143
Views
11
CrossRef citations to date
0
Altmetric
Review

The role of epithelial–mesenchymal transition programming in invasion and metastasis: a clinical perspective

, &
Pages 187-195 | Published online: 31 Jul 2013

References

  • HanahanDWeinbergRAThe hallmarks of cancerCell20001001577010647931
  • WeinbergRAThe Biology of Cancer1st edNew York, NYGarland Science2006
  • BoyerBVallésAEdmeNInduction and regulation of epithelial-mesenchymal transitionsBiochem Pharmacol20006081091109911007946
  • LeeJMDedharSKalluriRThompsonE WThe epithelial-mesenchymal transition: new insights in signaling, development, and diseaseJ Cell Biol2006172797398116567498
  • WeberCELiN YWaiPYKuoPCEpithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injuryJ Burn Care Res201233331131822561306
  • López-NovoaJMNietoMAInflammation and EMT: an alliance towards organ fibrosis and cancer progressionEMBO Mol Med200916–730331420049734
  • WellnerUSchubertJBurkUCThe EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsNat Cell Biol200911121487149519935649
  • EgerAAignerKSondereggerSDeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cellsOncogene200524142375238515674322
  • PeinadoHOlmedaDCanoASnail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Nat Rev Cancer20077641542817508028
  • YangYAhnYHGibbonsDLThe Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in miceJ Clin Invest201112141373138521403400
  • AignerKDampierBDescovichLThe transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarityOncogene200726496979698817486063
  • GaoDVahdatLTWongSChangJCMittalVMicroenvironmental regulation of epithelial-mesenchymal transitions in cancerCancer Res201272194883488923002209
  • GibbonsDLLinWCreightonCJContextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionGenes Dev200923182140215119759262
  • BrabletzTJungASpadernaSHlubekFKirchnerTOpinion: migrating cancer stem cells – an integrated concept of malignant tumour progressionNat Rev Cancer20055974474916148886
  • WuCYTsaiYPWuMZTengSCWuKJEpigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transitionTrends Genet201228945446322717049
  • GregoryPABertAGPatersonELThe miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nat Cell Biol200810559360118376396
  • BurkUSchubertJWellnerUA reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cellsEMBO Rep20089658258918483486
  • ParkSMGaurABLengyelEPeterMEThe miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Genes Dev200822789490718381893
  • WangBHerman-EdelsteinMKohPE-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-betaDiabetes20105971794180220393144
  • LamouilleSSubramanyamDBlellochRDerynckRRegulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAsCurr Opin Cell Biol201325220020723434068
  • EvdokimovaVTognonCNgTTranslational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transitionCancer Cell200915540241519411069
  • ChaudhuryAHusseyGSRayPSJinGFoxPLHowePHTGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEINat Cell Biol201012328629320154680
  • WarzechaCCJiangPAmirikianKAn ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transitionEMBO J201029193286330020711167
  • CreightonCJLiXLandisMResidual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresProc Natl Acad Sci U S A200910633138201382519666588
  • ManiSAGuoWLiaoMJThe epithelial-mesenchymal transition generates cells with properties of stem cellsCell2008133470471518485877
  • AhnYHGibbonsDLChakravartiDZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expressionJ Clin Invest201212293170318322850877
  • RoybalJDZangYAhnYHmiR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1Mol Cancer Res201191253521115742
  • SchepersAGSnippertHJStangeDELineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomasScience2012337609573073522855427
  • ChenJLiYYuTSA restricted cell population propagates glioblastoma growth after chemotherapyNature2012488741252252622854781
  • BertoliniGRozLPeregoPHighly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatmentProc Natl Acad Sci U S A200910638162811628619805294
  • DriessensGBeckBCaauweASimonsBDBlanpainCDefining the mode of tumour growth by clonal analysisNature2012488741252753022854777
  • Al-HajjMWichaMSBenito-HernandezAMorrisonSJClarkeMFProspective identification of tumorigenic breast cancer cellsProc Natl Acad Sci U S A200310073983398812629218
  • ShimonoYZabalaMChoRWDownregulation of miRNA-200c links breast cancer stem cells with normal stem cellsCell2009138359260319665978
  • PatersonELKazenwadelJBertAGKhew-GoodallYRuszkiewiczAGoodallGJDown-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progressionNeoplasia201315218019123441132
  • HennessyBTGonzalez-AnguloAMStemke-HaleKCharacterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsCancer Res200969104116412419435916
  • LiXLewisMTHuangJIntrinsic resistance of tumorigenic breast cancer cells to chemotherapyJ Natl Cancer Inst2008100967267918445819
  • LiuY PYangCJHuangMSCisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signalingCancer Res201373140641623135908
  • RenJChenYSongHChenLWangRInhibition of ZEB1 reverses EMT and chemoresistance in docetaxel-resistant human lung adenocarcinoma cell lineJ Cell Biochem201311461395140323255418
  • ByersLADiaoLWangJAn epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceClin Cancer Res201319127929023091115
  • KesslerJDKahleKTSunTA SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesisScience2012335606634835322157079
  • BeerDGKardiaSLHuangCCGene-expression profiles predict survival of patients with lung adenocarcinomaNat Med20028881682412118244
  • BhattacharjeeARichardsWGStauntonJClassification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesProc Natl Acad Sci U S A20019824137901379511707567
  • TomidaSTakeuchiTShimadaYRelapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosisJ Clin Oncol200927172793279919414676
  • ChitaleDGongYTaylorBSAn integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumorsOncogene200928312773278319525976
  • SheddenKTaylorJMEnkemannSADirector’s Challenge Consortium for the Molecular Classification of Lung AdenocarcinomaGene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation studyNat Med200814882282718641660
  • ZhuCQDingKStrumpfDPrognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancerJ Clin Oncol201028294417442420823422
  • BildAHYa oGChangJTOncogenic pathway signatures in human cancers as a guide to targeted therapiesNature2006439707435335716273092
  • TangHXiaoGBehrensCA 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patientsClin Cancer Res20131961577158623357979
  • OkayamaHKohnoTIshiiYIdentification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomasCancer Res201272110011122080568
  • BotlingJEdlundKLohrMBiomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validationClin Cancer Res201319119420423032747
  • HouJAertsJden HamerBGene expression-based Classification of non-small cell lung carcinomas and survival predictionPLoS One201054e1031220421987
  • Cancer Genome Atlas Research NetworkComprehensive genomic characterization of squamous cell lung cancersNature2012489741751952522960745
  • Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumoursNature20124907418617023000897
  • CieplyBRileyPPiferPMSuppression of the epithelial-mesenchymal transition by Grainyhead-like-2Cancer Res20127292440245322379025
  • PatnaikSKKannistoEKnudsenSYendamuriSEvaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resectionCancer Res2010701364520028859
  • CreightonCJChangJCRosenJMEpithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancerJ Mammary Gland Biol Neoplasia201015225326020354771
  • PratAParkerJSKarginovaOPhenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancerBreast Cancer Res2010125R6820813035
  • GuptaPBOnderTTJiangGIdentification of selective inhibitors of cancer stem cells by high-throughput screeningCell2009138464565919682730
  • Nana-SinkamS PCroceCMClinical applications for microRNAs in cancerClin Pharmacol Ther20139319810423212103
  • National Cancer Institute (NCI)Lapatinib Ditosylate, Trastuzumab, Paclitaxel, and Surgery in Treating Patients With Breast Cancer Available from http://clinicaltrials.gov/show/NCT01688609. NLM identification NCT01688609Accessed July 12, 2013
  • Northwestern UniversityCarboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients Available from http://clinicaltrials.gov/ct2/show/NCT01372579?term=NCT01372579&rank=1. NLM identifier NCT01372579Accessed July 12, 2013
  • National Cancer Institute (NCI)RO4929097 and Erlotinib Hydrochloride in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer Available from http://clinicaltrials.gov/ct2/show/NCT01193881?term=NCT01193881&rank=1. NLM identifier NCT01193884Accessed July 12, 2013
  • GillBJGibbonsDLRoudsariLCA synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma modelCancer Res201272226013602322952217
  • MishraDKSakamotoJHThrallMJHuman lung cancer cells grown in an ex vivo 3D lung model produce matrix metalloproteinases not produced in 2D culturePLoS One201279e4530823028922