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Review

Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy

Pages 711-721 | Published online: 01 Apr 2020

References

  • BoudewijnsEA, BabuGR, SalviS, SheikhA, van SchayckOC. Chronic obstructive pulmonary disease: a disease of old age? J Glob Health. 2018;8(2):020306. doi:10.7189/jogh.08.02030630333921
  • AryalS, Diaz-GuzmanE, ManninoDM. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes. Int J Chron Obstruct Pulmon Dis. 2014;9:1145–1154. doi:10.2147/COPD.S5447625342899
  • BischoffEW, SchermerTR, BorH, BrownP, van WeelC, van den BoschWJ. Trends in COPD prevalence and exacerbation rates in Dutch primary care. Br J Gen Pract. 2009;59(569):927–933. doi:10.3399/bjgp09X47307919891824
  • BuistAS, McBurnieMA, VollmerWM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. 2007;370(9589):741–750. doi:10.1016/S0140-6736(07)61377-417765523
  • GershonAS, WangC, WiltonAS, RautR, ToT. Trends in chronic obstructive pulmonary disease prevalence, incidence, and mortality in Ontario, Canada, 1996 to 2007: a population-based study. Arch Intern Med. 2010;170(6):560–565. doi:10.1001/archinternmed.2010.1720308643
  • ThunMJ, CarterBD, FeskanichD, et al. 50-year trends in smoking-related mortality in the United States. N Engl J Med. 2013;368(4):351–364. doi:10.1056/NEJMsa121112723343064
  • NtritsosG, FranekJ, BelbasisL, et al. Gender-specific estimates of COPD prevalence: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2018;13:1507–1514. doi:10.2147/COPD.S14639029785100
  • van DurmeYMTA, VerhammeKMC, StijnenT, et al. Prevalence, incidence, and lifetime risk for the development of COPD in the elderly: the Rotterdam study. Chest. 2009;135(2):368–377. doi:10.1378/chest.08-068419201711
  • ForemanMG, ZhangL, MurphyJ, et al. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene study. Am J Respir Crit Care Med. 2011;184(4):414–420. doi:10.1164/rccm.201011-1928OC21562134
  • MathersCD, LoncarD. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. doi:10.1371/journal.pmed.003044217132052
  • NiH, XuJ. COPD-related mortality by sex and race among adults aged 25 and over: United States, 2000–2014. NCHS Data Brief. 2016;(256):1–8. Hyattsville, MD: NCHS Data Brief.
  • SanaA, SomdaSMA, MedaN, BoulandC. Chronic obstructive pulmonary disease associated with biomass fuel use in women: a systematic review and meta-analysis. BMJ Open Respir Res. 2018;5(1):e000246. doi:10.1136/bmjresp-2017-000246
  • GordonSB, BruceNG, GriggJ, et al. Respiratory risks from household air pollution in low and middle income countries. Lancet Respir Med. 2014;2(10):823–860. doi:10.1016/S2213-2600(14)70168-725193349
  • AryalS, Diaz-GuzmanE, ManninoDM. COPD and gender differences: an update. Transl Res. 2013;162(4):208–218. doi:10.1016/j.trsl.2013.04.00323684710
  • ByrneAL, MaraisBJ, MitnickCD, LeccaL, MarksGB. Tuberculosis and chronic respiratory disease: a systematic review. Int J Infect Dis. 2015;32:138–146. doi:10.1016/j.ijid.2014.12.01625809770
  • DaiMY, QiaoJP, XuYH, FeiGH. Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD assessment test. Int J Chron Obstruct Pulmon Dis. 2015;10:2257–2263. doi:10.2147/COPD.S9216026527871
  • LamprechtB, McBurnieMA, VollmerWM, et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest. 2011;139(4):752–763. doi:10.1378/chest.10-125320884729
  • Lopez VarelaMV, Montes de OcaM, HalbertRJ, et al. Sex-related differences in COPD in five Latin American cities: the PLATINO study. Eur Respir J. 2010;36(5):1034–1041. doi:10.1183/09031936.0016540920378599
  • DransfieldMT, DavisJJ, GeraldLB, BaileyWC. Racial and gender differences in susceptibility to tobacco smoke among patients with chronic obstructive pulmonary disease. Respir Med. 2006;100(6):1110–1116. doi:10.1016/j.rmed.2005.09.01916236491
  • SilvermanEK, WeissST, DrazenJM, et al. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162(6):2152–2158. doi:10.1164/ajrccm.162.6.200311211112130
  • GanWQ, ManSF, PostmaDS, CampP, SinDD. Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Res. 2006;7:52. doi:10.1186/1465-9921-7-5216571126
  • AmaralAFS, StrachanDP, BurneyPGJ, JarvisDL. Female smokers are at greater risk of airflow obstruction than male smokers. UK biobank. Am J Respir Crit Care Med. 2017;195(9):1226–1235. doi:10.1164/rccm.201608-1545OC28075609
  • AgustiA, CalverleyPM, CelliB, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res. 2010;11(1):122. doi:10.1186/1465-9921-11-12220831787
  • CelliB, VestboJ, JenkinsCR, et al. Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience. Am J Respir Crit Care Med. 2011;183(3):317–322. doi:10.1164/rccm.201004-0665OC20813884
  • DeMeoDL, RamagopalanS, KavatiA, et al. Women manifest more severe COPD symptoms across the life course. Int J Chron Obstruct Pulmon Dis. 2018;13:3021–3029. doi:10.2147/COPD30319250
  • MoherD, LiberatiA, TetzlaffJ, AltmanDG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341. doi:10.1016/j.ijsu.2010.02.00720171303
  • BarnesPJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35(1):71–86. doi:10.1016/j.ccm.2013.10.00424507838
  • LundströmSL, BalgomaD, WheelockÅM, HaeggströmJZ, DahlénSE, WheelockCE. Lipid mediator profiling in pulmonary disease. Curr Pharm Biotechnol. 2011;12(7):1026–1052. doi:10.2174/13892011179590908721466458
  • BalgomaD, YangM, SjödinM, et al. Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. Eur Respir J. 2016;47(6):1645–1656. doi:10.1183/13993003.01080-201526965288
  • BreyerMK, RuttenEP, VernooyJH, et al. Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin. Respir Med. 2011;105(7):1046–1053. doi:10.1016/j.rmed.2011.02.00121367591
  • Ali AssadN, SoodA. Leptin, adiponectin and pulmonary diseases. Biochimie. 2012;94(10):2180–2189. doi:10.1016/j.biochi.2012.03.00622445899
  • FriedmanJM. Leptin and the regulation of body weight. Keio J Med. 2011;60(1):1–9. doi:10.2302/kjm.60.121460597
  • KennedyA, GettysTW, WatsonP, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab. 1997;82(4):1293–1300. doi:10.1210/jcem.82.4.38599100610
  • LönnqvistF, WennlundA, ArnerP. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obes Relat Metab Disord. 1997;21(4):255–260. doi:10.1038/sj.ijo.08003949130020
  • ZhangX, LiD, WangH, PangC, WuY, WenF. Gender difference in plasma fatty-acid-binding protein 4 levels in patients with chronic obstructive pulmonary disease. Biosci Rep. 2016;36(1):e00302. doi:10.1042/BSR20150281
  • SuzukiM, MakitaH, ÖstlingJ, et al. Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(10):1511–1519. doi:10.1513/AnnalsATS.201408-351OC25372271
  • KrommidasG, KostikasK, PapatheodorouG, et al. Plasma leptin and adiponectin in COPD exacerbations: associations with inflammatory biomarkers. Respir Med. 2010;104(1):40–46. doi:10.1016/j.rmed.2009.08.01219782551
  • DiazAA, ZhouL, YoungTP, et al. Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers. Acad Radiol. 2014;21(10):1255–1261. doi:10.1016/j.acra.2014.05.01325088837
  • de TorresJP, CasanovaC, Pinto-PlataV, et al. Gender differences in plasma biomarker levels in a cohort of COPD patients: a pilot study. PLoS One. 2011;6(1):e16021. doi:10.1371/journal.pone.001602121267454
  • LarssonS, NordensonA, GladerP, YoshiharaS, LindénA, SlindeF. A gender difference in circulating neutrophils in malnourished patients with COPD. Int J Chron Obstruct Pulmon Dis. 2011;6:83–88. doi:10.2147/COPD.S1535121407820
  • SharanyaA, CianoM, WithanaS, KempPR, PolkeyMI, SathyapalaSA. Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities. Chron Respir Dis. 2019;16:1479973119843650. doi:10.1177/147997311984365031131626
  • BridevauxPO, GerbaseMW, SchindlerC, et al. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. Eur Respir J. 2009;34(2):332–339. doi:10.1183/09031936.0016260819251780
  • ÓlafsdóttirIS, GíslasonT, ThjóđleifssonB, et al. Gender differences in the association between C-reactive protein, lung function impairment, and COPD. Int J Chron Obstruct Pulmon Dis. 2007;2(4):635–642.18268938
  • ForsslundH, YangM, MikkoM, et al. Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes. Int J Chron Obstruct Pulmon Dis. 2017;12:35–48. doi:10.2147/COPD.S11362528053515
  • FreemanCM, CurtisJL, ChensueSW. CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Am J Pathol. 2007;171(3):767–776. doi:10.2353/ajpath.2007.06117717640964
  • BoyaP, ReggioriF, CodognoP. Emerging regulation and functions of autophagy. Nat Cell Biol. 2013;15(7):713–720. doi:10.1038/ncb278823817233
  • MonickMM, PowersLS, WaltersK, et al. Identification of an autophagy defect in smokers’ alveolar macrophages. J Immunol. 2010;185(9):5425–5435. doi:10.4049/jimmunol.100160320921532
  • RacanelliAC, KikkersSA, ChoiAMK, CloonanSM. Autophagy and inflammation in chronic respiratory disease. Autophagy. 2018;14(2):221–232. doi:10.1080/15548627.2017.138982329130366
  • YangM, KohlerM, HeyderT, et al. Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype. Respir Res. 2018;19(1):39. doi:10.1186/s12931-017-0699-229514663
  • NazS, KolmertJ, YangM, et al. Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin–lysoPA axis in COPD. Eur Respir J. 2017;49(6):1602322. doi:10.1183/13993003.02322-201628642310
  • KohlerM, SandbergA, KjellqvistS, et al. Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2013;131(3):743–751. doi:10.1016/j.jaci.2012.09.02423146379
  • MauryJ, GouziF, De RigalP, et al. Heterogeneity of systemic oxidative stress profiles in COPD: a potential role of gender. Oxid Med Cell Longev. 2015;2015:201843. doi:10.1155/2015/20184326167238
  • NazS, BhatM, StahlS, et al. Dysregulation of the tryptophan pathway evidences gender differences in COPD. Metabolites. 2019;9(10):212. doi:10.3390/metabo9100212
  • GlassK, QuackenbushJ, SilvermanEK, et al. Sexually-dimorphic targeting of functionally-related genes in COPD. BMC Syst Biol. 2014;8(1):118. doi:10.1186/s12918-014-0118-y25431000
  • FanerR, GonzalezN, CruzT, KalkoSG, AgustíA. Systemic inflammatory response to smoking in chronic obstructive pulmonary disease: evidence of a gender effect. PLoS One. 2014;9(5):e97491. doi:10.1371/journal.pone.009749124830457
  • CamiciottoliG, DiciottiS, BigazziF, et al. Is intrathoracic tracheal collapsibility correlated to clinical phenotypes and sex in patients with COPD? Int J Chron Obstruct Pulmon Dis. 2015;10:843–852. doi:10.2147/COPD.S8055825960647
  • GuenetteJA, JensenD, WebbKA, OfirD, RaghavanN, O’DonnellDE. Sex differences in exertional dyspnea in patients with mild COPD: physiological mechanisms. Respir Physiol Neurobiol. 2011;177(3):218–227. doi:10.1016/j.resp.2011.04.01121524719
  • SmithBM, TraboulsiH, AustinJHM, et al. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018;115(5):E974–E981. doi:10.1073/pnas.171556411529339516
  • HardinM, ChoMH, SharmaS, et al. Sex-based genetic association study identifies CELSR1 as a possible chronic obstructive pulmonary disease risk locus among women. Am J Respir Cell Mol Biol. 2017;56(3):332–341. doi:10.1165/rcmb.2016-0172OC27854507
  • BhattSP, TerryNL, NathH, et al. Association between expiratory central airway collapse and respiratory outcomes among smokers. JAMA. 2016;315(5):498–505. doi:10.1001/jama.2015.1943126836732
  • MartinezFJ, CurtisJL, SciurbaF, et al. Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med. 2007;176(3):243–252. doi:10.1164/rccm.200606-828OC17431226
  • DransfieldMT, WashkoGR, ForemanMG, EsteparRS, ReillyJ, BaileyWC. Gender differences in the severity of CT emphysema in COPD. Chest. 2007;132(2):464–470. doi:10.1378/chest.07-086317573503
  • CampPG, CoxsonHO, LevyRD, et al. Sex differences in emphysema and airway disease in smokers. Chest. 2009;136(6):1480–1488. doi:10.1378/chest.09-067619617404
  • GuS, DengX, LiQ, SunX, XuJ, LiH. Gender differences of chronic obstructive pulmonary disease associated with manifestations on HRCT. Clin Respir J. 2017;11(1):28–35. doi:10.1111/crj.1229725833760
  • HardinM, ForemanM, DransfieldMT, et al. Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J. 2016;47(1):104–112. doi:10.1183/13993003.00996-201526541532
  • SverzellatiN, CalabroE, RandiG, et al. Sex differences in emphysema phenotype in smokers without airflow obstruction. Eur Respir J. 2009;33(6):1320–1328. doi:10.1183/09031936.0010980819164351
  • LiY, DaiYL, YuN, GuoYM. Sex-related differences in bronchial parameters and pulmonary function test results in patients with chronic obstructive pulmonary disease based on three-dimensional quantitative computed tomography. J Int Med Res. 2018;46(1):135–142. doi:10.1177/030006051772130928758847
  • ZachJA, NewellJDJ, SchroederJ, et al. Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol. 2012;47(10):596–602. doi:10.1097/RLI.0b013e318262292e22836310
  • CarterR, NicotraB, HuberG. Differing effects of airway obstruction on physical work capacity and ventilation in men and women with COPD. Chest. 1994;106(6):1730–1739. doi:10.1378/chest.106.6.17307988192
  • TangR, FraserA, MagnusMC. Female reproductive history in relation to chronic obstructive pulmonary disease and lung function in UK biobank: a prospective population-based cohort study. BMJ Open. 2019;9(10):e030318. doi:10.1136/bmjopen-2019-030318
  • DeMeoDL. The yin and yang of COPD: sex/gender differences in the National Emphysema Treatment Trial. Am J Respir Crit Care Med. 2007;176(3):222–223. doi:10.1164/rccm.200704-558ED17641161
  • JenkinsCR, ChapmanKR, DonohueJF, RocheN, TsiligianniI, HanMK. Improving the management of COPD in women. Chest. 2017;151(3):686–696. doi:10.1016/j.chest.2016.10.03127816445
  • OharJ, FromerL, DonohueJF. Reconsidering sex-based stereotypes of COPD. Prim Care Respir J. 2011;20(4):370–378. doi:10.4104/pcrj.2011.0007021922124
  • NicoliniA, BarbagelataE, TagliabueE, ColomboD, MonacelliF, BraidoF. Gender differences in chronic obstructive pulmonary diseases: a narrative review. Panminerva Med. 2018;60(4):192‒199. doi:10.23736/S0031-0808.18.03463-8
  • PrescottE, BjergAM, AndersenPK, LangeP, VestboJ. Gender difference in smoking effects on lung function and risk of hospitalization for COPD: results from a Danish longitudinal population study. Eur Respir J. 1997;10(4):822–827.9150319
  • GoelK, BaileyM, BorgstromM, et al. Trends in chronic obstructive pulmonary disease hospitalization and in-hospital deaths in the United States by sex: 2005 to 2014. Ann Am Thorac Soc. 2019;16(3):391–393. doi:10.1513/AnnalsATS.201807-488RL30395724
  • OhYM, JeongBH, WooSY, et al. Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression. Ann Am Thorac Soc. 2015;12(7):1005–1012. doi:10.1513/AnnalsATS.201501-005OC26010877
  • BurkartKM, BartonSJ, HollowayJW, et al. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006;117(1):86–91. doi:10.1016/j.jaci.2005.10.01116387589
  • AnderssonA, QvarfordtI, LaanM, et al. Impact of tobacco smoke on interleukin-16 protein in human airways, lymphoid tissue and T lymphocytes. Clin Exp Immunol. 2004;138(1):75–82. doi:10.1111/j.1365-2249.2004.02580.x15373908
  • MaenoT, HoughtonAM, QuinteroPA, GrumelliS, OwenCA, ShapiroSD. CD8+ T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol. 2007;178(12):8090–8096. doi:10.4049/jimmunol.178.12.809017548647
  • BoukhenounaS, WilsonMA, BahmedK, KosmiderB. Reactive oxygen species in chronic obstructive pulmonary disease. Oxid Med Cell Longev. 2018;2018:5730395. doi:10.1155/2018/573039529599897
  • Global Initiative for Chronic Obstructive Lung Disease. GOLD; 2020 Available from: https://goldcopd.org. Accessed 1223, 2019.
  • TashkinD, CelliB, KestenS, LystigT, DecramerM. Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trial. Respir Med. 2010;104(10):1495–1504. doi:10.1016/j.rmed.2010.03.03320418083
  • TsiligianniI, MezziK, FucileS, et al. Response to indacaterol/glycopyrronium (IND/GLY) by sex in patients with COPD: a pooled analysis from the IGNITE program. Copd. 2017;14(4):375–381. doi:10.1080/15412555.2017.132483728594587
  • VestboJ, SorianoJB, AndersonJA, CalverleyP, PauwelsR, JonesP. Gender does not influence the response to the combination of salmeterol and fluticasone propionate in COPD. Respir Med. 2004;98(11):1045–1050. doi:10.1016/j.rmed.2004.03.01715526804
  • WedzichaJA, SinghD, TsiligianniI, et al. Treatment response to indacaterol/glycopyrronium versus salmeterol/fluticasone in exacerbating COPD patients by gender: a post-hoc analysis in the FLAME study. Respir Res. 2019;20(1):4. doi:10.1186/s12931-019-0972-730621717