Cell Cycle-Related lncRNAs as Innovative Targets to Advance Cancer Management

References

• Wang Z. Regulation of cell cycle progression by growth factor-induced cell signaling. Cells. 2021;10(12):3327. doi:10.3390/cells10123327
   PubMed Web of Science ®Google Scholar
• Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer. Nat Rev Mol Cell Biol. 2022;23(1):74–88. doi:10.1038/s41580-021-00404-3
   PubMed Web of Science ®Google Scholar
• Kitagawa M, Kitagawa K, Kotake Y, Niida H, Ohhata T. Cell cycle regulation by long non-coding RNAs. Cell Mol Life Sci. 2013;70(24):4785–4794. doi:10.1007/s00018-013-1423-0
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhang L, Hei R, et al. CDK inhibitors in cancer therapy, an overview of recent development. Am J Cancer Res. 2021;11(5):1913–1935.
   PubMed Web of Science ®Google Scholar
• Wenzel ES, Singh ATK. Cell-cycle checkpoints and aneuploidy on the path to cancer. In Vivo. 2018;32(1):1–5. doi:10.21873/invivo.11197
   PubMed Web of Science ®Google Scholar
• Ghafouri-Fard S, Shoorei H, Anamag FT, Taheri M. The role of non-coding RNAs in controlling cell cycle related proteins in cancer cells. Front Oncol. 2020;10:608975. doi:10.3389/fonc.2020.608975
   PubMed Web of Science ®Google Scholar
• Mens MMJ, Ghanbari M. Cell cycle regulation of stem cells by MicroRNAs. Stem Cell Rev Rep. 2018;14(3):309–322. doi:10.1007/s12015-018-9808-y
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang W, Zhu W, et al. Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. Int J Mol Sci. 2019;20(22). doi:10.3390/ijms20225573
   Web of Science ®Google Scholar
• Yin X, Lin H, Lin L, Miao L, He J, Zhuo Z. LncRNAs and CircRNAs in cancer. Med Comm. 2022;3(2):e141. doi:10.1002/mco2.141
   Google Scholar
• Heydarnezhad Asl M, Pasban Khelejani F, Bahojb Mahdavi SZ, Emrahi L, Jebelli A, Mokhtarzadeh A. The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence. J Cell Biochem. 2022;123(6):995–1024. doi:10.1002/jcb.30221
   PubMed Web of Science ®Google Scholar
• Chen B, Dragomir MP, Fabris L, et al. The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology. 2020;159(6):2146–2162.e33. doi:10.1053/j.gastro.2020.08.018
   PubMed Web of Science ®Google Scholar
• Gennaro VJ, Stanek TJ, Peck AR, et al. Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. Proc Natl Acad Sci U S A. 2018;115(40):E9298–E9307. doi:10.1073/pnas.1807704115
   PubMed Web of Science ®Google Scholar
• Dumitru AMG, Compton DA. Identifying cyclin A/Cdk1 substrates in mitosis in human cells. Methods Mol Biol. 2022;2415:175–182. doi:10.1007/978-1-0716-1904-9_13
   PubMedGoogle Scholar
• Pan M, Hong K, Chen X, et al. BmCyclin B and BmCyclin B3 are required for cell cycle progression in the silkworm, Bombyx mori. Sci China Life Sci. 2013;56(4):360–365. doi:10.1007/s11427-013-4459-3
   PubMed Web of Science ®Google Scholar
• Fagundes R, Teixeira LK. Cyclin E/CDK2: DNA replication, replication stress and genomic instability. Front Cell Dev Biol. 2021;9:774845. doi:10.3389/fcell.2021.774845
   PubMed Web of Science ®Google Scholar
• Jiang D, Li H, Xiang H, et al. Long Chain non-coding RNA (lncRNA) HOTAIR knockdown increases miR-454-3p to suppress gastric cancer growth by targeting STAT3/Cyclin D1. Med Sci Monit. 2019;25:1537–1548. doi:10.12659/MSM.913087
   PubMed Web of Science ®Google Scholar
• Wen X, Han W, Liu C. Long non-coding RNA TTTY15 silencing inhibits gastric cancer progression by sponging microRNA-98-5p to down-regulate cyclin D2 expression. Bioengineered. 2022;13(3):7380–7391. doi:10.1080/21655979.2022.2047398
   PubMed Web of Science ®Google Scholar
• Lv H, Zhou D, Liu G. PVT1/miR-16/CCND1 axis regulates gastric cancer progression. Open Med. 2023;18(1):20220550. doi:10.1515/med-2022-0550
   Web of Science ®Google Scholar
• Li L, Dong Z, Shi P, et al. Bruceine D inhibits cell proliferation through downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 axis in gastric cancer. Front Pharmacol. 2020;11:584960. doi:10.3389/fphar.2020.584960
   PubMed Web of Science ®Google Scholar
• Ma P, Wang H, Sun J, et al. LINC00152 promotes cell cycle progression in hepatocellular carcinoma via miR-193a/b-3p/CCND1 axis. Cell Cycle. 2018;17(8):974–984. doi:10.1080/15384101.2018.1464834
   PubMed Web of Science ®Google Scholar
• Li J, Xia T, Cao J, et al. RP11-295G20.2 facilitates hepatocellular carcinoma progression via the miR-6884-3p/CCNB1 pathway. Aging. 2020;12(14):14918–14932. doi:10.18632/aging.103552
   PubMedGoogle Scholar
• Lin SL, Lin YH, Chi HC, et al. A novel long non-coding RNA-01488 suppressed metastasis and tumorigenesis by inducing miRNAs that reduce vimentin expression and ubiquitination of cyclin E. Cells. 2020;9(6). doi:10.3390/cells9061504
   Web of Science ®Google Scholar
• Zhou J, Song G, Su M, Zhang H, Yang T, Song Z. Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1. Environ Toxicol. 2023. doi:10.1002/tox.23761
   Web of Science ®Google Scholar
• Wang H, Li H, Yu Y, et al. Long non-coding RNA XIST promotes the progression of esophageal squamous cell carcinoma through sponging miR-129-5p and upregulating CCND1 expression. Cell Cycle. 2021;20(1):39–53. doi:10.1080/15384101.2020.1856497
   PubMed Web of Science ®Google Scholar
• Ma J, Han LN, Song JR, et al. Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation. Cell Oncol. 2020;43(3):377–394. doi:10.1007/s13402-019-00493-5
   PubMed Web of Science ®Google Scholar
• Yan F, Ma Y, Liu L, Li L, Deng J, Sun J. Long noncoding RNA HOXD-AS1 promotes the proliferation, migration, and invasion of colorectal cancer via the miR-526b-3p/CCND1 axis. J Surg Res. 2020;255:525–535. doi:10.1016/j.jss.2020.05.078
   PubMed Web of Science ®Google Scholar
• Huang FK, Zheng CY, Huang LK, Lin CQ, Zhou JF, Wang JX. Long non-coding RNA MCF2L-AS1 promotes the aggressiveness of colorectal cancer by sponging miR-874-3p and thereby up-regulating CCNE1. J Gene Med. 2021;23(1):e3285. doi:10.1002/jgm.3285
   PubMed Web of Science ®Google Scholar
• Bian Y, Wang Y, Xu S, et al. m(6)A modification of long non-coding RNA HNF1A-AS1 facilitates cell cycle progression in colorectal cancer via IGF2BP2-mediated CCND1 mRNA stabilization. Cells. 2022;11(19). doi:10.3390/cells11193008
   Web of Science ®Google Scholar
• Dasgupta P, Kulkarni P, Majid S, et al. LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma. Cell Death Dis. 2020;11(8):660. doi:10.1038/s41419-020-02877-0
   PubMed Web of Science ®Google Scholar
• Long B, Li N, Xu XX, et al. Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1. Biochem Biophys Res Commun. 2018;505(2):561–568. doi:10.1016/j.bbrc.2018.09.160
   PubMed Web of Science ®Google Scholar
• Zhou Z, Wu X, Zhou Y, Yan W. Long non-coding RNA ADAMTS9-AS1 inhibits the progression of prostate cancer by modulating the miR-142-5p/CCND1 axis. J Gene Med. 2021;23(5):e3331. doi:10.1002/jgm.3331
   PubMed Web of Science ®Google Scholar
• Liu Y, Gao S, Du Q, Zhao Q. Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis. Int J Mol Med. 2019;43(1):547–556. doi:10.3892/ijmm.2018.3959
   PubMed Web of Science ®Google Scholar
• Ai B, Kong X, Wang X, et al. LINC01355 suppresses breast cancer growth through FOXO3-mediated transcriptional repression of CCND1. Cell Death Dis. 2019;10(7):502. doi:10.1038/s41419-019-1741-8
   PubMed Web of Science ®Google Scholar
• Zhong H, Yang J, Zhang B, et al. LncRNA GACAT3 predicts poor prognosis and promotes cell proliferation in breast cancer through regulation of miR-497/CCND2. Cancer Biomark. 2018;22(4):787–797. doi:10.3233/CBM-181354
   PubMed Web of Science ®Google Scholar
• Zhang C, Yang T. Long non-coding RNA LINC00473 promotes breast cancer progression via miR-424-5p/CCNE1 pathway. Protein Pept Lett. 2023;30(1):72–84. doi:10.2174/0929866530666221026164454
   PubMed Web of Science ®Google Scholar
• Chang L, Guo R, Yuan Z, Shi H, Zhang D. LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging mir-206 in ovarian cancer. Cell Physiol Biochem. 2018;49(4):1289–1303. doi:10.1159/000493408
   PubMedGoogle Scholar
• Ding C, Wei R, Rodríguez RA, Del Mar Requena Mullor M. LncRNA PCAT-1 plays an oncogenic role in epithelial ovarian cancer by modulating cyclinD1/CDK4 expression. Int J Clin Exp Pathol. 2019;12(6):2148–2156.
   PubMed Web of Science ®Google Scholar
• Bai X, Wang W, Zhao P, et al. LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression. Carcinogenesis. 2020;41(1):111–121. doi:10.1093/carcin/bgz166
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li X, Zhang J, Mao L. E6 hijacks KDM5C/lnc_000231/miR-497-5p/CCNE1 axis to promote cervical cancer progression. J Cell Mol Med. 2020;24(19):11422–11433. doi:10.1111/jcmm.15746
   PubMed Web of Science ®Google Scholar
• Hou A, Zhang Y, Zheng Y, Fan Y, Liu H, Zhou X. LncRNA terminal differentiation-induced ncRNA (TINCR) sponges miR-302 to upregulate cyclin D1 in cervical squamous cell carcinoma (CSCC). Hum Cell. 2019;32(4):515–521. doi:10.1007/s13577-019-00268-y
   PubMed Web of Science ®Google Scholar
• Wu C, Zhu XT, Xia L, et al. High expression of long noncoding RNA PCNA-AS1 promotes non-small-cell lung cancer cell proliferation and oncogenic activity via upregulating CCND1. J Cancer. 2020;11(7):1959–1967. doi:10.7150/jca.39087
   PubMed Web of Science ®Google Scholar
• Sun HB, Han XL, Zhong M, Yu DJ. Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression. Eur Rev Med Pharmacol Sci. 2020;24(11):6131–6138. doi:10.26355/eurrev_202006_21508
   PubMed Web of Science ®Google Scholar
• Shan KZ, Yang SF, Deng YJ, Yue PY, Du ZQ. E2F1-induced long non-coding RNA MCF2L-AS1 modulates Cyclin D1 mRNA stability through ELAVL1 to induce Gefitinib resistance in non-small cell lung cancer. Acta Biochim Pol. 2022;69(4):795–804. doi:10.18388/abp.2020_6118
   PubMed Web of Science ®Google Scholar
• Ding H, Luo Y, Hu K, Liu P, Xiong M. Linc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression. Onco Targets Ther. 2019;12:6733–6743. doi:10.2147/OTT.S207748
   PubMed Web of Science ®Google Scholar
• Xue Y, Diao M, Lyu J, et al. Long noncoding RNAs PTPRG antisense RNA 1 targets cyclin D1 to facilitate cell proliferation in lung adenocarcinoma. Cancer Biother Radiopharm. 2021. doi:10.1089/cbr.2021.0168
   Web of Science ®Google Scholar
• Zhu H, Xu X, Zheng E, et al. LncRNA RP11‑805J14.5 functions as a ceRNA to regulate CCND2 by sponging miR‑34b‑3p and miR‑139‑5p in lung adenocarcinoma. Oncol Rep. 2022;48(3). doi:10.3892/or.2022.8376
   Web of Science ®Google Scholar
• Yang G, He F, Duan H, Shen J, Dong Q. lncRNA FLVCR-AS1 promotes osteosarcoma growth by targeting miR381-3p/CCND1. Onco Targets Ther. 2020;13:163–172. doi:10.2147/OTT.S214813
   PubMedGoogle Scholar
• Guo F, Fu Q, Wang Y, Sui G. Long non-coding RNA NR2F1-AS1 promoted proliferation and migration yet suppressed apoptosis of thyroid cancer cells through regulating miRNA-338-3p/CCND1 axis. J Cell Mol Med. 2019;23(9):5907–5919. doi:10.1111/jcmm.14386
   PubMed Web of Science ®Google Scholar
• Shen XM, Han S, Liu N, Xu HQ, Yan CX, Yu CJ. LINC00887 aggravates the malignant progression of glioma via upregulating CCND1. Eur Rev Med Pharmacol Sci. 2021;25(4):1928–1935. doi:10.26355/eurrev_202102_25091
   PubMed Web of Science ®Google Scholar
• Wu Z. MiR-195 connects lncRNA RUNX1-IT1 and cyclin D1 to regulate the proliferation of glioblastoma cells. Int J Neurosci. 2023;133(1):13–18. doi:10.1080/00207454.2021.1881090
   PubMed Web of Science ®Google Scholar
• Liu Q, Ran R, Song M, et al. LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/beta-catenin/cyclin D1 signaling via PLAGL2. Cell Biol Toxicol. 2021. doi:10.1007/s10565-021-09628-7
   Web of Science ®Google Scholar
• Zhang Y, Tan Y, Wang H, Xu M, Xu L. Long non-coding RNA Plasmacytoma Variant Translocation 1 (PVT1) enhances proliferation, migration, and Epithelial-Mesenchymal Transition (EMT) of pituitary adenoma cells by activating beta-Catenin, c-Myc, and Cyclin D1 expression. Med Sci Monit. 2019;25:7652–7659. doi:10.12659/MSM.917110
   PubMed Web of Science ®Google Scholar
• van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 1993;262(5142):2050–2054. doi:10.1126/science.8266103
   PubMed Web of Science ®Google Scholar
• Asghar U, Witkiewicz AK, Turner NC, Knudsen ES. The history and future of targeting cyclin-dependent kinases in cancer therapy. Nat Rev Drug Discov. 2015;14(2):130–146. doi:10.1038/nrd4504
   PubMed Web of Science ®Google Scholar
• Lin Z, Zhou Z, Guo H, et al. Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4. Cell Death Dis. 2018;9(6):607. doi:10.1038/s41419-018-0643-5
   PubMed Web of Science ®Google Scholar
• Gao H, Yin Y, Qian A, Guo R, Qi J. LncRNA LINC00974 upregulates CDK6 to promote cell cycle progression in gastric carcinoma. Cancer Biother Radiopharm. 2019;34(10):666–670. doi:10.1089/cbr.2019.2904
   PubMed Web of Science ®Google Scholar
• Kang J, Huang X, Dong W, Zhu X, Li M, Cui N. Long non-coding RNA LINC00630 facilitates hepatocellular carcinoma progression through recruiting transcription factor E2F1 to up-regulate cyclin-dependent kinase 2 expression. Hum Exp Toxicol. 2021;40(12_suppl):S257–S268. doi:10.1177/09603271211038744
   PubMed Web of Science ®Google Scholar
• Zhou N, Li S, Wu D, Zhang F, Tang F, Li Y. The lncRNA VPS9D1-AS1 promotes hepatocellular carcinoma cell cycle progression by regulating the HuR/CDK4 axis. DNA Cell Biol. 2021;40(10):1278–1289. doi:10.1089/dna.2021.0235
   PubMed Web of Science ®Google Scholar
• Cheng T, Yao Y, Zhang S, et al. LINC00205, a YY1-modulated lncRNA, serves as a sponge for miR-26a-5p facilitating the proliferation of hepatocellular carcinoma cells by elevating CDK6. Eur Rev Med Pharmacol Sci. 2021;25(20):6208–6219. doi:10.26355/eurrev_202110_26991
   PubMed Web of Science ®Google Scholar
• Lin C, Xiang Y, Sheng J, Liu S, Cui M, Zhang X. Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis. J Physiol Biochem. 2020;76(3):469–481. doi:10.1007/s13105-020-00754-0
   PubMed Web of Science ®Google Scholar
• Ma X, Luo J, Zhang Y, Sun D, Lin Y. LncRNA MCM3AP-AS1 upregulates CDK4 by sponging miR-545 to suppress G1 arrest in colorectal cancer. Cancer Manag Res. 2020;12:8117–8124. doi:10.2147/cmar.S247330
   PubMed Web of Science ®Google Scholar
• Li F, Jiang Z, Shao X, Zou N. Downregulation of lncRNA NR2F2 antisense RNA 1 induces G1 arrest of colorectal cancer cells by downregulating cyclin-dependent kinase 6. Dig Dis Sci. 2020;65(2):464–469. doi:10.1007/s10620-019-05782-5
   PubMed Web of Science ®Google Scholar
• Gong T, Li Y, Feng L, et al. CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6. Aging. 2020;12(12):12086–12106. doi:10.18632/aging.103376
   PubMedGoogle Scholar
• Sun W, Nie W, Wang Z, Zhang H, Li Y, Fang X. Lnc HAGLR promotes colon cancer progression through sponging miR-185-5p and activating CDK4 and CDK6 in vitro and in vivo. Onco Targets Ther. 2020;13:5913–5925. doi:10.2147/OTT.S246092
   PubMed Web of Science ®Google Scholar
• Guo N, Sun Q, Fu D, Zhang Y. Long non-coding RNA UCA1 promoted the growth of adrenocortical cancer cells via modulating the miR-298-CDK6 axis. Gene. 2019;703:26–34. doi:10.1016/j.gene.2019.03.066
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang H, Kang H, Huo W, Zhou Y, Zhang Y. Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis. Int J Mol Med. 2019;43(2):1049–1057. doi:10.3892/ijmm.2018.3995
   PubMed Web of Science ®Google Scholar
• Wang Y, Ding M, Yuan X, et al. lncRNA SNHG15 promotes ovarian cancer progression through regulated CDK6 via sponging miR-370-3p. Biomed Res Int. 2021;2021:9394563. doi:10.1155/2021/9394563
   PubMed Web of Science ®Google Scholar
• Zhai Y, Liu Y, Wang Z, Wang W, Zhou J, Lu J. Long non-coding RNA LINC00313 accelerates cervical carcinoma progression by miR-4677-3p/CDK6 axis. Onco Targets Ther. 2021;14:2213–2226. doi:10.2147/OTT.S265007
   PubMed Web of Science ®Google Scholar
• Jin J, Chen X, Chen J, Geng X. Long noncoding RNA MACC1-AS1 is a potential sponge of microRNA-34a in cervical squamous cell carcinoma and upregulates cyclin-dependent kinase 6. Oncol Lett. 2020;19(3):2339–2345. doi:10.3892/ol.2020.11346
   PubMed Web of Science ®Google Scholar
• Fu X, Wang D, Shu T, Cui D, Fu Q. LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma. Aging Male. 2020;23(5):1073–1079. doi:10.1080/13685538.2019.1670157
   PubMed Web of Science ®Google Scholar
• Xing Z, Zhang Z, Gao Y, et al. The lncRNA LINC01194/miR-486-5p axis facilitates malignancy in non-small cell lung cancer via regulating CDK4. Onco Targets Ther. 2020;13:3151–3163. doi:10.2147/ott.S235037
   PubMed Web of Science ®Google Scholar
• Guo H, Lin S, Gan Z, Xie J, Zhou J, Hu M. lncRNA FOXD3-AS1 promotes the progression of non-small cell lung cancer by regulating the miR-135a-5p/CDK6 axis. Oncol Lett. 2021;22(6):853. doi:10.3892/ol.2021.13114
   PubMed Web of Science ®Google Scholar
• Ma YF, Liang T, Li CR, Li YJ, Jin S, Liu Y. Long non-coding RNA HNF1A-AS1 up-regulation in non-small cell lung cancer correlates to poor survival. Eur Rev Med Pharmacol Sci. 2016;20(23):4858–4863.
   PubMed Web of Science ®Google Scholar
• Liu L, Chen Y, Li Q, Duan P. lncRNA HNF1A-AS1 modulates non-small cell lung cancer progression by targeting miR-149-5p/Cdk6. J Cell Biochem. 2019;120(11):18736–18750. doi:10.1002/jcb.29186
   PubMed Web of Science ®Google Scholar
• Liu Y, Li L, Shang P, Song X. LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis. Anticancer Drugs. 2020;31(10):1065–1073. doi:10.1097/cad.0000000000000970
   PubMed Web of Science ®Google Scholar
• Wu D, Qin BY, Qi XG, Hong LL, Zhong HB, Huang JY. LncRNA AWPPH accelerates the progression of non-small cell lung cancer by sponging miRNA-204 to upregulate CDK6. Eur Rev Med Pharmacol Sci. 2020;24(8):4281–4287. doi:10.26355/eurrev_202004_21008
   PubMed Web of Science ®Google Scholar
• Zhang Y, Ma L, Zhang T, Li P, Xu J, Wang Z. Long noncoding RNA TFAP2A-AS1 exerts promotive effects in non-small cell lung cancer progression via controlling the microRNA-548a-3p/CDK4 axis as a competitive endogenous RNA. Oncol Res. 2021;29(2):129–139. doi:10.32604/or.2022.03563
   PubMed Web of Science ®Google Scholar
• Cheng S, Zheng J, Liu X, et al. Knockdown of 91 H suppresses the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter. Technol Cancer Res Treat. 2021;20:1533033821990006. doi:10.1177/1533033821990006
   Web of Science ®Google Scholar
• Chen Y, Tang G, Qian H, et al. LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization. Aging. 2021;13(10):14258–14276. doi:10.18632/aging.203042
   PubMedGoogle Scholar
• Xu J, Liao M. Long noncoding RNA SNHG6 promotes papillary thyroid cancer cells proliferation via regulating miR-186/CDK6 axis. Gland Surg. 2021;10(10):2935–2944. doi:10.21037/gs-21-586
   PubMed Web of Science ®Google Scholar
• Liu SL, Chen MH, Wang XB, et al. LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis. Aging. 2021;13(4):5475–5484. doi:10.18632/aging.202476
   PubMedGoogle Scholar
• Chen X, Li Y, Zuo C, et al. Long non-coding RNA H19 regulates glioma cell growth and metastasis via miR-200a-Mediated CDK6 and ZEB1 expression. Front Oncol. 2021;11:757650. doi:10.3389/fonc.2021.757650
   PubMed Web of Science ®Google Scholar
• Liu S, Li Y. LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6. Neurol Res. 2022;44(8):677–683. doi:10.1080/01616412.2022.2035620
   PubMed Web of Science ®Google Scholar
• Wang Y, Tan QY, Shen Y, et al. LINC00704 contributes to the proliferation and accelerates the cell cycle of nasopharyngeal carcinoma cells via regulating ETS1/CDK6 axis. Kaohsiung J Med Sci. 2022. doi:10.1002/kjm2.12491
   Web of Science ®Google Scholar
• Hume S, Dianov GL, Ramadan K. A unified model for the G1/S cell cycle transition. Nucleic Acids Res. 2020;48(22):12483–12501. doi:10.1093/nar/gkaa1002
   PubMed Web of Science ®Google Scholar
• Guiducci G, Stojic L. Long noncoding RNAs at the crossroads of cell cycle and genome integrity. Trends Genet. 2021;37(6):528–546. doi:10.1016/j.tig.2021.01.006
   PubMed Web of Science ®Google Scholar
• Kotake Y, Tsuruda T. Long noncoding RNA ANROC on the INK4 locus functions to suppress cell proliferation. Cancer Genomics Proteomics. 2020;17(4):425–430. doi:10.21873/cgp.20201
   PubMed Web of Science ®Google Scholar
• Lou N, Liu G, Pan Y. Long noncoding RNA ANRIL as a novel biomarker in human cancer. Future Oncol. 2020;16(35):2981–2995. doi:10.2217/fon-2020-0470
   PubMed Web of Science ®Google Scholar
• Wan G, Mathur R, Hu X, et al. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cell Signal. 2013;25(5):1086–1095. doi:10.1016/j.cellsig.2013.02.006
   PubMed Web of Science ®Google Scholar
• Zhang K, Ni X, Ma X, Sun R, Qiu J, Luo C. LINC01012 upregulation promotes cervical cancer proliferation and migration via downregulation of CDKN2D. Oncol Lett. 2023;25(3):124. doi:10.3892/ol.2023.13710
   PubMed Web of Science ®Google Scholar
• Bury M, Le Calve B, Ferbeyre G, Blank V, Lessard F. New insights into CDK regulators: novel opportunities for cancer therapy. Trends Cell Biol. 2021;31(5):331–344. doi:10.1016/j.tcb.2021.01.010
   PubMed Web of Science ®Google Scholar
• Kong D, Hou Y, Li W, Ma X, Jiang J. LncRNA-ZXF1 stabilizes P21 expression in endometrioid endometrial carcinoma by inhibiting ubiquitination-mediated degradation and regulating the miR-378a-3p/PCDHA3 axis. Mol Oncol. 2022;16(3):813–829. doi:10.1002/1878-0261.12940
   PubMed Web of Science ®Google Scholar
• Gu J, Dai B, Shi X, et al. lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1. Aging. 2021;13(17):21743–21757. doi:10.18632/aging.203517
   PubMedGoogle Scholar
• Zhang G, Xu Y, Wang S, et al. LncRNA SNHG17 promotes gastric cancer progression by epigenetically silencing of p15 and p57. J Cell Physiol. 2019;234(4):5163–5174. doi:10.1002/jcp.27320
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhang W, Yin D, Tang Z, Zhang E, Wu W. Gene amplification-driven lncRNA SNHG6 promotes tumorigenesis via epigenetically suppressing p27 expression and regulating cell cycle in non-small cell lung cancer. Cell Death Discov. 2022;8(1):485. doi:10.1038/s41420-022-01276-y
   PubMed Web of Science ®Google Scholar
• Han D, Gao X, Wang M, et al. Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3. Oncotarget. 2016;7(16):22159–22173. doi:10.18632/oncotarget.8063
   PubMedGoogle Scholar
• Huang J, Zhou N, Watabe K, et al. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014;5(1):e1008. doi:10.1038/cddis.2013.541
   PubMedGoogle Scholar
• Zhang Y, Tang L. The application of lncRNAs in cancer treatment and diagnosis. Recent Pat Anticancer Drug Discov. 2018;13(3):292–301. doi:10.2174/1574892813666180226121819
   PubMed Web of Science ®Google Scholar
• Nandwani A, Rathore S, Datta M. LncRNAs in cancer: regulatory and therapeutic implications. Cancer Lett. 2021;501:162–171. doi:10.1016/j.canlet.2020.11.048
   PubMed Web of Science ®Google Scholar
• Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21(11):1253–1261. doi:10.1038/nm.3981
   PubMed Web of Science ®Google Scholar
• Jin T. LncRNA DRAIR is a novel prognostic and diagnostic biomarker for gastric cancer. Mamm Genome. 2021;32(6):503–507. doi:10.1007/s00335-021-09911-2
   PubMed Web of Science ®Google Scholar
• Amer RG, El Arab LR E, Abd El Ghany D, Saad AS, Bahie-Eldin N, Swellam M. Prognostic utility of lncRNAs (LINC00565 and LINC00641) as molecular markers in glioblastoma multiforme (GBM). J Neurooncol. 2022;158(3):435–444. doi:10.1007/s11060-022-04030-7
   PubMed Web of Science ®Google Scholar
• Chi J, Liu T, Shi C, et al. Long non-coding RNA LUCAT1 promotes proliferation and invasion in gastric cancer by regulating miR-134-5p/YWHAZ axis. Biomed Pharmacother. 2019;118:109201. doi:10.1016/j.biopha.2019.109201
   PubMed Web of Science ®Google Scholar
• Zhou Q, Hou Z, Zuo S, et al. LUCAT1 promotes colorectal cancer tumorigenesis by targeting the ribosomal protein L40-MDM2-p53 pathway through binding with UBA52. Cancer Sci. 2019;110(4):1194–1207. doi:10.1111/cas.13951
   PubMed Web of Science ®Google Scholar
• Wang W, Dong ML, Zhang W, Liu T. Long noncoding LUCAT1 promotes cisplatin resistance of non-small cell lung cancer by promoting IGF-2. Eur Rev Med Pharmacol Sci. 2019;23(12):5229–5234. doi:10.26355/eurrev_201906_18188
   PubMed Web of Science ®Google Scholar
• Badowski C, He B, Garmire LX. Blood-derived lncRNAs as biomarkers for cancer diagnosis: the good, the bad and the beauty. NPJ Precis Oncol. 2022;6(1):40. doi:10.1038/s41698-022-00283-7
   PubMed Web of Science ®Google Scholar
• Tantai J, Hu D, Yang Y, Geng J. Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer. Int J Clin Exp Pathol. 2015;8(7):7887–7895.
   PubMed Web of Science ®Google Scholar
• Zhang ZZ, Zhao G, Zhuang C, et al. Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes. Sci Rep. 2016;6:27435. doi:10.1038/srep27435
   PubMed Web of Science ®Google Scholar
• Li SP, Xu HX, Yu Y, et al. LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway. Oncotarget. 2016;7(27):42431–42446. doi:10.18632/oncotarget.9883
   PubMed Web of Science ®Google Scholar
• Fu X, Li H, Liu C, Hu B, Li T, Wang Y. Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/β-catenin signaling pathway. Onco Targets Ther. 2016;9:3815–3827. doi:10.2147/ott.S100633
   PubMed Web of Science ®Google Scholar