References
- VenterJCAdamsMDMyersEWThe sequence of the human genomeScience200129155071304135111181995
- LanderESLintonLMBirrenBInitial sequencing and analyses of the human genomeNature2001409682286092111237011
- DrukerBJTalpazMRestaDJEfficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaN Engl J Med2001344141031103711287972
- LossosISCzerwinskiDKAlizadehAAPrediction of survival in diffuse large-B-cell lymphoma based on the expression of six genesN Engl J Med2004350181828183715115829
- LevySSuttonGNgPCThe diploid genome sequence of an individual humanPLoS Biol2007510e25417803354
- WangJWangWLiRThe diploid genome sequence of an Asian individualNature20084567218606518987735
- International HapMap ConsortiumA haplotype map of the human genomeNature200543770631299132016255080
- ENCODE Project ConsortiumIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectNature2007447714679981617571346
- López-MauryLMargueratSBählerJTuning gene expression to changing environments: from rapid responses to evolutionary adaptationNat Rev Genet2008858359318591982
- CallinanPAFeinbergAPThe emerging science of epigenomicsHum Mol Genet200615Spec No 1R95R10116651376
- EstellerMEpigenetics in cancerN Engl J Med2008358111148115918337604
- WilsonVLJonesPAMomparlerRLInhibition of DNA methylation in L1210 leukemic cells by 5-aza-2′-deoxycytidine as a possible mechanism of chemotherapeutic actionCancer Res1983438349334966190553
- JonesPAAltering gene expression with 5-azacytidineCell19854034854862578884
- JonesPATaylorSMCellular differentiation, cytidine analogs and DNA methylationCell198020185936156004
- PintoAZagonelV5-Aza-2′-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trendsLeukemia19937Suppl 151607683358
- KaronMSiegerLLeimbrockS5-Azacytidine: a new active agent for the treatment of acute leukemiaBlood19734233593654125239
- SlamonDJGodolphinWJonesLAStudies of the HER-2/neu proto-oncogene in human breast and ovarian cancerScience198924449057077122470152
- PaikSKimCWolmarkNHER2 status and benefit from adjuvant trastuzumab in breast cancerN Engl J Med2008358131409141118367751
- LeyTJMardisERDingLDNA sequencing of a cytogenetically normal acute myeloid leukaemia genomeNature20084567218667218987736
- StephensPJMcBrideDJLinMLComplex landscapes of somatic rearrangement in human breast cancer genomesNature200946272761005101020033038
- LeeWJiangZLiuJThe mutation spectrum revealed by paired genome sequences from a lung cancer patientNature2010465729747347720505728
- PleasanceEDStephensPJO’MearaSA small-cell lung cancer genome with complex signatures of tobacco exposureNature2010463727818419020016488
- PleasanceEDCheethamRKStephensPJA comprehensive catalogue of somatic mutations from a human cancer genomeNature2010463727819119620016485
- BeroukhimRMermelCHPorterDThe landscape of somatic copy-number alteration across human cancersNature2010463728389990520164920
- DalglieshGLFurgeKGreenmanCSystematic sequencing of renal carcinoma reveals inactivation of histone modifying genesNature2010463727936036320054297
- ButlerDHuman genome at ten: science after the sequenceNature201046573011000100120577184
- KayeJThe regulation of direct-to-consumer genetic testsHum Mol Genet200817R2R180R18318852208
- EstellerMEpigenetic gene silencing in cancer: the DNA hypermethylomeHum Mol Genet200716Spec No 1R50R5917613547
- FeinbergAPVogelsteinBHypomethylation distinguishes genes of some human cancers from their normal counterpartsNature1983301589589926185846
- CostaFFPaixãoVACavalherFPSATR-1 hypomethylation is a common and early event in breast cancerCancer Genet Cytogenet2006165213514316527607
- JonesPABaylinSBThe fundamental role of epigenetic events in cancerNat Rev Genet20023641542812042769
- EstellerMCancer epigenomics: DNA methylomes and histone-modification mapsNat Rev Genet20078428629817339880
- TurkerMSGene silencing in mammalian cells and the spread of DNA methylationOncogene200221355388539312154401
- JonesPABaylinSBThe epigenomics of cancerCell2007128468369217320506
- BestorTHThe DNA methyltransferases of mammalsHum Mol Genet20009162395240211005794
- RobertsonKDDNA methylation, methyltransferases, and cancerOncogene200120243139315511420731
- EadsCADanenbergKDKawakamiKCpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpressionCancer Res199959102302230610344733
- FenauxPMuftiGJHellstrom-LindbergEEfficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III studyLancet Oncol200910322323219230772
- BernsteinBEMikkelsenTSXieXA bivalent chromatin structure marks key developmental genes in embryonic stem cellsCell2006125231532616630819
- KustatscherGLadurnerAGModular paths to ‘decoding’ and ‘wiping’ histone lysine methylationCurr Opin Chem Biol200711662863517988933
- StrahlBDAllisCDThe language of covalent histone modificationsNature20004036765414510638745
- SekeresMAListAFCuthbertsonDPhase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromesJ Clin Oncol201028132253225820354132
- LaraEMaiACalvaneseVSalermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effectOncogene200928678179119060927
- BrownCGThe DNA sequencing renaissance and its implications for epigenomicsEpigenomics20091158
- WangRYGehrkeCWEhrlichMComparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residuesNucleic Acids Res1980820477747907443525
- KanedaATakaiDKaminishiMMethylation-sensitive representational difference analysis and its application to cancer researchAnn N Y Acad Sci200398313114112724218
- RheeMBurnsMANanopore sequencing technology: research trends and applicationsTrends Biotechnol2006241258058617055093
- FlusbergBAWebsterDRLeeJHDirect detection of DNA methylation during single-molecule, real-time sequencingNat Methods20107646146520453866
- EhrlichMCancer-linked DNA hypomethylation and its relationship to hypermethylationCurr Top Microbiol Immunol200631025127416909914
- EstellerMRelevance of DNA methylation in the management of cancerLancet Oncol20034635135812788407
- WoodsonKO’ReillyKJHansonJCThe usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancerJ Urol2008179250851118076912
- YuJChengYYTaoQCheungKFMethylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancerGastroenterology2009136264065119084528
- KimDSKimMJLeeJYAberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic featuresCancer2007110122785279217960794
- CostaFFVerbisckNVSalimACEpigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumorsOncogene20042371481148814661055
- VerbisckNVCostaETCostaFFADAM23 negatively modulates αvβ3 integrin activation during metastasisCancer Res2009695546555219549921
- EstellerMGarcia-FoncillasJAndionEInactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agentsN Engl J Med2000343191350135411070098
- HegiMEDiserensACGorliaTMGMT gene silencing and benefit from temozolomide in glioblastomaN Engl J Med200535210997100315758010
- SeligsonDBHorvathSShiTGlobal histone modification patterns predict risk of prostate cancer recurrenceNature200543570461262126615988529
- WurdingerTCostaFFMolecular therapy in the microRNA eraPharmacogenomics J20077529730417189960
- LujambioACalinGAVillanuevaAA microRNA DNA methylation signature for human cancer metastasisProc Natl Acad Sci U S A200810536135561356118768788
- CostaFFSeftorEABischofJMEpigenetically reprogramming metastatic tumor cells with an embryonic microenvironmentEpigenomics20091238739820495621
- BartelDMicroRNAs: target recognition and regulatory functionsCell2009136221523319167326
- AmbrosVThe functions of animal microRNAsNature2004431700635035515372042
- PassettiFFerreiraCGCostaFFThe impact of microRNAs and alternative splicing in pharmacogenomicsPharmacogenomics J20099111319156160
- Richter-LarreaJARoblesEFFresquetVReversion of epigenetically-mediated BIM silencing overcomes chemoresistance in Burkitt lymphomaBlood2010 [Epub ahead of print].
- IssaJPDNA methylation as a therapeutic target in cancerClin Cancer Res20071361634163717363514
- HammCAXieHCostaFFGlobal demethylation of rat chondrosarcoma cells after treatment with 5-aza-2-deoxycytidine results in increased tumorigenicityPLoS One2009412e834020019818
- LiangGGonzalesFAJonesPAAnalysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidineCancer Res200262496196611861364
- de SmetCde BackerOFaraoniIThe activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylationProc Natl Acad Sci U S A19969314714971538692960
- SaitoYJonesPAEpigenetic activation of tumor suppressor microRNAs in human cancer cellsCell Cycle20065192220222217012846
- GimsingPHansenMKnudsenLMA phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasiaEur J Haematol200881317017618510700
- TanJCangSMaYNovel histone deacetylase inhibitors in clinical trials as anti-cancer agentsJ Hematol Oncol2010435
- PlimackERKantarjianHMIssaJPDecitabine and its role in the treatment of hematopoietic malignanciesLeuk Lymphoma20074881472148117701577
- AppletonKMackayHJJudsonIPhase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumorsJ Clin Oncol200725294603460917925555
- FiskusWWangYSreekumarACombined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cellsBlood2009114132733274319638619
- KakihanaMOhiraTChanDInduction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibitionJ Thorac Oncol20094121455146520009910
- GuptaMAnsellSMNovakAJInhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2Blood2009114142926293519641186
- ChenSYeJKijimaIEvansDThe HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expressionProc Natl Acad Sci U S A201010724110321103720534486
- KauhJFanSXiaMc-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589PLoS One201054e1037620442774
- BruecknerBGarcia BoyRSiedleckiPEpigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferasesCancer Res200565146305631116024632
- BruecknerBRiusMMarkelovaMRDelivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacyMol Cancer Ther2010951256126420442313
- ChuangJCWarnerSLVollmerDS110, a 5-aza-2′-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growthMol Cancer Ther2010951443145020442312
- GrantCRahmanFPiekarzRRomidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumorsExpert Rev Anticancer Ther2010107997100820645688
- Duenas-GonzalezACandelariaMPerez-PlascenciaCValproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumorsCancer Treat Rev200834320622218226465
- SiegelDHusseinMBelaniCVorinostat in solid and hematologic malignanciesJ Hematol Oncol200923119635146
- HrzenjakAKremserMLStrohmeierBSAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathwayJ Pathol2008216449550418850582
- AlcaínFJVillalbaJMSirtuin inhibitorsExpert Opin Ther Pat200919328329419441904
- HermanJGGraffJRMyöhänenSMethylation-specific PCR: a novel PCR assay for methylation status of CpG islandsProc Natl Acad Sci U S A19969318982198268790415
- FragaMFEstellerMDNA methylation: a profile of methods and applicationsBiotechniques200233363264912238773
- WuJSmithLTPlassCHuangTHChIP-chip comes of age for genome-wide functional analysisCancer Res200666146899690216849531
- ParkPJChIP-seq: advantages and challenges of a maturing technologyNat Rev Genet2009101066968019736561
- WangYHayakawaJLongF‘Promoter array’ studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cellsAnn N Y Acad Sci2005105816218516394135
- van SteenselBHenikoffSEpigenomic profiling using microarraysBiotechniques200335234635035235435635712951776
- MardisERThe impact of next generation sequencing technology on geneticsTrends Genet2008313314118262675
- KircherMKelsoJHigh-throughput DNA sequencing – concepts and limitationsBioessays201032652453620486139
- BrantonDDeamerDWMarzialiAThe potential and challenges of nanopore sequencingNat Biotechnol200826101146115318846088
- EidJFehrAGrayJReal-time DNA sequencing from single polymerase moleculesScience2009323591013313819023044
- DrmanacRSparksABCallowMJHuman genome sequencing using unchained base reads on self-assembling DNA nanoarraysScience20103275961788119892942
- RyanDRahimiMLundJToward nanoscale genome sequencingTrends Biotechnol200725938538917658190
- WettergrenYOdinENilssonSp16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancerMol Med2008147–841242118418463
- LeungRCLiuSSChanKYPromoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancerOncol Rep20081951339134518425396
- LiuMTaketaniTLiRLoss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylationLeuk Res200125644144711337015
- GazinCWajapeyeeNGobeilSAn elaborate pathway required for Ras-mediated epigenetic silencingNature200744971651073107717960246
- SeniskiGGCamargoAAIerardiDFADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinomaBMC Cancer200998019267929
- HermanJGUmarAPolyakKIncidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaProc Natl Acad Sci U S A19989512687068759618505
- ZhangHLiYLaiMThe microRNA network and tumor metastasisOncogene201029793794819935707