170
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Correlation of Metabolic Factors with Endometrial Atypical Hyperplasia and Endometrial Cancer: Development and Assessment of a New Predictive Nomogram

ORCID Icon, , , , ORCID Icon &
Pages 7937-7949 | Published online: 18 Oct 2021

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. doi:10.3322/caac.2159031912902
  • Sanderson PA, Critchley HO, Williams AR, et al. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23(2):232–254.27920066
  • Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–1428. doi:10.1016/S0140-6736(05)66378-715836891
  • Shou H, Yan K, Song J, et al. Metabolic syndrome affects the long-term survival of patients with non-endometrioid carcinoma of the uterine corpus. Int J Gynaecol Obstet. 2020;148(1):96–101. doi:10.1002/ijgo.1298431560127
  • ACOG Committee Opinion. The use of hysteroscopy for the diagnosis and treatment of intrauterine pathology. Obstet Gynecol. 2020;135(3):e138–e148. doi:10.1097/AOG.000000000000371232080054
  • Yen CF, Chou HH, Wu HM, et al. Effectiveness and appropriateness in the application of office hysteroscopy. J Formos Med Assoc. 2019;118(11):1480–1487. doi:10.1016/j.jfma.2018.12.01230611636
  • Morice P, Leary A, Creutzberg C, et al. Endometrial cancer. Lancet. 2016;387(10023):1094–1108. doi:10.1016/S0140-6736(15)00130-026354523
  • Raffone A, Travaglino A, Saccone G, et al. Diabetes mellitus is associated with occult cancer in endometrial hyperplasia. Pathol Oncol Res. 2020;26(3):1377–1384. doi:10.1007/s12253-019-00684-331203571
  • Esposito K, Chiodini P, Colao A, et al. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402–2411. doi:10.2337/dc12-033623093685
  • Kitson SJ, Lindsay J, Sivalingam VN, et al. The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: a prospective case control study. Gynecol Oncol. 2018;148(1):154–160. doi:10.1016/j.ygyno.2017.11.01929174567
  • Arthur RS, Kabat GC, Kim MY, et al. Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study. Cancer Causes Control. 2019;30(4):355–363. doi:10.1007/s10552-019-01139-530788634
  • Deng T, Lyon CJ, Bergin S, Caligiuri MA, Hsueh WA. Obesity, inflammation, and cancer. Annu Rev Pathol. 2016;11:421–449. doi:10.1146/annurev-pathol-012615-04435927193454
  • Secord AA, Hasselblad V, Von Gruenigen VE, et al. Body mass index and mortality in endometrial cancer: a systematic review and meta-analysis. Gynecol Oncol. 2016;140(1):184–190. doi:10.1016/j.ygyno.2015.10.02026524722
  • Sung H, Siegel RL, Torre LA, et al. Global patterns in excess body weight and the associated cancer burden. CA Cancer J Clin. 2019;69(2):88–112.30548482
  • Roque DR, Makowski L, Chen TH, et al. Association between differential gene expression and body mass index among endometrial cancers from The Cancer Genome Atlas Project. Gynecol Oncol. 2016;142(2):317–322. doi:10.1016/j.ygyno.2016.06.00627288544
  • Ward KK, Roncancio AM, Shah NR, et al. Bariatric surgery decreases the risk of uterine malignancy. Gynecol Oncol. 2014;133(1):63–66. doi:10.1016/j.ygyno.2013.11.01224680593
  • Lai Y, Sun C. Association of abnormal glucose metabolism and insulin resistance in patients with atypical and typical endometrial cancer. Oncol Lett. 2018;15(2):2173–2178.29434922
  • Mu N, Zhu Y, Wang Y, et al. Insulin resistance: a significant risk factor of endometrial cancer. Gynecol Oncol. 2012;125(3):751–757. doi:10.1016/j.ygyno.2012.03.03222449736
  • Gu CJ, Xie F, Zhang B, et al. High glucose promotes epithelial-mesenchymal transition of uterus endometrial cancer cells by increasing ER/GLUT4-mediated VEGF secretion. Cell Physiol Biochem. 2018;50(2):706–720. doi:10.1159/00049423730308493
  • Wallbillich JJ, Josyula S, Saini U, et al. High glucose-mediated STAT3 activation in endometrial cancer Is inhibited by metformin: therapeutic implications for endometrial cancer. PLoS One. 2017;12(1):e0170318. doi:10.1371/journal.pone.017031828114390
  • Friberg E, Orsini N, Mantzoros CS, et al. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia. 2007;50(7):1365–1374. doi:10.1007/s00125-007-0681-517476474
  • Yang X, Wang J. The role of metabolic syndrome in endometrial cancer: a review. Front Oncol. 2019;9:744. doi:10.3389/fonc.2019.0074431440472
  • Madak-Erdogan Z, Band S, Zhao YC, et al. Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling. Cancer Res. 2019;79(10):2494–2510.30862719
  • Schmandt RE, Iglesias DA, Co NN, et al. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol. 2011;205(6):518–525. doi:10.1016/j.ajog.2011.05.04221802066
  • Gibson DA, Collins F, Cousins FL, et al. The impact of 27-hydroxycholesterol on endometrial cancer proliferation. Endocr Relat Cancer. 2018;25(4):381–391. doi:10.1530/ERC-17-044929371332
  • Aune D, Sen A, Vatten LJ. Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies. Sci Rep. 2017;7:44808.28387226
  • Bjørge T, Stocks T, Lukanova A, et al. Metabolic syndrome and endometrial carcinoma. Am J Epidemiol. 2010;171(8):892–902. doi:10.1093/aje/kwq00620219764
  • Dovell F, Boffetta P. Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis. Eur J Cancer Prev. 2018;27(4):399–405. doi:10.1097/CEJ.000000000000044029570104
  • Yang J, Wang Y, Zhao Q, et al. Association of serum uric acid with increased risk of cancer among hypertensive Chinese. Int J Cancer. 2017;141(1):112–120. doi:10.1002/ijc.3073128393356
  • Kühn T, Sookthai D, Graf ME, et al. Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study. Br J Cancer. 2017;117(10):1572–1579. doi:10.1038/bjc.2017.31328898231
  • Yiu A, Van Hemelrijck M, Garmo H, et al. Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS study. Oncotarget. 2017;8(26):42332–42342. doi:10.18632/oncotarget.1619828418841
  • DeBerardinis RJ, Phimister EG. Tumor microenvironment, metabolism, and immunotherapy. N Engl J Med. 2020;382(9):869–871. doi:10.1056/NEJMcibr191489032101671
  • Iyengar NM, Gucalp A, Dannenberg AJ, et al. Obesity and cancer mechanisms: tumor microenvironment and inflammation. J Clin Oncol. 2016;34(35):4270–4276. doi:10.1200/JCO.2016.67.428327903155
  • Hutt S, Tailor A, Ellis P, et al. The role of biomarkers in endometrial cancer and hyperplasia: a literature review. Acta Oncol. 2019;58(3):342–352. doi:10.1080/0284186X.2018.154088630614360