LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer

References

• Wei L, Sun J, Zhang N, et al. Noncoding RNAs in gastric cancer: implications for drug resistance. Mol Cancer. 2020;19(1):62. doi:10.1186/s12943-020-01185-7
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Wei Z, Chen L, Meng L, Han W, Huang L, Xu A. LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1. Gastric Cancer. 2020;23(6):1018–1032. doi:10.1007/s10120-020-01091-3
   PubMed Web of Science ®Google Scholar
• Nieto MA, Huang RY, Jackson RA, Thiery JP. Emt: 2016. Cell. 2016;166(1):21–45. doi:10.1016/j.cell.2016.06.028
   PubMed Web of Science ®Google Scholar
• Bure IV, Nemtsova MV, Zaletaev DV. Roles of E-cadherin and noncoding RNAs in the epithelial-mesenchymal transition and progression in gastric cancer. Int J Mol Sci. 2019;20(12):2870. doi:10.3390/ijms20122870
   PubMed Web of Science ®Google Scholar
• Xu E, Xia X, Jiang C, et al. GPER1 silencing suppresses the proliferation, migration, and invasion of gastric cancer cells by inhibiting PI3K/AKT-Mediated EMT. Front Cell Dev Biol. 2020;8:591239. doi:10.3389/fcell.2020.591239
   PubMed Web of Science ®Google Scholar
• Cui H, Hu Y, Guo D, et al. DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer. Oncogene. 2018;37(32):4358–4371. doi:10.1038/s41388-018-0285-1
   PubMed Web of Science ®Google Scholar
• Fabbri M, Girnita L, Varani G, Calin GA. Decrypting noncoding RNA interactions, structures, and functional networks. Genome Res. 2019;29(9):1377–1388. doi:10.1101/gr.247239.118
   PubMed Web of Science ®Google Scholar
• Yao RW, Wang Y, Chen LL. Cellular functions of long noncoding RNAs. Nat Cell Biol. 2019;21(5):542–551. doi:10.1038/s41556-019-0311-8
   PubMed Web of Science ®Google Scholar
• Chen D, Ping S, Xu Y, et al. Non-coding RNAs in gastric cancer: from malignant hallmarks to clinical applications. Front Cell Dev Biol. 2021;9:732036. doi:10.3389/fcell.2021.732036
   PubMed Web of Science ®Google Scholar
• Yuan L, Xu ZY, Ruan SM, Mo S, Qin JJ, Cheng XD. Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance. Mol Cancer. 2020;19(1):96. doi:10.1186/s12943-020-01219-0
   PubMed Web of Science ®Google Scholar
• Liu ZQ, He WF, Wu YJ, et al. LncRNA SNHG1 promotes EMT process in gastric cancer cells through regulation of the miR-15b/DCLK1/Notch1 axis. BMC Gastroenterol. 2020;20(1):156. doi:10.1186/s12876-020-01272-5
   PubMed Web of Science ®Google Scholar
• Gong J, Wang Y, Shu C. LncRNA CHRF promotes cell invasion and migration via EMT in gastric cancer. Eur Rev Med Pharmacol Sci. 2020;24(3):1168–1176. doi:10.26355/eurrev_202002_20168
   PubMed Web of Science ®Google Scholar
• Li Q, Lei C, Lu C, Wang J, Gao M, Gao W. LINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2. Cell Death Dis. 2019;10(10):698. doi:10.1038/s41419-019-1896-3
   PubMed Web of Science ®Google Scholar
• Meng LD, Shi GD, Ge WL, et al. Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. Cancer Lett. 2020;494:107–120. doi:10.1016/j.canlet.2020.08.001
   PubMed Web of Science ®Google Scholar
• Guo L, Gao S, Sun W, Wang Y, Zhao J. Elevated LINC01232 is associated with poor prognosis and HBV infection in hepatocellular carcinoma patients and contributes to tumor progression in vitro. Clin Res Hepatol Gastroenterol. 2021;46:101813. doi:10.1016/j.clinre.2021.101813
   PubMed Web of Science ®Google Scholar
• Liu Q, Lei C. LINC01232 serves as a novel biomarker and promotes tumour progression by sponging miR-204-5p and upregulating RAB22A in clear cell renal cell carcinoma. Ann Med. 2021;53(1):2153–2164. doi:10.1080/07853890.2021.2001563
   PubMed Web of Science ®Google Scholar
• Liu J, Li Z, Yu G, Wang T, Qu G, Wang Y. LINC01232 promotes gastric cancer proliferation through interacting with EZH2 to inhibit the transcription of KLF2. J Microbiol Biotechnol. 2021;31(10):1358–1365. doi:10.4014/jmb.2106.06041
   PubMed Web of Science ®Google Scholar
• Zhao M, Cui H, Zhao B, Li M, Man H. Long intergenic noncoding RNA LINC01232 contributes to esophageal squamous cell carcinoma progression by sequestering microRNA6543p and consequently promoting hepatoma derived growth factor expression. Int J Mol Med. 2020;46(6):2007–2018. doi:10.3892/ijmm.2020.4750
   PubMed Web of Science ®Google Scholar
• Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393–407. doi:10.1016/j.cell.2018.01.011
   PubMed Web of Science ®Google Scholar
• Xiong G, Pan S, Jin J, et al. Long noncoding competing endogenous RNA networks in pancreatic cancer. Front Oncol. 2021;11:765216. doi:10.3389/fonc.2021.765216
   PubMed Web of Science ®Google Scholar
• Hu J, Huang L, Ding Q, Lv J, Chen Z. Long noncoding RNA HAGLR sponges miR-338-3p to promote 5-Fu resistance in gastric cancer through targeting the LDHA-glycolysis pathway. Cell Biol Int. 2021;46(2):173–184.
   PubMed Web of Science ®Google Scholar
• Landeros N, Santoro PM, Carrasco-Avino G, Corvalan AH. Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer. Cancers. 2020;12(10):2741. doi:10.3390/cancers12102741
   PubMed Web of Science ®Google Scholar
• Wang G, Zhang Z, Xia C. Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis. Bioengineered. 2021;12(2):9678–9691. doi:10.1080/21655979.2021.1983276
   PubMed Web of Science ®Google Scholar
• Ji Z, Tang T, Chen M, et al. C-Myc-activated long non-coding RNA LINC01050 promotes gastric cancer growth and metastasis by sponging miR-7161-3p to regulate SPZ1 expression. J Exp Clin Cancer Res. 2021;40(1):351. doi:10.1186/s13046-021-02155-7
   PubMed Web of Science ®Google Scholar
• Fang Y, Sun B, Gao J, Huang Y, Wang C. LncRNA SLCO4A1-AS1 accelerates growth and metastasis of gastric cancer via regulation of the miR-149/XIAP Axis. Front Oncol. 2021;11:683256. doi:10.3389/fonc.2021.683256
   PubMed Web of Science ®Google Scholar
• Li Z, Shi L, Li X, Wang X, Wang H, Liu Y. RNF144A-AS1, a TGF-beta1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer. Cell Biosci. 2021;11(1):177. doi:10.1186/s13578-021-00689-z
   PubMed Web of Science ®Google Scholar
• An J, Guo X, Yan B. DICER-AS1 functions as competing endogenous RNA that targets CSR1 by sponging microRNA-650 and suppresses gastric cancer progression. J Int Med Res. 2021;49(9):3000605211041466. doi:10.1177/03000605211041466
   Web of Science ®Google Scholar
• Zheng YL, Song G, Guo JB, et al. Interactions among lncRNA/circRNA, miRNA, and mRNA in musculoskeletal degenerative diseases. Front Cell Dev Biol. 2021;9:753931. doi:10.3389/fcell.2021.753931
   PubMed Web of Science ®Google Scholar
• Deng K, Wang H, Guo X, Xia J. The cross talk between long, non-coding RNAs and microRNAs in gastric cancer. Acta Biochim Biophys Sin. 2016;48(2):111–116. doi:10.1093/abbs/gmv120
   Google Scholar
• Chen Z, Zhong T, Li T, et al. LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression. Biosci Rep. 2021;41(7). doi:10.1042/BSR20204177
   Web of Science ®Google Scholar
• Zhao J, Zeng XB, Zhang HY, Xiang JW, Liu YS. Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p. Open Med. 2020;15(1):921–931. doi:10.1515/med-2020-0175
   Web of Science ®Google Scholar
• Liu F, Cheng Z, Li X, et al. A novel Pak1/ATF2/miR-132 signaling axis is involved in the hematogenous metastasis of gastric cancer cells. Mol Ther Nucleic Acids. 2017;8:370–382. doi:10.1016/j.omtn.2017.07.005
   PubMedGoogle Scholar
• Cao F, Yin LX. PAK1 promotes proliferation, migration and invasion of hepatocellular carcinoma by facilitating EMT via directly up-regulating Snail. Genomics. 2020;112(1):694–702. doi:10.1016/j.ygeno.2019.05.002
   PubMed Web of Science ®Google Scholar
• Li X, Zhu J, Liu Y, Duan C, Chang R, Zhang C. MicroRNA-331-3p inhibits epithelial-mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/beta-catenin axis in non-small-cell lung cancer. Cancer Sci. 2019;110(6):1883–1896. doi:10.1111/cas.14014
   PubMed Web of Science ®Google Scholar
• Lin XJ, He CL, Sun T, Duan XJ, Sun Y, Xiong SJ. hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma. Int J Mol Med. 2017;40(1):83–89. doi:10.3892/ijmm.2017.2992
   PubMed Web of Science ®Google Scholar
• Zhou Y, Fan RG, Qin CL, Jia J, Wu XD, Zha WZ. LncRNA-H19 activates CDC42/PAK1 pathway to promote cell proliferation, migration and invasion by targeting miR-15b in hepatocellular carcinoma. Genomics. 2019;111(6):1862–1872. doi:10.1016/j.ygeno.2018.12.009
   PubMed Web of Science ®Google Scholar