The Biological Synthesis and the Function of Mucin 2 in Pseudomyxoma Peritonei

References

• Govaerts K, Lurvink RJ, De Hingh IHJT, et al. Appendiceal tumours and pseudomyxoma peritonei: literature review with PSOGI/EURACAN clinical practice guidelines for diagnosis and treatment. Eur J Surg Oncol. 2021;47:11–35. doi:10.1016/j.ejso.2020.02.01232199769
   PubMed Web of Science ®Google Scholar
• Carr NJ, Cecil TD, Mohamed F, et al. A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: the results of the Peritoneal Surface Oncology Group International (PSOGI) modified Delphi process. Am J Surg Pathol. 2016;40:14–26. doi:10.1097/pas.000000000000053526492181
   PubMed Web of Science ®Google Scholar
• Li Y, Xu HB, Peng Z, Cui SZ, Wu W. Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei. Natl Med J China. 2019;99:1527–1535.
   Google Scholar
• O’Connell JT, Hacker CM, Barsky SH. MUC2 is a molecular marker for pseudomyxoma peritonei. Mod Pathol. 2002;15:958–972. doi:10.1097/01.Mp.0000026617.52466.9f12218214
   PubMed Web of Science ®Google Scholar
• O’Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH. Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells. Am J Pathol. 2002;161:551–564. doi:10.1016/s0002-9440(10)64211-312163380
   PubMed Web of Science ®Google Scholar
• Amini A, Masoumi-Moghaddam S, Ehteda A, Morris DL. Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects. Orphanet J Rare Dis. 2014;9:71. doi:10.1186/1750-1172-9-7124886459
   PubMed Web of Science ®Google Scholar
• Pillai K, Akhter J, Mekkawy A, Chua TC, Morris DL. Physical and chemical characteristics of mucin secreted by pseudomyxoma peritonei (PMP). Int J Med Sci. 2017;14:18–28. doi:10.7150/ijms.1642228138305
   PubMed Web of Science ®Google Scholar
• Amini A, Masoumi-Moghaddam S, Ehteda A, Liauw W, Morris DL. Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells. Am J Cancer Res. 2016;6:350–369.27186409
   PubMed Web of Science ®Google Scholar
• Amini A, Masoumi-Moghaddam S, Ehteda A, Liauw W, Morris DL. Depletion of mucin in mucin-producing human gastrointestinal carcinoma: results from in vitro and in vivo studies with bromelain and N-acetylcysteine. Oncotarget. 2015;6:33329–33344. doi:10.18632/oncotarget.525926436698
   PubMed Web of Science ®Google Scholar
• Pillai K, Akhter J, Chua TC, Morris DL. A formulation for in situ lysis of mucin secreted in pseudomyxoma peritonei. Int J Cancer. 2014;134:478–486. doi:10.1002/ijc.2838023843173
   PubMed Web of Science ®Google Scholar
• Yamashita MSA, Melo EO. Mucin 2 (MUC2) promoter characterization: an overview. Cell Tissue Res. 2018;374:455–463. doi:10.1007/s00441-018-2916-930218241
   PubMed Web of Science ®Google Scholar
• Van Seuningen I, Pigny P, Perrais M, Porchet N, Aubert JP. Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front Biosci. 2001;6:D1216–D1234.11578973
   PubMed Web of Science ®Google Scholar
• Javitt G, Khmelnitsky L, Albert L, et al. Assembly mechanism of mucin and von Willebrand factor polymers. Cell. 2020;183:717–729.e716. doi:10.1016/j.cell.2020.09.02133031746
   PubMed Web of Science ®Google Scholar
• Nilsson HE, Ambort D, Bäckström M, et al. Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J Mol Biol. 2014;426:2567–2579. doi:10.1016/j.jmb.2014.04.02724816392
   PubMed Web of Science ®Google Scholar
• Perez-Vilar J, Hill RL. The structure and assembly of secreted mucins. J Biol Chem. 1999;274:31751–31754. doi:10.1074/jbc.274.45.3175110542193
   PubMed Web of Science ®Google Scholar
• Johansson ME, Hansson GC. Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol. 2016;16:639–649. doi:10.1038/nri.2016.8827498766
   PubMed Web of Science ®Google Scholar
• Bansil R, Turner BS. The biology of mucus: composition, synthesis and organization. Adv Drug Deliv Rev. 2018;124:3–15. doi:10.1016/j.addr.2017.09.02328970050
   PubMed Web of Science ®Google Scholar
• Asker N, Axelsson MA, Olofsson SO, Hansson GC. Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus. J Biol Chem. 1998;273:18857–18863. doi:10.1074/jbc.273.30.188579668061
   PubMed Web of Science ®Google Scholar
• Bansil R, Turner BS. Mucin structure, aggregation, physiological functions and biomedical applications. Curr Opin Colloid Interface Sci. 2006;11:164–170. doi:10.1016/j.cocis.2005.11.001
   Web of Science ®Google Scholar
• Demouveaux B, Gouyer V, Gottrand F, Narita T, Desseyn J-L. Gel-forming mucin interactome drives mucus viscoelasticity. Adv Colloid Interface Sci. 2018;252:69–82. doi:10.1016/j.cis.2017.12.00529329667
   PubMed Web of Science ®Google Scholar
• Zanetta JP, Pons A, Richet C, et al. Quantitative gas chromatography/mass spectrometry determination of C-mannosylation of tryptophan residues in glycoproteins. Anal Biochem. 2004;329:199–206. doi:10.1016/j.ab.2004.02.03315158478
   PubMed Web of Science ®Google Scholar
• Chavan M, Lennarz W. The molecular basis of coupling of translocation and N-glycosylation. Trends Biochem Sci. 2006;31:17–20. doi:10.1016/j.tibs.2005.11.01016356726
   PubMed Web of Science ®Google Scholar
• Yan A, Lennarz WJ. Unraveling the mechanism of protein N-glycosylation. J Biol Chem. 2005;280:3121–3124. doi:10.1074/jbc.R40003620015590627
   PubMed Web of Science ®Google Scholar
• Yamashita K, Hara-Kuge S, Ohkura T. Intracellular lectins associated with N-linked glycoprotein traffic. Biochim Biophys Acta. 1999;1473:147–160. doi:10.1016/s0304-4165(99)00175-010580135
   PubMed Web of Science ®Google Scholar
• Brockhausen I. Pathways of O-glycan biosynthesis in cancer cells. Biochim Biophys Acta. 1999;1473:67–95. doi:10.1016/s0304-4165(99)00170-110580130
   PubMed Web of Science ®Google Scholar
• Silverman HS, Sutton-Smith M, McDermott K, et al. The contribution of tandem repeat number to the O-glycosylation of mucins. Glycobiology. 2003;13:265–277. doi:10.1093/glycob/cwg02812626424
   PubMed Web of Science ®Google Scholar
• van der Post S, Subramani DB, Bäckström M, et al. Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J Biol Chem. 2013;288:14636–14646. doi:10.1074/jbc.M113.45947923546879
   PubMed Web of Science ®Google Scholar
• Javitt G, Calvo MLG, Albert L, et al. Intestinal gel-forming mucins polymerize by disulfide-mediated dimerization of D3 domains. J Mol Biol. 2019;431:3740–3752. doi:10.1016/j.jmb.2019.07.01831310764
   PubMed Web of Science ®Google Scholar
• Borgert A, Heimburg-Molinaro J, Song X, et al. Deciphering structural elements of mucin glycoprotein recognition. ACS Chem Biol. 2012;7:1031–1039. doi:10.1021/cb300076s22444368
   PubMed Web of Science ®Google Scholar
• Sehnal D, Rose AS, Koča J, Burley SK, Velankar S. Mol*: towards a common library and tools for web molecular graphics. Proceedings of the workshop on molecular graphics and visual analysis of molecular data. Brno, Czech Republic: Eurographics Association; 2018:29–33.
   Google Scholar
• Davies HS, Singh P, Deckert-Gaudig T, et al. Secondary structure and glycosylation of mucus glycoproteins by Raman spectroscopies. Anal Chem. 2016;88:11609–11615. doi:10.1021/acs.analchem.6b0309527791356
   PubMed Web of Science ®Google Scholar
• Wagner CE, Turner BS, Rubinstein M, McKinley GH, Ribbeck K. A rheological study of the association and dynamics of MUC5AC gels. Biomacromolecules. 2017;18:3654–3664. doi:10.1021/acs.biomac.7b0080928903557
   PubMed Web of Science ®Google Scholar
• Cao X, Bansil R, Bhaskar KR, et al. pH-dependent conformational change of gastric mucin leads to sol-gel transition. Biophys J. 1999;76:1250–1258. doi:10.1016/s0006-3495(99)77288-710049309
   PubMed Web of Science ®Google Scholar
• Georgiades P, Pudney PD, Thornton DJ, Waigh TA. Particle tracking microrheology of purified gastrointestinal mucins. Biopolymers. 2014;101:366–377. doi:10.1002/bip.2237223955640
   PubMed Web of Science ®Google Scholar
• Thim L, Madsen F, Poulsen SS. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest. 2002;32:519–527. doi:10.1046/j.1365-2362.2002.01014.x12153553
   PubMed Web of Science ®Google Scholar
• Bell SL, Khatri IA, Xu G, Forstner JF. Evidence that a peptide corresponding to the rat Muc2 C-terminus undergoes disulphide-mediated dimerization. Eur J Biochem. 1998;253:123–131. doi:10.1046/j.1432-1327.1998.2530123.x9578469
   PubMedGoogle Scholar