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Original Research

Overexpression of the lncRNA AC012213.3 Promotes Proliferation, Migration and Invasion of Breast Cancer via RAD54B/PI3K/AKT Axis and is Associated with Worse Patient Prognosis

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Pages 7213-7223 | Published online: 16 Sep 2021

References

  • SiegelRL, MillerKD, JemalA. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.30620402
  • VeronesiU, BoyleP, GoldhirschA, OrecchiaR, VialeG. Breast cancer. Lancet. 2005;365(9472):1727–1741. doi:10.1016/S0140-6736(05)66546-415894099
  • OlivottoIA, BajdikCD, RavdinPM, et al. Population-based validation of the prognostic model ADJUVANT! For early breast cancer. J Clin Oncol. 2005;23(12):2716–2725. doi:10.1200/JCO.2005.06.17815837986
  • CaiP, OttenABC, ChengB, et al. A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis. Genome Res. 2020;30(1):22–34. doi:10.1101/gr.251561.11931804951
  • SatpathyAT, ChangHY. Long noncoding RNA in hematopoiesis and immunity. Immunity. 2015;42(5):792–804. doi:10.1016/j.immuni.2015.05.00425992856
  • SchmittAM, ChangHY. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29(4):452–463. doi:10.1016/j.ccell.2016.03.01027070700
  • ChenF, ChenJ, YangL, et al. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol. 2019;21(4):498–510. doi:10.1038/s41556-019-0299-030936474
  • KongX, DuanY, SangY, et al. LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215. J Cell Physiol. 2019;234(6):9105–9117. doi:10.1002/jcp.2758730362551
  • AugoffK, McCueB, PlowEF, Sossey-AlaouiK. miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer. 2012;11(1):5. doi:10.1186/1476-4598-11-522289355
  • XiuB, ChiY, LiuL, et al. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187. doi:10.1186/s12943-019-1115-y31856843
  • WangY, WuS, ZhuX, et al. LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis. J Exp Med. 2020;217(3):e20190950. doi:10.1084/jem.2019095031816634
  • XueX, YangYA, ZhangA, et al. LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer. Oncogene.2016;35(21):2746–2755. doi:10.1038/onc.2015.34026364613
  • ZhangZ, LiX, HanY, et al. RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer. Biomed Pharmacother. 2019;118:109341. doi:10.1016/j.biopha.2019.10934131545289
  • DeSantisCE, MaJ, Goding SauerA, NewmanLA, JemalA. Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 2017;67(6):439–448.28972651
  • KoppF, MendellJT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393–407. doi:10.1016/j.cell.2018.01.01129373828
  • HeH, WangY, YeP, et al. Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma. J Exp Clin Cancer Res. 2020;39(1):159. doi:10.1186/s13046-020-01664-132795316
  • JiangY, CaoW, WuK, et al. LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. J Exp Clin Cancer Res. 2019;38(1):365. doi:10.1186/s13046-019-1364-z31429766
  • YueB, LiuC, SunH, et al. A positive feed-forward loop between LncRNA-CYTOR and Wnt/β-catenin signaling promotes metastasis of colon cancer. Mol Ther. 2018;26(5):1287–1298. doi:10.1016/j.ymthe.2018.02.02429606502
  • YasuharaT, SuzukiT, KatsuraM, MiyagawaK. Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. Nat Commun. 2014;5:5426. doi:10.1038/ncomms642625384516
  • McAndrewEN, McManusKJ. The enigmatic oncogene and tumor suppressor-like properties of RAD54B: insights into genome instability and cancer. Genes Chromosomes Cancer. 2017;56(7):513–523. doi:10.1002/gcc.2245828295846
  • WangR, LiY, ChenY, et al. Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells. Oncol Rep. 2018;40(3):1233–1242.29956808
  • XuC, LiuD, MeiH, HuJ, LuoM. Knockdown of RAD54B expression reduces cell proliferation and induces apoptosis in lung cancer cells. J Int Med Res. 2019;47(11):5650–5659. doi:10.1177/030006051986942331558081
  • YangQ, JiangW, HouP. Emerging role of PI3K/AKT in tumor-related epigenetic regulation. Semin Cancer Biol. 2019;59:112–124. doi:10.1016/j.semcancer.2019.04.00130951826
  • SongM, BodeAM, DongZ, LeeMH. AKT as a therapeutic target for cancer. Cancer Res. 2019;79(6):1019–1031. doi:10.1158/0008-5472.CAN-18-273830808672
  • XuJ, XiaoY, LiuB, et al. Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway. J Exp Clin Cancer Res. 2020;39(1):54. doi:10.1186/s13046-020-01562-632209115
  • GaoT, ZhangX, ZhaoJ, et al. SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer. Cancer Lett. 2020;469:89–101. doi:10.1016/j.canlet.2019.10.02931639424
  • Guerrero-ZotanoA, MayerIA, ArteagaCL. PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment. Cancer Metastasis Rev. 2016;35(4):515–524. doi:10.1007/s10555-016-9637-x27896521