Blood Eosinophil Count and Hospital Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

References

• SegalLN, MartinezFJ. Chronic obstructive pulmonary disease subpopulations and phenotyping. J Allergy Clin Immunol. 2018;141(6):1961–1971. doi:10.1016/j.jaci.2018.02.03529884286
   PubMed Web of Science ®Google Scholar
• HanMK, AgustiA, CalverleyPM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med. 2010;182(5):598–604.20522794
   PubMed Web of Science ®Google Scholar
• BafadhelM, PavordID, RussellREK. Eosinophils in COPD: just another biomarker? Lancet Respir Med. 2017;5(9):747–759. doi:10.1016/S2213-2600(17)30217-528601554
   PubMed Web of Science ®Google Scholar
• TashkinDP, WechslerME. Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2018;13:335–349.29403271
   PubMed Web of Science ®Google Scholar
• Vedel-KroghS, NielsenSF, LangeP, VestboJ, NordestgaardBG. Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The copenhagen general population study. Am J Respir Crit Care Med. 2016;193(9):965–974. doi:10.1164/rccm.201509-1869OC26641631
   PubMed Web of Science ®Google Scholar
• WatzH, TetzlaffK, WoutersEF, et al. Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial. Lancet Respir Med. 2016;4(5):390–398. doi:10.1016/S2213-2600(16)00100-427066739
   PubMed Web of Science ®Google Scholar
• SinghD, KolsumU, BrightlingCE, et al. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J. 2014;44(6):1697–1700. doi:10.1183/09031936.0016241425323230
   PubMed Web of Science ®Google Scholar
• OshagbemiOA, BurdenAM, BraekenDCW, et al. Stability of blood eosinophils in patients with chronic obstructive pulmonary disease and in control subjects, and the impact of sex, age, smoking, and baseline counts. Am J Respir Crit Care Med. 2017;195(10):1402–1404. doi:10.1164/rccm.201701-0009LE28165763
   PubMed Web of Science ®Google Scholar
• BafadhelM, McKennaS, TerryS, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184(6):662–671. doi:10.1164/rccm.201104-0597OC21680942
   PubMed Web of Science ®Google Scholar
• SiddiquiSH, GuasconiA, VestboJ, et al. Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192(4):523–525.26051430
   PubMed Web of Science ®Google Scholar
• YunJH, LambA, ChaseR, et al. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018;141(6):2037–2047 e2010. doi:10.1016/j.jaci.2018.04.01029709670
   PubMed Web of Science ®Google Scholar
• CasanovaC, CelliBR, de-TorresJP, et al. Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD. Eur Respir J. 2017;50:5. doi:10.1183/13993003.01162-2017
   Web of Science ®Google Scholar
• TuratoG, SemenzatoU, BazzanE, et al. Blood eosinophilia neither reflects tissue eosinophils nor worsens clinical outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;197(9):1216–1219. doi:10.1164/rccm.201708-1684LE29035097
   PubMed Web of Science ®Google Scholar
• CouillardS, LariveeP, CourteauJ, VanasseA. Eosinophils in COPD exacerbations are associated with increased readmissions. Chest. 2017;151(2):366–373. doi:10.1016/j.chest.2016.10.00327746201
   PubMed Web of Science ®Google Scholar
• BafadhelM, GreeningNJ, Harvey-DunstanTC, et al. Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. Chest. 2016;150(2):320–328.26851799
   PubMed Web of Science ®Google Scholar
• BelangerM, CouillardS, CourteauJ, et al. Eosinophil counts in first COPD hospitalizations: a comparison of health service utilization. Int J Chron Obstruct Pulmon Dis. 2018;13:3045–3054. doi:10.2147/COPD.S17074330319252
   PubMed Web of Science ®Google Scholar
• DumanD, AksoyE, AgcaMC, et al. The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia. Int J Chron Obstruct Pulmon Dis. 2015;10:2469–2478.26648709
   PubMed Web of Science ®Google Scholar
• RutgersSR, TimensW, KaufmannHF, van der MarkTW, KoeterGH, PostmaDS. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J. 2000;15(1):109–115. doi:10.1183/09031936.00.1511090010678630
   PubMed Web of Science ®Google Scholar
• NegewoNA, McDonaldVM, BainesKJ, et al. Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:1495–1504. doi:10.2147/COPD.S10033827445469
   PubMed Web of Science ®Google Scholar
• KlionAD. Eosinophilia: a pragmatic approach to diagnosis and treatment. Hematology Am Soc Hematol Educ Program. 2015;2015:92–97. doi:10.1182/asheducation-2015.1.9226637706
   PubMed Web of Science ®Google Scholar
• PascoeS, LocantoreN, DransfieldMT, BarnesNC, PavordID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3(6):435–442. doi:10.1016/S2213-2600(15)00106-X25878028
   PubMed Web of Science ®Google Scholar
• LipsonDA, BarnhartF, BrealeyN, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671–1680. doi:10.1056/NEJMoa171390129668352
   PubMed Web of Science ®Google Scholar
• PavordID, LettisS, AnzuetoA, BarnesN. Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis. Lancet Respir Med. 2016;4(9):731–741. doi:10.1016/S2213-2600(16)30148-527460163
   PubMed Web of Science ®Google Scholar
• ZysmanM, DesleeG, CaillaudD, et al. Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:1819–1824.28694695
   PubMed Web of Science ®Google Scholar
• DiSantostefanoRL, HindsD, LeHV, BarnesNC. Relationship between blood eosinophils and clinical characteristics in a cross-sectional study of a US population-based COPD cohort. Respir Med. 2016;112:88–96. doi:10.1016/j.rmed.2016.01.01326872700
   PubMed Web of Science ®Google Scholar
• PavordID, LettisS, LocantoreN, et al. Blood eosinophils and inhaled corticosteroid/long-acting beta-2 agonist efficacy in COPD. Thorax. 2016;71(2):118–125. doi:10.1136/thoraxjnl-2015-20702126585525
   PubMed Web of Science ®Google Scholar
• HakimMA, GardenFL, JenningsMD, DoblerCC. Performance of the LACE index to predict 30-day hospital readmissions in patients with chronic obstructive pulmonary disease. Clin Epidemiol. 2018;10:51–59. doi:10.2147/CLEP.S14957429343987
   PubMed Web of Science ®Google Scholar
• GotoT, FaridiMK, CamargoCA Jr, HasegawaK. Time-varying readmission diagnoses during 30 days after hospitalization for COPD exacerbation. Med Care. 2018;56(8):673–678. doi:10.1097/MLR.000000000000094029912841
   PubMed Web of Science ®Google Scholar
• SharifR, ParekhTM, PiersonKS, KuoYF, SharmaG. Predictors of early readmission among patients 40 to 64 years of age hospitalized for chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(5):685–694.24784958
   PubMedGoogle Scholar
• WardlawAJ, MoqbelR, KayAB. Eosinophils: biology and role in disease. Adv Immunol. 1995;60:151–266.8607370
   PubMed Web of Science ®Google Scholar
• EssellierAF, JeanneretRL, MorandiL. The mechanism of glucocorticoid eosinopenia; contribution to the physiology of eosinophile granulocytes. Blood. 1954;9(5):531–549. doi:10.1182/blood.V9.5.531.53113149634
   PubMed Web of Science ®Google Scholar
• WallenN, KitaH, WeilerD, GleichGJ. Glucocorticoids inhibit cytokine-mediated eosinophil survival. J Immunol. 1991;147(10):3490–3495.1940348
   PubMed Web of Science ®Google Scholar
• GibsonPG. Inflammatory phenotypes in adult asthma: clinical applications. Clin Respir J. 2009;3(4):198–206. doi:10.1111/j.1752-699X.2009.00162.x20298405
   PubMed Web of Science ®Google Scholar
• DenlingerLC, PhillipsBR, RamratnamS, et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017;195(3):302–313. doi:10.1164/rccm.201602-0419OC27556234
   PubMed Web of Science ®Google Scholar
• KerkhofM, TranTN, van den BergeM, et al. Association between blood eosinophil count and risk of readmission for patients with asthma: historical cohort study. PLoS One. 2018;13(7):e0201143. doi:10.1371/journal.pone.020114330044863
   PubMed Web of Science ®Google Scholar
• WattMJ, HowlettKF, FebbraioMA, SprietLL, HargreavesM. Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. J Physiol. 2001;534(Pt 1):269–278. doi:10.1111/j.1469-7793.2001.t01-1-00269.x11433007
   PubMed Web of Science ®Google Scholar
• SteinBD, BautistaA, SchumockGT, et al. The validity of International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for identifying patients hospitalized for COPD exacerbations. Chest. 2012;141(1):87–93. doi:10.1378/chest.11-002421757568
   PubMed Web of Science ®Google Scholar
• DorseyK. Centers medicare medicaid services. 2015 condition-specific measures updates and specifications report hospital-level 30-day risk-standardized readmission measures. Available from: https://www.qualitynet.org/dcs/BlobServer?blobkey=id&blobnocache=true&blobwhere=1228890435217&blobheader=multipart%2Foctetstream&blobheadername1=Content-Disposition&blobheadervalue1=attachment%3Bfilename%3DRdmn_AMIHFPNCOPDSTK_Msr_UpdtRpt.pdf&blobcol=urldata&blobtable=MungoBlobs. Accessed 38, 2019.
   Google Scholar