207
Views
14
CrossRef citations to date
0
Altmetric
Original Research

Cardioprotective Effect of Quercetin and Sitagliptin in Doxorubicin-Induced Cardiac Toxicity in Rats

ORCID Icon
Pages 2349-2357 | Published online: 12 Mar 2021

References

  • Shaito A, Thuan DTB, Phu HT, et al. Herbal medicine for cardiovascular diseases: efficacy, mechanisms, and safety. Front Pharmacol. 2020;11(April):1–32. doi:10.3389/fphar.2020.0042232116689
  • Ferdinandy P, Baczkó I, Bencsik P, et al. Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications. Eur Heart J. 2019;40(22):1771–1777C. doi:10.1093/eurheartj/ehy36529982507
  • McGowan JV, Chung R, Maulik A, Piotrowska I, Walker JM, Yellon DM. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther. 2017;31(1):63–75. doi:10.1007/s10557-016-6711-028185035
  • Nayebi M. Ultrastructural and echocardiographic assessment of chronic doxorubicin-induced cardiotoxicity in rats. Arch Razi Inst. 2020;75(1):56. doi:10.22092/ARI.2019.116862.1177
  • Thorn CF, Oshiro C, Marsh S, et al. Doxorubicin pathways. Pharmacogenet Genomics. 2011;21(7):440–446. doi:10.1097/fpc.0b013e32833ffb5621048526
  • Reiner Ž, Laufs U, Cosentino F, Landmesser U. The year in cardiology 2018: prevention. Eur Heart J. 2019;40(4):336–344. doi:10.1093/eurheartj/ehy89430601998
  • Singh S, Sedha S. Medicinal plants and their pharmacological aspects. FPI. 2018;1(4):156–170.
  • Varga E, Bodi A, Ferdinandy P, Droy-Lefaix MT, Blasig IE, Tosaki A. The protective effect of EGb 761 in isolated ischemic/reperfused rat hearts: a link between cardiac function and nitric oxide production. J Cardiovasc Pharmacol. 1999;34(5):711–717. doi:10.1097/00005344-199911000-0001310547088
  • Pataki T, Bak I, Kovacs P, Bagchi D, Das DK, Tosaki A. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr. 2002;75(5):894–899. doi:10.1093/ajcn/75.5.89411976164
  • Bak I, Lekli I, Juhasz B, et al. Isolation and analysis of bioactive constituents of sour cherry (Prunus cerasus) seed kernel: an emerging functional food. J Med Food. 2010;13(4):905–910. doi:10.1089/jmf.2009.018820482278
  • Czompa A, Gyongyosi A, Czegledi A, et al. Cardioprotection afforded by sour cherry seed kernel: the role of heme oxygenase-1. J Cardiovasc Pharmacol. 2014;64(5):412–419. doi:10.1097/FJC.000000000000013224949584
  • Csiki Z, Papp-Bata A, Czompa A, et al. Orally delivered sour cherry seed extract (SCSE) affects cardiovascular and hematological parameters in humans. Phytother Res. 2015;29(3):444–449. doi:10.1002/ptr.527325640007
  • Jing Z, Wang Z, Li X, et al. Protective effect of quercetin on posttraumatic cardiac injury. Sci Rep. 2016;6(1):(February):1–10. doi:10.1038/srep30812
  • Shah P, Upaganlawar A, Balaraman R. Combined cardioprotective effects of quercetin and curcumin on doxorubicin induced cardiotoxicity in rats. Pharmacogn Mag. 2008;4(16SUPPL):246–250.
  • Zhou Y, Guo Z, Yan W, Wang W. Cardiovascular effects of sitagliptin – an anti-diabetes medicine. Clin Exp Pharmacol Physiol. 2018;45(7):628–635. doi:10.1111/1440-1681.1295329679391
  • Garber AJ, Abrahamson MJ, Barzilay JI, et al. Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary. Endocr Pract. 2019;25(1):69–100. doi:10.4158/CS-2018-053530742570
  • Green JB, Bethel MA, Armstrong PW, et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373(3):232–242. doi:10.1056/nejmoa150135226052984
  • Rehman MB, Tudrej BV, Soustre J, et al. Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: meta-analysis of placebo-controlled randomized clinical trials. Diabetes Metab. 2017;43(1):48–58. doi:10.1016/j.diabet.2016.09.00527745828
  • Yang TY, Liaw YP, Huang JY, Chang HR, Chang KW, Ueng KC. Association of sitagliptin with cardiovascular outcome in diabetic patients: a nationwide cohort study. Acta Diabetol. 2016;53(3):461–468. doi:10.1007/s00592-015-0817-x26687195
  • Ahmed ZA, Abtar AN, Othman HH, Aziz TA. Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats. Drug Des Devel Ther. 2019;13(September):3321–3329. doi:10.2147/DDDT.S222127
  • Bo MS, Cheah WL, Lwin S, Moe Nwe T, Win TT, Aung M. Understanding the relationship between atherogenic index of plasma and cardiovascular disease risk factors among staff of an university in Malaysia. J Nutr Metab. 2018;2018:2015. doi:10.1155/2018/7027624
  • Calling S, Johansson SE, Wolff M, Sundquist J, Sundquist K. The ratio of total cholesterol to high density lipoprotein cholesterol and myocardial infarction in women’s health in the Lund area (WHILA): a 17-year follow-up cohort study. BMC Cardiovasc Disord. 2019;19(1):1–9. doi:10.1186/s12872-019-1228-730606129
  • Rochette L, Guenancia C, Gudjoncik A, et al. Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. Trends Pharmacol Sci. 2015;36(6):326–348. doi:10.1016/J.TIPS.2015.03.00525895646
  • Kelleni MT, Abdelbasset M. Drug induced cardiotoxicity: mechanism, prevention and management. Cardiotoxicity. 2018. doi:10.5772/intechopen.79611
  • Viswanatha Swamy AHM, Wangikar U, Koti BC, Thippeswamy AHM, Ronad PM, Manjula DV. Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats. Indian J Pharmacol. 2011;43(5):507–511. doi:10.4103/0253-7613.8495222021990
  • Hasić S, Jadrić R, Kiseljaković E, Mornjaković Z, Winterhalter-Jadrić M. Troponin T and histological characteristics of rat myocardial infarction induced by isoproterenol. Bosn J BASIC Med Sci. 2007;7(3):212–217. doi:10.17305/bjbms.2007.304617848144
  • Kopel E, Kivity S, Morag-Koren N, Segev S, Sidi Y. Relation of serum lactate dehydrogenase to coronary artery disease. Am J Cardiol. 2012;110(12):1717–1722. doi:10.1016/j.amjcard.2012.08.00522981267
  • Jensen DM. Approach to asymptomatic creatine kinase elevation. Physiol Behav. 2018;176(1):1570–1573. doi:10.1038/s41395-018-0061-4
  • Zhang M, Swarts SG, Yin L, et al. Antioxidant properties of quercetin. In: Advances in Experimental Medicine and Biology. Vol. 701. 2011: 283–289. doi:10.1007/978-1-4419-7756-4_3821445799
  • Civantos E, Bosch E, Ramirez E, et al. Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway. Diabetes Metab Syndr Obes. 2017;10:207–222. doi:10.2147/DMSO.S13253728652790
  • Hrelia S, Fiorentini D, Maraldi T, et al. Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Biochim Biophys Acta. 2002;1567(SUPPL):150–156. doi:10.1016/S0005-2736(02)00612-012488048
  • Arunachalam S, Tirupathi Pichiah PB, Achiraman S. Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models. FEBS Lett. 2013;587(2):105–110. doi:10.1016/j.febslet.2012.11.01923219922
  • Eitah HE, Maklad YA, Abdelkader NF, Gamal El Din AA, Badawi MA, Kenawy SA. Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats. Toxicol Appl Pharmacol. 2019;365:30–40. doi:10.1016/J.TAAP.2018.12.01130576699
  • Nuransoy A, Beytur A, Polat A, Samdanci E, Sagir M, Parlakpinar H. Renal failure protective effect of sitagliptin against renal ischemia reperfusion injury in rats protective effect of sitagliptin against renal ischemia reperfusion injury in rats. Ren Fail. 2015;37(4):687–693. doi:10.3109/0886022X.2015.101099125703705
  • D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256–271. doi:10.1016/j.fitote.2015.09.01826393898
  • Chen S, Jiang H, Wu X, Fang J. Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes. Mediators Inflamm. 2016;2016(Article ID 9340637):5. doi:10.1155/2016/9340637
  • Majeed SA, Hadi NR, Al Mudhafar AM, Al-Janabi HA. Sitagliptin ameliorates the progression of atherosclerosis via down regulation of the inflammatory and oxidative pathways. SAGE Open Med. 2013;1:205031211349991. doi:10.1177/2050312113499912
  • Nayagam AAJ, Gunasekaran S, Rangarajan S, Muthaiah S. Myocardial potency of Caesalpinia bonducella Linn. on doxorubicin induced myocardial infarction in albino rats. Clin Phytoscience. 2019;5(1). doi:10.1186/s40816-019-0146-7
  • Chennuru A, Saleem MTS. Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats. Biomed Res Int. 2013;2013:934239. doi:10.1155/2013/93423924228260
  • Derakhshanian H, Djalali M, Djazayery A, et al. Quercetin ameliorates lipid and apolipoprotein profile in high-dose glucocorticoid treated rats. Arq Bras Cardiol. 2020;115(1):102–108. doi:10.36660/abc.2018039732813833
  • Huang H, Liao D, Dong Y, Pu R. Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutr Rev. 2020;78(8):615–626. doi:10.1093/nutrit/nuz07131940027
  • Patel RV, Mistry BM, Shinde SK, Syed R, Singh V, Shin HS. Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem. 2018;155:889–904. doi:10.1016/j.ejmech.2018.06.05329966915
  • Jia Q, Cao H, Shen D, et al. Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1. Int J Mol Med. 2019;44(3):893–902. doi:10.3892/ijmm.2019.426331524223