Genetic Variants in METTL14 are Associated with the Risk of Acute Lymphoblastic Leukemia in Southern Chinese Children: A Five-Center Case-Control Study

References

• Mosaad YM, Khashaba M, Darwish A, et al. ARID5B rs10821936 and rs10994982 gene polymorphisms and acute lymphoblastic leukemia: relation to disease susceptibility and outcome. Pediatric hematology and oncology. 2019;36(6):365–375.  doi:10.1080/08880018.2019.1649333
   Google Scholar
• Abaji R, Gagne V, Xu CJ, et al. Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients. Oncotarget. 2017;8(27):43752–43767. doi:10.18632/oncotarget.1795928574850
   PubMedGoogle Scholar
• Chen SS, Wu WZ, Zhang YP, Huang WJ. Gene polymorphisms of SOCS1 and SOCS2 and acute lymphoblastic leukemia. Eur Rev Med Pharmacol Sci. 2020;24(10):5564–5572. doi:10.26355/eurrev_202005_2134232495891
   PubMed Web of Science ®Google Scholar
• Nordlund J, Syvanen AC. Epigenetics in pediatric acute lymphoblastic leukemia. Semin Cancer Biol. 2018;51:129–138. doi:10.1016/j.semcancer.2017.09.00128887175
   PubMed Web of Science ®Google Scholar
• Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541–1552. doi:10.1056/NEJMra140097226465987
   PubMed Web of Science ®Google Scholar
• Pui CH. Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia. Front Med. 2015;9(1):1–9. doi:10.1007/s11684-015-0381-325511622
   PubMed Web of Science ®Google Scholar
• Yang X, Wu X, Fang N, et al. FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children. J Cell Biochem. 2020;121(2):2019–2026. doi:10.1002/jcb.2943631691337
   PubMed Web of Science ®Google Scholar
• Deng X, Su R, Weng H, Huang H, Li Z, Chen J. RNA N(6)-methyladenosine modification in cancers: current status and perspectives. Cell Res. 2018;28(5):507–517. doi:10.1038/s41422-018-0034-629686311
   PubMed Web of Science ®Google Scholar
• He L, Li H, Wu A, Peng Y, Shu G, Yin G. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019;18(1):176. doi:10.1186/s12943-019-1109-931801551
   PubMed Web of Science ®Google Scholar
• Dai D, Wang H, Zhu L, Jin H, Wang X. N6-methyladenosine links RNA metabolism to cancer progression. Cell Death Dis. 2018;9(2):124. doi:10.1038/s41419-017-0129-x29374143
   PubMed Web of Science ®Google Scholar
• Weng H, Huang H, Wu H, et al. METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification. Cell Stem Cell. 2018;22(2):191–205 e199. doi:10.1016/j.stem.2017.11.01629290617
   PubMed Web of Science ®Google Scholar
• Sun C, Chang L, Liu C, Chen X, Zhu X. The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. Mol Genet Genomic Med. 2019;7(10):e00933. doi:10.1002/mgg3.93331429529
   PubMed Web of Science ®Google Scholar
• Zhuo Z, Lu H, Zhu J, et al. METTL14 gene polymorphisms confer neuroblastoma susceptibility: an eight-center case-control study. Mol Ther Nucleic Acids. 2020;22:17–26. doi:10.1016/j.omtn.2020.08.00932891980
   PubMedGoogle Scholar
• Liu X, Huang L, Huang K, et al. Novel associations between METTL3 gene polymorphisms and pediatric acute lymphoblastic leukemia: a five-center case-control study. Front Oncol. 2021;11:635251. doi:10.3389/fonc.2021.63525134568001
   PubMed Web of Science ®Google Scholar
• He J, Yuan L, Lin H, et al. Genetic variants in m(6)A modification core genes are associated with glioma risk in Chinese children. Mol Ther Oncolytics. 2021;20:199–208. doi:10.1016/j.omto.2020.12.01333665358
   PubMed Web of Science ®Google Scholar
• Hua RX, Zhuo ZJ, Zhu J, et al. Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population. Aging. 2016;8(12):3311–3320. doi:10.18632/aging.10111927929383
   PubMedGoogle Scholar
• Zhuo ZJ, Liu W, Zhang J, et al. Functional polymorphisms at ERCC1/XPF genes confer neuroblastoma risk in Chinese children. EBioMedicine. 2018;30:113–119. doi:10.1016/j.ebiom.2018.03.00329544698
   PubMed Web of Science ®Google Scholar
• Yang X, He J, Chang Y, et al. HOTAIR gene polymorphisms contribute to increased neuroblastoma susceptibility in Chinese children. Cancer. 2018;124(12):2599–2606. doi:10.1002/cncr.3135329603181
   PubMed Web of Science ®Google Scholar
• Lin DY, Zeng D, Millikan R. Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies. Genet Epidemiol. 2005;29(4):299–312. doi:10.1002/gepi.2009816240443
   PubMed Web of Science ®Google Scholar
• Hua RX, Zhuo Z, Ge L, et al. LIN28A gene polymorphisms modify neuroblastoma susceptibility: a four-centre case-control study. J Cell Mol Med. 2020;24(1):1059–1066. doi:10.1111/jcmm.1482731747721
   PubMed Web of Science ®Google Scholar
• Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96(6):434–442. doi:10.1093/jnci/djh07515026468
   PubMed Web of Science ®Google Scholar
• Ma JZ, Yang F, Zhou CC, et al. METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6) -methyladenosine-dependent primary MicroRNA processing. Hepatology. 2017;65(2):529–543. doi:10.1002/hep.2888527774652
   PubMed Web of Science ®Google Scholar
• Chen X, Xu M, Xu X, et al. METTL14 suppresses CRC progression via regulating N6-methyladenosine-dependent primary miR-375 processing. Mol Ther. 2020;28(2):599–612. doi:10.1016/j.ymthe.2019.11.01631839484
   PubMed Web of Science ®Google Scholar
• Sun T, Wu Z, Wang X, et al. LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020;39(31):5358–5372. doi:10.1038/s41388-020-1338-932576970
   PubMed Web of Science ®Google Scholar
• Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease. J Clin Invest. 2008;118(5):1590–1605. doi:10.1172/JCI3477218451988
   PubMed Web of Science ®Google Scholar
• Fan D, Qiu B, Yang XJ, et al. LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis. Eur Rev Med Pharmacol Sci. 2020;24(22):11639–11649. doi:10.26355/eurrev_202011_2380833275231
   PubMed Web of Science ®Google Scholar
• Tian X, Liu Y, Wang Z, Wu S. lncRNA SNHG8 promotes aggressive behaviors of nasopharyngeal carcinoma via regulating miR-656-3p/SATB1 axis. Biomed Pharmacother. 2020;131:110564. doi:10.1016/j.biopha.2020.11056432920509
   PubMed Web of Science ®Google Scholar
• Qu X, Li Y, Wang L, Yuan N, Ma M, Chen Y. LncRNA SNHG8 accelerates proliferation and inhibits apoptosis in HPV-induced cervical cancer through recruiting EZH2 to epigenetically silence RECK expression. J Cell Biochem. 2020;121(10):4120–4129. doi:10.1002/jcb.2964631961005
   PubMed Web of Science ®Google Scholar
• Miao W, Lu T, Liu X, Yin W, Zhang H. LncRNA SNHG8 induces ovarian carcinoma cells cellular process and stemness through Wnt/beta-catenin pathway. Cancer Biomarkers. 2020;28(4):459–471. doi:10.3233/CBM-19064032538821
   PubMedGoogle Scholar
• Dong J, Teng F, Guo W, Yang J, Ding G, Fu Z. lncRNA SNHG8 promotes the tumorigenesis and metastasis by sponging miR-149-5p and predicts tumor recurrence in hepatocellular carcinoma. Cell Physiol Biochem. 2018;51(5):2262–2274. doi:10.1159/00049587130537734
   PubMedGoogle Scholar