Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD

References

• LeighR, PizzichiniMM, MorrisMM, MaltaisF, HargreaveFE, PizzichiniE. Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J. 2006;27:964–971. doi:10.1183/09031936.06.0007210516446316
   PubMed Web of Science ®Google Scholar
• BafadhelM, McKennaS, TerryS, et al. Acute exacerbations of COPD: identification of biological clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184:662–671. doi:10.1164/rccm.201104-0597OC21680942
   PubMed Web of Science ®Google Scholar
• FujimotoK, KuboK, YamamotoH, YamaguchiS, MatsuzawaY. Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. Chest. 1999;115:697–702. doi:10.1378/chest.115.3.69710084478
   PubMed Web of Science ®Google Scholar
• PizzichiniE, PizzichiniMM, GibsonP, et al. Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. Am J Respir Crit Care Med. 1998;158:1511–1517. doi:10.1164/ajrccm.158.5.98040289817701
   PubMed Web of Science ®Google Scholar
• BrightlingCE, MonteiroW, WardR, ParkerD, MorganMD, WardlawAJ. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2000;356:1480–1485. doi:10.1016/S0140-6736(00)02872-511081531
   PubMed Web of Science ®Google Scholar
• KolsumU, DonaldsonGC, SinghR, et al. Blood and sputum eosinophils in COPD; relationship with bacterial load. Respir Res. 2017;18:88. doi:10.1186/s12931-017-0570-528482840
   PubMed Web of Science ®Google Scholar
• SoterS, BartaI, AntusB. Predicting sputum eosinophilia in exacerbations of COPD using exhaled nitric oxide. Inflammation. 2013;36:1178–1185. doi:10.1007/s10753-013-9653-823681903
   PubMed Web of Science ®Google Scholar
• SinghD. Predicting corticosteroid response in chronic obstructive pulmonary disease. Blood eosinophils gain momentum. Am J Respir Crit Care Med. 2017;196:1098–1100. doi:10.1164/rccm.201703-0592ED29090962
   PubMed Web of Science ®Google Scholar
• KostikasK, BrindicciC, PatalanoF. Blood eosinophils as biomarkers to drive treatment choices in asthma and COPD. Curr Drug Targets. 2018;19:1882–1896. doi:10.2174/138945011966618021212001229437007
   PubMed Web of Science ®Google Scholar
• BarnesPJ, DweikRA, GelbAF, et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 2010;138:682–692. doi:10.1378/chest.09-209020822990
   PubMed Web of Science ®Google Scholar
• TaylorDR, PijnenburgMW, SmithAD, De JongsteJC. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax. 2006;61:817. doi:10.1136/thx.2005.05609316936238
   PubMed Web of Science ®Google Scholar
• NegewoNA, McDonaldVM, BainesKJ, et al. Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:1495–1504. doi:10.2147/COPD.S10033827445469
   PubMed Web of Science ®Google Scholar
• HastieAT, MartinezFJ, CurtisJL, et al. SPIROMICS investigators. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017;5:956–967. doi:10.1016/S2213-2600(17)30432-029146301
   PubMed Web of Science ®Google Scholar
• ChouKT, SuKC, HuangSF, et al. Exhaled nitric oxide predicts eosinophilic airway inflammation in COPD. Lung. 2014;192:499–504. doi:10.1007/s00408-014-9591-824816967
   PubMed Web of Science ®Google Scholar
• GaoJ, ZhangM, ZhouL, et al. Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:1287–1293. doi:10.2147/COPD.S13499828490872
   PubMed Web of Science ®Google Scholar
• FujimotoK, YasuoM, UrushibataK, HanaokaM, KoizumiT, KuboK. Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease. Eur Respir J. 2005;25:640–646. doi:10.1183/09031936.05.0004750415802337
   PubMed Web of Science ®Google Scholar
• BathoornE, LieskerJJ, PostmaDS, et al. Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation. Int J Chron Obstruct Pulmon Dis. 2009;4:101–109. doi:10.2147/COPD.S485419436694
   PubMedGoogle Scholar
• ÇolakY, AfzalS, NordestgaardBG, MarottJL, LangeP. Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen General Population Study. Eur Respir J. 2018;52:pii:1800616. doi:10.1183/13993003.00616-2018
   PubMed Web of Science ®Google Scholar
• RabeKF, HurdS, AnzuetoA, et al. Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532–555. doi:10.1164/rccm.200703-456SO17507545
   PubMed Web of Science ®Google Scholar
• DrozdovszkyO, BartaI, AntusB. Sputum eicosanoid profiling in exacerbations of chronic obstructive pulmonary disease. Respiration. 2014;87:408–415. doi:10.1159/00035809924714447
   PubMed Web of Science ®Google Scholar
• HorváthI, BarnesPJ, LoukidesS, et al. A European respiratory society technical standard: exhaled biomarkers in lung disease. Eur Respir J. 2017;49:1600965. doi:10.1183/13993003.00965-201628446552
   PubMed Web of Science ®Google Scholar
• HanleyJA, McNeilBJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29–36. doi:10.1148/radiology.143.1.70637477063747
   PubMed Web of Science ®Google Scholar
• FabbriLM, RomagnoliM, CorbettaL, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:418–4124. doi:10.1164/rccm.200203-183OC12426229
   PubMed Web of Science ®Google Scholar
• ChenFJ, HuangXY, LiuYL, LinGP, XieCM. Importance of fractional exhaled nitric oxide in the differentiation of asthma-COPD overlap syndrome, asthma, and COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2385–2390. doi:10.2147/COPD.S11537827713629
   PubMed Web of Science ®Google Scholar
• TakayamaY, OhnishiH, OgasawaraF, OyamaK, KubotaT, YokoyamaA. Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap. Int J Chron Obstruct Pulmon Dis. 2018;13:2525–2532. doi:10.2147/COPD.S16760030174422
   PubMed Web of Science ®Google Scholar
• Global Initiative for Chronic Obstructive Lung Disease. Available from: https://goldcopd.org/. Accessed 219, 2020.
   Google Scholar
• WagenerAH, de NijsSB, LutterR, et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 2015;70:115–120. doi:10.1136/thoraxjnl-2014-20563425422384
   PubMed Web of Science ®Google Scholar
• KimVL, CoombsNA, StaplesKJ, AERIS study group, et al. Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort. Eur Respir J. 50;2017:1700853. doi:10.1183/13993003.00853-201729025891
   PubMed Web of Science ®Google Scholar
• PapiA, BellettatoCM, BraccioniF, et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med. 2006;173:1114–1121. doi:10.1164/rccm.200506-859OC16484677
   PubMed Web of Science ®Google Scholar
• HögmanM, ThornadtssonA, BrömsK, et al. Different relationships between F(E)NO and COPD characteristics in smokers and ex-Smokers. COPD. 2019;16:227–233. doi:10.1080/15412555.2019.163835531357875
   PubMedGoogle Scholar
• LimCS, RaniFA, TanLE. Response of exhaled nitric oxide to inhaled corticosteroids in patients with stable COPD: a systematic review and meta-analysis. Clin Respir J. 2018;12:218–226. doi:10.1111/crj.1251827328740
   PubMed Web of Science ®Google Scholar
• LiuJ, SandriniA, ThurstonMC, YatesDH, ThomasPS. Nitric oxide and exhaled breath nitrite/nitrates in chronic obstructive pulmonary disease patients. Respiration. 2007;74:617–623. doi:10.1159/00010637917643055
   PubMed Web of Science ®Google Scholar
• KreindlerJL, WatkinsML, LettisS, Tal-SingerR, LocantoreN. Effect of inhaled corticosteroids on blood eosinophil count in steroid-naïve patients with COPD. BMJ Open Respir Res. 2016;3:e000151. doi:10.1136/bmjresp-2016-000151
   PubMed Web of Science ®Google Scholar
• LandisSH, SurukiR, HiltonE, ComptonC, GalweyNW. Stability of blood eosinophil count in patients with COPD in the UK clinical practice research datalink. COPD. 2017;14:382–388. doi:10.1080/15412555.2017.131382728569614
   PubMedGoogle Scholar
• GreulichT, MagerS, LuckeT, et al. Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort. Int J Chron Obstruct Pulmon Dis. 2018;13:2999–3002. doi:10.2147/COPD.S16590930319247
   PubMed Web of Science ®Google Scholar
• SouthworthT, BeechG, FodenP, KolsumU, SinghD. The reproducibility of COPD blood eosinophil counts. Eur Respir J. 2018;52:1800427. doi:10.1183/13993003.00427-201829724922
   PubMed Web of Science ®Google Scholar
• BhowmikA, SeemungalTA, DonaldsonGC, WedzichaJA. Effects of exacerbations and seasonality on exhaled nitric oxide in COPD. Eur Respir J. 2005;26:1009–1015. doi:10.1183/09031936.05.0004730516319329
   PubMed Web of Science ®Google Scholar
• BrindicciC, ItoK, RestaO, PrideN, BarnesPJ, KharitonovSA. Exhaled nitric oxide from lung periphery is increased in COPD. Eur Respir J. 2005;26:52–59. doi:10.1183/09031936.04.0012530415994389
   PubMed Web of Science ®Google Scholar
• AntusB, HorvathI, BartaI. Assessment of exhaled nitric oxide by a new hand-held device. Respir Med. 2010;104:1377–1380. doi:10.1016/j.rmed.2010.06.00520594818
   PubMed Web of Science ®Google Scholar
• RouhosA, KainuA, PiiriläP, et al. Repeatability of exhaled nitric oxide measurements in patients with COPD. Clin Physiol Funct Imaging. 2011;31:26–31. doi:10.1111/j.1475-097X.2010.00975.x21143751
   PubMed Web of Science ®Google Scholar