High Endothelin Receptor Type A Expression as an Independent Prognostic Biomarker and Correlated with Immune Infiltrates in Stomach Adenocarcinoma

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• Tirino G, Pompella L, Petrillo A, et al. What’s new in gastric cancer: the therapeutic implications of molecular classifications and future perspectives. Int J Mol Sci. 2018;19(9):2659. doi:10.3390/ijms19092659
   PubMed Web of Science ®Google Scholar
• Procaccio L, Schirripa M, Fassan M, et al. Immunotherapy in gastrointestinal cancers. Biomed Res Int. 2017;2017:4346576. doi:10.1155/2017/434657628758114
   PubMed Web of Science ®Google Scholar
• Yasuno K, Bakircioglu M, Low SK, et al. Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc Natl Acad Sci. 2011;108(49):19707–19712. doi:10.1073/pnas.111713710822106312
   PubMed Web of Science ®Google Scholar
• Gordon CT, Weaver KN, Zechi-Ceide RM, et al. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015;96(4):519–531. doi:10.1016/j.ajhg.2015.01.01525772936
   PubMed Web of Science ®Google Scholar
• Miao J, Wang F, Fang Y. Association of 231G>A polymorphism of endothelin type A receptor gene with migraine: a meta-analysis. J Neurol Sci. 2012;323(1–2):232–235. doi:10.1016/j.jns.2012.09.02723058564
   PubMed Web of Science ®Google Scholar
• Rosanò L, Spinella F, Bagnato A. Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2013;13(9):637–651. doi:10.1038/nrc354623884378
   PubMed Web of Science ®Google Scholar
• Gupta S, Prajapati A, Gulati M, et al. Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer. Neoplasia. 2020;22(2):98–110. doi:10.1016/j.neo.2019.11.00131923844
   PubMed Web of Science ®Google Scholar
• Cabral-Marques O, Marques A, Giil LM, et al. GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. Nat Commun. 2018;9(1):5224. doi:10.1038/s41467-018-07598-930523250
   PubMed Web of Science ®Google Scholar
• Patel KV, Sheth HG, Schrey MP. Stimulation or endothelin–1 secretion byhuman breast cancer cells through protein kinase A activation: a possiblenovel paracrine loop involving breast fibroblast-derived prostaglandin E2. Mol Cell Endocrinol. 1997;126:143–151. doi:10.1016/S0303-7207(96)03983-49089652
   PubMed Web of Science ®Google Scholar
• Guruli G, Pflug BR, Pecher S, Makarenkova V, Shurin MR, Nelson JB. Functionand survival of dendritic cells depend on endothelin-1 and endothelinreceptor autocrine loops. Blood. 2004;104:2107–2115. doi:10.1182/blood-2003-10-355915213100
   PubMed Web of Science ®Google Scholar
• Kandalaft LE, Motz GT, Duraiswamy J, Coukos G. Tumor immune surveillanceand ovarian cancer: lessons on immune mediated tumor rejection ortolerance. Cancer Metastasis Rev. 2011;30:141–151. doi:10.1007/s10555-011-9289-921298574
   PubMed Web of Science ®Google Scholar
• Kandalaft LE, Facciabene A, Buckanovich RJ, Coukos G. Endothelin B receptor, a new target in cancer immune therapy. Clin Cancer Res. 2009;15:4521–4528. doi:10.1158/1078-0432.CCR-08-054319567593
   PubMed Web of Science ®Google Scholar
• Tocci P, Blandino G, Bagnato A. YAP and endothelin-1 signaling: an emerging alliance in cancer. J Exp Clin Cancer Res. 2021;40(1):27. doi:10.1186/s13046-021-01827-833422090
   PubMed Web of Science ®Google Scholar
• Liu L, Hu J, Wang Y, et al. Establishment of a novel risk score model by comprehensively analyzing the immunogen database of bladder cancer to indicate clinical significance and predict prognosis. Aging. 2020;12(12):11967–11989. doi:10.18632/aging.10336432570217
   PubMedGoogle Scholar
• Wei W, Shi L, Chen W, et al. miR-200c regulates the proliferation, apoptosis and invasion of gastric carcinoma cells through the downregulation of EDNRA expression. Int J Mol Med. 2018;41(3):1619–1626. doi:10.3892/ijmm.2017.331729286062
   PubMed Web of Science ®Google Scholar
• Blum A, Wang P, Zenklusen JC. SnapShot: TCGA-analyzed tumors. Cell. 2018;173(2):530. doi:10.1016/j.cell.2018.03.05929625059
   PubMed Web of Science ®Google Scholar
• Yu G, Wang L-G, Han Y, et al. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.011822455463
   PubMed Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci. 2005;102(43):15545–15550. doi:10.1073/pnas.050658010216199517
   PubMed Web of Science ®Google Scholar
• Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 2013;14(1):1–15. doi:10.1186/1471-2105-14-7
   PubMed Web of Science ®Google Scholar
• Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–795. doi:10.1016/j.immuni.2013.10.00324138885
   PubMed Web of Science ®Google Scholar
• Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 2004;6(1):1–6. doi:10.1016/S1476-5586(04)80047-215068665
   PubMed Web of Science ®Google Scholar
• Li T, Fu J, Zeng Z, et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48(W1):W509–W514. doi:10.1093/nar/gkaa40732442275
   PubMed Web of Science ®Google Scholar
• Suzuki S, Takahashi A, Ishikawa T, et al. Surgically treated gastric cancer in Japan: 2011 annual report of the national clinical database gastric cancer registry. Gastric Cancer. 2021;24(3):545–566. doi:10.1007/s10120-021-01178-533811588
   PubMed Web of Science ®Google Scholar
• Bassani B, Baci D, Gallazzi M, Poggi A, Bruno A, Mortara L. Natural killer cells as key players of tumor progression and angiogenesis: old and novel tools to divert their pro-tumor activities into potent anti-tumor effects. Cancers. 2019;11(4):461. doi:10.3390/cancers11040461
   PubMed Web of Science ®Google Scholar
• Lee K, Hwang H, Nam KT. Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer. Gut Liver. 2014;8(2):131–139. doi:10.5009/gnl.2014.8.2.13124672653
   PubMed Web of Science ®Google Scholar
• Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889–896. doi:10.1038/ni.193720856220
   PubMed Web of Science ®Google Scholar
• Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukocyte Biol. 2009;86(5):1065–1073. doi:10.1189/jlb.060938519741157
   PubMed Web of Science ®Google Scholar
• Fehlings M, Drobbe L, Moos V, et al. Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, mac-rophages, and monocytes. Infect Immun. 2012;80:2724–2734. doi:10.1128/IAI.00381-1222615251
   PubMed Web of Science ®Google Scholar