75
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Clinical Value of Combined Detection of Serum sTim-3 and Pepsinogen for Gastric Cancer Diagnosis

, , ORCID Icon, , , , , , ORCID Icon, , , & show all
Pages 7759-7769 | Published online: 09 Oct 2021

References

  • Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020;396(10251):635–648. doi:10.1016/S0140-6736(20)31288-532861308
  • Emoto S, Ishigami H, Yamashita H, Yamaguchi H, Kaisaki S, Kitayama J. Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination. Gastric Cancer. 2012;15(2):154–161. doi:10.1007/s10120-011-0091-821892754
  • He CZ, Zhang KH, Li Q, Liu XH, Hong Y, Lv NH. Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer. BMC Gastroenterol. 2013;13:87. doi:10.1186/1471-230X-13-8723672279
  • Huang ZB, Zhou X, Xu J, et al. Prognostic value of preoperative serum tumor markers in gastric cancer. World J Clin Oncol. 2014;5(2):170–176. doi:10.5306/wjco.v5.i2.17024829865
  • Chen C, Chen Q, Zhao Q, Liu M, Guo J. Value of combined detection of serum CEA, CA72-4, CA19-9, CA15-3 and CA12-5 in the diagnosis of gastric cancer. Ann Clin Lab Sci. 2017;47(3):260–263.28667025
  • Yu J, Zheng W. An alternative method for screening gastric cancer based on serum levels of CEA, CA19-9, and CA72-4. J Gastrointest Cancer. 2018;49(1):57–62. doi:10.1007/s12029-016-9912-728028765
  • Miao J, Liu Y, Zhao G, et al. Feasibility of plasma-methylated SFRP2 for early detection of gastric cancer. Cancer Control. 2020;27(2):1073274820922559. doi:10.1177/107327482092255932379490
  • Huang C, Liu Z, Xiao L, et al. Clinical significance of serum CA125, CA19-9, CA72-4, and fibrinogen-to-lymphocyte ratio in gastric cancer with peritoneal dissemination. Front Oncol. 2019;9:1159. doi:10.3389/fonc.2019.0115931750248
  • Miftahussurur M, Waskito LA, Aftab H, et al. Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations. PLoS One. 2020;15(4):e0230064. doi:10.1371/journal.pone.023006432271765
  • Chiang TH, Chiu SY, Chen SL, et al. Serum pepsinogen as a predictor for gastric cancer death: a 16-year community-based cohort study. J Clin Gastroenterol. 2019;53(5):e186–e193. doi:10.1097/MCG.000000000000099229369241
  • Bang CS, Lee JJ, Baik GH. Diagnostic performance of serum pepsinogen assay for the prediction of atrophic gastritis and gastric neoplasms: protocol for a systematic review and meta-analysis. Medicine. 2019;98(4):e14240. doi:10.1097/MD.000000000001424030681610
  • Zoalfaghari A, Aletaha N, Roushan N, Taslimi R, Foroutan H, Faridnia B. Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population. Med J Islam Repub Iran. 2014;28:150.25695008
  • Zeng W, Zhang S, Yang L, et al. Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer. BMC Med Genet. 2020;21(1):28. doi:10.1186/s12881-020-0967-832041551
  • Yu G, Wang GX, Wang HG, Mo FF, Tang BB. The value of detecting pepsinogen and gastrin-17 levels in serum for pre-cancerous lesion screening in gastric cancer. Neoplasma. 2019;66(4):637–640. doi:10.4149/neo_2018_180825N64731058531
  • Yu J, Zhang H, Sun S, Sun S, Li L. The effects of Tim-3 activation on T-cells in gastric cancer progression. Oncol Lett. 2019;17(2):1461–1466.30675200
  • Gantuya B, Oyuntsetseg K, Bolor D, et al. Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area. Gastric Cancer. 2019;22(1):104–112. doi:10.1007/s10120-018-0844-829934751
  • Qin S, Xu L, Yi M, Yu S, Wu K, Luo S. Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4. Mol Cancer. 2019;18(1):155. doi:10.1186/s12943-019-1091-231690319
  • Zhuang X, Zhang X, Xia X, et al. Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC. Am J Clin Pathol. 2012;137(6):978–985. doi:10.1309/AJCP9Q6OVLVSHTMY22586058
  • Shang Y, Li Z, Li H, Xia H, Lin Z. TIM- 3 expression in human osteosarcoma: correlation with the expression of epithelial-mesenchymal transition-specific biomarkers. Oncol Lett. 2013;6(2):490–494. doi:10.3892/ol.2013.141024137353
  • Marcq E, Siozopoulou V, De Waele J, et al. Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma. Oncoimmunology. 2017;6(1):e1261241. doi:10.1080/2162402X.2016.126124128197385
  • Komohara Y, Morita T, Annan DA, et al. The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas. Cancer Immunol Res. 2015;3(9):999–1007. doi:10.1158/2326-6066.CIR-14-015625783986
  • Yang M, Yu Q, Liu J, et al. T-cell immunoglobulin mucin-3 expression in bladder urothelial carcinoma: clinicopathologic correlations and association with survival. J Surg Oncol. 2015;112(4):430–435. doi:10.1002/jso.2401226265374
  • Chen M, Wang L, Wang Y, et al. Soluble Tim3 detection by time-resolved fluorescence immunoassay and its application in membranous nephropathy. J Clin Lab Anal. 2020;34(6):e23248.32077157
  • Samloff IM. Immunologic studies of human group I pepsinogens. J Immunol. 1971;106(4):962–968.4396533
  • Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology. 2003;125(6):1636–1644. doi:10.1053/j.gastro.2003.08.03314724815
  • Huang YK, Yu JC, Kang WM, et al. Significance of serum pepsinogens as a biomarker for gastric cancer and atrophic gastritis screening: a systematic review and meta-analysis. PLoS One. 2015;10(11):e0142080. doi:10.1371/journal.pone.014208026556485
  • Li P, He C, Sun L, Dong N, Yuan Y. Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease. BMC Clin Pathol. 2013;13(1):22. doi:10.1186/1472-6890-13-2224004680
  • Nam SY, Jeon SW, Lee HS, Kwon YH, Park H, Choi JW. Long-term follow-up of pepsinogen I/II ratio after eradication of Helicobacter pylori in patients who underwent endoscopic mucosal resection for gastric cancer. Dig Liver Dis. 2017;49(5):500–506. doi:10.1016/j.dld.2016.12.01628057446
  • Cho JH, Jeon SR, Kim HG, Jin SY, Park S. The serum pepsinogen levels for risk assessment of gastric neoplasms: new proposal from a case-control study in Korea. Medicine. 2017;96(29):e7603. doi:10.1097/MD.000000000000760328723806
  • Lorente S, Doiz O, Trinidad Serrano M, Castillo J, Lanas A. Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells. Gut. 2002;50(1):13–18. doi:10.1136/gut.50.1.1311772960
  • Liu H, Zhi L, Duan N, Su P. Abnormal expression of Tim-3 antigen on peripheral blood T cells is associated with progressive disease in osteosarcoma patients. FEBS Open Bio. 2016;6(8):807–815. doi:10.1002/2211-5463.12079
  • Lei L, Zhong XN, He ZY, Zhao C, Sun XJ. IL-21 induction of CD4+ T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice. Cell Biol Int. 2015;39(4):388–399. doi:10.1002/cbin.1041025492803
  • Solinas C, De Silva P, Bron D, Willard-Gallo K, Sangiolo D. Significance of TIM3 expression in cancer: from biology to the clinic. Semin Oncol. 2019;46(4–5):372–379. doi:10.1053/j.seminoncol.2019.08.00531733828
  • Gao X, Zhu Y, Li G, et al. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One. 2012;7(2):e30676. doi:10.1371/journal.pone.003067622363469
  • Wu J, Liu C, Qian S, Hou H. The expression of Tim-3 in peripheral blood of ovarian cancer. DNA Cell Biol. 2013;32(11):648–653. doi:10.1089/dna.2013.211624007284
  • Cao Y, Zhou X, Huang X, et al. Tim-3 expression in cervical cancer promotes tumor metastasis. PLoS One. 2013;8(1):e53834. doi:10.1371/journal.pone.005383423335978
  • Zhang Y, Cai P, Liang T, Wang L, Hu L. TIM-3 is a potential prognostic marker for patients with solid tumors: a systematic review and meta-analysis. Oncotarget. 2017;8(19):31705–31713. doi:10.18632/oncotarget.1595428423646
  • Wang Z, Yin N, Zhang Z, Zhang Y, Zhang G, Chen W. Upregulation of T-cell immunoglobulin and mucin-domain Containing-3 (Tim-3) in monocytes/macrophages associates with gastric cancer progression. Immunol Investig. 2017;46(2):134–148. doi:10.1080/08820139.2016.122979027911104
  • Yegin ZA, Can F, Aydın Kaynar L, et al. Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients. Hematology. 2020;25(1):125–133. doi:10.1080/16078454.2020.173809732153257
  • Geng H, Zhang GM, Li D, et al. Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 2006;176(3):1411–1420. doi:10.4049/jimmunol.176.3.141116424168
  • Lu X, Yang L, Yao D, et al. Tumor antigen-specific CD8+ T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer. Cell Immunol. 2017;313:43–51. doi:10.1016/j.cellimm.2017.01.00128110884
  • Naghavi-Alhosseini M, Tehrani M, Ajami A, et al. Tim-3 up-regulation in patients with gastric cancer and peptic ulcer disease. Asian Pac J Cancer Prev. 2017;18(3):765–770.28441784
  • Wang Z, Zhu J, Gu H, et al. The clinical significance of abnormal Tim-3 expression on NK cells from patients with gastric cancer. Immunol Investig. 2015;44(6):578–589. doi:10.3109/08820139.2015.105214526214042
  • Hu CC, Jeng WJ, Chen YC, et al. Memory regulatory T cells increase only in inflammatory phase of chronic hepatitis B infection and related to galectin-9/Tim-3 interaction. Sci Rep. 2017;7(1):15280. doi:10.1038/s41598-017-15527-x29127350