Fecal Carriage of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Enterobacteriaceae Among Oncology and Non-Oncology Patients at Jimma Medical Center in Ethiopia: A Comparative Cross-Sectional Study

References

• Catho G, Huttner BD. Strategies for the eradication of extended-spectrum beta-lactamase or carbapenemase-producing Enterobacteriaceae intestinal carriage. Expert Rev Anti Infect Ther. 2019;17(8):557–569. doi:10.1080/14787210.2019.1645007
   PubMed Web of Science ®Google Scholar
• Rottier WC, Ammerlaan HS, Bonten MJ. Effects of confounders and intermediates on the association of bacteraemia caused by extended-spectrum β-lactamase-producing Enterobacteriaceae and patient outcome: a meta-analysis. J Antimicrob Chemother. 2012;67(6):1311–1320. doi:10.1093/jac/dks065
   PubMed Web of Science ®Google Scholar
• The global cancer observatory; 2018. Available from: https://gco.iarc.fr/today. Accessed October 14, 2023.
   Google Scholar
• National cancer control plan 2016–2020. Available from: https://www.iccpportal.org/sites/default/files/plans/NCCP%20Ethiopia%20Final%20261015.pdf. Accessed October 14, 2023.
   Google Scholar
• Woodworth KR, Walters MS, Weiner LM, et al. Vital signs: containment of novel multidrug-resistant organisms and resistance mechanisms—United States, 2006–2017. Morbid Mortal Weekly Rep. 2018;67(13):396. doi:10.15585/mmwr.mm6713e1
   PubMed Web of Science ®Google Scholar
• Montes CV, Vilar-Compte D, Velazquez C, Golzarri MF, Cornejo-Juarez P, Larson EL. Risk factors for extended spectrum β-lactamase-producing Escherichia coli versus susceptible E. coli in surgical site infections among cancer patients in Mexico. Surg Infect. 2014;15(5):627–634. doi:10.1089/sur.2013.189
   PubMed Web of Science ®Google Scholar
• Kariuki S, Hart CA. Global aspects of antimicrobial-resistant enteric bacteria. Curr Opin Infect Dis. 2001;14(5):579–586. doi:10.1097/00001432-200110000-00012
   PubMed Web of Science ®Google Scholar
• Falagas M, Karageorgopoulos DE. Extended-spectrum β-lactamase-producing organisms. J Hosp Infect. 2009;73(4):345–354. doi:10.1016/j.jhin.2009.02.021
   PubMed Web of Science ®Google Scholar
• Pitout JD, Laupland KB. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8(3):159–166. doi:10.1016/S1473-3099(08)70041-0
   PubMed Web of Science ®Google Scholar
• Lin L, Jia L, Fu Y, et al. A comparative analysis of infection in patients with malignant cancer: a clinical pharmacist consultation study. J Infect Public Health. 2019;12(6):789–793. doi:10.1016/j.jiph.2019.03.021
   PubMed Web of Science ®Google Scholar
• Jiang A-M, Shi X, Liu N, et al. Nosocomial infections due to multidrug-resistant bacteria in cancer patients: a six-year retrospective study of an oncology Center in Western China. BMC Infect Dis. 2020;20(1):1–12. doi:10.1186/s12879-020-05181-6
   Web of Science ®Google Scholar
• Medboua-Benbalagh C, Touati A, Kermas R, et al. Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae strains is associated with worse outcome in patients hospitalized in the pediatric oncology unit of Beni-Messous hospital in Algiers, Algeria. Microb Drug Resist. 2017;23(6):757–763. doi:10.1089/mdr.2016.0153
   PubMed Web of Science ®Google Scholar
• Safdar A, Armstrong D. Infections in patients with hematologic neoplasms and hematopoietic stem cell transplantation: neutropenia, humoral, and splenic defects. Clin Infect Dis. 2011;53(8):798–806. doi:10.1093/cid/cir492
   PubMed Web of Science ®Google Scholar
• Abdallah H, Alnaiemi N, Reuland E, et al. Fecal carriage of extended-spectrum β-lactamase-and carbapenemase-producing Enterobacteriaceae in Egyptian patients with community-onset gastrointestinal complaints: a hospital-based cross-sectional study. Antimicrob Resist Infect Control. 2017;6(1):1–7. doi:10.1186/s13756-017-0219-7
   Web of Science ®Google Scholar
• Reddy P, Malczynski M, Obias A, et al. Screening for extended-spectrum β-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia. Clin Infect Dis. 2007;45(7):846–852. doi:10.1086/521260
   PubMed Web of Science ®Google Scholar
• Cornejo-Juárez P, Suárez-Cuenca JA, Volkow-Fernández P, et al. Fecal ESBL Escherichia coli carriage as a risk factor for bacteremia in patients with hematological malignancies. Support Care in Cancer. 2016;24(1):253–259. doi:10.1007/s00520-015-2772-z
   PubMed Web of Science ®Google Scholar
• Arnan M, Gudiol C, Calatayud L, et al. Risk factors for, and clinical relevance of, faecal extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) carriage in neutropenic patients with haematological malignancies. Eur j Clin Microbiol Infect Dis. 2011;30(3):355–360. doi:10.1007/s10096-010-1093-x
   PubMed Web of Science ®Google Scholar
• WHO publishes list of bacteria for which new antibiotics are urgently needed. Available from: https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-newantibiotics-are-urgently-needed. Accessed October 14, 2023.
   Google Scholar
• The pediatric cancer unit at Jimma university specialized hospital treated more than 100 children with cancer. Available from: https://semonegna.com/jush-pediatric-cancer-unit-treated-children-cancer/. Accessed October 14, 2023.
   Google Scholar
• Nagata N, Tohya M, Takeuchi F, et al. Effects of storage temperature, storage time, and Cary-Blair transport medium on the stability of the gut microbiota. Drug Discov Ther. 2019;13(5):256–260. doi:10.5582/ddt.2019.01071
   PubMed Web of Science ®Google Scholar
• Disc tests for detection of ESBL-producing Enterobacteriaceae. Available from: https://www.liofilchem.com/images/prodottievidenza/antibiotic-disc/ESBL_DISC_TESTS.pdf. Accessed October 14, 2023.
   Google Scholar
• Jing X, Zhou H, Min X, et al. The simplified carbapenem inactivation method (sCIM) for simple and accurate detection of carbapenemase-producing gram-negative bacilli. Front Microbiol. 2018;9:2391. doi:10.3389/fmicb.2018.02391
   PubMed Web of Science ®Google Scholar
• Hudzicki J. Kirby-Bauer disk diffusion susceptibility test protocol. Am Soc Microbiol. 2009;15:55–63.
   Google Scholar
• M100: performance standards for antimicrobial susceptibility testing. Available from: https://www.nih.org.pk/wpcontent/uploads/2021/02/CLSI-2020.pdf. Accessed October 14, 2023.
   Google Scholar
• Thacker N, Pereira N, Banavali S, et al. Alarming prevalence of community-acquired multidrug-resistant organisms colonization in children with cancer and implications for therapy: a prospective study. Indian J Cancer. 2014;51(4):442. doi:10.4103/0019-509X.175310
   PubMed Web of Science ®Google Scholar
• Kibwana UO, Majigo M, Kamori D, Manyahi J. High fecal carriage of extended Beta Lactamase producing Enterobacteriaceae among adult patients admitted in referral hospitals in Dar es Salaam, Tanzania. BMC Infect Dis. 2020;20(1):1–7. doi:10.1186/s12879-020-05272-4
   Web of Science ®Google Scholar
• Arhoune B, Oumokhtar B, Hmami F, et al. Rectal carriage of extended-spectrum β-lactamase-and carbapenemase-producing Enterobacteriaceae among hospitalised neonates in a neonatal intensive care unit in Fez, Morocco. J Global Antimicrob Resist. 2017;8:90–96. doi:10.1016/j.jgar.2016.11.004
   PubMed Web of Science ®Google Scholar
• Desta K, Woldeamanuel Y, Azazh A, et al. High gastrointestinal colonization rate with extended-spectrum β-lactamase-producing Enterobacteriaceae in hospitalized patients: emergence of carbapenemase-producing K. pneumoniae in Ethiopia. PLoS One. 2016;11(8):e0161685. doi:10.1371/journal.pone.0161685
   PubMed Web of Science ®Google Scholar
• Andriatahina T, Randrianirina F, Hariniana ER, et al. High prevalence of fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar. BMC Infect Dis. 2010;10(1):1–8. doi:10.1186/1471-2334-10-204
   PubMed Web of Science ®Google Scholar
• Ouchar Mahamat O, Tidjani A, Lounnas M, et al. Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in hospital and community settings in Chad. Antimicrob Resist Infect Control. 2019;8(1):1–7. doi:10.1186/s13756-019-0626-z
   PubMed Web of Science ®Google Scholar
• Chaudhary U, Agarwal S, Raghuraman K. Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre. Avicenna J Med. 2018;8(02):46–50. doi:10.4103/ajm.AJM_156_17
   PubMedGoogle Scholar
• Hazirolan G, Mumcuoglu I, Altan G, Özmen B, Aksu N, Karahan Z. Fecal carriage of extended‑spectrum beta‑lactamase and AmpC Beta‑lactamase‑producing Enterobacteriaceae in a Turkish Community. Niger J Clin Pract. 2018;21(1):81–86. doi:10.4103/njcp.njcp_79_17
   PubMed Web of Science ®Google Scholar
• Aklilu A, Manilal A, Ameya G, Woldemariam M, Siraj M. Gastrointestinal tract colonization rate of extended-spectrum beta-lactamase-and carbapenemase-producing Enterobacteriaceae and associated factors among hospitalized patients in Arba Minch general hospital, Arba Minch, Ethiopia. Infect Drug Resist. 2020;13:1517–1526. doi:10.2147/IDR.S239092
   PubMed Web of Science ®Google Scholar
• Babu R, Kumar A, Karim S, et al. Faecal carriage rate of extended-spectrum β-lactamase-producing Enterobacteriaceae in hospitalised patients and healthy asymptomatic individuals coming for health check-up. J Global Antimicrob Resist. 2016;6:150–153. doi:10.1016/j.jgar.2016.05.007
   PubMed Web of Science ®Google Scholar
• Ruh E, Zakka J, Hoti K, et al. Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae: fecal carriage rates and associated risk factors in the community of Northern Cyprus. Antimicrob Resist Infect Control. 2019;8(1):1–10. doi:10.1186/s13756-019-0548-9
   PubMed Web of Science ®Google Scholar
• Pérez CD-A, López-Fresneña N, Carlavilla ALR, et al. Local prevalence of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae intestinal carriers at admission and co-expression of ESBL and OXA-48 carbapenemase in Klebsiella pneumoniae: a prevalence survey in a Spanish University Hospital. BMJ open. 2019;9(3):e024879. doi:10.1136/bmjopen-2018-024879
   PubMed Web of Science ®Google Scholar
• Askari P, Hakimi F, Moghanni M, Sebzari AR, Namaei MH. Evaluation of fecal colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae and risk factors among cancer patients in Eastern Iran. Infect Epidemiol Microbiol. 2021;7(4):2. doi:10.52547/iem.7.4.277
   Google Scholar
• Dolejska M, Brhelova E, Dobiasova H, et al. Dissemination of IncFIIK-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from children in hospital paediatric oncology wards. Int J Antimicrob Agents. 2012;40(6):510–515. doi:10.1016/j.ijantimicag.2012.07.016
   PubMed Web of Science ®Google Scholar
• Woerther P-L, Angebault C, Jacquier H, et al. Massive increase, spread, and exchange of extended spectrum β-lactamase–encoding genes among intestinal Enterobacteriaceae in hospitalized children with severe acute malnutrition in Niger. Clin Infect Dis. 2011;53(7):677–685. doi:10.1093/cid/cir522
   PubMed Web of Science ®Google Scholar
• Hijazi S, Fawzi M, Ali F, Abd el galil K. Prevalence and characterization of extended-spectrum beta-lactamases producing Enterobacteriaceae in healthy children and associated risk factors. Ann Clin Microbiol Antimicrob. 2016;15(1):1–9. doi:10.1186/s12941-016-0121-9
   PubMed Web of Science ®Google Scholar
• Calatayud L, Arnan M, Liñares J, et al. Prospective study of fecal colonization by extended-spectrum-β-lactamase-producing Escherichia coli in neutropenic patients with cancer. Antimicrob Agents Chemother. 2008;52(11):4187–4190. doi:10.1128/AAC.00367-08
   PubMed Web of Science ®Google Scholar
• Golzarri MF, Silva-Sánchez J, Cornejo-Juárez P, et al. Colonization by fecal extended-spectrum β-lactamase-producing Enterobacteriaceae and surgical site infections in patients with cancer undergoing gastrointestinal and gynecologic surgery. Am J Infect Control. 2019;47(8):916–921. doi:10.1016/j.ajic.2019.01.020
   PubMed Web of Science ®Google Scholar
• Christophy R, Osman M, Mallat H, et al. Prevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon. J Infect Public Health. 2017;10(6):716–720. doi:10.1016/j.jiph.2016.10.009
   PubMed Web of Science ®Google Scholar
• Zachariah M, Al-Yazidi L, Bashir W, Al Rawas A, Wali Y, Pathare A. Spectrum of external catheter-related infections in children with acute leukemia—Single-center experience. J Infect Public Health. 2014;7(1):38–43. doi:10.1016/j.jiph.2013.06.005
   PubMed Web of Science ®Google Scholar
• Abbasi Montazeri E, Khosravi AD, Saki M, Sirous M, Keikhaei B, Seyed-Mohammadi S. Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae causing bloodstream infections in cancer patients from southwest of Iran. Infect Drug Resist. 2020;Volume 13:1319–1326. doi:10.2147/IDR.S254357
   Web of Science ®Google Scholar
• Wilmore SS, Kranzer K, Williams A, et al. Carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in HIV-infected children in Zimbabwe. J Med Microbiol. 2017;66(5):609. doi:10.1099/jmm.0.000474
   PubMed Web of Science ®Google Scholar
• Ouédraogo A-S, Sanou S, Kissou A, et al. Fecal carriage of Enterobacteriaceae producing extended-spectrum beta-lactamases in hospitalized patients and healthy community volunteers in Burkina Faso. Microb Drug Resist. 2017;23(1):63–70. doi:10.1089/mdr.2015.0356
   PubMed Web of Science ®Google Scholar
• Day KM, Ali S, Mirza IA, et al. Prevalence and molecular characterization of Enterobacteriaceae producing NDM-1 carbapenemase at a military hospital in Pakistan and evaluation of two chromogenic media. Diagn Microbiol Infect Dis. 2013;75(2):187–191. doi:10.1016/j.diagmicrobio.2012.11.006
   PubMed Web of Science ®Google Scholar
• Li B, Xu X-H, Zhao Z-C, Wang M-H, Cao Y-P. High prevalence of metallo-β-lactamase among carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China. Can J Microbiol. 2014;60(10):691–695. doi:10.1139/cjm-2014-0291
   PubMed Web of Science ®Google Scholar
• Liu B, Trout REL, Chu G-H, et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine-and Metallo-Β-Lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. ACS Publications; 2019.
   Google Scholar