Retrospective Review of Efficacy and Safety of Anlotinib in Advanced Leiomyosarcoma: A Real-World Study

References

• George S, Serrano C, Hensley ML, Ray-Coquard I. Soft tissue and uterine leiomyosarcoma. J Clin Oncol. 2018;36(2):144–150. doi:10.1200/jco.2017.75.9845
   PubMed Web of Science ®Google Scholar
• Dangoor A, Seddon B, Gerrand C, et al. UK guidelines for the management of soft tissue sarcomas. Clin Sarcoma Res. 2016;6(1):20. doi:10.1186/s13569-016-0060-4
   PubMedGoogle Scholar
• Tap WD, Jones RL, Van Tine BA, et al. Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised Phase 2 trial. Lancet. 2016;388(10043):488–497. doi:10.1016/s0140-6736(16)30587-6
   PubMed Web of Science ®Google Scholar
• von Mehren M, Randall RL, Benjamin RS, et al. Soft tissue sarcoma, Version 2.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2018;16(5):536–563. doi:10.6004/jnccn.2018.0025
   PubMed Web of Science ®Google Scholar
• Hensley ML, Blessing JA, Mannel R, Rose PG. Fixed-dose rate gemcitabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma: a gynecologic oncology group phase II trial. Gynecol Oncol. 2008;109(3):329–334. doi:10.1016/j.ygyno.2008.03.010
   PubMed Web of Science ®Google Scholar
• Seddon B, Scurr M, Jones RL, et al. A phase II trial to assess the activity of gemcitabine and docetaxel as first line chemotherapy treatment in patients with unresectable leiomyosarcoma. Clin Sarcoma Res. 2015;5(1):13. doi:10.1186/s13569-015-0029-8
   PubMedGoogle Scholar
• Hensley ML, Miller A, O’Malley DM, et al. Randomized Phase III trial of gemcitabine plus docetaxel plus bevacizumab or placebo as first-line treatment for metastatic uterine leiomyosarcoma: an NRG Oncology/Gynecologic oncology group study. J Clin Oncol. 2015;33(10):1180–1185. doi:10.1200/jco.2014.58.3781
   PubMed Web of Science ®Google Scholar
• Li F, Liao Z, Zhao J, et al. Efficacy and safety of Apatinib in stage IV sarcomas: experience of a major sarcoma center in China. Oncotarget. 2017;8(38):64471–64480. doi:10.18632/oncotarget.16293
   PubMedGoogle Scholar
• Mir O, Brodowicz T, Italiano A, et al. Safety and efficacy of regorafenib in patients with advanced soft tissue sarcoma (REGOSARC): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol. 2016;17(12):1732–1742. doi:10.1016/s1470-2045(16)30507-1
   PubMed Web of Science ®Google Scholar
• van der Graaf WT, Blay J-Y, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled Phase 3 trial. Lancet. 2012;379(9829):1879–1886. doi:10.1016/s0140-6736(12)60651-5
   PubMed Web of Science ®Google Scholar
• Chi Y, Fang Z, Hong X, et al. Safety and efficacy of anlotinib, a multikinase angiogenesis inhibitor, in patients with refractory metastatic soft-tissue sarcoma. Clin Cancer Res. 2018;24(21):5233–5238. doi:10.1158/1078-0432.Ccr-17-3766
   PubMed Web of Science ®Google Scholar
• Lin B, Song X, Yang D, et al. Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1. Gene. 2018;654:77–86. doi:10.1016/j.gene.2018.02.026
   PubMed Web of Science ®Google Scholar
• Xie C, Wan X, Quan H, et al. Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor. Cancer Sci. 2018;109(4):1207–1219. doi:10.1111/cas.13536
   PubMed Web of Science ®Google Scholar
• Chen XZ. Anlotinib for refractory advanced non-small cell lung cancer in China. JAMA Oncol. 2019;5(1):116–117. doi:10.1001/jamaoncol.2018.5526
   Web of Science ®Google Scholar
• Sun Y, Du F, Gao M, et al. Anlotinib for the treatment of patients with locally advanced or metastatic medullary thyroid cancer. Thyroid. 2018;28(11):1455–1461. doi:10.1089/thy.2018.0022
   PubMed Web of Science ®Google Scholar
• Zhou AP, Bai Y, Song Y, et al. Anlotinib versus Sunitinib as first-line treatment for metastatic renal cell carcinoma: a randomized phase II clinical trial. Oncologist. 2019;24(8):e702–e708. doi:10.1634/theoncologist.2018-0839
   PubMed Web of Science ®Google Scholar
• Chi Y, Yao Y, Wang S, et al. Anlotinib for metastasis soft tissue sarcoma: a randomized, double-blind, placebo-controlled and multi-centered clinical trial. J Clin Oncol. 2018;36(15_suppl):11503. doi:10.1200/JCO.2018.36.15_suppl.11503
   Web of Science ®Google Scholar
• Singhi EK, Moore DC, Muslimani A. Metastatic soft tissue sarcomas: a review of treatment and new pharmacotherapies. P t. 2018;43(7):410–429.
   PubMedGoogle Scholar
• Tian Z, Liu H, Zhang F, et al. Retrospective review of the activity and safety of apatinib and anlotinib in patients with advanced osteosarcoma and soft tissue sarcoma. Invest New Drugs. 2020;38:1559–1569. doi:10.1007/s10637-020-00912-7
   PubMed Web of Science ®Google Scholar
• Ben-Ami E, Barysauskas CM, Solomon S, et al. Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: results of a phase 2 study. Cancer. 2017;123(17):3285–3290. doi:10.1002/cncr.30738
   PubMed Web of Science ®Google Scholar
• Italiano A, Bellera C, D’Angelo S. PD1/PD-L1 targeting in advanced soft-tissue sarcomas: a pooled analysis of phase II trials. J Hematol Oncol. 2020;13(1):55. doi:10.1186/s13045-020-00891-5
   PubMed Web of Science ®Google Scholar
• Monga V, Skubitz KM, Maliske S, et al. A retrospective analysis of the efficacy of immunotherapy in metastatic soft-tissue sarcomas. Cancers. 2020;12(7):1873. doi:10.3390/cancers12071873
   PubMed Web of Science ®Google Scholar
• Xi C, Wencheng Z, Dong Q, et al. Tumor regression after combination of radiation and PD-1 antibody nivolumab treatment in a patient with metastatic mediastinal leiomyosarcoma: a case report. Cancer Biol Ther. 2019;20(4):408–412. doi:10.1080/15384047.2018.1537577
   PubMed Web of Science ®Google Scholar
• Heine A, Kristiansen G, Schild HH, Brossart P. Successful treatment of refractory leiomyosarcoma with the PD-1 inhibitor nivolumab. Ann Oncol. 2016;27(9):1813–1814. doi:10.1093/annonc/mdw243
   PubMed Web of Science ®Google Scholar
• Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018;15(5):325–340. doi:10.1038/nrclinonc.2018.29
   PubMed Web of Science ®Google Scholar
• Martin-Broto J, Hindi N, Grignani G, et al. Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial. J Immunother Cancer. 2020;8(2):e001561. doi:10.1136/jitc-2020-001561
   PubMed Web of Science ®Google Scholar
• You Y, Guo X, Zhuang R, et al. Activity of PD-1 inhibitor combined with anti-angiogenic therapy in advanced sarcoma: a single-center retrospective analysis. Front Mol Biosci. 2021;8:747650. doi:10.3389/fmolb.2021.747650
   PubMed Web of Science ®Google Scholar
• Liu J, Deng YT, Jiang Y. Switch maintenance therapy with anlotinib after chemotherapy in unresectable or metastatic soft tissue sarcoma: a single-center retrospective study. Invest New Drugs. 2020. doi:10.1007/s10637-020-01015-z
   Web of Science ®Google Scholar
• Wang HY, Chu J-F, Zhang P, et al. Safety and efficacy of chemotherapy combined with anlotinib plus anlotinib maintenance in Chinese patients with advanced/metastatic soft tissue sarcoma. Onco Targets Ther. 2020;13:1561–1568. doi:10.2147/ott.S235349
   PubMed Web of Science ®Google Scholar