92
Views
20
CrossRef citations to date
0
Altmetric
Original Research

Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease

, , &
Pages 541-550 | Published online: 08 Feb 2017

References

  • ConnorsAFJDawsonNVThomasCOutcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)Am J Respir Crit Care Med19961544 Pt 19599678887592
  • McDonaldVMGibsonPGExacerbations of severe asthmaClin Exp Allergy201242567067722515389
  • BaiTRVonkJMPostmaDSBoezenHMSevere exacerbations predict excess lung function decline in asthmaEur Resp J2007303452456
  • DonaldsonGCSeemungalTABhowmikAWedzichaJARelationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary diseaseThorax2002571084785212324669
  • KupczykMten BrinkeASterkPJFrequent exacerbators-a distinct phenotype of severe asthmaClin Exp Allergy201444221222124447083
  • SpencerSCalverleyPMBurgePSJonesPWImpact of preventing exacerbations on deterioration of health status in COPDEur Respir J200423569870215176682
  • DoughertyRHFahyJVAcute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotypeClin Exp Allergy200939219320219187331
  • HurstJRVestboJAnzuetoASusceptibility to exacerbation in chronic obstructive pulmonary diseaseN Engl J Med2010363121128113820843247
  • ten BrinkeASterkPJMascleeAARisk factors of frequent exacerbations in difficult-to-treat asthmaEur Respir J200526581281816264041
  • MiravitllesMCalleMSoler-CatalunaJJClinical phenotypes of COPD: identification, definition and implications for guidelinesArch Bronconeumol2012483869822196477
  • SimpsonJLGrissellTVDouwesJScottRJBoyleMJGibsonPGInnate immune activation in neutrophilic asthma and bronchiectasisThorax200762321121816844729
  • WoodLGBainesKJFuJScottHAGibsonPGThe neutrophilic inflammatory phenotype is associated with systemic inflammation in asthmaChest20121421869322345378
  • DonaldsonGCSeemungalTAPatelISAirway and systemic inflammation and decline in lung function in patients with COPDChest200512841995200416236847
  • DahlMVestboJLangePBojesenSETybjaerg-HansenANordestgaardBGC-reactive protein as a predictor of prognosis in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2007175325025517053205
  • AgustiAEdwardsLDRennardSIPersistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotypePLoS One201275e3748322624038
  • ThomsenMIngebrigtsenTSMarottJLInflammatory biomarkers and exacerbations in chronic obstructive pulmonary diseaseJAMA2013309222353236123757083
  • FuJ-JMcDonaldVMBainesKJGibsonPGAirway il-1β and systemic inflammation as predictors of future exacerbation risk in asthma and COPDChest2015148361862925950204
  • SlackJMcMahanCJWaughSIndependent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptorsJ Biol Chem19932684251325248428929
  • BainesKJSimpsonJLWoodLGScottRJGibsonPGTranscriptional phenotypes of asthma defined by gene expression profiling of induced sputum samplesJ Allergy Clin Immunol20111271153160e1e921211650
  • PauwelsNSBrackeKRDupontLLRole of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPDEur Respir J20113851019102821622588
  • BafadhelMMcKennaSTerrySAcute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkersAm J Respir Crit Care Med2011184666267121680942
  • FuJJBainesKJWoodLGGibsonPGSystemic inflammation is associated with differential gene expression and airway neutrophilia in asthmaOMICS201317418719923438328
  • BainesKJSimpsonJLWoodLGSputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypesJ Allergy Clin Immunol20141334997100724582314
  • SimpsonJLPhippsSBainesKJOreoKMGunawardhanaLGibsonPGElevated expression of the NLRP3 inflammasome in neutrophilic asthmaEur Respir J20144341067107624136334
  • Global Initiative for Asthma (GINA)Global strategy for asthma management and prevention. [Updated 2012] Available from: http://www.ginasthma.com
  • Global Initiative for Chronic Obstructive Lung Disease (GOLD)Global strategy for the diagnosis, management and prevention of COPD. [Updated 2011] Available from: www.goldcopd.comAccessed on June 31st, 2016
  • GibsonPGWlodarczykJWHensleyMJEpidemiological association of airway inflammation with asthma symptoms and airway hyperresponsiveness in childhoodAm J Respir Crit Care Med199815813641Accessed on June 31st, 20169655704
  • ReddelHKTaylorDRBatemanEDAn official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practiceAm J Respir Crit Care Med20091801599919535666
  • BrusselleGGVandersticheleCJordensPAzithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trialThorax201368432232923291349
  • CoteCGDordellyLJCelliBRImpact of COPD exacerbations on patient-centered outcomesChest2007131369670417356082
  • WeberAWasiliewPKrachtMInterleukin-1 (IL-1) pathwaySci Signal20103105cm120086235
  • KobayashiKHernandezLDGalanJEJanewayCAJrMedzhitovRFlavellRAIRAK-M is a negative regulator of Toll-like receptor signalingCell2002110219120212150927
  • ZhouHYuMFukudaKIRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine productionEMBO J201332458359623376919
  • van’t VeerCvan den PangaartPSvan ZoelenMADInduction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia modelJ Immunol2007179107110712017982103
  • DengJCChengGNewsteadMWSepsis-induced suppression of lung innate immunity is mediated by IRAK-MJ Clin Invest200611692532254216917541
  • WuQvan DykLFJiangDInterleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathwayVirology20134461–219920624074582
  • ZacharioudakiVAndroulidakiAArranzAVrentzosGMargiorisANTsatsanisCAdiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expressionJ Immunol2009182106444645119414798
  • BalaciLSpadaMCOllaNIRAK-M is involved in the pathogenesis of early-onset persistent asthmaAm J Hum Genet20078061103111417503328
  • MedvedevAEMurphyMZhouHLiXE3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responsesImmunol Rev2015266110912226085210
  • BainesKJUphamJWYerkovichSTMediators of neutrophil function in children with protracted bacterial bronchitisChest201414641013102024874501
  • BainesKHsuAToozeMGunawardhanaLPGibsonPGWarkPANovel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPDRespir Res2013141523384071
  • BennettJAPrinceLRParkerLCPellino-1 Selectively Regulates Epithelial Cell Responses to RhinovirusJ Virol201286126595660422514342
  • BathoornEKerstjensHPostmaDTimensWMacNeeWAirways inflammation and treatment during acute exacerbations of COPDInt J Chron Obstruct Pulmon Dis200832321722918686731
  • DinarelloCASimonAvan der MeerJWTreating inflammation by blocking interleukin-1 in a broad spectrum of diseasesNat Rev Drug Discov201211863365222850787