113
Views
21
CrossRef citations to date
0
Altmetric
Original Research

A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD

, &
Pages 2747-2752 | Published online: 18 Sep 2017

References

  • BarnesPJShapiroSDPauwelsRAChronic obstructive pulmonary disease: molecular and cellular mechanismsEur Respir J20032267267814582923
  • ShapiroSDProteinases in chronic obstructive pulmonary diseaseBiochem Soc Trans2002309810212023833
  • KunaPJenkinsMO’BrienCDFahyWAAZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPDRespir Med201210653153922197578
  • LucasSDCostaEGuedesRCMoreiraRTargeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastaseMed Res Rev201333Suppl 1E73E10121681767
  • GroutasWCDouDAllistonKRNeutrophil elastase inhibitorsExpert OpinTher Pat201121339354
  • CantorJOShteyngartBCerretaJMThe effect of hyaluronan on elastic fiber injury in vitro and elastase-induced airspace enlargement in vivoProc Soc Exp Biol Med2000225657110998200
  • CantorJOCerretaJMArmandGTurinoGMAerosolized hyaluronic acid decreases alveolar injury induced by human neutrophil elastaseProc Soc Exp Biol Med19982174714759521096
  • CantorJOCerretaJMArmandGTurinoGMFurther investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysemaExp Lung Res1997232292449184790
  • CantorJOCerretaJMKellerSTurinoGMModulation of airspace enlargement in elastase-induced emphysema by intratracheal instillment of hyaluronidase and hyaluronic acidExp Lung Res1995214234367621778
  • CantorJOCerretaJMOchoaMAerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysemaExp Lung Res20053141743016025922
  • CantorJOCerretaJOchoaMTherapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy?Lung2011189515621153833
  • MaSTurinoGMHayashiTStable deuterium internal standard for the isotope-dilution LC–MS/MS analysis of elastin degradationAnal Biochem201344015816523727558
  • MaSLinYYCantorJOThe effect of alpha-1 protease inhibitor (A1PI) on biomarkers of elastin degradation in alpha-1 antitrypsin deficiency (AATD): an analysis of the RAPID/RAPID Extension trialsChronic Obstr Pulm Dis201743444
  • GarantziotisSLiZPottsENHyaluronan mediates ozone-induced airway hyperresponsiveness in miceJ Biol Chem2009284113091131719164299
  • NadkarniPPKulkarniGSCerretaJMDichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injuryExpert Lung Res200531807818
  • NoblePWJiangDMatrix regulation of lung injury, inflammation, and repair: the role of innate immunityProc Am Thorac Soc2006340140416799081
  • Baccarani-ContriMVincenziDCicchettiFImmunocytochemical localization of proteoglycans within normal elastin fibersEur J Cell Biol1990533053122127920
  • TakahashiAMajumdarAParameswaranHProteoglycans maintain lung stability in an elastase-treated mouse model of emphysemaAm J Respir Cell Mol Biol201451263324450478
  • CantorJArmandGTurinoGLung hyaluronan levels are decreased in alpha-1antiprotease deficiency COPDRespir Med201510965665925862598