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Original Research

Comprehensive Analysis of the Prognostic Value and Immune Infiltrates of the Three-m5C Signature in Colon Carcinoma

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Pages 7989-8002 | Published online: 20 Oct 2021

References

  • Sung H, Ferlay J, Siegel RL. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.2166033538338
  • Mejri N, Dridi M, El Benna H, et al. Tumor location impact in stage II and III colon cancer: epidemiological and outcome evaluation. J Gastrointest Oncol. 2018;9(2):263–268. doi:10.21037/jgo.2017.12.0229755764
  • Favoriti P, Carbone G, Greco M, et al. Worldwide burden of colorectal cancer: a review. Updates Surg. 2016;68(1):7–11. doi:10.1007/s13304-016-0359-y27067591
  • Mody K, Bekaii-Saab T. Clinical trials and progress in metastatic colon cancer. Surg Oncol Clin N Am. 2018;27(2):349–365. doi:10.1016/j.soc.2017.11.00829496094
  • Jahanafrooz Z, Mosafer J, Akbari M, et al. Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment. J Cell Physiol. 2020;235(5):4153–4166. doi:10.1002/jcp.2933731647128
  • Argilés G, Tabernero J, Labianca R, et al. Localised colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(10):1291–1305. doi:10.1016/j.annonc.2020.06.02232702383
  • Wang X, Duanmu J, Fu X, et al. Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment. J Transl Med. 2020;18(1):324. doi:10.1186/s12967-020-02491-w32859214
  • Cohn WE. Pseudouridine, a carbon-carbon linked ribonucleoside in ribonucleic acids: isolation, structure, and chemical characteristics. J Biol Chem. 1960;235:1488–1498. doi:10.1016/S0021-9258(18)69432-313811056
  • Pan J, Huang Z, Xu Y. m5C RNA methylation regulators predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma. Front Oncol. 2021;11:657466. doi:10.3389/fonc.2021.65746634195072
  • Roundtree IA, Evans ME, Pan T, et al. Dynamic RNA modifications in gene expression regulation. Cell. 2017;169(7):1187–1200. doi:10.1016/j.cell.2017.05.04528622506
  • Edelheit S, Schwartz S, Mumbach MR, et al. Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs. PLoS Genet. 2013;9(6):e1003602. doi:10.1371/journal.pgen.100360223825970
  • He Y, Yu X, Li J, et al. Role of m(5) C-related regulatory genes in the diagnosis and prognosis of hepatocellular carcinoma. Am J Transl Res. 2020;12(3):912–922.32269723
  • Nombela P, Miguel-López B, Blanco S. The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: novel therapeutic opportunities. Mol Cancer. 2021;20(1):18. doi:10.1186/s12943-020-01263-w33461542
  • Du E, Li J, Sheng F, et al. A pan-cancer analysis reveals genetic alterations, molecular mechanisms, and clinical relevance of m(5) C regulators. Clin Transl Med. 2020;10(5):e180. doi:10.1002/ctm2.18032997404
  • Chen H, Yang H, Zhu X, et al. m(5)C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat Commun. 2020;11(1):2834. doi:10.1038/s41467-020-16722-732503981
  • Mei L, Shen C, Miao R, et al. RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57(Kip2) by an m(5) C-dependent manner. Cell Death Dis. 2020;11(4):270. doi:10.1038/s41419-020-2487-z32332707
  • Bohnsack KE, Höbartner C. Eukaryotic 5-methylcytosine (m5C) RNA methyltransferases: mechanisms, cellular functions, and links to disease. Genes (Basel). 2019;10(2):102. doi:10.3390/genes10020102
  • Okamoto M, Hirata S, Sato S, et al. Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers. DNA Cell Biol. 2012;31(5):660–671. doi:10.1089/dna.2011.144622136356
  • Goldman MJ, Craft B. Visualizing and interpreting cancer genomics data via the Xena platform. Nature Biotechnol. 2020;38(6):675–678. doi:10.1038/s41587-020-0546-832444850
  • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252–7259. doi:10.1158/1078-0432.ccr-04-071315534099
  • Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559. doi:10.1186/1471-2105-9-559
  • Mollica Poeta V, Massara M, Capucetti A, et al. Chemokines and chemokine receptors: new targets for cancer immunotherapy. Front Immunol. 2019;10:379. doi:10.3389/fimmu.2019.0037930894861
  • Burger JA, Wiestner A. Targeting B cell receptor signalling in cancer: preclinical and clinical advances. Nat Rev Cancer. 2018;18(3):148–167. doi:10.1038/nrc.2017.12129348577
  • Coperchini F, Croce L, Marinò M, et al. Role of chemokine receptors in thyroid cancer and immunotherapy. Endocr Relat Cancer. 2019;26(8):R465–r478. doi:10.1530/erc-19-016331146261
  • Liang F, Ren C, Wang J, et al. The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy. Oncogenesis. 2019;8(10):59. doi:10.1038/s41389-019-0165-831597912
  • Selmi T, Hussain S, Dietmann S, et al. Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6. Nucleic Acids Res. 2021;49(2):1006–1022. doi:10.1093/nar/gkaa119333330931
  • Chen X, Li A, Sun BF, et al. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat Cell Biol. 2019;21(8):978–990. doi:10.1038/s41556-019-0361-y31358969
  • Garrett WS. The gut microbiota and colon cancer. Science. 2019;364(6446):1133–1135. doi:10.1126/science.aaw236731221845
  • Stoffel EM, Murphy CC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology. 2020;158(2):341–353. doi:10.1053/j.gastro.2019.07.05531394082
  • Gelibter AJ, Caponnetto S, Urbano F, et al. Adjuvant chemotherapy in resected colon cancer: when, how and how long? Surg Oncol. 2019;30:100–107. doi:10.1016/j.suronc.2019.06.00331500770
  • Angell HK, Bruni D. The immunoscore: colon cancer and beyond. Clin Cancer Res. 2020;26(2):332–339. doi:10.1158/1078-0432.ccr-18-185131413009
  • Pagès F, Mlecnik B, Marliot F, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391(10135):2128–2139. doi:10.1016/s0140-6736(18)30789-x29754777
  • Subramaniam D, Thombre R, Dhar A, et al. DNA methyltransferases: a novel target for prevention and therapy. Front Oncol. 2014;4:80. doi:10.3389/fonc.2014.0008024822169
  • Bloniarz D, Adamczyk-Grochala J, Lewinska A, et al. The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. Aging. 2021;13(12):15833–15874. doi:10.18632/aging.20320334139673
  • Chen Q, Yang H, Zhu X, et al. Integrative analysis of the doxorubicin-associated LncRNA-mRNA network identifies chemoresistance-associated lnc-TRDMT1-5 as a biomarker of breast cancer progression. Front Genet. 2020;11:566. doi:10.3389/fgene.2020.0056632547604
  • Haag S, Warda AS, Kretschmer J, et al. NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. Rna. 2015;21(9):1532–1543. doi:10.1261/rna.051524.11526160102
  • Chen YS, Yang WL, Zhao YL, et al. Dynamic transcriptomic m(5) C and its regulatory role in RNA processing. Wiley Interdiscip Rev RNA. 2021;12(4):e1639. doi:10.1002/wrna.163933438329
  • Yang R, Liang X, Wang H, et al. The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. EBioMedicine. 2021;63:103195. doi:10.1016/j.ebiom.2020.10319533418496
  • Huang Z, Pan J, Wang H, et al. Prognostic significance and tumor immune microenvironment heterogenicity of m5C RNA methylation regulators in triple-negative breast cancer. Front Cell Dev Biol. 2021;9:657547. doi:10.3389/fcell.2021.65754733928086
  • Li H, Zhang Y, Guo Y, et al. ALKBH1 promotes lung cancer by regulating m6A RNA demethylation. Biochem Pharmacol. 2021;189:114284. doi:10.1016/j.bcp.2020.11428433068553
  • Burotto M, Chiou VL, Lee JM, et al. The MAPK pathway across different malignancies: a new perspective. Cancer. 2014;120(22):3446–3456. doi:10.1002/cncr.2886424948110
  • Liu Y, Shepherd EG, Nelin LD. MAPK phosphatases–regulating the immune response. Nat Rev Immunol. 2007;7(3):202–212. doi:10.1038/nri203517318231
  • Shin MH, Kim J, Lim SA, et al. Current insights into combination therapies with MAPK inhibitors and immune checkpoint blockade. Int J Mol Sci. 2020;21(7). doi:10.3390/ijms21072531