• Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev. 2007;18(1–2):171–182. doi:10.1016/j.cytogfr.2007.01.01517329145
   PubMed Web of Science ®Google Scholar
• Kim PY. Platelets: connecting clotting and lysis. Blood. 2015;125(16):2459. doi:10.1182/blood-2015-03-63215825883230
   PubMed Web of Science ®Google Scholar
• Jain S, Harris J, Ware J. Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol. 2010;30(12):2362–2367. doi:10.1161/ATVBAHA.110.20751421071699
   PubMed Web of Science ®Google Scholar
• Garraud O, Cognasse F. Are platelets cells? And if yes, are they immune cells? Front Immunol. 2015;6:70. doi:10.3389/fimmu.2015.0007025750642
   PubMed Web of Science ®Google Scholar
• Nieswandt B, Hafner M, Echtenacher B, et al. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 1999;59:1295–1300.10096562
   PubMed Web of Science ®Google Scholar
• Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?. Lancet. 2001;357:539–545.11229684
   PubMed Web of Science ®Google Scholar
• Tavares-Murta BM, Mendonça MAO, Duarte NL, et al. Systemic leukocyte alterations are associated with invasive uterine cervical cancer. Int J Gynecol Cancer. 2010;20:1154–1159. doi:10.1111/IGC.0b013e3181ef8deb21495217
   PubMed Web of Science ®Google Scholar
• Pichler M, Hutterer GC, Stoeckigt C, et al. Validation of the pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients. Br J Cancer. 2013;108:901–907. doi:10.1038/bjc.2013.2823385728
   PubMed Web of Science ®Google Scholar
• Mehrazin R, Uzzo RG, Kutikov A, et al. Lymphopenia is an independent predictor of inferior outcome in papillary renal cell carcinoma. Urol Oncol. 2015;33:388e319. doi:10.1016/j.urolonc.2014.06.004
   Web of Science ®Google Scholar
• Wu ES, Oduyebo T, Cobb LP, et al. Lymphopenia and its association with survival in patients with locally advanced cervical cancer. Gynecol Oncol. 2016;140(1):76–82. doi:10.1016/j.ygyno.2015.11.01326571200
   PubMed Web of Science ®Google Scholar
• Kocer D, Karakukcu C, Karaman H, et al. May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different thyroid disorders? Asian Pac J Cancer Prev. 2015;16(9):3875–3879. doi:10.7314/APJCP.2015.16.9.387525987053
   PubMedGoogle Scholar
• Liu J, Du J, Fan J, et al. The neutrophil-to-lymphocyte ratio correlates with age in patients with papillary thyroid carcinoma. ORL. 2015;77(2):109–116. doi:10.1159/00037553425896501
   PubMedGoogle Scholar
• Kim SM, Kim EH, Kim BH, et al. Association of the Preoperative Neutrophil-to-lymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer. Endocrinol Metab. 2015;30:494–501. doi:10.3803/EnM.2015.30.4.494
   Google Scholar
• Gong W, Yang S, Yang X, Guo F. Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer. Clinics. 2016;71:311–314. doi:10.6061/clinics/2016(06)0427438563
   PubMed Web of Science ®Google Scholar
• Templeton AJ, Ace O, McNamara MG, et al. Prognostic Role of Platelet to Lymphocyte Ratio in Solid Tumors: a Systematic Review and Meta-Analysis. Cancer Epidemiol Biomarkers Prev. 2014;23:1204–1212. doi:10.1158/1055-9965.EPI-14-014624793958
   PubMed Web of Science ®Google Scholar
• Mi KS, Heui KE, Hyun KB, et al. Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer[J]. Endocrinol Metab. 2015;30:4.
   Google Scholar
• Lee KH, Seok EY, Kim EY, et al. Different prognostic values of individual hematologic parameters in papillary thyroid cancer due to age-related changes in immunity[J]. Ann Surg Treat Res. 2019;96(2):2. doi:10.4174/astr.2019.96.2.70
   Web of Science ®Google Scholar
• Amin M, Greene F, Edge S, et al. The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging: the Eighth Edition AJCC Cancer Staging Manual. CA. 2017;67(2):93–99. doi:10.3322/caac.2138828094848
   PubMed Web of Science ®Google Scholar
• Smith RA, Bosonnet L, Raraty M, et al. Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg. 2009;197(4):466–472. doi:10.1016/j.amjsurg.2007.12.05718639229
   PubMed Web of Science ®Google Scholar
• Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol. 2013;107:493–497. doi:10.1002/jso.2327022996403
   PubMed Web of Science ®Google Scholar
• Feng JF, Huang Y, Liu JS. Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. Onco Targets Ther. 2013;6:1605–1612. doi:10.2147/OTT.S5250124403837
   PubMed Web of Science ®Google Scholar
• Calò PG, Medas F, Conzo G, et al. Intraoperative neuromonitoring in thyroid surgery: is the two-staged thyroidectomy justified?[J]. Int J Surg. 2017;41:S13–S20. doi:10.1016/j.ijsu.2017.02.00128506407
   PubMed Web of Science ®Google Scholar
• Docimo G, Tolone S, Ruggiero R, et al. Total thyroidectomy without prophylactic central neck dissection combined with routine oral calcium and vitamin D supplements: is it a good option to achieve a low recurrence rate avoiding hypocalcemia? A retrospective study[J]. Minerva Chirurgica. 2013;68(3):321.23774098
   PubMed Web of Science ®Google Scholar