Triple Therapy with Budesonide/Glycopyrrolate/Formoterol Fumarate Improves Inspiratory Capacity in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap

References

• LopezAD, ShibuyaK, RaoC, et al. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J. 2006;27:397–412. doi:10.1183/09031936.06.0002580516452599
   PubMed Web of Science ®Google Scholar
• PauwelsRA, BuistAS, CalverleyPM, JenkinsCR, HurdSS; GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001;163:1256–1276. doi:10.1164/ajrccm.163.5.210103911316667
   PubMedGoogle Scholar
• MathersCD, LoncarD. Projection of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3:e442. doi:10.1371/journal.pmed.003044217132052
   PubMed Web of Science ®Google Scholar
• WHO. Chronic Obstructive Pulmonary Disease Phenotypes (COPD). Burden of COPD. WHO; 2019 Available from: https://www.who.int/respiratory/copd/burden/en/. Accessed 52, 2019.
   Google Scholar
• MarshSE, TraversJ, WeatherallM, et al. Proportional classification of COPD phenotypes. Thorax. 2008;63:761–767. doi:10.1136/thx.2007.08919318728201
   PubMed Web of Science ®Google Scholar
• GibsonPG, SimpsonJL. The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax. 2009;64:728–735. doi:10.1136/thx.2008.10802719638566
   PubMed Web of Science ®Google Scholar
• FuJJ, GibsonPG, SimpsonJL, McDonaldVM. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration. 2014;87:63–74. doi:10.1159/00035205324029561
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma [webpage on the Internet]. 2018 GINA Report, Global Strategy for Asthma Management and Prevention. GINA; 2018 Available from: https://ginasthma.org. Accessed 52, 2019.
   Google Scholar
• IshiuraY, FujimuraM, ShibaY, OhkuraN, HaraJ, KasaharaK. A comparison of the efficacy of once-daily fluticasone furoate/vilanterole with twice-daily fluticasone propionate/salmeterol in asthma-COPD overlap syndrome. Pulm Pharmacol Ther. 2015;35:28–33. doi:10.1016/j.pupt.2015.10.00526497109
   PubMed Web of Science ®Google Scholar
• IshiuraY, FujimuraM, OhkuraN, et al. Effect of triple therapy in patients with asthma-COPD overlap. Int J Clin Pharmacol Ther. 2019;57(8):384–392. doi:10.5414/CP20338231232275
   PubMed Web of Science ®Google Scholar
• LangeP, ParnerJ, VestboJ, SchnohrP, JensenG. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med. 1998;339:1194–1200. doi:10.1056/NEJM1998102233917039780339
   PubMed Web of Science ®Google Scholar
• HardinM, SilvermanEK, BarrRG, et al. The clinical features of the overlap between COPD and asthma. Respir Res. 2011;12:127. doi:10.1186/1465-9921-12-12721951550
   PubMed Web of Science ®Google Scholar
• ShayaFT, DongyiD, AkazawaMO, et al. Burden of concomitant asthma and COPD in a medicaid population. Chest. 2008;134(1):14–19. doi:10.1378/chest.07-231718339789
   PubMed Web of Science ®Google Scholar
• SorianoJB, VisickGT, MuellerovaH, PayvandiN, HansellAL. Patterns of comorbidities in newly diagnosed COPD and asthma in primary care. Chest. 2005;128:2099–2107. doi:10.1378/chest.128.4.209916236861
   PubMed Web of Science ®Google Scholar
• FuJJ, McDonaldVM, GibsonPG, SimpsonJL. Systemic inflammation in older adults with asthma-COPD overlap syndrome. Allergy Asthma Immunol Res. 2014;6:316–324. doi:10.4168/aair.2014.6.4.31624991455
   PubMed Web of Science ®Google Scholar
• TashkinDP, CelliB, SennS, et al.; UPLIFT Study Investigators. Bronchodilator responsiveness in patients with COPD. Eur Respir J. 2008;31:742–750. doi:10.1183/09031936.0012960718256071
   PubMed Web of Science ®Google Scholar
• Diaz-GuzmanE, KhosraviM, ManninoDM. Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population. COPD. 2011;8(6):400–407. doi:10.3109/15412555.2011.61120022149399
   PubMedGoogle Scholar
• KauppiP, KupiainenH, LindqvistA, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma. 2011;48(3):279–285. doi:10.3109/02770903.2011.55557621323613
   PubMed Web of Science ®Google Scholar
• McDonaldVM, HigginsI, GibsonPG. Managing older peoples with coexistent asthma and chronic obstructive lung disease; diagnostic and therapeutic challenge. Drugs Aging. 2013;30:1–17. doi:10.1007/s40266-012-0042-z23229768
   PubMed Web of Science ®Google Scholar
• ZekiAA, SchivoM, ChanA, AlbertsonTE, LouieS. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo). 2011;861926. doi:10.1155/2011/86192622121384
   PubMedGoogle Scholar
• VanfleterenL, FabbriLM, PapiA, PetruzzelliS, CelliB. Triple therapy (ICS/LABA/LAMA) in COPD: time for a reappraisal. Int J COPD. 2018;13:3971–3981. doi:10.2147/COPD.S185975
   Google Scholar
• DingB, SmallM. Treatment trends in patients with asthma-COPD overlap syndrome in a COPD cohort: findings from a real world survey. Int J COPD. 2017;12:1753–1763. doi:10.2147/COPD.S136314
   Google Scholar
• IsmailaAS, BirkR, ShahD, et al. Once-daily triple therapy in patients with advanced COPD: healthcare resource utilization data and associated costs from the FULFIL trial. Adv Ther. 2017;34(9):2163–2172. doi:10.1007/s12325-017-0604-x28875459
   PubMed Web of Science ®Google Scholar
• LipsonDA, BarnhartF, BrealeyN, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671–1680. doi:10.1056/NEJMoa171390129668352
   PubMed Web of Science ®Google Scholar
• PetersSP. Tiotropium bromide triple combination therapy improves lung function and decreases asthma exacerbations. Evid Based Med. 2013;18(5):179. doi:10.1136/eb-2012-10110023349214
   PubMedGoogle Scholar
• MiravitllesM, Soler-CataluñaJJ, CalleM, et al. Spanish guideline for COPD (GesEPOC). Update 2014. Arch Bronconeumol. 2014;50(Suppl 1):1–16. doi:10.1016/S0300-2896(14)70070-5
   PubMed Web of Science ®Google Scholar
• Japanese Respiratory Society[The JRS Guidelines for the Management of ACO 2018]. Medical Review. Tokyo; 2018. in Japanese.
   Google Scholar
• TantucciC, DonatiP, NicosiaF, et al. Inspiratory capacity predicts mortality in patients with chronic obstructive pulmonary disease. Respir Med. 2008;102(4):613–619. doi:10.1016/j.rmed.2007.11.00418083020
   PubMed Web of Science ®Google Scholar
• DiazO, VillafrancaC, GhezzoH, et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest. Eur Respir J. 2000;16(2):269–275. doi:10.1034/j.1399-3003.2000.16b14.x10968502
   PubMed Web of Science ®Google Scholar
• O’DonnellDE, RevillSM, WebbKA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(5):770–777. doi:10.1164/ajrccm.164.5.201212211549531
   PubMed Web of Science ®Google Scholar
• IshiuraY, FujimuraM, YamamotoH, IshiguroT, OhkuraN, MyouS. COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. J Investig Allergol Clin Immunol. 2009;19:370–374.
   PubMedGoogle Scholar
• IshiuraY, FujimuraM, YamamotoH, OhkuraN, MyouS. Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome. Cough. 2010;6:7. doi:10.1186/1745-9974-6-720696045
   PubMedGoogle Scholar
• IshiuraY, FujimuraM, ShibaY, et al. A comparison of the efficacy of once-daily fluticasone furoate/vilanterole with twice-daily fluticasone propionate/salmeterol in elderly asthmatics. Drug Res (Stuttg). 2018;68(1):38–44. doi:10.1055/s-0043-11853628926855
   PubMed Web of Science ®Google Scholar
• AlvingK, JansonC, NordvallL. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Respir Res. 2006;7:67. doi:10.1186/1465-9921-7-6716626491
   PubMed Web of Science ®Google Scholar
• MackayAJ, DonaldsonGC, PatelAR, JonesPW, HurstJR, WedzichaJA. Usefulness of the chronic obstructive pulmonary disease assessment test to evaluate severity of COPD exacerbations. Am J Respir Crit Care Med. 2012;185:1218–1224. doi:10.1164/rccm.201110-1843OC22281834
   PubMed Web of Science ®Google Scholar
• WernerCU, LindeK, SchäffnerJ, StorrC, SchneiderA. Weekly self-measurement of FEV1 and PEF and its impact on ACQ (asthma control questionnaire)-scores: 12-week observational study with 76 patients. NPJ Prim Care Respir Med. 2017;27(1):64. doi:10.1038/s41533-017-0064-429222436
   PubMed Web of Science ®Google Scholar
• MatzaLS, ParkJ, CoyneKS, SkinnerEP, MalleyKG, WoleverRQ. Derivation and validation of the ASK-12 adherence barrier survey. Ann Pharmacother. 2009;43(10):1621–1630. doi:10.1345/aph.1M17419776298
   PubMed Web of Science ®Google Scholar
• BelmanMJ, BotnickWC, ShinJW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996;153(3):967–975. doi:10.1164/ajrccm.153.3.86305818630581
   PubMed Web of Science ®Google Scholar
• D’UrzoA, KerwinE, OverendT, D’AndreaP, ChenH, GoyalP. Once daily glycopyrronium for the treatment of COPD: pooled analysis of the GLOW1 and GLOW2 studies. Curr Med Res Opin. 2014;30(3):493–508. doi:10.1185/03007995.2013.85861824156566
   PubMed Web of Science ®Google Scholar
• PriceD, FromerL, KaplanA, van der MolenT, Román-RodríguezM. Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma? NPJ Prim Care Respir Med. 2014;24(1):14023. doi:10.1038/npjpcrm.2014.2325030457
   PubMed Web of Science ®Google Scholar
• BlaisCM, DavisBE, CockcroftDW. The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study. Respir Res. 2017;18(1):146. doi:10.1186/s12931-017-0628-428768531
   PubMed Web of Science ®Google Scholar
• VirchowJC, KunaP, PaggiaroP, et al. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled Phase 3 trials. Lancet. 2019;394(10210):1737–1749. doi:10.1016/S0140-6736(19)32215-931582314
   PubMed Web of Science ®Google Scholar
• MapelDW, RobertsMH. Management of asthma and chronic obstructive pulmonary disease with combination inhaled corticosteroids and long-acting β-agonists: a review of comparative effectiveness research. Drugs. 2014;74(7):737–755. doi:10.1007/s40265-014-0214-824797158
   PubMed Web of Science ®Google Scholar
• HozawaS, TeradaM, HarutaY, HozawaM. Comparison of early effects of budesonide/formoterol maintenance and reliever therapy with fluticasone furoate/vilanterol for asthma patients requiring step-up from inhaled corticosteroid monotherapy. Pulm Pharmacol Ther. 2016;37:15–23. doi:10.1016/j.pupt.2016.01.00526850307
   PubMed Web of Science ®Google Scholar
• PriceD, DutchmanD, MawsonA, BodaliaB, DugganS, ToddP. FLOW (formoterol in the management of mild asthma–formoterol Turbuhaler with budesonide Turbuhaler) research group. Early asthma control and maintenance with formoterol following reduction of inhaled corticosteroid dose. Thorax. 2002;57(9):791–798. doi:10.1136/thorax.57.9.79112200524
   PubMed Web of Science ®Google Scholar
• FergusonGT, RabeKF, MartinezFJ, et al. Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised controlled trial. Lancet Respir Med. 2018;6(10):747–758. doi:10.1016/S2213-2600(18)30327-830232048
   PubMed Web of Science ®Google Scholar
• BarnesPJ. Triple inhalers for obstructive airways disease: will they be useful? Expert Rev Respir Med. 2011;5(3):297–300. doi:10.1586/ers.11.2621702649
   PubMed Web of Science ®Google Scholar
• BenfanteA, BraidoF, ScichiloneN. The anti-inflammatory properties of tiotropium. Lancet Respir Med. 2018;6(8):e37. doi:10.1016/S2213-2600(18)30190-529793856
   PubMed Web of Science ®Google Scholar