198
Views
10
CrossRef citations to date
0
Altmetric
Original Research

C8B in Complement and Coagulation Cascades Signaling Pathway is a predictor for Survival in HBV-Related Hepatocellular Carcinoma Patients

, , & ORCID Icon
Pages 3503-3515 | Published online: 22 Apr 2021

References

  • The International Agency for Research on Cancer. Latest global cancer data: cancer burden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020; 2020. https://www.iarc.who.int/wp-content/uploads/2020/2012/pr2292_E.pdf.
  • Pandyarajan V, Govalan R, Yang JD. Risk factors and biomarkers for chronic hepatitis B associated hepatocellular carcinoma. Int J Mol Sci. 2021;22(2):479. doi:10.3390/ijms22020479
  • Sharma R. Descriptive epidemiology of incidence and mortality of primary liver cancer in 185 countries: evidence from GLOBOCAN 2018. Jpn J Clin Oncol. 2020;50(12):1370–1379. doi:10.1093/jjco/hyaa13032719873
  • Yan SY, Fan JG, Qio L. Hepatitis B Virus (HBV) infection and hepatocellular carcinoma- new insights for an old topic. Curr Cancer Drug Targets. 2017;17(6):505–511. doi:10.2174/156800961666616092612453027677954
  • Girardi DM, Pacifico JPM, Guedes de Amorim FPL, et al. Immunotherapy and targeted therapy for hepatocellular carcinoma: a literature review and treatment perspectives. Pharmaceuticals. 2020;14(1):28. doi:10.3390/ph1401002833396181
  • Kudo M. Recent Advances in Systemic Therapy for Hepatocellular Carcinoma in an Aging Society: 2020 Update. Liver Cancer. 2020;9(6):640–662. doi:10.1159/00051100133442538
  • Omata M, Cheng AL, Kokudo N, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int. 2017;11(4):317–370.28620797
  • Mejia JC, Pasko J. Primary Liver Cancers: intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Surg Clin North Am. 2020;100(3):535–549. doi:10.1016/j.suc.2020.02.01332402299
  • Petrick JL, Kelly SP, Altekruse SF, McGlynn KA, Rosenberg PS. Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030. J Clin Oncol. 2016;34(15):1787–1794. doi:10.1200/JCO.2015.64.741227044939
  • Teufel A. Bioinformatics and database resources in hepatology. J Hepatol. 2015;62(3):712–719. doi:10.1016/j.jhep.2014.10.03625450718
  • Wang L, Yang Z, Cao Y. Regulatory T cell and activated natural killer cell infiltration in hepatocellular carcinoma: immune cell profiling using the CIBERSORT. Ann Transl Med. 2020;8(22):1483. doi:10.21037/atm-20-583033313228
  • Zhang Y, Yang L, Shi J, Lu Y, Chen X, Yang Z. The Oncogenic Role of CENPA in hepatocellular carcinoma development: evidence from bioinformatic analysis. Biomed Res Int. 2020;2020:3040839.32337237
  • Muller-Calleja N, Ritter S, Hollerbach A, Falter T, Lackner KJ, Ruf W. Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies. Blood Adv. 2018;2(9):979–986. doi:10.1182/bloodadvances.201801709529716893
  • Chen L, Yue J, Han X, Li J, Hu Y. Ouabain rescues rat nephrogenesis during intrauterine growth restriction by regulating the complement and coagulation cascades and calcium signaling pathway. J Dev Orig Health Dis. 2016;7(1):91–101. doi:10.1017/S204017441500724226442628
  • Liu W. Complement proteins detected through iTRAQ-based proteomics analysis of serum from black carp Mylopharyngodon piceus in response to experimentally induced Aeromonas hydrophila infection. Dis Aquat Organ. 2020;140:187–201. doi:10.3354/dao0349732815527
  • Zhang J, Chen M, Zhao Y, et al. Complement and coagulation cascades pathway correlates with chemosensitivity and overall survival in patients with soft tissue sarcoma. Eur J Pharmacol. 2020;879:173121. doi:10.1016/j.ejphar.2020.17312132339514
  • Liu Y, Xiong S, Liu S, et al. Analysis of gene expression in bladder cancer: possible involvement of mitosis and complement and coagulation cascades signaling pathway. J Comput Biol. 2020;27(6):987–998. doi:10.1089/cmb.2019.023731545079
  • Castiblanco-Valencia MM, Fraga TR, Pagotto AH, et al. Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: a new role of LigA and LigB in invasion and complement immune evasion. Immunobiology. 2016;221(5):679–689. doi:10.1016/j.imbio.2016.01.00126822552
  • Ekdahl KN, Teramura Y, Asif S, Jonsson N, Magnusson PU, Nilsson B. Thromboinflammation in Therapeutic Medicine. Adv Exp Med Biol. 2015;865:3–17.26306440
  • Nilsson B, Teramura Y, Ekdahl KN. The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies. Mol Immunol. 2014;61(2):185–190. doi:10.1016/j.molimm.2014.06.00924998801
  • Palacios-Acedo AL, Mege D, Crescence L, Dignat-George F, Dubois C, Panicot-Dubois L. Platelets, Thrombo-Inflammation, and Cancer: collaborating With the Enemy. Front Immunol. 2019;10:1805. doi:10.3389/fimmu.2019.0180531417569
  • Schattner M, Jenne CN, Negrotto S, Ho-Tin-Noe B. Editorial: platelets and immune responses during thromboinflammation. Front Immunol. 2020;11:1079. doi:10.3389/fimmu.2020.0107932547562
  • Suzuki-Inoue K. Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin. Blood. 2019;134(22):1912–1918. doi:10.1182/blood.201900138831778548
  • Roessler S, Jia HL, Budhu A, et al. A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res. 2010;70(24):10202–10212. doi:10.1158/0008-5472.CAN-10-260721159642
  • Roessler S, Long EL, Budhu A, et al. Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology. 2012;142(4):957–966 e912. doi:10.1053/j.gastro.2011.12.03922202459
  • Gautier L, Cope L, Bolstad BM, Irizarry RA. affy–analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 2004;20(3):307–315. doi:10.1093/bioinformatics/btg40514960456
  • Dong X, Lin L, Zhang R, et al. TOBMI: trans-omics block missing data imputation using a k-nearest neighbor weighted approach. Bioinformatics. 2019;35(8):1278–1283. doi:10.1093/bioinformatics/bty79630202885
  • Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi:10.1093/nar/gkv00725605792
  • Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.011822455463
  • Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–W102. doi:10.1093/nar/gkx24728407145
  • Menyhart O, Nagy A, Gyorffy B. Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 2018;5(12):181006. doi:10.1098/rsos.18100630662724
  • Nagy A, Lanczky A, Menyhart O, Gyorffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8(1):9227. doi:10.1038/s41598-018-27521-y29907753
  • Revel M, Daugan MV, Sautes-Fridman C, Fridman WH, Roumenina LT. Complement system: promoter or suppressor of cancer progression? Antibodies. 2020;9(4). doi:10.3390/antib9040057
  • Thurman JM, Laskowski J, Nemenoff RA. Complement and Cancer-A Dysfunctional Relationship? Antibodies. 2020;9(4). doi:10.3390/antib9040061
  • Li L, Yang W, Shen Y, Xu X, Li J. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Mol Immunol. 2020;128:235–248. doi:10.1016/j.molimm.2020.10.01333160183
  • Plumb ME, Scibek JJ, Barber TD, Dunlap RJ, Platteborze PL, Sodetz JM. Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region. Biochemistry. 1999;38(26):8478–8484. doi:10.1021/bi990485810387094
  • Grumach AS, Kirschfink M. Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach. Mol Immunol. 2014;61(2):110–117. doi:10.1016/j.molimm.2014.06.03025037634
  • Turley AJ, Gathmann B, Bangs C, et al. Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe. J Clin Immunol. 2015;35(2):199–205. doi:10.1007/s10875-015-0137-525663093
  • Kaufmann T, Hansch G, Rittner C, Spath P, Tedesco F, Schneider PM. Genetic basis of human complement C8 beta deficiency. J Immunol. 1993;150(11):4943–4947.8098723
  • Rao L, Li YB, Chen GD, Zhou B, Schneider PM, Zhang L. [Further study on heterogeneic basis of complement C8 beta deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004;21(1):10–13. Chinese.14767900
  • Bradley DT, Bourke TW, Fairley DJ, et al. Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. PLoS One. 2015;10(3):e0120757. doi:10.1371/journal.pone.012075725798599
  • Dellepiane RM, Dell’Era L, Pavesi P, et al. Invasive meningococcal disease in three siblings with hereditary deficiency of the 8(th) component of complement: evidence for the importance of an early diagnosis. Orphanet J Rare Dis. 2016;11(1):64. doi:10.1186/s13023-016-0448-527183977
  • Karlsson E, Shaat N, Groop L. Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)? Diabet Med. 2008;25(7):788–791. doi:10.1111/j.1464-5491.2008.02467.x18513302
  • Ye Z, Zeng Z, Shen Y, Chen Z. Identification of hub genes in peripheral blood mononuclear cells for the diagnosis of hepatocellular carcinoma using a weighted gene co-expression network analysis. Exp Ther Med. 2020;20(2):890–900. doi:10.3892/etm.2020.873632742331
  • Akhir FNM, Noor MHM, Leong KWK, et al. An Immunoregulatory role for complement receptors in murine models of breast cancer. Antibodies. 2021;10(1). doi:10.3390/antib10010002
  • Kavvadas E. Autoantibodies specific for C1q, C3b, beta2-glycoprotein 1 and annexins may amplify complement activity and reduce apoptosis-mediated immune suppression. Med Hypotheses. 2020;144:110286. doi:10.1016/j.mehy.2020.11028633254588
  • Repetto O, Maiero S, Magris R, et al. Quantitative Proteomic Approach Targeted to Fibrinogen beta Chain in Tissue Gastric Carcinoma. Int J Mol Sci. 2018;19(3). doi:10.3390/ijms19030759
  • Feng Z, Wen H, Bi R, Duan Y, Yang W, Wu X. Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients. BMC Cancer. 2016;16(1):43. doi:10.1186/s12885-016-2070-226817451
  • Lee KW, Bang SM, Kim S, et al. The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer. J Thromb Haemost. 2010;8(3):540–547. doi:10.1111/j.1538-7836.2009.03731.x20040044
  • Li H, Zhao T, Ji X, et al. Hyperfibrinogenemia predicts poor prognosis in patients with advanced biliary tract cancer. Tumour Biol. 2016;37(3):3535–3542. doi:10.1007/s13277-015-4184-626453118
  • Wang H, Gao J, Bai M, et al. The pretreatment platelet and plasma fibrinogen level correlate with tumor progression and metastasis in patients with pancreatic cancer. Platelets. 2014;25(5):382–387. doi:10.3109/09537104.2013.82778224001199
  • Repetto O, De Re V. Coagulation and fibrinolysis in gastric cancer. Ann N Y Acad Sci. 2017;1404(1):27–48. doi:10.1111/nyas.1345428833193
  • Kong W, Xu H, Cheng J, et al. The Prognostic role of a combined fibrinogen and neutrophil-to-lymphocyte ratio score in patients with resectable hepatocellular carcinoma: a Retrospective Study. Med Sci Monit. 2020;26:e918824. doi:10.12659/MSM.91882431929496
  • Zhang X, Long Q. Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients. Medicine. 2017;96(17):e6694. doi:10.1097/MD.000000000000669428445272
  • Yang W, Shi J, Zhou Y, et al. Co-expression network analysis identified key proteins in association with hepatic metastatic colorectal cancer. Proteomics Clin Appl. 2019;13(6):e1900017. doi:10.1002/prca.20190001731397080
  • He J, Zeng ZC, Xiang ZL, Yang P. Mass spectrometry-based serum peptide profiling in hepatocellular carcinoma with bone metastasis. World J Gastroenterol. 2014;20(11):3025–3032. doi:10.3748/wjg.v20.i11.302524659894