Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease

References

• From the global strategy for the diagnosis, management and prevention of COPD, global initiative for chronic obstructive lung disease (GOLD). 2019 Available from: http://goldcopd.org. Accessed 1211, 2018.
   Google Scholar
• Stockley RA. Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med. 1999;160(5 Pt 2):S49–S52. doi:10.1164/ajrccm.160.supplement_1.1310556170
   PubMed Web of Science ®Google Scholar
• Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59(7):574–580. doi:10.1136/thx.2003.01958815223864
   PubMed Web of Science ®Google Scholar
• Makita H, Nasuhara Y, Nagai K, et al. Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax. 2007;62(11):932–937. doi:10.1136/thx.2006.07277717573447
   PubMed Web of Science ®Google Scholar
• Nishimura M, Makita H, Nagai K, et al. Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(1):44–52. doi:10.1164/rccm.201106-0992OC22016444
   PubMed Web of Science ®Google Scholar
• Suzuki M, Makita H, Ito YM, et al. Clinical features and determinants of COPD exacerbation in the hokkaido COPD cohort study. Eur Respir J. 2014;43(5):1289–1297. doi:10.1183/09031936.0011021324232696
   PubMed Web of Science ®Google Scholar
• Suzuki M, Makita H, Konno S, et al. Asthma-like features and clinical course of chronic obstructive pulmonary disease. An analysis from the hokkaido COPD cohort study. Am J Respir Crit Care Med. 2016;194(11):1358–1365. doi:10.1164/rccm.201602-0353OC27224255
   PubMed Web of Science ®Google Scholar
• Goddard PR, Nicholson EM, Laszlo G, Watt I. Computed tomography in pulmonary emphysema. Clin Radiol. 1982;33(4):379–387. doi:10.1016/S0009-9260(82)80301-27083738
   PubMed Web of Science ®Google Scholar
• Suzuki M, Makita H, Ostling J, et al. Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(10):1511–1519. doi:10.1513/AnnalsATS.201408-351OC25372271
   PubMedGoogle Scholar
• Seyama K, Hirai T, Mishima M, et al. A nationwide epidemiological survey of alpha1-antitrypsin deficiency in Japan. Respir Investig. 2016;54(3):201–206. doi:10.1016/j.resinv.2015.12.002
   Google Scholar
• Ingebrigtsen TS, Marott JL, Rode L, Vestbo J, Lange P, Nordestgaard BG. Fibrinogen and alpha1-antitrypsin in COPD exacerbations. Thorax. 2015;70(11):1014–1021. doi:10.1136/thoraxjnl-2015-20756126304913
   PubMed Web of Science ®Google Scholar
• Agusti A, Edwards LD, Rennard SI, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One. 2012;7(5):e37483. doi:10.1371/journal.pone.003748322624038
   PubMed Web of Science ®Google Scholar
• Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175(3):250–255. doi:10.1164/rccm.200605-713OC17053205
   PubMed Web of Science ®Google Scholar
• Duvoix A, Dickens J, Haq I, et al. Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease. Thorax. 2013;68(7):670–676. doi:10.1136/thoraxjnl-2012-20187122744884
   PubMed Web of Science ®Google Scholar
• Groenewegen KH, Postma DS, Hop WC, et al. Increased systemic inflammation is a risk factor for COPD exacerbations. Chest. 2008;133(2):350–357. doi:10.1378/chest.07-134218198263
   PubMed Web of Science ®Google Scholar
• Thomsen M, Ingebrigtsen TS, Marott JL, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA. 2013;309(22):2353–2361. doi:10.1001/jama.2013.573223757083
   PubMed Web of Science ®Google Scholar
• Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187(7):728–735. doi:10.1164/rccm.201209-1665OC23392440
   PubMed Web of Science ®Google Scholar
• Higashimoto Y, Yamagata T, Honda N, et al. Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease. Geriatr Gerontol Int. 2011;11(1):32–38. doi:10.1111/j.1447-0594.2010.00629.x20609004
   PubMed Web of Science ®Google Scholar
• Senn O, Russi EW, Schindler C, et al. Circulating alpha1-antitrypsin in the general population: determinants and association with lung function. Respir Res. 2008;9:35. doi:10.1186/1465-9921-9-3518439253
   PubMed Web of Science ®Google Scholar
• Fleixo-Lima G, Ventura H, Medini M, Bar L, Strauss P, Lewis EC. Mechanistic evidence in support of alpha1-antitrypsin as a therapeutic approach for type 1 diabetes. J Diabetes Sci Technol. 2014;8(6):1193–1203. doi:10.1177/193229681454709625155845
   PubMedGoogle Scholar
• Sandstrom CS, Ohlsson B, Melander O, Westin U, Mahadeva R, Janciauskiene S. An association between type 2 diabetes and alpha-antitrypsin deficiency. Diabet Med. 2008;25(11):1370–1373. doi:10.1111/j.1464-5491.2008.02584.x19046232
   PubMed Web of Science ®Google Scholar
• Rachmiel M, Strauss P, Dror N, et al. Alpha-1 antitrypsin therapy is safe and well tolerated in children and adolescents with recent onset type 1 diabetes mellitus. Pediatr Diabetes. 2016;17(5):351–359. doi:10.1111/pedi.2016.17.issue-526073583
   PubMed Web of Science ®Google Scholar
• American Thoracic S, European Respiratory S. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168(7):818–900.14522813
   PubMed Web of Science ®Google Scholar
• de Serres FJ, Blanco I, Fernandez-Bustillo E. Estimated numbers and prevalence of PI*S and PI*Z deficiency alleles of alpha1-antitrypsin deficiency in Asia. Eur Respir J. 2006;28(6):1091–1099. doi:10.1183/09031936.0002980617005586
   PubMed Web of Science ®Google Scholar