PM2.5 Induces the Expression of Inflammatory Cytokines via the Wnt5a/Ror2 Pathway in Human Bronchial Epithelial Cells

References

• LancetT. Air pollution: a major threat to lung health. Lancet. 2019;393(10183):1774. doi:10.1016/S0140-6736(19)30992-4
   Web of Science ®Google Scholar
• AtkinsonRW, CareyIM, KentAJ, van StaaTP, AndersonHR, CookDG. Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort. Occup Environ Med. 2015;72(1):42–48. doi:10.1136/oemed-2014-10226625146191
   PubMed Web of Science ®Google Scholar
• ZhaoB, ZhengH, WangS, et al. Change in household fuels dominates the decrease in PM2.5 exposure and premature mortality in China in 2005–2015. Proc Natl Acad Sci U S A. 2018;115(49):12401–12406. doi:10.1073/pnas.181295511530455309
   PubMed Web of Science ®Google Scholar
• SchultzES, LitonjuaAA, MelenE. Effects of long-term exposure to traffic-related air pollution on lung function in children. Curr Allergy Asthma Rep. 2017;17(6):41. doi:10.1007/s11882-017-0709-y28551888
   PubMed Web of Science ®Google Scholar
• HuangW, WangG, LuSE, et al. Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing olympics. Am J Respir Crit Care Med. 2012;186(11):1150–1159. doi:10.1164/rccm.201205-0850OC22936356
   PubMed Web of Science ®Google Scholar
• KoppJ, FlessaS, LiebW, et al. Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study. BMC Health Serv Res. 2016;16:41. doi:10.1186/s12913-016-1289-626847197
   PubMed Web of Science ®Google Scholar
• BaarsmaHA, Skronska-WasekW, MutzeK, et al. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017;214(1):143–163. doi:10.1084/jem.2016067527979969
   PubMed Web of Science ®Google Scholar
• LiaoHD, MaoY, YingYG. The involvement of the laminin-integrin α7β1 signaling pathway in mechanical ventilation-induced pulmonary fibrosis. J Thorac Dis. 2017;9(10):3961–3972. doi:10.21037/jtd.2017.09.6029268407
   PubMed Web of Science ®Google Scholar
• FellerD, KunJ, RuzsicsI, et al. Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines. Front Immunol. 2018;9:1724. doi:10.3389/fimmu.2018.0172430090106
   PubMed Web of Science ®Google Scholar
• WangY, XuJ, MengY, AdcockIM, YaoX. Role of inflammatory cells in airway remodeling in COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:3341–3348. doi:10.2147/COPD.S17612230349237
   PubMed Web of Science ®Google Scholar
• HeF, LiaoB, PuJ, et al. Exposure to ambient particulate matter induced COPD in a rat model and a description of the underlying mechanism. Sci Rep. 2017;7:45666. doi:10.1038/srep4566628361885
   PubMed Web of Science ®Google Scholar
• ZouW, HeF, LiuS, et al. PM2.5 induced the expression of fibrogenic mediators via HMGB1-RAGE signaling in human airway epithelial cells. Can Respir J. 2018;2018:1817398. doi:10.1155/2018/181739829670673
   PubMed Web of Science ®Google Scholar
• LiuS, ZhouY, LiuS, et al. Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China. Thorax. 2017;72(9):788–795. doi:10.1136/thoraxjnl-2016-20891027941160
   PubMed Web of Science ®Google Scholar
• ZhaoJ, LiM, WangZ, et al. Role of PM2.5 in the development and progression of COPD and its mechanisms. Respir Res. 2019;20(1):120. doi:10.1186/s12931-019-1081-331196090
   PubMed Web of Science ®Google Scholar
• EzegbunamW, ForonjyR. Posttranscriptional control of airway inflammation. Wiley Interdiscip Rev RNA. 2018;9(1):e1455. doi:10.1002/wrna.1455
   Web of Science ®Google Scholar
• ChenY, ThomasPS, KumarRK, HerbertC. The role of noncoding RNAs in regulating epithelial responses in COPD. Am J Physiol Lung Cell Mol Physiol. 2018;315(2):L184–L92. doi:10.1152/ajplung.00063.201829722561
   PubMed Web of Science ®Google Scholar
• CatalanV, Gomez-AmbrosiJ, RodriguezA, et al. Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation. J Clin Endocrinol Metab. 2014;99(8):E1407–17. doi:10.1210/jc.2014-119124840810
   PubMed Web of Science ®Google Scholar
• LiC, HuL, XiaoJ, et al. Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 2005;287(1):86–97. doi:10.1016/j.ydbio.2005.08.03516169547
   PubMed Web of Science ®Google Scholar
• WangZ, ZhaoJ, WangT, DuX, XieJ. Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:979–994. doi:10.2147/COPD.S19579431190784
   PubMed Web of Science ®Google Scholar
• RoperC, ChubbLG, CambalL, et al. Association of IL-6 with PM2.5 components: importance of characterizing filter-based PM2.5 following extraction. Water Air Soil Pollut. 2017;228. doi:10.1007/s11270-016-3219-y
   PubMed Web of Science ®Google Scholar
• HoHY, SusmanMW, BikoffJB, et al. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012;109(11):4044–4051. doi:10.1073/pnas.120042110922343533
   PubMed Web of Science ®Google Scholar
• WangB, TangZ, GongH, ZhuL, LiuX. Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer. Biosci Rep. 2017;37(6). doi:10.1042/BSR20171092
   Web of Science ®Google Scholar
• SatoA, KayamaH, ShojimaK, et al. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis. Sci Rep. 2015;5:10536.26030277
   PubMed Web of Science ®Google Scholar
• BarberoG, CastroMV, VillanuevaMB, et al. An autocrine Wnt5a loop promotes NF-kappaB pathway activation and cytokine/chemokine secretion in melanoma. Cells. 2019;8(9):1060. doi:10.3390/cells8091060
   PubMed Web of Science ®Google Scholar
• YuT, DongD, GuanJ, SunJ, GuoM, WangQ. Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-kappaB pathway. Herz. 2019. doi:10.1007/s00059-019-4837-0
   Web of Science ®Google Scholar
• KafouryRM, KelleyJ. Ozone enhances diesel exhaust particles (DEP)-induced interleukin-8 (IL-8) gene expression in human airway epithelial cells through activation of nuclear factors- kappaB (NF-kappaB) and IL-6 (NF-IL6). Int J Environ Res Public Health. 2005;2(3–4):403–410. doi:10.3390/ijerph200503000416819095
   PubMedGoogle Scholar
• JingY, ZhangH, CaiZ, et al. Bufei Huo Xue capsule attenuates PM2.5-induced pulmonary inflammation in mice. Evid Based Complement Alternat Med. 2017;2017:1575793. doi:10.1155/2017/157579328337225
   PubMed Web of Science ®Google Scholar