78
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Alterations of Signaling Pathways in Essential Thrombocythemia with Calreticulin Mutation

, , , , &
Pages 6231-6238 | Published online: 07 Aug 2021

References

  • TefferiA, PardananiA, SolomonCG. Essential thrombocythemia. N Engl J Med. 2019;381(22):2135–2144. doi:10.1056/NEJMcp181608231774958
  • JamesC, UgoV, Le CouedicJ-P, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144–1148. doi:10.1038/nature0354615793561
  • KralovicsR, PassamontiF, BuserAS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779–1790. doi:10.1056/NEJMoa05111315858187
  • KralovicsR, Teo-S-S, BuserAS, et al. Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2. Blood. 2005;106(10):3374–3376. doi:10.1182/blood-2005-05-188916081684
  • PikmanY, LeeBH, MercherT, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270. doi:10.1371/journal.pmed.003027016834459
  • PardananiAD, LevineRL, LashoT, et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006;108(10):3472–3476. doi:10.1182/blood-2006-04-01887916868251
  • KlampflT, GisslingerH, HarutyunyanAS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379–2390. doi:10.1056/NEJMoa131134724325356
  • NangaliaJ, MassieCE, BaxterEJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369(25):2391–2405. doi:10.1056/NEJMoa131254224325359
  • WernigG, MercherT, OkabeR, et al. Expression of Jak2V617F causes a polycythemia vera–like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006;107(11):4274–4281. doi:10.1182/blood-2005-12-482416478879
  • AkadaH, YanD, ZouH, et al. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera–like disease. Blood. 2010;115(17):3589–3597. doi:10.1182/blood-2009-04-21584820197548
  • ElfS, AbdelfattahNS, ChenE, et al. Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation. Cancer Discov. 2016;6(4):368–381. doi:10.1158/2159-8290.CD-15-143426951227
  • LiJ, PrinsD, ParkHJ, et al. Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. Blood. 2018;131(6):649–661. doi:10.1182/blood-2017-09-80635629282219
  • MartyC, PecquetC, NivarthiH, et al. Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood. 2016;127(10):1317–1324. doi:10.1182/blood-2015-11-67957126608331
  • ZhangDY, YeF, GaoL, et al. Proteomics, pathway array and signaling network-based medicine in cancer. Cell Div. 2009;4(1):20. doi:10.1186/1747-1028-4-2019863813
  • YeF, CheY, McMillenE, et al. The effect of Scutellaria Baicalensis on the signaling network in hepatocellular carcinoma cells. Nutr Cancer. 2009;61(4):530–537. doi:10.1080/0163558090280371919838925
  • WangD, YeF, SunY, et al. Protein signatures for classification and prognosis of gastric cancer a signaling pathway-based approach. Am J Pathol. 2011;179(4):1657–1666. doi:10.1016/j.ajpath.2011.06.01021854745
  • BauerS, AbdgawadM, GunnarssonL, et al. Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol. 2007;81(2):458–464. doi:10.1189/jlb.080651417077162
  • VardimanJW, ThieleJ, ArberDA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937–951. doi:10.1182/blood-2009-03-20926219357394
  • Al AssafC, Van ObberghF, BillietJ, et al. Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations. Haematologica. 2015;100(7):893–897. doi:10.3324/haematol.2014.11829925934766
  • MalherbeJAJ, FullerKA, MirzaiB, et al. Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms. J Clin Pathol. 2016;69(11):1017–1024. doi:10.1136/jclinpath-2016-203625
  • KoopmansSM, SchoutenHC, van MarionAMW. Anti-apoptotic pathways in bone marrow and megakaryocytes in myeloproliferative neoplasia. Pathobiology. 2014;81(2):60–68. doi:10.1159/00035618724280934
  • MondetJ, HusseinK, MossuzP. Circulating cytokine levels as markers of inflammation in Philadelphia negative myeloproliferative neoplasms: diagnostic and prognostic interest. Mediators Inflamm. 2015;2015:670580. doi:10.1155/2015/67058026525644
  • MaC, FanR, AhmadH, et al. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat Med. 2011;17(6):738–743. doi:10.1038/nm.237521602800
  • TefferiA, VaidyaR, CaramazzaD, et al. Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study. J Clin Oncol. 2011;29(10):1356–1363. doi:10.1200/JCO.2010.32.949021300928
  • PourcelotE, TrocmeC, MondetJ, et al. Cytokine profiles in polycythemia vera and essential thrombocythemia patients: clinical implications. Exp Hematol. 2014;42(5):360–368. doi:10.1016/j.exphem.2014.01.00624463275
  • JonesCI, TuckerKL, SasikumarP, et al. Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. J Thromb Haemost. 2014;12(8):1342–1352. doi:10.1111/jth.1262024888521
  • TuckerKL, SageT, StevensJM, et al. A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion. Blood. 2008;112(12):4523–4531. doi:10.1182/blood-2008-03-14850218772455
  • KleppeM, KocheR, ZouL, et al. Dual targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms. Cancer Cell. 2018;33(1):29–43.e27. doi:10.1016/j.ccell.2017.11.00929249691
  • VainchenkerW, ConstantinescuSN. JAK/STAT signaling in hematological malignancies. Oncogene. 2013;32(21):2601–2613. doi:10.1038/onc.2012.34722869151
  • KollmannK, NangaliaJ, WarschW, et al. MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling. Leukemia. 2015;29(2):494–497. doi:10.1038/leu.2014.28525249012
  • KollmannK, WarschW, Gonzalez-AriasC, et al. A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation. Leukemia. 2017;31(4):934–944. doi:10.1038/leu.2016.28027740635
  • LauWWY, HannahR, GreenAR, GottgensB. The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients. Blood. 2015;125(10):1679–1681. doi:10.1182/blood-2014-12-61807425745188