References
- Siegel RL , Miller KD , Jemal A . Cancer statistics. CA Cancer J Clin . 2020;1–24.
- Herzberg B , Campo MJ , Gainor JF . Immune checkpoint inhibitors in non-small cell lung cancer. Oncologist . 2017;22(1):81–88. doi:10.1634/theoncologist.2016-0189 27534574
- Gandhi L , Rodríguez D , Gadgeel S , et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med . 2018;378(22):2078–2092. doi:10.1056/NEJMoa1801005 29658856
- Socinski MA , Jotte RM , Cappuzzo F , et al. Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N Engl J Med . 2018;378(24):2288–2301. doi:10.1056/NEJMoa1716948 29863955
- Mitsuhashi A , Okuma Y . Perspective on immune oncology with liquid biopsy, peripheral blood mononuclear cells, and microbiome with non-invasive biomarkers in cancer patients. Clin Transl Oncol . 2018;20:966–974. doi:10.1007/s12094-017-1827-7 29313208
- Topalian SL , Taube JM , Anders RA , Pardoll DM . Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer . 2016;16:275–287. doi:10.1038/nrc.2016.36 27079802
- Kim KH , Cho J , Ku BM , et al. The first-week proliferative response of peripheral blood PD-1+CD8+T cells predicts the response to anti-PD-1 therapy in solid tumors. Clin Cancer Res . 2019;25:2144–2154. doi:10.1158/1078-0432.CCR-18-1449 30647082
- Taghizadeh N , Boezen HM , Schouten JP , et al. BMI and lifetime changes in BMI and cancer mortality risk. PLoS One . 2015;10(4):e0125261. doi:10.1371/journal.pone.0125261eCollection2015 25881129
- Kaur J . A comprehensive review on metabolic syndrome. Cardiol Res Pract . 2014;2014:943162. doi:10.1155/2014/943162 24711954
- Cortellini A , Bersanelli M , Buti S , et al. A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable. J Immunother Cancer . 2019;7:57–67. doi:10.1186/s40425-019-0527-y 30813970
- Cottrell TR , Thompson ED , Forde PM , et al. Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell-lung-carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC). Ann Oncol . 2018;29:1853–1860. doi:10.1093/annonc/mdy218 29982279
- Ito A , Hong C , Oka K , et al. Cholesterol accumulation in CD11c + immune cells is a causal and targetable factor in autoimmune disease. Immunity . 2016;45(6):1311–1326. doi:10.1016/j.immuni.2016.11.008 28002731
- Yang W , Bai Y , Xiong Y , et al. Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism. Nature . 2016;531(7596):651–655. doi:10.1038/nature17412 26982734
- Perrone F , Minari R , Bersanelli M , et al. The prognostic role of high blood cholesterol in advanced cancer patients treated with immune checkpoint inhibitors. J Immunother . 2020;43(6):196–203. doi:10.1097/CJI.0000000000000321 32404654
- Omori M , Okuma Y , Hakozaki T , et al. Statins improve survival in patients previously treated with nivolumab for advanced non-small cell lung cancer: an observational study. Mol Clin Oncol . 2019;10(1):137–143. doi:10.3892/mco.2018.1765 30655989
- Mok TSK , Wu YL , Kudaba I , et al. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomized, open-label, controlled, Phase 3 trial. Lancet . 2019;393:1819–1830. doi:10.1016/S0140-6736(18)32409-7 30955977
- Reck M , Rodríguezabreu D , Robinson AG , et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med . 2016;375:1823–1833. doi:10.1056/NEJMoa1606774 27718847
- Grundy SM , Stone NJ , Bailey AL , et al. AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. J Am Coll Cardiol . 2019;73:3168–3209.30423391
- Liu Z , Liu X , Liu S , et al. Cholesterol promotes the migration and invasion of renal carcinoma cells by regulating the KLF5/miR-27a/FBXW7 pathway. Biochem Biophys Res Commun . 2018;502:69–75. doi:10.1016/j.bbrc.2018.05.122 29782853
- Wang Y , Liu C , Hu L . Cholesterol regulates cell proliferation and apoptosis of colorectal cancer by modulating miR-33a-PIM3 pathway. Biochem Biophys Res Commun . 2019;511:685–692. doi:10.1016/j.bbrc.2019.02.123 30827510
- Galli G , Corsetto P , Ferrara R , et al. Impact of cholesterolemia and body mass index on outcome of metastatic non-small cell lung cancer treated with immunotherapy. J Clin Oncol . 2019;37(suppl):e20691. doi:10.1200/JCO.2019.37.15_suppl.e20691
- Ding X , Zhang W , Li S , Yang H . The role of cholesterol metabolism in cancer. Am J Cancer Res . 2019;9:219–227.30906624
- Finlayschultz J , Sartorius CA . Steroid hormones, steroid receptors, and breast cancer stem cells. J Mammary Gland Biol Neoplasia . 2015;20:39–50. doi:10.1007/s10911-015-9340-5 26265122
- Degirolamo C , Modica S , Palasciano G , Moschetta A . Bile acids and colon cancer: solving the puzzle with nuclear receptors. Trends Mol Med . 2011;17:564–572. doi:10.1016/j.molmed.2011.05.010 21724466
- Heir T , Falk RS , Robsahm TE , et al. Cholesterol and prostate cancer risk: a long-term prospective cohort study. BMC Cancer . 2016;16(1):643. doi:10.1186/s12885-016-2691-5 27535659
- Fox CJ , Hammerman PS , Thompson CB . Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol . 2005;5:844–852. doi:10.1038/nri1710 16239903
- Bensinger SJ , Bradley MN , Joseph SB , et al. LXR signalling couples’ sterol metabolism to proliferation in the acquired immune response. Cell . 2008;134:97–111. doi:10.1016/j.cell.2008.04.052 18614014
- Fessler MB , Parks JS . Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling. J.Immunol . 2011;187:1529–1535. doi:10.4049/jimmunol.1100253 21810617
- Ma X , Bi E , Huang C , et al. Cholesterol negatively regulates IL-9-producing CD8+T cell differentiation and antitumor activity. J Exp Med . 2018;215:1555–1569. doi:10.1084/jem.20171576 29743292
- Xingzhe M , Enguang B , Yong L , et al. Cholesterol induces CD8+T cell exhaustion in the tumor microenvironment. Cell Metab . 2019;30:143–156. doi:10.1016/j.cmet.2019.04.002 31031094
- Xingzhe M , Qing Y . Cholesterol induces T cell exhaustion. Aging . 2019;11(18):7334–7335. doi:10.18632/aging.102305 31532755
- Qin WH , Yang ZS , Li M , et al. High serum levels of cholesterol increase antitumor functions of nature killer cells and reduce growth of liver tumors in mice. Gastroenterology . 2020;158(6):1713–1727. doi:10.1053/j.gastro.2020.01.028 31972238
- Villablanca EJ , Raccosta L , Zhou D , et al. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med . 2010;16(1):98–105. doi:10.1038/nm.2074 20037595