Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives

References

• SiebelC, LendahlU. Notch Signaling in Development, Tissue Homeostasis, and Disease. Physiol Rev. 2017;97:1235–1294. doi:10.1152/physrev.00005.201728794168
   PubMed Web of Science ®Google Scholar
• KopanR, IlaganMX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009;137:216–233. doi:10.1016/j.cell.2009.03.04519379690
   PubMed Web of Science ®Google Scholar
• EhebauerM, HaywardP, Martinez-AriasA. Notch signaling pathway. Sci STKE. 2006;2006:cm7.17148788
   PubMedGoogle Scholar
• CarrieriFA, DaleJK. Turn It Down a Notch. Front Cell Develop Biol. 2016;4:151.
   PubMed Web of Science ®Google Scholar
• LiuJ, LiH, MaoA, et al. DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation. Cell Cycle. 2020;19(24):3622–3631. doi:10.1080/15384101.2020.1859196
   Web of Science ®Google Scholar
• GharaibehL, ElmadanyN, AlwosaibaiK, AlshaerW. Notch1 in Cancer Therapy: possible Clinical Implications and Challenges. Mol Pharmacol. 2020;98:559–576. doi:10.1124/molpharm.120.00000632913140
   PubMed Web of Science ®Google Scholar
• XiuMX, LiuYM. The role of oncogenic Notch2 signaling in cancer: a novel therapeutic target. Am J Cancer Res. 2019;9:837–854.31218097
   PubMed Web of Science ®Google Scholar
• AburjaniaZ, JangS, WhittJ, Jaskula-StzulR, ChenH, RoseJB. The Role of Notch3 in Cancer. oncologist. 2018;23:900–911. doi:10.1634/theoncologist.2017-067729622701
   PubMed Web of Science ®Google Scholar
• XiuMX, LiuYM, KuangBH. The Role of DLLs in Cancer: a Novel Therapeutic Target. Onco Targets Ther. 2020;13:3881–3901. doi:10.2147/OTT.S24486032440154
   PubMed Web of Science ®Google Scholar
• XiuMX, LiuYM, KuangBH. The oncogenic role of Jagged1/Notch signaling in cancer. Biomed Pharmacother. 2020;129:110416. doi:10.1016/j.biopha.2020.11041632593969
   PubMed Web of Science ®Google Scholar
• SnijdersAM, SchmidtBL, FridlyandJ, et al. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene. 2005;24:4232–4242. doi:10.1038/sj.onc.120860115824737
   PubMed Web of Science ®Google Scholar
• LundeMLS, RomanE, WarnakulasuriyaS, et al. Profiling of chromosomal changes in potentially malignant and malignant oral mucosal lesions from South and South-East Asia using array-comparative genomic hybridization. Cancer Genomics Proteomics. 2014;11:127–140.24969693
   PubMed Web of Science ®Google Scholar
• HuZ-Y, XieN, TianC, et al. Identifying Circulating Tumor DNA Mutation Profiles in Metastatic Breast Cancer Patients with Multiline Resistance. EBioMedicine. 2018;32:111–118. doi:10.1016/j.ebiom.2018.05.01529807833
   PubMed Web of Science ®Google Scholar
• LiangX, VacherS, BoulaiA, et al. Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer. Breast Cancer Res. 2018;20:88. doi:10.1186/s13058-018-1007-x30086764
   PubMed Web of Science ®Google Scholar
• XieM, WeiS, WuX, LiX, YouY, HeC. Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival. Lung Cancer (Amsterdam, Netherlands). 2018;121:41–47. doi:10.1016/j.lungcan.2018.04.020
   PubMed Web of Science ®Google Scholar
• CuiM, HuY, BiY, et al. Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas. Int j Cancer. 2019;144:525–532. doi:10.1002/ijc.3194830362515
   PubMed Web of Science ®Google Scholar
• HoAS, OchoaA, JayakumaranG, et al. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest. 2019;129:4276–4289. doi:10.1172/JCI12822731483290
   PubMed Web of Science ®Google Scholar
• SuhJ, JeongCW, ChoiS, et al. Sharing the initial experience of pan-cancer panel analysis in high-risk renal cell carcinoma in the Korean population. BMC Urol. 2020;20:125. doi:10.1186/s12894-020-00687-232811483
   PubMed Web of Science ®Google Scholar
• XuH, DuanN, WangY, et al. The clinicopathological and genetic features of ovarian diffuse large B-cell lymphoma. Pathology. 2020;52:206–212. doi:10.1016/j.pathol.2019.09.01431883669
   PubMed Web of Science ®Google Scholar
• AhnS, HyeonJ, ParkC-K. Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2013;12:286–294. doi:10.1016/S1499-3872(13)60046-623742774
   PubMed Web of Science ®Google Scholar
• WuW-R, ShiX-D, ZhangR, et al. Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma. Int J Clin Exp Pathol. 2014;7(6):3272–3279.25031748
   PubMed Web of Science ®Google Scholar
• LinX, SunB, ZhuD, et al. Notch4+ cancer stem-like cells promote the metastatic and invasive ability of melanoma. Cancer Sci. 2016;107:1079–1091. doi:10.1111/cas.1297827234159
   PubMed Web of Science ®Google Scholar
• MkH, PrinceS, MohanAM, KrishnanKV, DeviA. Association of Notch4 with metastasis in human oral squamous cell carcinoma. Life Sci. 2016;156:38–46. doi:10.1016/j.lfs.2016.05.01927197026
   PubMed Web of Science ®Google Scholar
• WangJ-W, WeiX-L, DouX-W, HuangW-H, DuC-W, ZhangG-J. The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer. Oncol Lett. 2018;15:8749–8755.29805613
   PubMed Web of Science ®Google Scholar
• KimDC, JinH, LeeJS, SonE, LeeGW, KimHJ. P2Y(2)R has a significant correlation with Notch-4 in patients with breast cancer. Oncol Lett. 2020;20:647–654. doi:10.3892/ol.2020.1163032565989
   PubMed Web of Science ®Google Scholar
• ZhouL, WangD, ShengD, et al. NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Theranostics. 2020;10:2405–2421. doi:10.7150/thno.3887532104513
   PubMed Web of Science ®Google Scholar
• WuX, LiuW, TangD, et al. Prognostic values of four Notch receptor mRNA expression in gastric cancer. Sci Rep. 2016;6:28044. doi:10.1038/srep2804427363496
   PubMed Web of Science ®Google Scholar
• WuG, ChenZ, LiJ, et al. NOTCH4 Is a Novel Prognostic Marker that Correlates with Colorectal Cancer Progression and Prognosis. J Cancer. 2018;9(13):2374–2379. doi:10.7150/jca.2635930026833
   PubMed Web of Science ®Google Scholar
• ShaikJP, AlanaziIO, PathanAAK, et al. Frequent Activation of Notch Signaling Pathway in Colorectal Cancers and Its Implication in Patient Survival Outcome. J Oncol. 2020;2020:6768942. doi:10.1155/2020/676894232211044
   PubMed Web of Science ®Google Scholar
• WangY, YangR, WangX, et al. Evaluation of the correlation of vasculogenic mimicry, Notch4, DLL4, and KAI1/CD82 in the prediction of metastasis and prognosis in non-small cell lung cancer. Medicine. 2018;97:e13817. doi:10.1097/MD.000000000001381730593175
   PubMed Web of Science ®Google Scholar
• Takam KamgaP, Dal ColloG, ResciF, et al. Notch Signaling Molecules as Prognostic Biomarkers for Acute Myeloid Leukemia. Cancers (Basel). 2019;11(12):1958.
   Google Scholar
• SasnauskienėA, JonušienėV, KrikštaponienėA, et al. NOTCH1, NOTCH3, NOTCH4, and JAG2 protein levels in human endometrial cancer. Medicina. 2014;50:14–18. doi:10.1016/j.medici.2014.05.00225060200
   PubMed Web of Science ®Google Scholar
• VioletaJ, AusraS, NadezdaL, et al. Down-regulated expression of Notch signaling molecules in human endometrial cancer. Med Onco. 2013;30:1–7.
   Web of Science ®Google Scholar
• ZhangZ, BuX, YangJ, et al. NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patients. J Cell Physiol. 2018;233:6975–6985. doi:10.1002/jcp.26619
   PubMed Web of Science ®Google Scholar
• ChenC, WangX, HuangS, WangL, HanL, YuS. Prognostic roles of Notch receptor mRNA expression in human ovarian cancer. Oncotarget. 2017;8:32731–32740. doi:10.18632/oncotarget.1638728415574
   PubMedGoogle Scholar
• HarrisonH, FarnieG, HowellSJ, et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010;70:709–718. doi:10.1158/0008-5472.CAN-09-168120068161
   PubMed Web of Science ®Google Scholar
• D’AngeloRC, OuzounovaM, DavisA, et al. Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther. 2015;14:779–787. doi:10.1158/1535-7163.MCT-14-022825673823
   PubMed Web of Science ®Google Scholar
• KimS-H, SinghSV. The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. Breast Cancer Res Treat. 2015;149:681–692. doi:10.1007/s10549-015-3279-525663545
   PubMed Web of Science ®Google Scholar
• ApostolouP, ToloudiM, IoannouE, et al. Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells. J Recept Signal Transduct Res. 2013;33:353–358. doi:10.3109/10799893.2013.82807223964856
   PubMed Web of Science ®Google Scholar
• NguyenCH, BauerK, HacklH, et al. All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia. Cell Death Dis. 2019;10:944. doi:10.1038/s41419-019-2172-231822659
   PubMed Web of Science ®Google Scholar
• RustighiA, ZanniniA, TiberiL, et al. Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast. EMBO Mol Med. 2014;6:99–119. doi:10.1002/emmm.20130290924357640
   PubMed Web of Science ®Google Scholar
• ReipasKM, LawJH, CoutoN, et al. Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget. 2013;4:329–345. doi:10.18632/oncotarget.83423593654
   PubMedGoogle Scholar
• DingLC, SheL, ZhengDL, et al. Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma. Oncol Rep. 2010;24:363–368.20596622
   PubMed Web of Science ®Google Scholar
• StrizziL, MargaryanNV, GeramiP, et al. Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi. Oncol Lett. 2016;12:1349–1354. doi:10.3892/ol.2016.475527446436
   PubMed Web of Science ®Google Scholar
• ZhangJ, KuangY, YanW, XuQ, RenQ. Notch-4 silencing inhibits prostate cancer growth and EMT via the NF-κB pathway. Apoptosis. 2017;22:1–8. doi:10.1007/s10495-017-1368-027815720
   PubMed Web of Science ®Google Scholar
• FukusumiT, GuoTW, SakaiA, et al. The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2018;24:619–633. doi:10.1158/1078-0432.CCR-17-136629146722
   PubMed Web of Science ®Google Scholar
• CostaFF, SeftorEA, BischofJM, et al. Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment. Epigenomics. 2009;1:387–398. doi:10.2217/epi.09.2520495621
   PubMed Web of Science ®Google Scholar
• HardyKM, KirschmannDA, SeftorEA, et al. Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res. 2010;70:10340–10350. doi:10.1158/0008-5472.CAN-10-070521159651
   PubMed Web of Science ®Google Scholar
• BonyadiRE, HammerlindlH, WelsC, et al. Notch4 signaling induces a mesenchymal-epithelial-like transition in melanoma cells to suppress malignant behaviors. Cancer Res. 2016;76:222.
   Google Scholar
• BuiQT, ImJH, JeongSB, et al. Essential role of Notch4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancer. Cancer Lett. 2017;390:115–125. doi:10.1016/j.canlet.2017.01.01428108315
   PubMed Web of Science ®Google Scholar
• FengyanY, YuJ, YinghuaZ, et al. MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem. 2012;287:465–473. doi:10.1074/jbc.M111.28076822074923
   PubMed Web of Science ®Google Scholar
• PeifferDS, WyattD, ZlobinA, et al. DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-Positive Breast Cancer Following Endocrine Therapy. Cancer Res. 2019;79:4965–4977. doi:10.1158/0008-5472.CAN-19-111031387918
   PubMed Web of Science ®Google Scholar
• GelsominoL, PanzaS, GiordanoC, et al. Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines. Cancer Lett. 2018;428:12–20. doi:10.1016/j.canlet.2018.04.02329702197
   PubMed Web of Science ®Google Scholar
• SimõesBM, O’BrienCS, EyreR, et al. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity. Cell Rep. 2015;12:1968–1977. doi:10.1016/j.celrep.2015.08.05026387946
   PubMed Web of Science ®Google Scholar
• LombardoY, FilipovićA, MolyneuxG, et al. Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2012;109:16558–16563. doi:10.1073/pnas.120626810923012411
   PubMed Web of Science ®Google Scholar
• LombardoY, FaronatoM, FilipovicA, VircilloV, MagnaniL, CoombesRC. Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. Breast Cancer Res. 2014;16(3):R62. doi:10.1186/bcr367524919951
   PubMed Web of Science ®Google Scholar
• YunJ, PannutiA, EspinozaI, et al. Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells. Oncogenesis. 2013;2:e60. doi:10.1038/oncsis.2013.2623917222
   PubMed Web of Science ®Google Scholar
• SainiN, SarinA. Nucleolar localization of the Notch4 intracellular domain underpins its regulation of the cellular response to genotoxic stressors. Cell Death Discovery. 2020;6:7. doi:10.1038/s41420-020-0242-y32123583
   PubMed Web of Science ®Google Scholar
• NaikS, MacFarlaneM, SarinA. Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells. J Cell Biochem. 2015;116:1371–1380. doi:10.1002/jcb.2509425704336
   PubMed Web of Science ®Google Scholar
• QianC-J, Chen-Y-Y, ZhangX, et al. Notch4 inhibition reduces migration and invasion and enhances sensitivity to docetaxel by inhibiting Akt/fascin in pancreatic cancer cells. Oncol Lett. 2016;12:3499–3505. doi:10.3892/ol.2016.509727900027
   PubMed Web of Science ®Google Scholar
• Takam KamgaP, Dal ColloG, MidoloM, et al. Inhibition of Notch Signaling Enhances Chemosensitivity in B-cell Precursor Acute Lymphoblastic Leukemia. Cancer Res. 2019;79:639–649. doi:10.1158/0008-5472.CAN-18-161730563887
   PubMed Web of Science ®Google Scholar
• Nwabo KamdjeAH, BassiG, PacelliL, et al. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Blood Cancer J. 2012;2:e73. doi:10.1038/bcj.2012.1722829975
   PubMed Web of Science ®Google Scholar
• CostaMJ, WuX, CuervoH, et al. Notch4 is required for tumor onset and perfusion. Vasc Cell. 2013;5(1):7. doi:10.1186/2045-824X-5-723601498
   PubMedGoogle Scholar
• ZhangJ-F, ChenY, Qiu-X-X, et al. The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study. Tumour Biol. 2016;37:3797–3805. doi:10.1007/s13277-015-4202-826472724
   PubMedGoogle Scholar
• LeongKG, HuX, LiL, et al. Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol. 2002;22:2830–2841. doi:10.1128/MCB.22.8.2830-2841.200211909975
   PubMed Web of Science ®Google Scholar
• MacKenzieF, DuriezP, LarriveeB, et al. Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. Blood. 2004;104:1760–1768. doi:10.1182/blood-2003-12-424415187023
   PubMed Web of Science ®Google Scholar
• WilliamsCK, LiJL, MurgaM, HarrisAL, TosatoG. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 2006;107:931–939. doi:10.1182/blood-2005-03-100016219802
   PubMed Web of Science ®Google Scholar
• HainaudP, ContrerèsJ-O, VillemainA, et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res. 2006;66:8501–8510. doi:10.1158/0008-5472.CAN-05-422616951162
   PubMed Web of Science ®Google Scholar
• ZhangJ, QiaoL, LiangN, et al. Vasculogenic mimicry and tumor metastasis. J BUON. 2016;21:533–541.27569069
   PubMed Web of Science ®Google Scholar
• ChengR, CaiXR, KeK, ChenYL. Notch4 inhibition suppresses invasion and vasculogenic mimicry formation of hepatocellular carcinoma cells. J Huazhong Univ Sci Technolog Med Sci. 2017;37:719–725.29058285
   PubMedGoogle Scholar
• BaoS, JinS, WangC, TuP, HuK, LuJ. Androgen receptor suppresses vasculogenic mimicry in hepatocellular carcinoma via circRNA7/miRNA7-5p/VE-cadherin/Notch4 signalling. J Cell Mol Med. 2020. doi:10.1111/jcmm.16022
   Web of Science ®Google Scholar
• NagamatsuI, OnishiH, MatsushitaS, et al. NOTCH4 is a potential therapeutic target for triple-negative breast cancer. Anticancer Res. 2014;34:69–80.24403446
   PubMed Web of Science ®Google Scholar
• MishraS, YadavT, RaniV. Exploring miRNA based approaches in cancer diagnostics and therapeutics. Crit Rev Oncol Hematol. 2016;98:12–23. doi:10.1016/j.critrevonc.2015.10.00326481951
   PubMed Web of Science ®Google Scholar
• LongLM, ZhanJK, WangHQ, LiS, ChenYY, LiuYS. The Clinical Significance of miR-34a in Pancreatic Ductal Carcinoma and Associated Molecular and Cellular Mechanisms. Pathobiology. 2017;84:38–48. doi:10.1159/00044730227458977
   PubMed Web of Science ®Google Scholar
• CheungCM, LunWM, ChungTY, et al. MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma. Bmc Cancer. 2016;16:495. doi:10.1186/s12885-016-2525-527431799
   PubMed Web of Science ®Google Scholar
• YutakaH, YoshimitsuA, TakeshiO, ShuS, YasuhitoY. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis. 2010;31:777–784. doi:10.1093/carcin/bgq01320080834
   PubMed Web of Science ®Google Scholar
• LiWJ, XieXX, BaiJ, WangC, ZhaoL, JiangDQ. Increased expression of miR-1179 inhibits breast cancer cell metastasis by modulating Notch signaling pathway and correlates with favorable prognosis. Eur Rev Med Pharmacol Sci. 2018;22:8374–8382.30556878
   PubMed Web of Science ®Google Scholar
• Nwabo KamdjeAH, MosnaF, BifariF, et al. Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells. Blood. 2011;118:380–389. doi:10.1182/blood-2010-12-32669421602525
   PubMed Web of Science ®Google Scholar
• López-NievaP, González-SánchezL, Cobos-FernándezM, CórdobaR, SantosJ, Fernández-PiquerasJ. More Insights on the Use of γ-Secretase Inhibitors in Cancer Treatment. oncologist. 2021;26:e298–e305. doi:10.1002/onco.1359533191568
   PubMed Web of Science ®Google Scholar
• OkuboY, SugawaraT, Abe-KodukaN, KannoJ, KimuraA, SagaY. Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Nat Commun. 2012;3:1141. doi:10.1038/ncomms213323072809
   PubMed Web of Science ®Google Scholar
• KarR, JhaSK, OjhaS, et al. The FBXW7-NOTCH interactome: a ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues. Cancer Rep (Hoboken, NJ). 2021;e1369{EPub]. doi:10.1002/cnr2.1369
   Google Scholar
• DuttaD, SharmaV, MutsuddiM, MukherjeeA. Regulation of Notch signaling by E3 ubiquitin ligases. FEBS J. 2021. doi:10.1111/febs.15792
   Web of Science ®Google Scholar
• FunahashiY, HernandezSL, DasI, et al. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 2008;68:4727–4735. doi:10.1158/0008-5472.CAN-07-649918559519
   PubMed Web of Science ®Google Scholar
• JamesAC, SzotJO, IyerK, et al. Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochim Biophys Acta. 2014;1843:1272–1284. doi:10.1016/j.bbamcr.2014.03.01524667410
   PubMed Web of Science ®Google Scholar
• PedrosaAR, TrindadeA, FernandesAC, et al. Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1. Arterioscler Thromb Vasc Biol. 2015;35:1134–1146. doi:10.1161/ATVBAHA.114.30474125767274
   PubMed Web of Science ®Google Scholar
• DonnemT, AndersenS, Al-ShibliK, Al-SaadS, BusundLT, BremnesRM. Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer. 2010;116:5676–5685. doi:10.1002/cncr.2555120737536
   PubMed Web of Science ®Google Scholar