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Review

Biogenesis, Functions, and Role of CircRNAs in Lung Cancer

, , , , & ORCID Icon
Pages 6651-6671 | Published online: 24 Aug 2021

References

  • SungH, FerlayJ, SiegelRL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.2166033538338
  • MolinaJR, YangP, CassiviSD, SchildSE, AdjeiAA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83(5):584–594. doi:10.1016/S0025-6196(11)60735-018452692
  • EttingerDS, WoodDE, AisnerDL, et al. Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2017;15(4):504–535. doi:10.6004/jnccn.2017.005028404761
  • SangerHL, KlotzG, RiesnerD, GrossHJ, KleinschmidtAK. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–3856. doi:10.1073/pnas.73.11.38521069269
  • MemczakS, JensM, ElefsiniotiA, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–338. doi:10.1038/nature1192823446348
  • ChenRX, LiuHL, YangLL, et al. Circular RNA circRNA_0000285 promotes cervical cancer development by regulating FUS. Eur Rev Med Pharmacol Sci. 2019;23(20):8771–8778.31696463
  • ChenY, WeiS, WangX, ZhuX, HanS. Progress in research on the role of circular RNAs in lung cancer. World J Surg Oncol. 2018;16(1):215. doi:10.1186/s12957-018-1515-230400981
  • JeckWR, SorrentinoJA, WangK, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19(2):141–157. doi:10.1261/rna.035667.11223249747
  • WangJ, ZhuM, PanJ, ChenC, XiaS, SongY. Circular RNAs: a rising star in respiratory diseases. Respir Res. 2019;20(1):3. doi:10.1186/s12931-018-0962-130611252
  • HuW, BiZY, ChenZL, et al. Emerging landscape of circular RNAs in lung cancer. Cancer Lett. 2018;427:18–27. doi:10.1016/j.canlet.2018.04.00629653267
  • ZhangY, ZhangXO, ChenT, et al. Circular intronic long noncoding RNAs. Mol Cell. 2013;51(6):792–806. doi:10.1016/j.molcel.2013.08.01724035497
  • LiZ, HuangC, BaoC, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–264. doi:10.1038/nsmb.295925664725
  • GaoY, WangJ, ZhaoF. CIRI: an efficient and unbiased algorithm for de novo circular RNA identification. Genome Biol. 2015;16:4. doi:10.1186/s13059-014-0571-325583365
  • SchmidtCA, MateraAG. tRNA introns: presence, processing, and purpose. Wiley Interdiscip Rev RNA. 2020;11(3):e1583. doi:10.1002/wrna.158331883233
  • HansenTB, WiklundED, BramsenJB, et al. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J. 2011;30(21):4414–4422. doi:10.1038/emboj.2011.35921964070
  • YuJ, XuQG, WangZG, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol. 2018;68(6):1214–1227. doi:10.1016/j.jhep.2018.01.01229378234
  • HoldtLM, StahringerA, SassK, et al. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Commun. 2016;7:12429. doi:10.1038/ncomms1242927539542
  • BeermannJ, PiccoliMT, ViereckJ, ThumT. Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev. 2016;96(4):1297–1325. doi:10.1152/physrev.00041.201527535639
  • HansenTB, JensenTI, ClausenBH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–388. doi:10.1038/nature1199323446346
  • KulcheskiFR, ChristoffAP, MargisR. Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 2016;238:42–51. doi:10.1016/j.jbiotec.2016.09.01127671698
  • LiRC, KeS, MengFK, et al. CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell Death Dis. 2018;9(8):838. doi:10.1038/s41419-018-0852-y30082829
  • ZhangY, ZhaoH, ZhangL. Identification of the tumor suppressive function of circular RNA FOXO3 in nonsmall cell lung cancer through sponging miR155. Mol Med Rep. 2018;17(6):7692–7700. doi:10.3892/mmr.2018.883029620202
  • HanC, WangS, WangH, ZhangJ. Exosomal Circ-HIPK3 facilitates tumor progression and temozolomide resistance by regulating miR-421/ZIC5 axis in glioma. Cancer Biother Radiopharm. 2020. doi:10.1089/cbr.2019.3492
  • QianW, HuangT, FengW. Circular RNA HIPK3 promotes EMT of cervical cancer through sponging miR-338-3p to up-regulate HIF-1alpha. Cancer Manag Res. 2020;12:177–187. doi:10.2147/CMAR.S23223532021434
  • ZhangH, DaiQ, ZhengL, YuanX, PanS, DengJ. Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis. Biochem Biophys Res Commun. 2020;533(3):501–509. doi:10.1016/j.bbrc.2020.09.05032977948
  • YangY, FanX, MaoM, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res. 2017;27(5):626–641. doi:10.1038/cr.2017.3128281539
  • WangY, WangZ. Efficient backsplicing produces translatable circular mRNAs. RNA. 2015;21(2):172–179. doi:10.1261/rna.048272.11425449546
  • ChenCY, SarnowP. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science. 1995;268(5209):415–417. doi:10.1126/science.75363447536344
  • KosA, DijkemaR, ArnbergAC, van der MeidePH, SchellekensH. The hepatitis delta (delta) virus possesses a circular RNA. Nature. 1986;323(6088):558–560. doi:10.1038/323558a02429192
  • LegniniI, Di TimoteoG, RossiF, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 2017;66(1):22–37 e9. doi:10.1016/j.molcel.2017.02.01728344082
  • AbeN, MatsumotoK, NishiharaM, et al. Rolling circle translation of circular RNA in living human cells. Sci Rep. 2015;5:16435. doi:10.1038/srep1643526553571
  • DuWW, YangW, LiuE, YangZ, DhaliwalP, YangBB. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 2016;44(6):2846–2858. doi:10.1093/nar/gkw02726861625
  • DuWW, YangW, ChenY, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J. 2017;38(18):1402–1412.26873092
  • GuangS, BochnerAF, BurkhartKB, BurtonN, PavelecDM, KennedyS. Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription. Nature. 2010;465(7301):1097–1101. doi:10.1038/nature0909520543824
  • Ashwal-FlussR, MeyerM, PamudurtiNR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66. doi:10.1016/j.molcel.2014.08.01925242144
  • YangZ, XieL, HanL, et al. Circular RNAs: regulators of cancer-related signaling pathways and potential diagnostic biomarkers for human cancers. Theranostics. 2017;7(12):3106–3117. doi:10.7150/thno.1901628839467
  • WanL, ZhangL, FanK, ChengZX, SunQC, WangJJ. Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/beta-catenin pathway. Biomed Res Int. 2016;2016:1579490. doi:10.1155/2016/157949027642589
  • LiX, ZhangZ, JiangH, et al. Circular RNA circPVT1 promotes proliferation and invasion through sponging miR-125b and activating E2F2 signaling in non-small cell lung cancer. Cell Physiol Biochem. 2018;51(5):2324–2340. doi:10.1159/00049587630537738
  • PeiX, ChenSW, LongX, et al. circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the Mir-145-5p/CXCL3 axis. Aging. 2020;12(13):13038–13058.32614785
  • YaoJ, XuG, ZhuL, ZhengH. circGFRA1 enhances NSCLC progression by sponging miR-188-3p. Onco Targets Ther. 2020;13:549–558. doi:10.2147/OTT.S23079532021297
  • ZhuX, WangX, WeiS, et al. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. FEBS J. 2017;284(14):2170–2182. doi:10.1111/febs.1413228685964
  • de FraipontF, GazzeriS, ChoWC, EyminB. Circular RNAs and RNA splice variants as biomarkers for prognosis and therapeutic response in the liquid biopsies of lung cancer patients. Front Genet. 2019;10:390. doi:10.3389/fgene.2019.0039031134126
  • QiuBQ, ZhangPF, XiongD, et al. CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non-small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling. J Cell Physiol. 2019;234(7):11256–11264. doi:10.1002/jcp.2778330565694
  • ChungLY, TangSJ, SunGH, et al. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. Clin Cancer Res. 2012;18(15):4037–4047. doi:10.1158/1078-0432.CCR-11-334822696230
  • ZhangPF, LiKS, ShenYH, et al. Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling. Cell Death Dis. 2016;7:e2201. doi:10.1038/cddis.2015.32427100895
  • AnJ, ShiH, ZhangN, SongS. Elevation of circular RNA circ_0003645 forecasts unfavorable prognosis and facilitates cell progression via miR-1179/TMEM14A pathway in non-small cell lung cancer. Biochem Biophys Res Commun. 2019;511(4):921–925. doi:10.1016/j.bbrc.2019.03.01130853176
  • ZhangX, YangD, WeiY. Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer. Onco Targets Ther. 2018;11:3979–3987. doi:10.2147/OTT.S15831630022841
  • FanZ, BaiY, ZhangQ, QianP. CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR-326/GNB1 axis. Environ Toxicol. 2020;35(10):1146–1156. doi:10.1002/tox.2298032511866
  • LiuG, ShiH, DengL, et al. Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer. Biochem Biophys Res Commun. 2019;513(1):207–212. doi:10.1016/j.bbrc.2019.03.21330954221
  • MaoZ, LiX, MaX, WangX, ZhangJ, FanX. Pancreatic progenitor cell differentiation and proliferation factor predicts poor prognosis in hepatocellular carcinoma. Medicine. 2019;98(9):e14552. doi:10.1097/MD.000000000001455230817571
  • SteinU, WaltherW, ArltF, et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 2009;15(1):59–67. doi:10.1038/nm.188919098908
  • ZhangW, SongC, RenX. Circ_0003998 regulates the progression and docetaxel sensitivity of DTX-resistant non-small cell lung cancer cells by the miR-136-5p/CORO1C axis. Technol Cancer Res Treat. 2021;20:1533033821990040. doi:10.1177/153303382199004033511909
  • XiaoG, HuangW, ZhanY, LiJ, TongW. CircRNA_103762 promotes multidrug resistance in NSCLC by targeting DNA damage inducible transcript 3 (CHOP). J Clin Lab Anal. 2020;34(6):e23252. doi:10.1002/jcla.2325232118311
  • DilsharaMG, JayasooriyaRG, ParkSR, ChoiYH, ChoiIW, KimGY. Caffeic acid phenethyl ester enhances TRAIL-mediated apoptosis via CHOP-induced death receptor 5 upregulation in hepatocarcinoma Hep3B cells. Mol Cell Biochem. 2016;418(1–2):13–20. doi:10.1007/s11010-016-2726-x27260301
  • TanW, LiaoY, QiuY, et al. miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP). Cancer Lett. 2018;428:55–68. doi:10.1016/j.canlet.2018.04.02829702190
  • QuD, YanB, XinR, MaT. A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer. Am J Cancer Res. 2018;8(8):1387–1402.30210911
  • ChengF, YuJ, ZhangX, DaiZ, FangA. CircSEC31A promotes the malignant progression of non-small cell lung cancer through regulating SEC31A expression via sponging miR-376a. Cancer Manag Res. 2020;12:11527–11539. doi:10.2147/CMAR.S28012433204164
  • BianWX, XueF, WangLY, XingXF. Circular RNA CircCDYL regulates proliferation and apoptosis in non-small cell lung cancer cells by sponging miR-185-5p and upregulating TNRC6A. Cancer Manag Res. 2021;13:633–642. doi:10.2147/CMAR.S28031533531835
  • YanB, ZhangW, MaoXW, JiangLY. Circular RNA ciRS-7 correlates with advance disease and poor prognosis, and its down-regulation inhibits cells proliferation while induces cells apoptosis in non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2018;22(24):8712–8721.30575911
  • ZhaoF, HanY, LiuZ, ZhaoZ, LiZ, JiaK. circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498. Biosci Rep. 2018;38:4. doi:10.1042/BSR20180570
  • GaoN, WangFX, WangG, ZhaoQS. Targeting the HMGA2 oncogene by miR-498 inhibits non-small cell lung cancer biological behaviors. Eur Rev Med Pharmacol Sci. 2018;22(6):1693–1699.29630114
  • LiL, DuM, WangC, HeP. Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer. J Thorac Dis. 2020;12(12):7281–7289. doi:10.21037/jtd-20-297733447417
  • ChenD, MaW, KeZ, XieF. CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. Cell Cycle. 2018;17(16):2080–2090. doi:10.1080/15384101.2018.151555330176158
  • ZongL, SunQ, ZhangH, et al. Increased expression of circRNA_102231 in lung cancer and its clinical significance. Biomed Pharmacother. 2018;102:639–644. doi:10.1016/j.biopha.2018.03.08429602132
  • ZhengG, HuangJ, ChenW, YouP, DingY, TuP. circUBAP2 exacerbates malignant capabilities of NSCLC by targeting KLF4 through miR-3182 modulation. Aging. 2021;13(8):11083–11095. doi:10.18632/aging.20274533882454
  • ChenL, NanA, ZhangN, et al. Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer. Mol Cancer. 2019;18(1):13. doi:10.1186/s12943-019-0943-030665425
  • WangL, TongX, ZhouZ, et al. Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial-mesenchymal transition and metastasis by controlling TIF1gamma in non-small cell lung cancer. Mol Cancer. 2018;17(1):140. doi:10.1186/s12943-018-0889-730261900
  • ZhangPF, PeiX, LiKS, et al. Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells. Mol Cancer. 2019;18(1):179. doi:10.1186/s12943-019-1111-231815619
  • ZhouJ, ZhangS, ChenZ, HeZ, XuY, LiZ. CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis. 2019;10(12):885. doi:10.1038/s41419-019-2127-731767835
  • HuangMS, LiuJY, XiaXB, et al. Hsa_circ_0001946 inhibits lung cancer progression and mediates cisplatin sensitivity in non-small cell lung cancer via the nucleotide excision repair signaling pathway. Front Oncol. 2019;9:508. doi:10.3389/fonc.2019.0050831249811
  • LiuW, MaW, YuanY, ZhangY, SunS. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. Biochem Biophys Res Commun. 2018;500(4):846–851. doi:10.1016/j.bbrc.2018.04.17229698681
  • LiX, FengY, YangB, et al. A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558. Mol Oncol. 2021;15:2235–2248. doi:10.1002/1878-0261.12852
  • HangD, ZhouJ, QinN, et al. A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. Cancer Med. 2018;7(6):2783–2791. doi:10.1002/cam4.151429722168
  • ChangH, QuJ, WangJ, LiangX, SunW. Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287. Biomed Pharmacother. 2019;112:108743. doi:10.1016/j.biopha.2019.10874330970529
  • MaoY, HeJX, ZhuM, DongYQ, HeJX. Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558. Hum Cell. 2021;34(2):468–477. doi:10.1007/s13577-020-00453-433128699
  • HanJ, ZhaoG, MaX, et al. CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. Biochem Biophys Res Commun. 2018;503(4):2429–2435. doi:10.1016/j.bbrc.2018.06.17229969631
  • YuanY, ZhouX, KangY, et al. Circ-CCS is identified as a cancer-promoting circRNA in lung cancer partly by regulating the miR-383/E2F7 axis. Life Sci. 2021;267:118955. doi:10.1016/j.lfs.2020.11895533359669
  • ChenX, MaoR, SuW, et al. Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKalpha signaling in STK11 mutant lung cancer. Autophagy. 2020;16(4):659–671. doi:10.1080/15548627.2019.163494531232177
  • HongW, ZhangY, DingJ, YangQ, XieH, GaoX. circHIPK3 acts as competing endogenous RNA and promotes non-small-cell lung cancer progression through the miR-107/BDNF signaling pathway. Biomed Res Int. 2020;2020:6075902. doi:10.1155/2020/607590233015172
  • GuF, ZhangJ, YanL, LiD. CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway. Open Life Sci. 2020;15(1):683–695. doi:10.1515/biol-2020-007033817257
  • LuH, HanX, RenJ, RenK, LiZ, SunZ. Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149. Cancer Biol Ther. 2020;21(2):113–121. doi:10.1080/15384047.2019.166999531597523
  • XuZ, XiangW, ChenW, et al. Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer. Thorac Cancer. 2020;11(4):875–887. doi:10.1111/1759-7714.1332932107851
  • MaX, YangX, BaoW, et al. Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. Biochem Biophys Res Commun. 2018;498(4):1009–1015. doi:10.1016/j.bbrc.2018.03.10529550475
  • LiB, ZhuL, LuC, et al. circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity. Nat Commun. 2021;12(1):295. doi:10.1038/s41467-020-20527-z33436560
  • WangL, XuC, WangC, et al. Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung cancer cells. Int J Clin Exp Pathol. 2018;11(7):3793–3801.31949766
  • ChiY, LuoQ, SongY, et al. Circular RNA circPIP5K1A promotes non-small cell lung cancer proliferation and metastasis through miR-600/HIF-1alpha regulation. J Cell Biochem. 2019;120(11):19019–19030. doi:10.1002/jcb.2922531241217
  • ShaoN, SongL, SunX. Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis. Mol Cell Biochem. 2021;476(6):2253–2267. doi:10.1007/s11010-021-04083-833570734
  • WeiS, ZhengY, JiangY, et al. The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p. EBioMedicine. 2019;44:182–193. doi:10.1016/j.ebiom.2019.05.03231160270
  • YangH, ZhaoM, ZhaoL, LiP, DuanY, LiG. CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145. Cell Oncol. 2020;43(3):477–488. doi:10.1007/s13402-020-00503-x
  • LiY, ZhangJ, PanS, ZhouJ, DiaoX, LiuS. CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis. Thorac Cancer. 2020;11(3):537–548. doi:10.1111/1759-7714.1327431917898
  • ZhaoY, ZhengR, ChenJ, NingD. CircRNA CDR1as/miR-641/HOXA9 pathway regulated stemness contributes to cisplatin resistance in non-small cell lung cancer (NSCLC). Cancer Cell Int. 2020;20:289. doi:10.1186/s12935-020-01390-w32655321
  • WangQ, KangPM. CircRNA_001010 adsorbs miR-5112 in a sponge form to promote proliferation and metastasis of non-small cell lung cancer (NSCLC). Eur Rev Med Pharmacol Sci. 2020;24(8):4271–4280.32373963
  • ZhangP, XueXF, LingXY, et al. CircRNA_010763 promotes growth and invasion of lung cancer through serving as a molecular sponge of miR-715 to induce c-Myc expression. Eur Rev Med Pharmacol Sci. 2020;24(13):7310–7319.32706069
  • ZhangZY, GaoXH, MaMY, ZhaoCL, ZhangYL, GuoSS. CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis. Sci Rep. 2020;10(1):9024. doi:10.1038/s41598-020-65920-232494004
  • ZhouZF, WeiZ, YaoJC, et al. CircRNA_102179 promotes the proliferation, migration and invasion in non-small cell lung cancer cells by regulating miR-330-5p/HMGB3 axis. Pathol Res Pract. 2020;216(11):153144. doi:10.1016/j.prp.2020.15314432911346
  • ZhangN, NanA, ChenL, et al. Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells. Mol Cancer. 2020;19(1):101. doi:10.1186/s12943-020-01221-632493389
  • WangY, XuR, ZhangD, et al. Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression. Transl Lung Cancer Res. 2019;8(6):862–875. doi:10.21037/tlcr.2019.11.0432010565
  • LiX, YangB, RenH, et al. Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. Cell Death Dis. 2019;10(12):953. doi:10.1038/s41419-019-2180-231844042
  • GaoS, YuY, LiuL, MengJ, LiG. Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. Life Sci. 2019;233:116692. doi:10.1016/j.lfs.2019.11669231351967
  • QinH, LiuJ, DuZH, HuR, YuYK, WangQA. Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis. Eur Rev Med Pharmacol Sci. 2020;24(4):1841–1852.32141553
  • YaoJT, ZhaoSH, LiuQP, et al. Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value. Pathol Res Pract. 2017;213(5):453–456. doi:10.1016/j.prp.2017.02.01128343871
  • ZhaoH, WeiH, HeJ, et al. Propofol disrupts cell carcinogenesis and aerobic glycolysis by regulating circTADA2A/miR-455-3p/FOXM1 axis in lung cancer. Cell Cycle. 2020;19(19):2538–2552. doi:10.1080/15384101.2020.181039332857667
  • MaJ, QiG, LiL. A novel serum exosomes-based biomarker hsa_circ_0002130 facilitates osimertinib-resistance in non-small cell lung cancer by sponging miR-498. Onco Targets Ther. 2020;13:5293–5307. doi:10.2147/OTT.S24321432606748
  • LiC, LiuH, NiuQ, GaoJ. Circ_0000376, a novel circRNA, promotes the progression of non-small cell lung cancer through regulating the miR-1182/NOVA2 network. Cancer Manag Res. 2020;12:7635–7647. doi:10.2147/CMAR.S25834032922073
  • TaiG, ZhangM, LiuF. Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis. Exp Lung Res. 2021;47(3):136–148. doi:10.1080/01902148.2021.188118833560141
  • HuangW, XuX, LiuM, CuiW, PengG. Downregulation of Hsa_circ_0000735 inhibits the proliferation, migration, invasion, and glycolysis in non-small-cell lung cancer by targeting miR-940/BMPER axis. Onco Targets Ther. 2020;13:8427–8439. doi:10.2147/OTT.S25347432922033
  • WangM, ShiJ, JiangH, XuK, HuangZ. Circ_0014130 participates in the proliferation and apoptosis of nonsmall cell lung cancer cells via the miR-142-5p/IGF-1 axis. Cancer Biother Radiopharm. 2020;35(3):233–240. doi:10.1089/cbr.2019.296531916848
  • GengY, BaoY, ZhangW, DengL, SuD, ZhengH. Circular RNA hsa_circ_0014130 inhibits apoptosis in non-small cell lung cancer by sponging miR-136-5p and upregulating BCL2. Mol Cancer Res. 2020;18(5):748–756. doi:10.1158/1541-7786.MCR-19-099832060230
  • LiY, HuJ, LiL, et al. Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. Biochem Biophys Res Commun. 2018;503(3):2089–2094. doi:10.1016/j.bbrc.2018.07.16430103946
  • YanX, WangT, WangJ. Circ_0016760 acts as a sponge of MicroRNA-4295 to enhance E2F transcription factor 3 expression and facilitates cell proliferation and glycolysis in nonsmall cell lung cancer. Cancer Biother Radiopharm. 2020. doi:10.1089/cbr.2020.3621
  • WanJ, HaoL, ZhengX, LiZ. Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR-488-3p to regulate ADAM9 expression. Biochem Biophys Res Commun. 2019;515(2):303–309. doi:10.1016/j.bbrc.2019.05.15831153639
  • LuJ, MaX, LinJ, HouP. Circ_0020123 increases ZFX expression to facilitate non-small cell lung cancer progression by sponging miR-142-3p. Cancer Manag Res. 2021;13:1687–1698. doi:10.2147/CMAR.S29559533633466
  • LiL, WeiH, ZhangH, XuF, CheG. Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p. Cancer Cell Int. 2020;20:160. doi:10.1186/s12935-020-01241-832425695
  • ZhangH, WangX, HuB, ZhangF, WeiH, LiL. Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression. Artif Cells Nanomed Biotechnol. 2019;47(1):3410–3416. doi:10.1080/21691401.2019.165262331407591
  • LiJ, FanR, XiaoH. Circ_ZFR contributes to the paclitaxel resistance and progression of non-small cell lung cancer by upregulating KPNA4 through sponging miR-195-5p. Cancer Cell Int. 2021;21(1):15. doi:10.1186/s12935-020-01702-033407505
  • TianX, ZhangL, JiaoY, ChenJ, ShanY, YangW. CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis. J Cell Biochem. 2019;120(3):3765–3772. doi:10.1002/jcb.2765730417418
  • MaD, QinY, HuangC, et al. Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p. Cell Cycle. 2020;19(13):1611–1620. doi:10.1080/15384101.2020.176161732420810
  • XueYB, DingMQ, XueL, LuoJH. CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression. Thorac Cancer. 2019;10(8):1692–1701. doi:10.1111/1759-7714.1313131243884
  • WangY. circ-ANXA7 facilitates lung adenocarcinoma progression via miR-331/LAD1 axis. Cancer Cell Int. 2021;21(1):85. doi:10.1186/s12935-021-01791-533536022
  • LiangY, WangH, ChenB, et al. circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression. Mol Ther Nucleic Acids. 2021;23:355–368. doi:10.1016/j.omtn.2020.11.01233425493
  • ZhangY, ShanC, ChenY, et al. CircDENND2A promotes non-small cell lung cancer progression via regulating MiR-34a/CCNE1 signaling. Front Genet. 2020;11:987. doi:10.3389/fgene.2020.0098733033491
  • XieY, WangL, YangD. CircEPSTI1 promotes the progression of non-small cell lung cancer through miR-145/HMGB3 axis. Cancer Manag Res. 2020;12:6827–6836. doi:10.2147/CMAR.S25289332801908
  • YangT, LiM, LiH, ShiP, LiuJ, ChenM. Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation. Biochem Biophys Res Commun. 2020;530(1):348–354. doi:10.1016/j.bbrc.2020.06.10632828310
  • LiO, KangJ, ZhangJJ, et al. Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(12):6767–6778.32633368
  • LuJ, ZhuY, QinY, ChenY. CircNFIX acts as a miR-212-3p sponge to enhance the malignant progression of non-small cell lung cancer by up-regulating ADAM10. Cancer Manag Res. 2020;12:9577–9587. doi:10.2147/CMAR.S27230933061643
  • YueQ, XuY, DengX, et al. Circ-PITX1 promotes the progression of non-small cell lung cancer through regulating the miR-1248/CCND2 axis. Onco Targets Ther. 2021;14:1807–1819. doi:10.2147/OTT.S28682033727831
  • ZhangSJ, MaJ, WuJC, HaoZZ, ZhangYN, ZhangYJ. CircRNA EPB41L2 inhibits tumorigenicity of lung adenocarcinoma through regulating CDH4 by miR-211-5p. Eur Rev Med Pharmacol Sci. 2020;24(7):3749–3760.32329852
  • YaoY, ZhouY, HuaQ. circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1. Mol Ther Nucleic Acids. 2021;23:783–796. doi:10.1016/j.omtn.2020.12.03133614229
  • LiL, WanK, XiongL, LiangS, TouF, GuoS. CircRNA hsa_circ_0087862 acts as an oncogene in non-small cell lung cancer by targeting miR-1253/RAB3D axis. Onco Targets Ther. 2020;13:2873–2886. doi:10.2147/OTT.S24353332308420
  • WangF, LiX, JiaX, GengL. CircRNA ZNF609 knockdown represses the development of non-small cell lung cancer via miR-623/FOXM1 axis. Cancer Manag Res. 2021;13:1029–1039. doi:10.2147/CMAR.S28216233574702
  • LiuS, YangN, JiangX, WangJ, DongJ, GaoY. FUS-induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR-142-3p in lung cancer. J Cell Physiol. 2021;236(1):79–92. doi:10.1002/jcp.2948133459380
  • WangJY, ZhangF, HongL, WeiSJ. CircRNA_0000429 regulates development of NSCLC by acting as a sponge of miR-1197 to control MADD. Cancer Manag Res. 2021;13:861–870. doi:10.2147/CMAR.S27079033542659
  • ZhongY, LinH, LiQ, LiuC, ShenJ. CircRNA_100565 contributes to cisplatin resistance of NSCLC cells by regulating proliferation, apoptosis and autophagy via miR-337-3p/ADAM28 axis. Cancer Biomark. 2021;30(2):261–273. doi:10.3233/CBM-20170533682697
  • GaoN, YeB. Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway. Cancer Cell Int. 2020;20:2. doi:10.1186/s12935-019-1065-x31911754
  • LiL, ZhangQ, LianK. Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion. Cancer Cell Int. 2020;20:247. doi:10.1186/s12935-020-01310-y32550825
  • ZhangCC, LiY, FengXZ, LiDB. Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. Bioengineered. 2021;12(1):414–425. doi:10.1080/21655979.2021.187219133467964
  • GaoP, WangZ, HuZ, JiaoX, YaoY. Circular RNA circ_0074027 indicates a poor prognosis for NSCLC patients and modulates cell proliferation, apoptosis, and invasion via miR-185-3p mediated BRD4/MADD activation. J Cell Biochem. 2020;121(3):2632–2642. doi:10.1002/jcb.2948431680319
  • GuoF, LiS, GuoC, et al. Circular RNA circMAGI3 accelerates the glycolysis of non-small cell lung cancer through miR-515-5p/HDGF. Am J Transl Res. 2020;12(7):3953–3963.32774748
  • WangY, LiY, HeH, WangF. Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498. Gene. 2019;720:144099. doi:10.1016/j.gene.2019.14409931479715
  • WangY, WangZ, LuJ, ZhangH. Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells. Hum Cell. 2021:1–11. doi:10.1007/s13577-021-00526-y33033884
  • WangHL, WangHR, LiangY, et al. Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma. Transl Lung Cancer Res. 2020;9(6):2411–2427. doi:10.21037/tlcr-20-125033489803
  • GuR, ShaoK, XuQ, ZhaoX, QiuH, HuH. Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non-small cell lung carcinoma via modulating miR-488/ZNF281 axis. J Cell Mol Med. 2020;34:1174–1184. doi:10.1111/jcmm.15987
  • WangY, LiH, LuH, QinY. Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis. Onco Targets Ther. 2019;12:7055–7065. doi:10.2147/OTT.S21632031564891
  • YangJ, JiaY, WangB, et al. Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p. Cell Signal. 2020;74:109693. doi:10.1016/j.cellsig.2020.10969332599139
  • ChenS, LuS, YaoY, et al. Downregulation of hsa_circ_0007580 inhibits non-small cell lung cancer tumorigenesis by reducing miR-545-3p sponging. Aging. 2020;12(14):14329–14340. doi:10.18632/aging.10347232681720
  • LvYS, WangC, LiLX, HanS, LiY. Effects of circRNA_103993 on the proliferation and apoptosis of NSCLC cells through miR-1271/ERG signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(16):8384–8393.32894545
  • LuoYH, ZhuXZ, HuangKW, et al. Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. Biomed Pharmacother. 2017;96:892–898. doi:10.1016/j.biopha.2017.12.01529223555
  • LiuQ, CaoG, WanY, XuC, HeY, LiG. Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression. Environ Toxicol. 2021;36(6):1052–1060. doi:10.1002/tox.2310433475233
  • ZhangF, ChengR, LiP, LuC, ZhangG. Hsa_circ_0010235 functions as an oncogenic drive in non-small cell lung cancer by modulating miR-433-3p/TIPRL axis. Cancer Cell Int. 2021;21(1):73. doi:10.1186/s12935-021-01764-833494763
  • DuH, HeZ, FengF, et al. Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3. Oncol Lett. 2020;20(1):266–274.
  • LiuY, YangC, CaoC, LiQ, JinX, ShiH. Hsa_circ_RNA_0011780 represses the proliferation and metastasis of non-small cell lung cancer by decreasing FBXW7 via targeting miR-544a. Onco Targets Ther. 2020;13:745–755. doi:10.2147/OTT.S23616232158226
  • XuJ, NiL, ZhaoF, et al. Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway. Aging. 2021;13(4):5986–6009. doi:10.18632/aging.20252133612481
  • WangY, ZhaoW, ZhangS. STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis. Biomed Pharmacother. 2020;126:110019. doi:10.1016/j.biopha.2020.11001932151944
  • WangT, WangX, DuQ, et al. The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p. Biochem Biophys Res Commun. 2019;513(4):904–911. doi:10.1016/j.bbrc.2019.04.10831005252
  • JinM, ShiC, YangC, LiuJ, HuangG. Upregulated circRNA ARHGAP10 predicts an unfavorable prognosis in NSCLC through regulation of the miR-150-5p/GLUT-1 axis. Mol Ther Nucleic Acids. 2019;18:219–231. doi:10.1016/j.omtn.2019.08.01631561126
  • WangL, MaH, KongW, LiuB, ZhangX. Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2. Biosci Rep. 2019;39(6):BSR20182433.31076544
  • GengQQ, WuQF, ZhangY, ZhangGJ, FuJK, ChenNZ. Clinical significance of circ-MTHFD2 in diagnosis, pathological staging and prognosis of NSCLC. Eur Rev Med Pharmacol Sci. 2020;24(18):9473–9479.33015789
  • ZhuX, HanJ, LanH, LinQ, WangY, SunX. A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC). BMC Cancer. 2020;20(1):1190. doi:10.1186/s12885-020-07680-w33276753