The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes

References

• Global Initiative for Chronic Obstructive Lung DGPocket Guide to COPD Diagnosis, Management and Prevention Available from: http://www.goldcopd.it/materiale/2015/GOLD_Pocket_2015.pdfAccessed July 25, 2016
   Google Scholar
• NewmanSPInhaler treatment options in COPDEur Respir Rev200514102108
   Google Scholar
• NewmanSPPaviaDGarlandNClarkeSWEffects of various inhalation modes on the deposition of radioactive pressurized aerosolsEur J Respir Dis Suppl198211957656807705
   PubMedGoogle Scholar
• LaubeBLJanssensHMde JonghFHWhat the pulmonary specialist should know about the new inhalation therapiesEur Respir J20113761308133121310878
   PubMed Web of Science ®Google Scholar
• ChrystynHIs inhalation rate important for a dry powder inhaler? Using the In-Check Dial to identify these ratesRespir Med200397218118712587970
   PubMed Web of Science ®Google Scholar
• HolmesMSSeheultJNO’ConnellPAn acoustic-based method to detect and quantify the effect of exhalation into a dry powder inhalerJ Aerosol Med Pulm Drug Deliv201528424725325393346
   PubMed Web of Science ®Google Scholar
• Al-ShowairRATarsinWYAssiKHPearsonSBChrystynHCan all patients with COPD use the correct inhalation flow with all inhalers and does training help?Respir Med2007101112395240117629471
   PubMed Web of Science ®Google Scholar
• AroraPKumarLVohraVEvaluating the technique of using inhalation device in COPD and bronchial asthma patientsRespir Med2014108799299824873874
   PubMed Web of Science ®Google Scholar
• BroedersMEMolemaJHopWCFolgeringHTInhalation profiles in asthmatics and COPD patients: reproducibility and effect of instructionJ Aerosol Med200316213114112823907
   PubMedGoogle Scholar
• LavoriniFLevyMLCorriganCCromptonGADMIT Working GroupThe ADMIT series – issues in inhalation therapy. 6) Training tools for inhalation devicesPrim Care Respir J201019433534121049263
   PubMedGoogle Scholar
• MelaniASBracciLSRossiMReduced peak inspiratory effort through the diskus((R)) and the turbuhaler((R)) due to mishandling is common in clinical practiceClin Drug Investig2005258543549
   PubMed Web of Science ®Google Scholar
• PriceDBosnic-AnticevichSBriggsAInhaler Error Steering CommitteeInhaler competence in asthma: common errors, barriers to use and recommended solutionsRespir Med20131071374623098685
   PubMed Web of Science ®Google Scholar
• van der PalenJKleinJJvan HerwaardenCLZielhuisGASeydelERMultiple inhalers confuse asthma patientsEur Respir J19991451034103710596686
   PubMed Web of Science ®Google Scholar
• YuAPGuerinAde LeonDPClinical and economic outcomes of multiple versus single long-acting inhalers in COPDRespir Med2011105121861187121807487
   PubMed Web of Science ®Google Scholar
• ChrischillesEGildenDKubisiakJRubensteinLShahHDelivery of ipratropium and albuterol combination therapy for chronic obstructive pulmonary disease: effectiveness of a two-in-one inhaler versus separate inhalersAm J Manag Care200281090291112395958
   PubMed Web of Science ®Google Scholar
• KetelaarsCASchlosserMAMostertRHuyer Abu-SaadHHalfensRJWoutersEFDeterminants of health-related quality of life in patients with chronic obstructive pulmonary diseaseThorax199651139438658367
   PubMed Web of Science ®Google Scholar
• StahlELindbergAJanssonSAHealth-related quality of life is related to COPD disease severityHealth Qual Life Outcomes200535616153294
   PubMedGoogle Scholar
• Optimum Patient Care Research Database (OPCRD) Available from: http://optimumpatientcare.org/our-database/Accessed July 25, 2016
   Google Scholar
• RocheNReddelHMartinRQuality standards for real-world research. Focus on observational database studies of comparative effectivenessAnn Am Thorac Soc201411Suppl 2S99S10424559028
   PubMedGoogle Scholar
• European Network of Centres for Pharmacoepidemiology and Pharmacovigilance Available from: http://www.encepp.eu/Accessed July 25, 2016
   Google Scholar
• GOLDGold Initiative for Chronic Obstructive Lung Disease Available from: http://www.goldcopd.org/Accessed July 25, 2016
   Google Scholar
• PriceDChrystynHKaplanAEffectiveness of same versus mixed asthma inhaler devices: a retrospective observational study in primary careAllergy Asthma Immunol Res20124418419122754711
   PubMed Web of Science ®Google Scholar
• MelaniASBonaviaMCilentiVInhaler mishandling remains common in real life and is associated with reduced disease controlRespir Med2011105693093821367593
   PubMed Web of Science ®Google Scholar
• WieshammerSDreyhauptJDry powder inhalers: which factors determine the frequency of handling errors?Respiration2008751182517911976
   PubMed Web of Science ®Google Scholar
• YuAPGuerinAPonce de LeonDTherapy persistence and adherence in patients with chronic obstructive pulmonary disease: multiple versus single long-acting maintenance inhalersJ Med Econ201114448649621679019
   PubMedGoogle Scholar
• PunekarYSLandisSHWurstKLeHCharacteristics, disease burden and costs of COPD patients in the two years following initiation of long-acting bronchodilators in UK primary careRespir Res20151614126572740
   PubMed Web of Science ®Google Scholar
• PriceDBatemanEDChisholmAComplementing the randomized controlled trial evidence base. Evolution not revolutionAnn Am Thorac Soc201411Suppl 2S92S9824559027
   PubMedGoogle Scholar
• RoyABattleKLurslurchachaiLHalmEAWisniveskyJPInhaler device, administration technique, and adherence to inhaled corticosteroids in patients with asthmaPrim Care Respir J201120214815421437565
   PubMedGoogle Scholar
• BroedersMEVinckenWCorbettaLADMIT Working GroupThe ADMIT series – issues in inhalation therapy. 7. Ways to improve pharmacological management of COPD: the importance of inhaler choice and inhalation techniquePrim Care Respir J201120333834321808941
   PubMedGoogle Scholar
• CaliskanerAZOzturkCCeylanEThe knowledge and considerations of the physicians regarding the inhaler devices in asthma and COPD: the INTEDA-1 studyTuberk Toraks201361318319224298959
   PubMedGoogle Scholar